R. Arnold

Publication List Details

Period

1900 - 2009

Number

222

Co-Authors

Measurement of the two neutrino double beta decay half-life of Zr-96 and search for associated neutrinoless processes with the NEMO-3 detector (2009)

Argyriades, J., Arnold, R., Augier, C., Baker, J., Barabash, A. S., Basharina-Freshville, A., ...

Using 1221 days of data from the NEMO-3 detector, the measurement of Zr-96 2vbb decay half-life is [2.35 +/- 0.14(stat) +/- 0.19(syst)] x 10^19 yr. Different characteristics of the final state...

Measurement of the background in the NEMO 3 double beta decay experiment (2009)

Argyriades, J., Arnold, R., Augier, C., Baker, J., Barabash, A. S., Bongrand, M., ...

In the double beta decay experiment NEMO 3 a precise knowledge of the background in the signal region is of outstanding importance. This article presents the methods used in NEMO 3 to evaluate the...

Measurement of the background in the NEMO 3 double beta decay experiment (2009)

Argyriades, NEMO Collaboration: J., Arnold, R., Augier, C., Baker, J., Barabash, A. S., Bongrand, M., ...

In the double beta decay experiment NEMO~3 a precise knowledge of the background in the signal region is of outstanding importance. This article presents the methods used in NEMO~3 to evaluate the...

Understanding social dysfunction in the behavioural variant of frontotemporal dementia: the role of emotion and sarcasm processing (2009)

Kipps, C. M., Nestor, P. J., Acosta-Cabronero, J., Arnold, R., Hodges, J. R.

Social interaction is profoundly affected in the behavioural form of frontotemporal dementia (bvFTD) yet there are few means of objectively assessing this. Diagnosis of bvFTD is based on informant...

Cavity BPM system tests for the ILC energy spectrometer (2008)

Slater, M., Adolphsen, C., Arnold, R., Boogert, S., Boorman, G., Gournaris, F., ...

The main physics programme of the International Linear Collider (ILC) requires a measurement of the beam energy at the interaction point with an accuracy of 10-4 or better. To achieve this goal a...

A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16 (2008)

Asherson, P., Zhou, K., Anney, R.J.L., Franke, B., Buitelaar, J., Ebstein, R., ...

As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth...

DSM-IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage (2008)

Chen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., ...

Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments....

Cavity BPM System Tests for the ILC Spectrometer (2007)

Slater, M., Adolphsen, C., Arnold, R., Boogert, S., Boorman, G., Gournaris, F., ...

The main physics programme of the International Linear Collider (ILC) requires a measurement of the beam energy at the interaction point with an accuracy of $10^{-4}$ or better. To achieve this goal...

Advanced Altitude Simulation P8 - Current Status (2007)

Schäfer, Klaus, Zimmermann, Herbert, Schmidt, Volker, Stark, Ralf, Suslov, Dmitry, Arnold, R.

To meet the challenges for the altitude simulation techniques like the development of advanced nozzle designs a project Advanced Altitude Simulation P8, AAS–P8 has started. The objective is to...

Limits on different Majoron decay modes of $^{100}$Mo and $^{82}$Se for neutrinoless double beta decays in the NEMO-3 experiment (2007)

Arnold, R., Augier, C., Baker, J., Barabash, A.S., Brudanin, V., Caffrey, A.J., ...

The NEMO-3 tracking detector is located in the Fr\'ejus Underground Laboratory. It was designed to study double beta decay in a number of different isotopes. Presented here are the experimental...

Design of the beam delivery system for the International Linear Collider (2007)

Seryi, A., Amann, J., Arnold, R., Asiri, F., Bane, K., Bellomo, P., ...

The beam delivery system for the linear collider focuses beams to nanometer sizes at its interaction point, collimates the beam halo to provide acceptable background in the detector and has a...

Design of the beam delivery system for the International Linear Collider (2007)

Seryi, A., Amann, J., Arnold, R., Asiri, F., Bane, K., Bellomo, P., ...

The beam delivery system for the linear collider focuses beams to nanometer sizes at its interaction point, collimates the beam halo to provide acceptable background in the detector and has a...

Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes (2007)

Brenner, D., Golks, A., Becker, M., Muller, W., Frey, C. R., Novak, R., ...

Life and death of peripheral lymphocytes is strictly controlled to maintain physiologic levels of T and B cells. Activation-induced cell death (AICD) is one mechanism to delete superfluous...

Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation (2007)

Arnold, R., Frey, C. R., Muller, W., Brenner, D., Krammer, P. H., Kiefer, F.

We studied monocytic differentiation of primary mouse progenitor cells to understand molecular mechanisms of differentiation. We found a tightly controlled non-apoptotic activation of caspase-3 that...

Design of the beam delivery system for the International Linear Collider (2007)

Seryi, A., Amann, J., Arnold, R., Asiri, F., Bane, K., Bellomo, P., ...

The beam delivery system for the linear collider focuses beams to nanometer sizes at its interaction point, collimates the beam halo to provide acceptable background in the detector and has a...

Electromagnetic background tests for the ILC interaction-point feedback system (2007)

Burrows, PN, Christian, G, Clarke, C, Constance, B, Dabiri Khah, H, Hartin, T, ...

