Purpose of this program was to subject one assembly of the Titan I first stage thrust chamber controls to the flight simulation test phase of a qualification test program. A detailed description of...
PERFORMANCE EVALUATION OF THE MIG GYRO FOR BALLISTIC MISSILE APPLICATIONS, (2005)
This report describes a series of tests performed on two Minneapolis-Honeywell miniature integrating (MIG) gyros. Performance of gyros during the tests is given in detail, and the philosophy,...
Adams,J. A. S., Clark,H. C., Clark,R. B., Duval,J. S., Schwarzer,T. F.
;Contents: Experimental comparison of NaI(T1) and solid organic scintillation detectors for use in remote sensing of terrestrial gamma rays; Hydrologic investigations and the significance of...
Ames,C. B., Clark,R. B., LaHue,P. M., Peterson,R. W.
The purpose of this contract was to further the development of the Hughes Rotating Gravity Gradiometer (RGG). The scope of effort was limited to studies and performance tests and demonstrations in...
Rotating Gravity Gradiometer Development. Volume 1. (2002)
Ames, C. B., Clark, R. B., LaHue, P. M., Peterson, R. W.
Because the scope of work included both the development of the (RGG) Rotating Gravity Gradiometers and studies of platform requirements, this Final Report is written in two volumes to better...
Adams,J. A. S., Clark,H. C., Clark,R. B., Cook,B. G., Duval,J. S.
A major emphasis in recent years has been the development, calibration, and field testing of airborne gamma-ray spectrometer systems, particularly with the low levels and slow speeds attainable with...
Heterogeneity of action potential waveforms and potassium currents in rat ventricle (1993)
Clark, R B, Bouchard, R A, Salinas-Stefanon, E, Sanchez-Chapula, J, Giles, W R
Objective: The ionic mechanisms for differences in action potential waveforms in rat left ventricle were studied by recording L-type Ca2+ current, transient outward K+ current, and inwardly...
Influence of Radiation Level on Apparent Hydrocyanic Acid Potential of Sorghum Seedlings (1982)
Haskins, Francis A., Gorz, Herman J., Clark, R. B.
The hydrocyanic acid potential (HCN-p) of forage sorghum [Sorghum bicolor (L.) Moench] and sudangrass [S. sudanense (Piper) Stapf] seedlings may be estimated by a spectrophotometric procedure that is...
MATERNAL AND NEONATAL EFFECTS OF 1% AND 2% MEPIVACAINE FOR LUMBAR EXTRADURAL ANALGESIA (1975)
CLARK, R. B., JONES, G. L., BARCLAY, D. L., GREIFENSTEIN, F. E., MCANINCH, P. E.
Continuous lumbar extradural analgesia with mepivacaine was administered to two groups of patients in normal labour. One group (26 patients: 1% mepivacaine) received a mean total dose of 342 mg (4.93...
THE EFFECT OF METHOXYFLURANE ON THE FOETUS (1970)
CLARK, R. B., COOPER, J. O., BROWN, W. E., GREIFENSTEIN, F. E.
Sixty-four patients received methoxyflurane analgesia and/or anaesthesia for labour and delivery. Analgesia with methoxyflurane-air produced satisfactory analgesia for labour and delivery in the...
Effect of longitudinal steps on skipping characteristics of PB2Y-6 flying boat (1949)
Landing tests were made with the PB2Y-6 flying boat to determine the effect of production step vents and forebody longitudinal steps on skipping.
Clark, R B, Lister, P D, Arneson-Rotert, L, Janda, J M
The antibiotic susceptibilities of 29 isolates of Plesiomonas shigelloides were studied with 24 antibiotics and antibiotic-inhibitor combinations. Results indicated that all isolates were susceptible...
Clark, R B, Sanders, C C, Pakiz, C B, Hostetter, M K
In recent years, a number of clinical microbiology laboratories have isolated Pseudomonas aeruginosa with the unusual aminoglycoside disk diffusion result of resistance to both amikacin and...
Bakken, J S, Sanders, C C, Clark, R B, Hori, M
Use of cefoperazone in a patient with Aeromonas caviae in the respiratory tract selected a mutant that constitutively produced beta-lactamase. This mutant, in contrast to its parental strain with an...
