Belshe, R. B., Newman, F. K., Anderson, E. L., Wright, P. F., Karron, R. A., Tollefson, S., ...
© 2004 by the Infectious Diseases Society of America. All rights reserved.
Belshe, R. B., Newman, F. K., Tsai, T. F., Karron, R. A., Reisinger, K., Roberton, Donal Muir, ...
© 2004 by the Infectious Diseases Society of America. All rights reserved.
Belshe, R. B., Newman, F. K., Anderson, E. L., Wright, P. F., Karron, R. A., Tollefson, S., ...
© 2004 by the Infectious Diseases Society of America. All rights reserved.
Belshe, R. B., Newman, F. K., Tsai, T. F., Karron, R. A., Reisinger, K., Roberton, Donal Muir, ...
© 2004 by the Infectious Diseases Society of America. All rights reserved.
Gorse, G J, Patel, G B, Newman, F K, Belshe, R B, Berman, P W, Gregory, T J, ...
The ability of antibody induced by MN and IIIB recombinant gp120 (rgp120) human immunodeficiency virus type 1 (HIV-1) vaccines the bind to oligomeric native and monomeric recombinant HIV-1 envelope...
Gorse, G J, Yang, E Y, Belshe, R B, Berman, P W
Salivary binding antibodies induced by candidate human immunodeficiency virus type 1 (HIV-1) vaccines in healthy, HIV-1 uninfected volunteers were assessed in a clinical trial evaluating...
Westblom, T U, Duriex, D E, Madan, E, Belshe, R B
An animal model for antibiotic secretion across gastric mucosa was developed using adult guinea pigs. Antibiotics were given intramuscularly, and levels in serum and gastric mucosa were measured by...
Pharmacokinetics of a single dose of rimantadine in young adults and children.
Anderson, E L, Van Voris, L P, Bartram, J, Hoffman, H E, Belshe, R B
Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/-...
Characterization of a live, attenuated human parainfluenza type 3 virus candidate vaccine strain.
Ray, R, Meyer, K, Newman, F K, Belshe, R B
Characterization of a temperature-sensitive and live, attenuated human parainfluenza type 3 virus strain (cp45) grown at a permissive temperature (32 degrees C) suggested that the virus efficiently...
Immune responses to plasmid DNA encoding the hepatitis C virus core protein.
Lagging, L M, Meyer, K, Hoft, D, Houghton, M, Belshe, R B, Ray, R
Hepatitis C virus (HCV) is a major causative agent of parenterally transmitted non-A, non-B hepatitis. The genomic region encoding the virion-associated core protein is relatively conserved among HCV...
Ray, R, Galinski, M S, Heminway, B R, Meyer, K, Newman, F K, Belshe, R B
We have previously demonstrated that the temperature sensitivity of a human parainfluenza virus type 3 (HPIV-3) candidate vaccine strain (cp45), which is currently under evaluation in humans, is...
Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine.
Hayden, F G, Sperber, S J, Belshe, R B, Clover, R D, Hay, A J, Pyke, S
The therapeutic activity of rimantadine and its relationship to the shedding of drug-resistant influenza A virus were assessed in two randomized, double-blind, placebo-controlled trials involving...
Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection.
Belshe, R B, Smith, M H, Hall, C B, Betts, R, Hay, A J
The emergence of influenza A viruses which had acquired resistance to rimantadine during a clinical trial (C. B. Hall, R. Dolin, C. L. Gala, D. M. Markovitz, Y. Q. Zhang, P. H. Madore, F. A. Disney,...
Karron, R A, Froehlich, J L, Bobo, L, Belshe, R B, Yolken, R H
Parainfluenza virus type 3 (PIV-3), an important lower respiratory tract pathogen in young children and immunocompromised individuals, may be underdiagnosed because of the insensitivity of available...
Evaluation of a live attenuated, cold-adapted parainfluenza virus type 3 vaccine in children.
Belshe, R B, Karron, R A, Newman, F K, Anderson, E L, Nugent, S L, Steinhoff, M, ...