We present results obtained with the T-488 experiment at SLAC Endstation A (ESA). A material model of the ILC extraction-line design was assembled and installed in ESA. The module includes materials...

Simulation of ILC feedback BPM signals in an intense background environment (2007)

Hartin, A, Burrows, PN, Christian, G, Clarke, C, Constance, B, Khah, H, ...

Experiment T-488 at SLAC, End Station A recorded distorted BPM voltage signals and an accurate simulation of these signals was performed. Geant simulations provided the energy and momentum spectrum...

Bone-marrow-derived cells for cardiac stem cell therapy: safe or still under scrutiny? (2007)

Bartunek, J., Vanderheyden, M., Wijns, W., TIMMERMANS, FRANK, Vandekerckhove, Bart, Villa, A., ...

Cardiac stem cell therapy with bone-marrow-derived stem cells is a promising approach to facilitate myocardial regeneration after acute myocardial infarction or in congestive heart failure. The...

Measurement of double beta decay of 100Mo to excited states in the NEMO 3 experiment (2006)

Arnold, R., Augier, C., Baker, J., Barabash, A. S., Bongrand, M., Broudin, G., ...

The double beta decay of 100Mo to the 0^+_1 and 2^+_1 excited states of 100Ru is studied using the NEMO 3 data. After the analysis of 8024 h of data the half-life for the two-neutrino double beta...

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes (2006)

Brookes, K, Xu, X, Chen, W, Zhou, K, Neale, B, Lowe, N, ...

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies...

Technical design and performance of the NEMO 3 detector (2006)

Arnold, R., Augier, C., Baker, J., Barabash, A., Bernaudin, Ph., Bouchel, M., ...

The development of the NEMO3 detector, which is now running in the Frejus Underground Laboratory (L.S.M. Laboratoire Souterrain de Modane), was begun more than ten years ago. The NEMO3 detector uses...

Liquid Hydrogen Target Experience at SLAC (2006)

Arnold, R., Bosted, P., Boyce, R., Candia, A., Gao, J., ...

Liquid hydrogen targets have played a vital role in the physics program at SLAC for the past 40 years. These targets have ranged from small "beer can" targets to the 1.5 m long E158 target that was...

First results of the search for neutrinoless double beta decay with the NEMO 3 detector (2006)

Arnold, R., Augier, C., Baker, J., Barabash, A., Broudin, G., Brudanin, V., ...

The NEMO 3 detector, which has been operating in the Frejus underground laboratory since February 2003, is devoted to the search for neutrinoless double beta decay ($\beta\beta0\nu$). Half-lives of...

Possible background reductions in double beta decay experiments (2006)

Arnold, R., Augier, C., Baker, J., Barabash, A.S., Bing, O., Brudanin, V., ...

The background induced by radioactive impurities of $^{208}\rm Tl$ and $^{214}\rm Bi$ in the source of the double beta experiment NEMO-3 has been investigated. New methods of data analysis which...

Limits on different Majoron decay modes of $^{100}$Mo and $^{82}$Se for neutrinoless double beta decays in the NEMO-3 experiment (2006)

Arnold, R.

The NEMO-3 tracking detector is located in the Fr\'ejus Underground Laboratory. It was designed to study double beta decay in a number of different isotopes. Presented here are the experimental...

Evidence-based treatment and quality of life in heart failure (2006)

Dobre, D., Ranchor, A.V., Arnold, R., Haaijer-Ruskamp, F.M.

To explore whether prescription of evidence-based drug therapy is associated with better quality of life (QoL) in patients with heart failure (HF). Patients (n = 62) were recruited in the outpatient...

Changes in personal control as a predictor of quality of life after pulmonary rehabilitation (2006)

Arnold, R., Ranchor, A.V., Koëter, G.H., Wempe, J.B., ...

Objective: Perceptions of mastery and self-efficacy may be related to better outcomes in pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). This study examined...

Evidence-based treatment and quality of life in heart failure (2006)

Dobre, D., Ranchor, A.V., Arnold, R., Haaijer-Ruskamp, F.M.

To explore whether prescription of evidence-based drug therapy is associated with better quality of life (QoL) in patients with heart failure (HF). Patients (n = 62) were recruited in the outpatient...

Changes in personal control as a predictor of quality of life after pulmonary rehabilitation (2006)

Arnold, R., Ranchor, A.V., Koëter, G.H., Wempe, J.B., ...

Objective: Perceptions of mastery and self-efficacy may be related to better outcomes in pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). This study examined...

Radial velocities in the globular cluster omega Centauri (2006)

Reijns, R. A., Seitzer, P., Arnold, R., Freeman, K. C., Ingerson, T., ...

We have used the ARGUS multi-object spectrometer at the CTIO 4 m Blanco telescope to obtain 2756 radial velocity measurements for 1966 individual stars in the globular cluster omega Centauri brighter...

Prognostic value of N-terminal pro-B-type natriuretic peptide for conservatively and surgically treated patients with aortic valve stenosis (2006)

Weber, M., Hausen, M., Arnold, R., Nef, H., Moellman, H., Berkowitsch, A., ...