Clark, R B, Gordon, R E, Bottone, E J, Reitano, M
A strain of a nutritionally deficient streptococcus was shown to undergo morphological aberrations according to pyridoxal concentrations in the growth medium. Filamentous rod-shaped cells, observed...
Osteomyelitis and synovitis produced by Mycobacterium marinum in a fisherman.
Clark, R B, Spector, H, Friedman, D M, Oldrati, K J, Young, C L, Nelson, S C
We report a case of osteomyelitis and synovitis produced by Mycobacterium marinum in the left index finger of a fisherman. A combination of surgical intervention and antimicrobial therapy with...
Clark, R B, Janda, J M, Bottone, E J
Previous reports have suggested that clinical strains of gentamicin-resistant Pseudomonas aeruginosa (GRPA) generally produce only superficial infections (wounds, urinary tract infections) in...
Clark, R B, Berrafati, J F, Janda, J M, Bottone, E J
Group G streptococci were isolated from throat and extrapharyngeal cultures from 75 patients during an 18-month period. Of 29 throat isolates, 18 were recovered from patients with pharyngitis, 8 were...
Janda, J M, Dixon, A, Raucher, B, Clark, R B, Bottone, E J
The simultaneous recovery of Aeromonas hydrophila and Aeromonas caviae from the stool of a 49-year-old woman with watery diarrhea was facilitated through the use of a blood agar medium which detected...
Isolation of Serratia plymuthica from a human burn site.
The saprophytic bacterium Serratia plymuthica was recovered from a facial wound (burn) site of a pediatric patient. The clinical significance of the organism was undetermined due to its apparent...
Clark, R B, Kunkel, M W, Friedman, J, Goka, T J, Johnson, J A
We report here that, contrary to previously reported findings, treatment of S49 wild-type (WT) lymphoma cells with 0-50 nM epinephrine resulted in a heterologous desensitization of adenylyl cyclase...
Clark, R B, Nachamkin, I, Schatzki, P F, Dalton, H P
Monoclonal antibodies were produced against the HAR-13 strain (A) of Chlamydia trachomatis. By an indirect immunofluorescence technique, three clones (1-7, 2-8, 9F) were found to produce antibody...
Organic Acids and Iron Translocation in Maize Genotypes
Clark, R. B., Tiffin, L. O., Brown, J. C.
Translocation of Fe was studied in WF9 (Fe-efficient) and ys1/ys1 (Fe-inefficient) maize (Zea mays L.) genotypes. Iron-deficient WF9 translocated more Fe to the tops than Fe-deficient ys1/ys1. Malate...
Rashidbaigi, A, Ruoho, A E, Green, D A, Clark, R B
The beta-adrenergic antagonist [125I]iodoazidobenzylpindolol ( [125I]IABP) specifically photolabeled two polypeptides in membrane preparations from wild-type (WT) and coupling protein-deficient cyc-...
Padula, S J, Pollard, M K, Lingenheld, E G, Clark, R B
The in vitro growth of T cells obtained from localized anatomic sites of pathology may offer a new approach to the investigation of certain human autoimmune diseases. However, if...
Padula, S J, Sgroi, D C, Lingenheld, E G, Love, J T, Chou, C H, Clark, R B
Advances in our understanding of the structure and molecular biology of the T lymphocyte antigen-receptor have now made it feasible to study human autoimmune diseases using new approaches. One such...
Recent studies with phorbol esters have suggested that protein kinase C (PKC) may play a role in the regulation of adenylate cyclase in mammalian cells. Since D-sphingosine has been reported to...
Wadzinski, B E, Shanahan, M F, Clark, R B, Ruoho, A E
The glucose transporter has been identified in a variety of mammalian cell membranes using a photoactivatable carrier-free radioiodinated derivative of forskolin,...
Clark, R B, Goka, T J, Proll, M A, Friedman, J
We had previously demonstrated that the cyc- mutant of S49 wild-type lymphoma cells both desensitizes and undergoes a sequestration-internalization of the beta-receptor in response to short-term...
Sheng, J Z, Prinsen, C F, Clark, R B, Giles, W R, Schnetkamp, P P
The recently cloned retinal cone Na(+)-Ca(2+)-K(+) exchanger (NCKX) was expressed in cultured insect cells, and whole-cell patch clamp was used to measure transmembrane currents generated by this...
A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes.