Cold passage 18 (CP18) parainfluenza virus type 3 (PIV-3) vaccine was evaluated in a double-blind, randomized, placebo-controlled study of 95 infants and young children. None of 19 seropositive older...
Anderson, E L, Newman, F K, Maassab, H F, Belshe, R B
A cold-adapted (ca) influenza B reassortant virus vaccine that contained the six internal RNA segments from influenza B/Ann Arbor/1/66 ca virus and the neuraminidase and hemagglutinin genes from...
Gorse, G J, Belshe, R B, Munn, N J
Forty seropositive older adults with chronic diseases were vaccinated intranasally with either influenza A/California/10/78 (H1N1) (CR37) or influenza A/Washington/897/80 (H3N2) (CR48) virus. No...
Evaluation of cold-recombinant influenza A/Korea (CR-59) virus vaccine in infants.
Anderson, E L, Belshe, R B, Burk, B, Bartram, J, Maassab, H F
Twenty-four infants 5 to 13 months of age were intranasally vaccinated with a live cold-recombinant influenza A/Korea (CR-59, H3N2) virus vaccine. Nineteen infants served as controls. The inocula...
We studied anti-influenza cytotoxicity by bulk peripheral blood mononuclear leukocyte (PBL) cultures derived from older, chronically ill volunteers undergoing vaccination. Vaccinees received either...
Gorse, G J, Belshe, R B, Munn, N J
Forty older adults with chronic diseases were vaccinated intranasally with either influenza A/California/10/78 (H1N1) (CR37) or influenza A/Washington/897/80 (H3N2) (CR48) virus. No clinically...
Mufson, M A, Belshe, R B, Orvell, C, Norrby, E
Respiratory syncytial virus strains from 13 children who had repeat infections at least 1 year apart were identified as either subgroup A or subgroup B according to reaction patterns with several...
Mufson, M A, Akerlind-Stopner, B, Orvell, C, Belshe, R B, Norrby, E
Respiratory syncytial virus strains isolated from infants and children hospitalized with acute respiratory tract disease in Huntington, W. Va., from July 1979 through June 1988 were categorized by...
Clements, M L, Belshe, R B, King, J, Newman, F, Westblom, T U, Tierney, E L, ...
In an attempt to evaluate the level of attenuation of live parainfluenza type 3 virus (PIV3) vaccine candidates, we compared the responses of partially immune adult volunteers inoculated intranasally...
Gorse, G J, Frey, S E, Newman, F K, Belshe, R B
The ability of antibody induced by vaccination with recombinant gp160 (rgp160) to bind to native and recombinant human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins was measured....
Turner, R, Lathey, J L, Van Voris, L P, Belshe, R B
The sensitivity of an enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to influenza B virus was compared with that of the hemagglutination inhibition test on acute- and...
Safety and immunogenicity of meningococcal A and C polysaccharide conjugate vaccine in adults.
Anderson, E L, Bowers, T, Mink, C M, Kennedy, D J, Belshe, R B, Harakeh, H, ...
A meningococcal vaccine containing group A and C polysaccharides conjugated to CRM197 was evaluated in 50 adults. Vaccinees were entered into one of five groups: 30 adults received a single dose of...
Belshe, R B, Van Voris, L P, Mufson, M A, Buynak, E B, McLean, A A, Hilleman, M A
The sensitivity of an enzyme-linked immunosorbent assay (ELISA) to detect low levels of antibody to respiratory syncytial (RS) virus was compared with a tube dilution neutralization test (NEUT) on...
Wright, P F, Belshe, R B, Kim, H W, Van Voris, L P, Chanock, R M
A highly attenuated respiratory syncytial virus (RSV) experimental vaccine, RSV ts-2, was sequentially evaluated in adults, seropositive children, and finally, fully susceptible seronegative...
Richardson, L S, Yolken, R H, Belshe, R B, Camargo, E, Kim, H W, Chanock, R M
An enzyme-linked immunosorbent assay was applied to the detection of serum antibodies against respiratory syncytial virus. The end points of the various sera tested in the assay were approximately...
Belshe, R B, Richardson, L S, Schnitzer, T J, Prevar, D A, Camargo, E, Chanock, R M
ts-2, a temperature-sensitive and plaque morphology mutant of respiratory syncytial virus and sole representative of complementation group B, was compared with members of the other complementation...