OBJECTIVE: To evaluate the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with aortic stenosis being treated conservatively or undergoing aortic valve...

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes (2006)

Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., ...

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies...

First results of the search for neutrinoless double-beta decay with the NEMO 3 detector (2005)

Arnold, R., Augier, C., Baker, J., Barrabash, A., Broudin, G., Brudanin, V., ...

The NEMO 3 detector, which has been operating in the Frejus underground laboratory since February 2003, is devoted to the search for neutrinoless double beta decay (bb0nu). Half-lives of the two...

Radial velocities in the globular cluster omega Centauri (2005)

Reijns, R. A., Seitzer, P., Arnold, R., Freeman, K. C., Ingerson, T., ...

We have used the ARGUS multi-object spectrometer at the CTIO 4m Blanco telescope to obtain 2756 radial velocity measurements for 1966 individual stars in the globular cluster omega Centauri brighter...

A Test Facility for the International Linear Collider at SLAC End Station A, for Prototypes of Beam Delivery and IR Components (2005)

Woods, M., Erickson, R., Frisch, J., Hast, C., Jobe, R. K., Keller, L., ...

The SLAC Linac can deliver damped bunches with ILC parameters for bunch charge and bunch length to End Station A. A 10Hz beam at 28.5 GeV energy can be delivered there, parasitic with PEP-II...

The relationship between self-efficacy and self-reported physical functioning in chronic obstructive pulmonary disease and chronic heart failure (2005)

Arnold, R., Ranchor, A.V., DeJongste, M.J., Koëter, G.H., Ten Hacken, N.H., Aalbers, R., ...

In this study, the authors investigated whether self-reported physical functioning of patients with chronic obstructive pulmonary disease (COPD) and chronic systolic heart failure (CHF) was primarily...

Consequences of chronic obstructive pulmonary disease and chronic heart failure: The relationship between objective and subjective health (2005)

Arnold, R., Ranchor, A.V., Koëter, G.H., De Jongste, M.J., Sanderman, R.

This study investigates whether the relationship between objective health parameters and general health perceptions was mediated by symptoms of dyspnoea and physical functioning in patients with...

The relationship between self-efficacy and self-reported physical functioning in chronic obstructive pulmonary disease and chronic heart failure (2005)

Arnold, R., Ranchor, A.V., DeJongste, M.J., Koëter, G.H., Ten Hacken, N.H., Aalbers, R., ...

In this study, the authors investigated whether self-reported physical functioning of patients with chronic obstructive pulmonary disease (COPD) and chronic systolic heart failure (CHF) was primarily...

Consequences of chronic obstructive pulmonary disease and chronic heart failure: The relationship between objective and subjective health (2005)

Arnold, R., Ranchor, A.V., Koëter, G.H., De Jongste, M.J., Sanderman, R.

This study investigates whether the relationship between objective health parameters and general health perceptions was mediated by symptoms of dyspnoea and physical functioning in patients with...

Study of 2β-decay of 100Mo and 82Se using the NEMO3 detector (2004)

Arnold, R., Augier, C., Baker, J., Barabash, A., Brudanin, V., Caffrey, A.J., ...

After analysis of 5797 h of data from the detector NEMO3, new limits on neutrinoless double beta decay of Mo-100 (T_{1/2} > 3.1 10^{23} y, 90% CL) and Se-82 (T_{1/2} > 1.4 10^{23} y, 90% CL) have...

The relative contribution of domains of quality of life to overall quality of life for different chronic diseases (2004)

Arnold, R., Ranchor, A.V., Sanderman, R., Ormel, J.

This study examined the contribution of the quality of life (QoL) domains physical, social and psychological functioning to the explanation of overall QoL. Various disorders may differentially affect...

The relative contribution of domains of quality of life to overall quality of life for different chronic diseases (2004)

Arnold, R., Ranchor, A.V., Sanderman, R., Ormel, J.

This study examined the contribution of the quality of life (QoL) domains physical, social and psychological functioning to the explanation of overall QoL. Various disorders may differentially affect...

MIPS: analysis and annotation of proteins from whole genomes (2004)

Mewes, H. W., Amid, C., Arnold, R., Frishman, D., Güldener, U., Mannhaupt, G., ...

The Munich Information Center for Protein Sequences (MIPS‐GSF), Neuherberg, Germany, provides protein sequence‐related information based on whole‐genome analysis. The main focus of the...

Possible background reductions in double beta decay experiments (2003)

Arnold, R., Augier, C., Baker, J., Barabash, A., Bing, O., Brudanin, V., ...

The background induced by radioactive impurities of $^{208}\rm Tl$ and $^{214}\rm Bi$ in the source of the double beta experiment NEMO-3 has been investigated. New methods of data analysis which...

Signal transduction and co-stimulatory pathways (2002)

Kiefer, F., Vogel, W. F., Arnold, R.

Using specific cell surface receptors lymphocytes continuously sample their environment. Maturation of the immune system and initiation of a specific immune response rely on an array of extracellular...

DNA bending by the silencer protein NeP1 is modulated by TR and RXR. (1996)

Arnold, R, Burcin, M, Kaiser, Bruno, Muller, Marc, Renkawitz, R

NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing...