Pandit, S V, Clark, R B, Giles, W R, Demir, S S
Mathematical models were developed to reconstruct the action potentials (AP) recorded in epicardial and endocardial myocytes isolated from the adult rat left ventricle. The main goal was to obtain...
Bouchard, R A, Clark, R B, Giles, W R
1. Regulation of unloaded cell shortening and relaxation by sarcolemmal Na(+)-Ca2+ exchange was investigated in rat ventricular myocytes. Contraction of single cells at 22 +/- 1 degrees C was...
Chiamvimonvat, N, Kargacin, M E, Clark, R B, Duff, H J
1. Na+ channel mRNA levels in the heart can be modulated by changes in intracellular Ca2+ ([Ca2+]i). We have investigated whether this regulation of Na+ channel biosynthesis by cytosolic Ca2+...
Shal-type channels contribute to the Ca2+-independent transient outward K+ current in rat ventricle.
Fiset, C, Clark, R B, Shimoni, Y, Giles, W R
1. The hypothesis that Kv4.2 and Kv4.3 are two of the essential K+ channel isoforms underlying the Ca2+-independent transient outward K+ current (It) in rat ventricle has been tested using a...
Thyroid hormone regulates postnatal expression of transient K+ channel isoforms in rat ventricle.
Shimoni, Y, Fiset, C, Clark, R B, Dixon, J E, McKinnon, D, Giles, W R
1. The ability of thyroid hormone to regulate the postnatal changes of the Ca2+-independent transient outward K+ current (It) was studied in rat ventricular myocytes. 2. In rat ventricle, It is very...
Fiset, C, Clark, R B, Larsen, T S, Giles, W R
1. The K+ currents which control repolarization in adult mouse ventricle, and the effects of changes in action potential duration on excitation-contraction coupling in this tissue, have been studied...
Role of sodium-calcium exchange in activation of contraction in rat ventricle.
Bouchard, R A, Clark, R B, Giles, W R
1. The functional role of reverse Na(+)-Ca2+ exchange in the activation of contraction of rat ventricular myocytes has been studied. Mechanical activity of single cells, measured as unloaded cell...
Shimoni, Y, Banno, H, Clark, R B
1. Transient outward potassium currents (I(t)) were compared in single cardiac myocytes obtained from normal and hyperthyroid rabbits. Currents were recorded using the suction electrode whole-cell...
Role of an inwardly rectifying potassium current in rabbit ventricular action potential.
Shimoni, Y, Clark, R B, Giles, W R
1. Whole-cell voltage-clamp measurements were made of the time- and voltage-dependent properties of the inwardly rectifying background potassium current IK1, in single myocytes from rabbit ventricle....
Braun, A P, Fedida, D, Clark, R B, Giles, W R
1. The intracellular mechanism(s) underlying the decrease of a transient outward K+ current (It) induced by alpha 1-adrenergic agonists was studied in isolated adult rabbit atrial myocytes using...
Two distinct types of inwardly rectifying K+ channels in bull-frog atrial myocytes.
Clark, R B, Nakajima, T, Giles, W, Kanai, K, Momose, Y, Szabo, G
1. Single atrial myocytes were enzymatically isolated from the bull-frog as previously described (Hume & Giles, 1981), and patch-clamp techniques were used in an attempt to identify and separate two...
Clark, R B, Tse, A, Giles, W R
1. Whole-cell voltage-clamp techniques were used to study the voltage-dependent membrane conductances in parasympathetic neurones enzymatically isolated from the interatrial septum of bull-frog heart...
Muscarinic modulation of calcium current in neurones from the interatrial septum of bull-frog heart.
Tse, A, Clark, R B, Giles, W R
1. The effects of activation of muscarinic receptors on the voltage-dependent calcium current, ICa, in parasympathetic neurones were examined. 2. Neurones were enzymatically isolated from the...
Properties of the transient outward current in rabbit atrial cells.
Clark, R B, Giles, W R, Imaizumi, Y
1. Whole-cell and patch clamp techniques have been used to study the steady-state voltage dependence and the kinetics of a transient outward current, It, in single cells from rabbit atrium. 2. The...
Sodium current in single cells from bullfrog atrium: voltage dependence and ion transfer properties.
1. Whole-cell and patch-clamp techniques (Hamill, Marty, Neher, Sakmann & Sigworth, 1981) have been used to make quantitative measurements of the transient inward sodium current (INa) in single cells...