Gorse, G J, Patel, G B, Newman, F K, Belshe, R B, Berman, P W, Gregory, T J, ...
The ability of antibody induced by MN and IIIB recombinant gp120 (rgp120) human immunodeficiency virus type 1 (HIV-1) vaccines the bind to oligomeric native and monomeric recombinant HIV-1 envelope...
Gorse, G J, Yang, E Y, Belshe, R B, Berman, P W
Salivary binding antibodies induced by candidate human immunodeficiency virus type 1 (HIV-1) vaccines in healthy, HIV-1 uninfected volunteers were assessed in a clinical trial evaluating...
Westblom, T U, Duriex, D E, Madan, E, Belshe, R B
An animal model for antibiotic secretion across gastric mucosa was developed using adult guinea pigs. Antibiotics were given intramuscularly, and levels in serum and gastric mucosa were measured by...
Pharmacokinetics of a single dose of rimantadine in young adults and children.
Anderson, E L, Van Voris, L P, Bartram, J, Hoffman, H E, Belshe, R B
Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/-...
Characterization of a live, attenuated human parainfluenza type 3 virus candidate vaccine strain.
Ray, R, Meyer, K, Newman, F K, Belshe, R B
Characterization of a temperature-sensitive and live, attenuated human parainfluenza type 3 virus strain (cp45) grown at a permissive temperature (32 degrees C) suggested that the virus efficiently...
Immune responses to plasmid DNA encoding the hepatitis C virus core protein.
Lagging, L M, Meyer, K, Hoft, D, Houghton, M, Belshe, R B, Ray, R
Hepatitis C virus (HCV) is a major causative agent of parenterally transmitted non-A, non-B hepatitis. The genomic region encoding the virion-associated core protein is relatively conserved among HCV...
Ray, R, Galinski, M S, Heminway, B R, Meyer, K, Newman, F K, Belshe, R B
We have previously demonstrated that the temperature sensitivity of a human parainfluenza virus type 3 (HPIV-3) candidate vaccine strain (cp45), which is currently under evaluation in humans, is...
Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine.
Hayden, F G, Sperber, S J, Belshe, R B, Clover, R D, Hay, A J, Pyke, S
The therapeutic activity of rimantadine and its relationship to the shedding of drug-resistant influenza A virus were assessed in two randomized, double-blind, placebo-controlled trials involving...
Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection.
Belshe, R B, Smith, M H, Hall, C B, Betts, R, Hay, A J
The emergence of influenza A viruses which had acquired resistance to rimantadine during a clinical trial (C. B. Hall, R. Dolin, C. L. Gala, D. M. Markovitz, Y. Q. Zhang, P. H. Madore, F. A. Disney,...
Karron, R A, Froehlich, J L, Bobo, L, Belshe, R B, Yolken, R H
Parainfluenza virus type 3 (PIV-3), an important lower respiratory tract pathogen in young children and immunocompromised individuals, may be underdiagnosed because of the insensitivity of available...
Evaluation of a live attenuated, cold-adapted parainfluenza virus type 3 vaccine in children.
Belshe, R B, Karron, R A, Newman, F K, Anderson, E L, Nugent, S L, Steinhoff, M, ...
Cold passage 18 (CP18) parainfluenza virus type 3 (PIV-3) vaccine was evaluated in a double-blind, randomized, placebo-controlled study of 95 infants and young children. None of 19 seropositive older...
Anderson, E L, Newman, F K, Maassab, H F, Belshe, R B
A cold-adapted (ca) influenza B reassortant virus vaccine that contained the six internal RNA segments from influenza B/Ann Arbor/1/66 ca virus and the neuraminidase and hemagglutinin genes from...
Gorse, G J, Belshe, R B, Munn, N J
Forty seropositive older adults with chronic diseases were vaccinated intranasally with either influenza A/California/10/78 (H1N1) (CR37) or influenza A/Washington/897/80 (H3N2) (CR48) virus. No...
Evaluation of cold-recombinant influenza A/Korea (CR-59) virus vaccine in infants.