Measurements of the proton elastic form factors for 1≤Q^2≤3 (GeV/c)^2 at SLAC (1994)

Walker, R. C., Filippone, B. W., Jourdan, J., Milner, R., McKeown, R., Potterveld, D., ...

We report measurements of the proton form factors GEp and GMp extracted from elastic scattering in the range 1≤Q^2≤3 (GeV/c)^2 with total uncertainties < 15% in GEp and < 3% in GMp. Comparisons...

Distributing and Maintaining Knowledge: Agents in Variable Structure Environments (1994)

A. M. Uhrmacher, R. Arnold

The maintaining and adaptation of knowledge within changing environments is one of the crucial aspects in decentralized controlled and distributed systems. To explore different strategies and their...

Release of tryptophan and serotonin into the portal vein of the isolated perfused rat small intestine (1989)

Herrmann, C., Richter, Gerd, Arnold, R., Göke, B.

To investigate the release of serotonin from intestinal enterochromaffin cells, we used an in vitro technique which allows studies excluding overlapping influences from outside the gut. The entire...

COOLING OF INTENSE HEAVY-ION BEAMS BY COLLISIONAL-RADIATIVE PROCESSES (1988)

Arnold, R.

Intra-beam (ion-ion) collisions cause electronic excitations in partially stripped beam ions. De-excitation photons carry energy out of the beam, resulting in cooling of the beam kinetic temperature....

THERMAL CONVERSION EFFICIENCY FOR HEAVY-ION BEAM HEATED CYLINDERS (1988)

Tahir, N., Arnold, R.

Based on a parameter study of radiation transport in homogeneous cylindrical targets, we have developed a formula which approximately represents the conversion efficiency of deposited energy into...

Experimental observation of enhanced stopping of heavy ions in a hydrogen plasma (1988)

Hoffmann, D.H.H., Weyrich, K., Wahl, H., Peter, T., Jacoby, J., ...

Enhanced energy loss of 333 MeV(238) U ions in a hydrogen discharge plasma with a high degree of ionization has been observed. The ion stopping in a plasma environment exceeds the stopping in cold...

COOLING OF INTENSE HEAVY-ION BEAMS BY COLLISIONAL-RADIATIVE PROCESSES (1988)

Arnold, R.

Intra-beam (ion-ion) collisions cause electronic excitations in partially stripped beam ions. De-excitation photons carry energy out of the beam, resulting in cooling of the beam kinetic temperature....

THERMAL CONVERSION EFFICIENCY FOR HEAVY-ION BEAM HEATED CYLINDERS (1988)

Tahir, N., Arnold, R.

Based on a parameter study of radiation transport in homogeneous cylindrical targets, we have developed a formula which approximately represents the conversion efficiency of deposited energy into...

COOLING OF INTENSE HEAVY-ION BEAMS BY COLLISIONAL-RADIATIVE PROCESSES (1988)

Arnold, R.

Intra-beam (ion-ion) collisions cause electronic excitations in partially stripped beam ions. De-excitation photons carry energy out of the beam, resulting in cooling of the beam kinetic temperature....

THERMAL CONVERSION EFFICIENCY FOR HEAVY-ION BEAM HEATED CYLINDERS (1988)

Tahir, N., Arnold, R.

Based on a parameter study of radiation transport in homogeneous cylindrical targets, we have developed a formula which approximately represents the conversion efficiency of deposited energy into...

Search for short-lived axions in an electron-beam-dump experiment (1987)

Riordan, E. M., Krasny, M. W., Lang, K., De Barbaro, P., Bodek, A., Dasu, S., ...

We report results of an electron-beam-dump search for neutral particles with masses in the range 1 to 15 MeV and lifetimes τ between 10^-14 and 10^-10 s. No evidence was found for such an object. We...

Chromosome studies in patients with acute nonlymphocytic or acute lymphocytic leukemia submitted to bone marrow transplantation--results of a European cooperative study (1987)

Rosti, G, Testoni, N, Arnold, R, Bandini, G, Becher, R, ...

The chromosomal data of 58 acute nonlymphocytic leukemia (ANLL) patients and of 32 acute lymphocytic leukemia (ALL) patients submitted to bone marrow transplantation and collected from nine...

ASSESSMENT OF THE DATEX RELAXOGRAPH DURING ANAESTHESIA AND ATRACURIUM-INDUCED NEUROMUSCULAR BLOCKADE (1986)

CARTER, J. A., ARNOLD, R., YATE, P. M., FLYNN, P. J.

The Datex Relaxograph is a recently introduced electromyographic monitor of neuromuscular transmission. It has been assessed in patients requiring neuromuscular blockade and the results compared with...

HEAVY ION BEAM HEATED CYLINDERS : PLANNING FOR HOT DENSE MATTER EXPERIMENTS AT GSI (1983)

Arnold, R.

Stopping power calculations for heavy ions of 1-100 GeV energy and results of 1D and 2D simulations of stretched target cylinders heated by intense heavy ion beams are presented. Plans to perform...