Influence of agonists on desensitization of glutamate receptors on locust muscle.
Anis, N A, Clark, R B, Gration, K A, Usherwood, P N
1. The desensitization, by ionophoretically and bath-applied L-glutamate and agonists, of excitatory post-junctional receptor populations on locust extensor tibiae muscle was investigated. 2. The...
Desensitization of glutamate receptors on innervated and denervated locust muscle fibres.
Clark, R B, Gration, K A, Usherwood, P N
Depolarizations to L-glutamate, applied locally by microinophoresis to the extrajunctional membrane of locust extensor tibiae muscle fibres and measured either in current clamp or voltage clamp,...
Clark, R B, Lister, P D, Arneson-Rotert, L, Janda, J M
The antibiotic susceptibilities of 29 isolates of Plesiomonas shigelloides were studied with 24 antibiotics and antibiotic-inhibitor combinations. Results indicated that all isolates were susceptible...
Clark, R B, Sanders, C C, Pakiz, C B, Hostetter, M K
In recent years, a number of clinical microbiology laboratories have isolated Pseudomonas aeruginosa with the unusual aminoglycoside disk diffusion result of resistance to both amikacin and...
Bakken, J S, Sanders, C C, Clark, R B, Hori, M
Use of cefoperazone in a patient with Aeromonas caviae in the respiratory tract selected a mutant that constitutively produced beta-lactamase. This mutant, in contrast to its parental strain with an...
Clark, R B, Gordon, R E, Bottone, E J, Reitano, M
A strain of a nutritionally deficient streptococcus was shown to undergo morphological aberrations according to pyridoxal concentrations in the growth medium. Filamentous rod-shaped cells, observed...
Osteomyelitis and synovitis produced by Mycobacterium marinum in a fisherman.
Clark, R B, Spector, H, Friedman, D M, Oldrati, K J, Young, C L, Nelson, S C
We report a case of osteomyelitis and synovitis produced by Mycobacterium marinum in the left index finger of a fisherman. A combination of surgical intervention and antimicrobial therapy with...
Clark, R B, Janda, J M, Bottone, E J
Previous reports have suggested that clinical strains of gentamicin-resistant Pseudomonas aeruginosa (GRPA) generally produce only superficial infections (wounds, urinary tract infections) in...
Clark, R B, Berrafati, J F, Janda, J M, Bottone, E J
Group G streptococci were isolated from throat and extrapharyngeal cultures from 75 patients during an 18-month period. Of 29 throat isolates, 18 were recovered from patients with pharyngitis, 8 were...
Janda, J M, Dixon, A, Raucher, B, Clark, R B, Bottone, E J
The simultaneous recovery of Aeromonas hydrophila and Aeromonas caviae from the stool of a 49-year-old woman with watery diarrhea was facilitated through the use of a blood agar medium which detected...
Isolation of Serratia plymuthica from a human burn site.
The saprophytic bacterium Serratia plymuthica was recovered from a facial wound (burn) site of a pediatric patient. The clinical significance of the organism was undetermined due to its apparent...
Clark, R B, Kunkel, M W, Friedman, J, Goka, T J, Johnson, J A
We report here that, contrary to previously reported findings, treatment of S49 wild-type (WT) lymphoma cells with 0-50 nM epinephrine resulted in a heterologous desensitization of adenylyl cyclase...
Clark, R B, Nachamkin, I, Schatzki, P F, Dalton, H P
Monoclonal antibodies were produced against the HAR-13 strain (A) of Chlamydia trachomatis. By an indirect immunofluorescence technique, three clones (1-7, 2-8, 9F) were found to produce antibody...
Organic Acids and Iron Translocation in Maize Genotypes
Clark, R. B., Tiffin, L. O., Brown, J. C.
Translocation of Fe was studied in WF9 (Fe-efficient) and ys1/ys1 (Fe-inefficient) maize (Zea mays L.) genotypes. Iron-deficient WF9 translocated more Fe to the tops than Fe-deficient ys1/ys1. Malate...
Rashidbaigi, A, Ruoho, A E, Green, D A, Clark, R B
The beta-adrenergic antagonist [125I]iodoazidobenzylpindolol ( [125I]IABP) specifically photolabeled two polypeptides in membrane preparations from wild-type (WT) and coupling protein-deficient cyc-...
