Understanding the slow depletion of memory CD4+ T cells in HIV infection (2007)
Yates, A., Stark, J., Klein, N., Antia, R., Callard, R.
Background: The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4+ T cells. Why this decline is slow is not understood. One potential explanation is that...
Quantifying cell turnover using CFSE data (2005)
Ganusov, V.V., Pilyugin, S.S., Boer, R.J. De, Murali-Krishna, K., Ahmed, R., Antia, R.
The CFSE dye dilution assay is widely used to determine the number of divisions a given CFSE labelled cell has undergone in vitro and in vivo. In this paper, we consider how the data obtained with...
Epidemiological models for the spread of anti-malarial resistance (2003)
Abstract Background The spread of drug resistance is making malaria control increasingly difficult. Mathematical models for the transmission dynamics of drug sensitive and resistant strains can be a...
Boer, R.J. De, Oprea, M. (Mihaela), Antia, R. (Rustom), Murali-Krishna, K. (Kaja), Ahmed, R. (Rafi), Perelson, A.S. (Alan)
The specific CD8+ T-cell response during acute lymphocytic choriomeningitis virus (LCMV) infection of mice is characterized by a rapid proliferation phase, followed by a rapid death phase and...
Antigenic variation and the within-host dynamics of parasites.
Antia, R, Nowak, M A, Anderson, R M
Many parasites exhibit antigenic variation within their hosts. We use mathematical models to investigate the dynamical interaction between an antigenically varying parasite and the host's immune...
Mechanism of killing by virus-induced cytotoxic T lymphocytes elicited in vivo.
Welsh, R M, Nishioka, W K, Antia, R, Dundon, P L
The mechanism of lysis by in vivo-induced cytotoxic T lymphocytes (CTL) was examined with virus-specific CTL from mice infected with lymphocytic choriomeningitis virus (LCMV). LCMV-induced T cells...
Antigenic variation and the within-host dynamics of parasites.
Antia, R, Nowak, M A, Anderson, R M
Many parasites exhibit antigenic variation within their hosts. We use mathematical models to investigate the dynamical interaction between an antigenically varying parasite and the host's immune...
Mechanism of killing by virus-induced cytotoxic T lymphocytes elicited in vivo.
Welsh, R M, Nishioka, W K, Antia, R, Dundon, P L
The mechanism of lysis by in vivo-induced cytotoxic T lymphocytes (CTL) was examined with virus-specific CTL from mice infected with lymphocytic choriomeningitis virus (LCMV). LCMV-induced T cells...