HEAVY ION BEAM HEATED CYLINDERS : PLANNING FOR HOT DENSE MATTER EXPERIMENTS AT GSI (1983)

Arnold, R.

Stopping power calculations for heavy ions of 1-100 GeV energy and results of 1D and 2D simulations of stretched target cylinders heated by intense heavy ion beams are presented. Plans to perform...

HEAVY ION BEAM HEATED CYLINDERS : PLANNING FOR HOT DENSE MATTER EXPERIMENTS AT GSI (1983)

Arnold, R.

Stopping power calculations for heavy ions of 1-100 GeV energy and results of 1D and 2D simulations of stretched target cylinders heated by intense heavy ion beams are presented. Plans to perform...

Mesure de l'énergie d'électrons dans une chambre à bulles (1969)

Bugadov, Y., Vénus, W., Arnold, R.

Une calibration réalisée à l'aide de photons issus de désintégrations de pions neutres dans un volume limité de fréon a permis d'obtenir une relation entre l'énergie d'un électron et la...

Mesure de l'énergie d'électrons dans une chambre à bulles (1969)

Bugadov, Y., Vénus, W., Arnold, R.

Une calibration réalisée à l'aide de photons issus de désintégrations de pions neutres dans un volume limité de fréon a permis d'obtenir une relation entre l'énergie d'un électron et la...

Mesure de l'énergie d'électrons dans une chambre à bulles (1969)

Bugadov, Y., Vénus, W., Arnold, R.

Une calibration réalisée à l'aide de photons issus de désintégrations de pions neutres dans un volume limité de fréon a permis d'obtenir une relation entre l'énergie d'un électron et la...

Mesure de l'énergie d'électrons dans une chambre à bulles (1969)

Bugadov, Y., Vénus, W., Arnold, R.

Une calibration réalisée à l'aide de photons issus de désintégrations de pions neutres dans un volume limité de fréon a permis d'obtenir une relation entre l'énergie d'un électron et la...

National Academy of Sciences. Biographical Memoirs, VOLUME 87 PUBLISHED 2005 BY THE NATIONAL ACADEMIES PRESS (1909)

Hans E. Suess, Heinrich Waenke, R. Arnold, Hans E. Suess, ...

Any opinions expressed in this memoir are those of the authors and do not necessarily reflect the views of the

DNA bending by the silencer protein NeP1 is modulated by TR and RXR.

Arnold, R, Burcin, M, Kaiser, B, Muller, M, Renkawitz, R

NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing...

Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF.

Burcin, M, Arnold, R, Lutz, M, Kaiser, B, Runge, D, Lottspeich, F, ...

The transcriptional repressor negative protein 1 (NeP1) binds specifically to the F1 element of the chicken lysozyme gene silencer and mediates synergistic repression by v-ERBA, thyroid hormone...

Effects of Listeria monocytogenes and Yersinia enterocolitica on cytokine gene expression and release from human polymorphonuclear granulocytes and epithelial (HEp-2) cells.

Arnold, R, Scheffer, J, König, B, König, W

The gene expression and cytokine release of the proinflammatory cytokines interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha (TNF-alpha) after infection of human epithelial cells...

A randomized trial of roxithromycin in patients with acute leukemia and bone marrow transplant recipients receiving fluoroquinolone prophylaxis.

Kern, W V, Hay, B, Kern, P, Marre, R, Arnold, R

Fluoroquinolone prophylaxis in patients with profound neutropenia may be useful for preventing gram-negative bacterial infection, but it is ineffective against gram-positive bacterial infections in...

MIPS: analysis and annotation of proteins from whole genomes

Mewes, H. W., Amid, C., Arnold, R., Frishman, D., Güldener, U., Mannhaupt, G., ...

The Munich Information Center for Protein Sequences (MIPS-GSF), Neuherberg, Germany, provides protein sequence-related information based on whole-genome analysis. The main focus of the work is...

Inhibition of dental plaque acid production by the salivary lactoperoxidase antimicrobial system.

Tenovuo, J, Mansson-Rahemtulla, B, Pruitt, K M, Arnold, R

Resting human whole saliva inhibited acid production by glucose-stimulated, homologous plaque. The degree of inhibition of plaque acid production correlated positively with the concentration of...

Lactoperoxidase binding to streptococci.

Pruitt, K M, Adamson, M, Arnold, R

There have been conflicting reports regarding the binding of lactoperoxidase to bacterial cell surfaces. We describe here the effects of cell-bound lactoperoxidase on acid production by suspensions...

Gastric emptying and release of incretin hormones after glucose ingestion in humans.

Schirra, J, Katschinski, M, Weidmann, C, Schäfer, T, Wank, U, Arnold, R, ...

This study investigated in eight healthy male volunteers (a) the gastric emptying pattern of 50 and 100 grams of glucose; (b) its relation to the phase of interdigestive motility (phase I or II)...

Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.

Schirra, J, Sturm, K, Leicht, P, Arnold, R, Göke, B, Katschinski, M

The gastrointestinal hormone, glucagon-like peptide-1(7-36)amide (GLP-1) is released after a meal. The potency of synthetic GLP-1 in stimulating insulin secretion and in inhibiting glucagon secretion...