Anderson, E L, Belshe, R B, Burk, B, Bartram, J, Maassab, H F
Twenty-four infants 5 to 13 months of age were intranasally vaccinated with a live cold-recombinant influenza A/Korea (CR-59, H3N2) virus vaccine. Nineteen infants served as controls. The inocula...
We studied anti-influenza cytotoxicity by bulk peripheral blood mononuclear leukocyte (PBL) cultures derived from older, chronically ill volunteers undergoing vaccination. Vaccinees received either...
Gorse, G J, Belshe, R B, Munn, N J
Forty older adults with chronic diseases were vaccinated intranasally with either influenza A/California/10/78 (H1N1) (CR37) or influenza A/Washington/897/80 (H3N2) (CR48) virus. No clinically...
Mufson, M A, Belshe, R B, Orvell, C, Norrby, E
Respiratory syncytial virus strains from 13 children who had repeat infections at least 1 year apart were identified as either subgroup A or subgroup B according to reaction patterns with several...
Mufson, M A, Akerlind-Stopner, B, Orvell, C, Belshe, R B, Norrby, E
Respiratory syncytial virus strains isolated from infants and children hospitalized with acute respiratory tract disease in Huntington, W. Va., from July 1979 through June 1988 were categorized by...
Clements, M L, Belshe, R B, King, J, Newman, F, Westblom, T U, Tierney, E L, ...
In an attempt to evaluate the level of attenuation of live parainfluenza type 3 virus (PIV3) vaccine candidates, we compared the responses of partially immune adult volunteers inoculated intranasally...
Gorse, G J, Frey, S E, Newman, F K, Belshe, R B
The ability of antibody induced by vaccination with recombinant gp160 (rgp160) to bind to native and recombinant human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins was measured....
Turner, R, Lathey, J L, Van Voris, L P, Belshe, R B
The sensitivity of an enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to influenza B virus was compared with that of the hemagglutination inhibition test on acute- and...
Safety and immunogenicity of meningococcal A and C polysaccharide conjugate vaccine in adults.
Anderson, E L, Bowers, T, Mink, C M, Kennedy, D J, Belshe, R B, Harakeh, H, ...
A meningococcal vaccine containing group A and C polysaccharides conjugated to CRM197 was evaluated in 50 adults. Vaccinees were entered into one of five groups: 30 adults received a single dose of...
Belshe, R B, Van Voris, L P, Mufson, M A, Buynak, E B, McLean, A A, Hilleman, M A
The sensitivity of an enzyme-linked immunosorbent assay (ELISA) to detect low levels of antibody to respiratory syncytial (RS) virus was compared with a tube dilution neutralization test (NEUT) on...
Wright, P F, Belshe, R B, Kim, H W, Van Voris, L P, Chanock, R M
A highly attenuated respiratory syncytial virus (RSV) experimental vaccine, RSV ts-2, was sequentially evaluated in adults, seropositive children, and finally, fully susceptible seronegative...
Richardson, L S, Yolken, R H, Belshe, R B, Camargo, E, Kim, H W, Chanock, R M
An enzyme-linked immunosorbent assay was applied to the detection of serum antibodies against respiratory syncytial virus. The end points of the various sera tested in the assay were approximately...
Belshe, R B, Richardson, L S, Schnitzer, T J, Prevar, D A, Camargo, E, Chanock, R M
ts-2, a temperature-sensitive and plaque morphology mutant of respiratory syncytial virus and sole representative of complementation group B, was compared with members of the other complementation...
Studies in children and adults revealed cold-adapted, live, attenuated, trivalent, intranasal influenza vaccine (CAIV-T) to be well accepted, well tolerated and highly protective against...
HIV-1 recombinant gp160 vaccine given in accelerated dose schedules
Gorse, G. J., Schwartz, D. H., Graham, B. S., Matthews, T. J., Stablein, D. M., Frey, S. E., ...
The purpose of this randomized, double-blind study was to test the safety and immunogenicity of an HIV-1LAI recombinant gp160 (rgp160) vaccine in healthy, uninfected volunteers using accelerated...