Preoperative localization of gastrointestinal endocrine tumors using somatostatin-receptor scintigraphy.

Weinel, R J, Neuhaus, C, Stapp, J, Klotter, H J, Trautmann, M E, Joseph, K, ...

OBJECTIVE: The purpose of this study was to determine the value of somatostatin-receptor scintigraphy (SRS) in the preoperative localization of gastrointestinal endocrine tumors. The authors report...

Cytokine (IL-8, IL-6, TNF-alpha) and soluble TNF receptor-I release from human peripheral blood mononuclear cells after respiratory syncytial virus infection.

Arnold, R, König, B, Galatti, H, Werchau, H, König, W

During the initial phase of respiratory syncytial virus (RSV) infection, when a low virus-cell ratio is most probable, signs of inflammation are detectable in the infected respiratory tissue....

Effect of respiratory syncytial virus-antibody complexes on cytokine (IL-8, IL-6, TNF-alpha) release and respiratory burst in human granulocytes.

Arnold, R, Werner, F, Humbert, B, Werchau, H, König, W

The release of interleukin-8 (IL-8), IL-6, and tumour necrosis factor-alpha (TNF-alpha) from human polymorphonuclear granulocytes (PMN) after exposure to infectious respiratory syncytial virus (RSV)...

Interleukin-8, interleukin-6, and soluble tumour necrosis factor receptor type I release from a human pulmonary epithelial cell line (A549) exposed to respiratory syncytial virus.

Arnold, R, Humbert, B, Werchau, H, Gallati, H, König, W

The release of interleukin-8 (IL-8), interleukin-6 (IL-6) and the soluble forms of the tumour necrosis factor receptor (sTNF-R) from human pulmonary type II-like epithelial cells (A549) after...

Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease

Binks, M, Passweg, J, Furst, D, McSweeney, P, Sullivan, K, Besenthal, C, ...

BACKGROUND—Systemic sclerosis (SSc, scleroderma) in either its diffuse or limited skin forms has a high mortality when vital organs are affected. No treatment has been shown to influence the...

Prospective multicentre study of risk factors associated with delayed healing of recurrent duodenal ulcers (RUDER). RUDER Study Group.

Armstrong, D, Arnold, R, Classen, M, Fischer, M, Goebell, H, Blum, A L

Risk factors for delayed duodenal ulcer healing during treatment with ranitidine (300 mg daily) were examined in a multicentre German study of 1923 patients with endoscopically proved, recurrent...

Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumours.

Arnold, R, Trautmann, M E, Creutzfeldt, W, Benning, R, Benning, M, Neuhaus, C, ...

Antiproliferative treatment of patients with metastatic endocrine gastroenteropancreatic tumours (GEP) is based mainly on chemotherapeutic protocols whereby drug toxicity is a major handicap....

Mucosal gastrin concentration, molecular forms of gastrin, number and ultrastructure of G-cells in patients with duodenal ulcer.

Creutzfeldt, W, Arnold, R, Creutzfeldt, C, Track, N S

The mean antral immunoreactive gastrin (IRG) concentration of 38 duodenal ulcer (DU) patients was significantly higher (35-9+/-5-2 mug/g) than that of 21 controls (15-9+/-2-6 mug/g). Also the mean...

Lowering of fasting and food stimulated serum immunoreactive gastric inhibitory polypeptide (GIP) by glucagon.

Ebert, R, Arnold, R, Creutzfeldt, W

The effect of intravenous glucagon infusion on serum levels of immunoreactive GIP (IR-GIP), insulin (IRI), gastrin (IRG), and on blood glucose has been investigated in six healthy volunteers in the...

Gastrointestinal somatostatin: extraction and radioimmunoassay in different species.

McIntosh, C, Arnold, R, Bothe, E, Becker, H, Köbberling, J, Creutzfeldt, W

A radioimmunoassay capable of detecting 300 fg somatostatin has been developed and levels of the polypeptide in gastrointestinal tissues from man, dog, and rat have been measured. Rapid freezing of...

Antral gastrin-producing G-cells and somatostatin-producing D-cells in different states of gastric acid secretion.

Arnold, R, Hülst, M V, Neuhof, C H, Schwarting, H, Becker, H D, Creutzfeldt, W

The number of G- and D-cells per area and the ratio of G/D-cells were investigated in biopsy specimens of the pyloric antrum from normochlorhydric subjects without peptic ulcer, from patients with...

Effect of pancreatic atrophy and hypertrophy on the small intestine.

Adler, G, Hausmann, W, Elsebach, K, Goke, B, Lorenz-Meyer, H, Herberg, L, ...

Intestinal enzyme activities were investigated in mice with spontaneously occurring exocrine pancreatic insufficiency (EPI), in rats after induction of pancreatic insufficiency by intraductal...

Tryptophan rich diet as a new approach to study the serotoninergic enteropancreatic axis.

Goke, B, Richter, G, Keim, V, Arnold, R

The influence of a tryptophan enriched diet (L-tryptophan added as 1% of total diet), fed over 10 days, on the rat duodenum and pancreas was studied by immunohistology, measurements of serotonin and...

Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans

Schirra, J, Houck, P, Wank, U, Arnold, R, Goke, B, Katschinski, M

BACKGROUND—Glucagon-like peptide-1(7-36)amide (GLP-1) is a gut hormone released postprandially. Synthetic GLP-1 strongly inhibits gastric emptying in healthy subjects and in patients with diabetes...

Short course acid suppressive treatment for patients with functional dyspepsia: results depend on Helicobacter pylori status

Blum, A, Arnold, R, Stolte, M, Fischer, M, Koelz, H, The, F

BACKGROUND AND AIMS—Treatment of functional dyspepsia with acid inhibitors is controversial and it is not known if the presence of Helicobacter pylori infection influences the...

Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype specific antibodies

Kulaksiz, H, Eissele, R, Rössler, D, Schulz, S, Höllt, V, Cetin, Y, ...

Background and aims: Recently, novel somatostatin receptor (sstr) subtype specific ligand analogues have been developed for medical treatment of neuroendocrine tumours expressing different sstrs...

Effects of glucagon-like peptide-1(7–36)amide on motility and sensation of the proximal stomach in humans

Schirra, J, Wank, U, Arnold, R, Göke, B, Katschinski, M

Background: Glucagon-like peptide-1(7–36)amide (GLP-1) retards gastric emptying, reduces food intake, and inhibits antroduodenal and stimulates pyloric motility.

Treatment of Helicobacter pylori in functional dyspepsia resistant to conventional management: a double blind randomised trial with a six month follow up

Koelz, H R, Arnold, R, Stolte, M, Fischer, M, Blum, A L

Background: Previous studies on the treatment of Helicobacter pylori infection in functional dyspepsia have shown little, if any, effect on dyspeptic symptoms. However, whether such treatment might...

Immunoreactivity and expression of amylin in gastroenteropancreatic endocrine tumors.

Eissele, R., Neuhaus, C., Trautmann, M. E., Funk, A., Arnold, R., Höfler, H.

Amylin was isolated from human insulinomas, but there has been only preliminary data regarding whether this peptide can also be detected in other types of gastroenteropancreatic endocrine tumors. In...

Fate of infants with transposition of the great arteries in relation to balloon atrial septostomy.

Powell, T G, Dewey, M, West, C R, Arnold, R

The palliation afforded by balloon atrial septostomy to 124 infants with transposition of the great arteries was assessed in terms of survival to 6 months of age without the need for further...

Ventricular septal defect in children born in Liverpool 1960 to 1969. Evaluation of natural course and surgical implications in an unselected population.

Dickinson, D F, Arnold, R, Wilkinson, J L

We have reviewed data on all patients born between 1960 and 1969 and registered in the Liverpool Registry of Congenital Malformations as having congenital heart disease. There were 385 with a...

Congenital heart disease among 160 480 liveborn children in Liverpool 1960 to 1969. Implications for surgical treatment.

Dickinson, D F, Arnold, R, Wilkinson, J L

Among 160 480 children born alive between 1960 and 1969 in Liverpool, 884 patients with structural congenital heart disease were identified. Data on these patients have been reviewed in order to...

'Posterior' transposition reconsidered.

Wilkinson, J L, Arnold, R, Anderson, R H, Acerete, F

Seven cases of transposition with an unusually posterior aorta and mitral-aortic fibrous continuity are described. The cases are similar to four cases published by Van Praagh et al. in 1971. The use...

Prognosis of supravalve aortic stenosis in 81 patients in Liverpool (1960-1993).

Kitchiner, D., Jackson, M., Walsh, K., Peart, I., Arnold, R.

OBJECTIVE: To determine the prognosis of supravalve aortic stenosis into early adult life and the factors affecting this prognosis. DESIGN: 81 patients with supravalve aortic stenosis were followed...

Transcatheter occlusion of the patent ductus arteriosus with Cook detachable coils.

Tometzki, A. J., Arnold, R., Peart, I., Sreeram, N., Abdulhamed, J. M., Godman, M. J., ...

OBJECTIVE: To report initial experience with a new occlusion device for native and residual patent ductus arteriosus. DESIGN: Descriptive study of consecutive non-randomised patients undergoing a new...

Doppler echocardiographic evaluation of pulmonary artery flow after modified Fontan operation: importance of atrial contraction.

Qureshi, S A, Richheimer, R, McKay, R, Arnold, R

Doppler echocardiography was used to evaluate blood flow in the pulmonary artery in 14 patients 2 to 42 months (mean (SD) 17 (12) months) after a modified Fontan operation incorporating a direct...

Incidence and prognosis of congenital aortic valve stenosis in Liverpool (1960-1990).

Kitchiner, D J, Jackson, M, Walsh, K, Peart, I, Arnold, R

OBJECTIVE--To determine the incidence and prognosis of congenital aortic valve stenosis in the five Health Districts of Liverpool that make up the Merseyside area. DESIGN--The records of the...

Arterial duct angioplasty as an adjunct to dilatation of the valve for critical pulmonary stenosis.

Walsh, K P, Abrams, S E, Arnold, R

OBJECTIVE--To assess the efficacy of arterial duct angioplasty in maintaining adequate ductal patency in neonates with critical pulmonary valve stenosis. PATIENTS--Two neonates presenting with...

Incidence and prognosis of obstruction of the left ventricular outflow tract in Liverpool (1960-91): a study of 313 patients.

Kitchiner, D., Jackson, M., Malaiya, N., Walsh, K., Peart, I., Arnold, R.

OBJECTIVE--To determine the incidence of the various types of obstruction of the left ventricular outflow tract in patients born in the five health districts of Liverpool and to compare their...

Morphology of left ventricular outflow tract structures in patients with subaortic stenosis and a ventricular septal defect.

Kitchiner, D, Jackson, M, Malaiya, N, Walsh, K, Peart, I, Arnold, R, ...

OBJECTIVE--To compare the incidence and prognosis of subaortic stenosis associated with a ventricular septal defect and to define the morphological basis of subaortic stenosis. DESIGN--Presentation...

Balloon dilatation of the pulmonary valve in the first year of life in patients with tetralogy of Fallot: a preliminary study.

Qureshi, S A, Kirk, C R, Lamb, R K, Arnold, R, Wilkinson, J L

Fifteen infants with tetralogy of Fallot, who would otherwise have required a palliative operation, underwent balloon dilatation of the right ventricular outflow tract. The mean period of palliation...

Operative findings after percutaneous pulmonary balloon dilatation of the right ventricular outflow tract in tetralogy of Fallot.

Battistessa, S A, Robles, A, Jackson, M, Miyamoto, S, Arnold, R, McKay, R

Since 1983 percutaneous balloon dilatation of the right ventricular outflow tract has been performed as an alternative to surgical palliation in selected cases of tetralogy of Fallot at the Royal...

Balloon expandable stents for systemic venous pathway stenosis late after Mustard's operation

Bu'Lock, F, Tometzki, A, Kitchiner, D, Arnold, R, Peart, I, Walsh, K

Objectives—Description and evaluation of current experience with the use of balloon expandable stents for the relief of systemic venous pathway stenosis late after Mustard's...

Occlusion of Fontan fenestrations using the Amplatzer septal occluder

Tofeig, M, Walsh, K, Chan, C, Ladusans, E, Gladman, G, Arnold, R

Objective—To evaluate the efficacy and safety of the Amplatzer septal occluder device for occlusion of Fontan fenestrations.
Subjects—Five children aged 5-10 years who had undergone a...

Transcatheter occlusion of a post-Fontan residual hepatic vein to pulmonary venous atrium communication using the Amplatzer septal occluder

Tofeig, M, Walsh, K, Arnold, R

A residual hepatic vein to left atrial communication may result in progressive cyanosis after the Fontan procedure. This problem has usually been treated surgically by ligation or re-inclusion of the...

Autologous stem cell transplantation in the treatment of systemic sclerosis: report from the EBMT/EULAR Registry

Farge, D, Passweg, J, Van Laar, J M, Marjanovic, Z, Besenthal, C, Finke, J, ...

Objective: To analyse the durability of the responses after haematopoietic stem cell transplantation (HSCT) for severe systemic sclerosis (SSc) and determine whether the high transplant related...

Risk of mortality, cancer incidence, and stroke in a population potentially exposed to cadmium

Elliott, P., Arnold, R., Cockings, S., Eaton, N., Jarup, L., Jones, J., ...

OBJECTIVES—To follow up mortality and cancer incidence in a cohort potentially exposed to cadmium and to perform a geographical (ecological) analysis to further assess the health effects of...

Clinical lead poisoning in England: an analysis of routine sources of data

Elliott, P., Arnold, R., Barltrop, D., Thornton, I., House, I. M., Henry, J. A.

OBJECTIVE: To examine the occurrence of clinical lead poisoning in England based on routine sources of data. METHODS: Three routine data sources were examined, over different periods according to...

Outcome of treatment for neonates referred to a supraregional cardiac centre 1976-78.

Dickinson, D F, Arnold, R, Wilkinson, J L

The clinical course and outcome of treatment for 322 consecutive neonates referred to a supraregional paediatric cardiac unit are reviewed. Two hundred and forty-eight (77%) had structural congenital...

Necrotising enterocolitis after neonatal cardiac catheterisation

Dickinson, D F, Galloway, R W, Wilkinson, J L, Arnold, R

Evidence of necrotising enterocolitis was found in 14 of 111 neonatal cardiac catheterisations. A close temporal relationship between investigation and the onset of necrotising enterocolitis was...

Pulmonary artery growth during treatment with oral prostaglandin E2 in ductus dependent cyanotic congenital heart disease.

MacMahon, P, Gorham, P F, Arnold, R, Wilkinson, J L, Hamilton, D I

Growth of the pulmonary arteries was assessed in 11 patients with cyanotic congenital heart disease treated with oral prostaglandin E2. Each patient was dependent on patency of the ductus arteriosus...

Asystole in the prolonged QT syndrome.

Rennie, J M, Arnold, R

We report a 4 1/2 year old boy with the Romano-Ward syndrome in whom an asystolic period of 18 seconds duration followed an episode of ventricular tachycardia. Treatment with propranolol and...