Padula, S J, Pollard, M K, Lingenheld, E G, Clark, R B
The in vitro growth of T cells obtained from localized anatomic sites of pathology may offer a new approach to the investigation of certain human autoimmune diseases. However, if...
Padula, S J, Sgroi, D C, Lingenheld, E G, Love, J T, Chou, C H, Clark, R B
Advances in our understanding of the structure and molecular biology of the T lymphocyte antigen-receptor have now made it feasible to study human autoimmune diseases using new approaches. One such...
Recent studies with phorbol esters have suggested that protein kinase C (PKC) may play a role in the regulation of adenylate cyclase in mammalian cells. Since D-sphingosine has been reported to...
Wadzinski, B E, Shanahan, M F, Clark, R B, Ruoho, A E
The glucose transporter has been identified in a variety of mammalian cell membranes using a photoactivatable carrier-free radioiodinated derivative of forskolin,...
Bouchard, R A, Clark, R B, Giles, W R
1. Regulation of unloaded cell shortening and relaxation by sarcolemmal Na(+)-Ca2+ exchange was investigated in rat ventricular myocytes. Contraction of single cells at 22 +/- 1 degrees C was...
Clark, R B, Goka, T J, Proll, M A, Friedman, J
We had previously demonstrated that the cyc- mutant of S49 wild-type lymphoma cells both desensitizes and undergoes a sequestration-internalization of the beta-receptor in response to short-term...
Chiamvimonvat, N, Kargacin, M E, Clark, R B, Duff, H J
1. Na+ channel mRNA levels in the heart can be modulated by changes in intracellular Ca2+ ([Ca2+]i). We have investigated whether this regulation of Na+ channel biosynthesis by cytosolic Ca2+...
Shal-type channels contribute to the Ca2+-independent transient outward K+ current in rat ventricle.
Fiset, C, Clark, R B, Shimoni, Y, Giles, W R
1. The hypothesis that Kv4.2 and Kv4.3 are two of the essential K+ channel isoforms underlying the Ca2+-independent transient outward K+ current (It) in rat ventricle has been tested using a...
Thyroid hormone regulates postnatal expression of transient K+ channel isoforms in rat ventricle.
Shimoni, Y, Fiset, C, Clark, R B, Dixon, J E, McKinnon, D, Giles, W R
1. The ability of thyroid hormone to regulate the postnatal changes of the Ca2+-independent transient outward K+ current (It) was studied in rat ventricular myocytes. 2. In rat ventricle, It is very...
Fiset, C, Clark, R B, Larsen, T S, Giles, W R
1. The K+ currents which control repolarization in adult mouse ventricle, and the effects of changes in action potential duration on excitation-contraction coupling in this tissue, have been studied...
Role of sodium-calcium exchange in activation of contraction in rat ventricle.
Bouchard, R A, Clark, R B, Giles, W R
1. The functional role of reverse Na(+)-Ca2+ exchange in the activation of contraction of rat ventricular myocytes has been studied. Mechanical activity of single cells, measured as unloaded cell...
Shimoni, Y, Banno, H, Clark, R B
1. Transient outward potassium currents (I(t)) were compared in single cardiac myocytes obtained from normal and hyperthyroid rabbits. Currents were recorded using the suction electrode whole-cell...
Role of an inwardly rectifying potassium current in rabbit ventricular action potential.
Shimoni, Y, Clark, R B, Giles, W R
1. Whole-cell voltage-clamp measurements were made of the time- and voltage-dependent properties of the inwardly rectifying background potassium current IK1, in single myocytes from rabbit ventricle....
Braun, A P, Fedida, D, Clark, R B, Giles, W R
1. The intracellular mechanism(s) underlying the decrease of a transient outward K+ current (It) induced by alpha 1-adrenergic agonists was studied in isolated adult rabbit atrial myocytes using...
Two distinct types of inwardly rectifying K+ channels in bull-frog atrial myocytes.
Clark, R B, Nakajima, T, Giles, W, Kanai, K, Momose, Y, Szabo, G
1. Single atrial myocytes were enzymatically isolated from the bull-frog as previously described (Hume & Giles, 1981), and patch-clamp techniques were used in an attempt to identify and separate two...
Clark, R B, Tse, A, Giles, W R
1. Whole-cell voltage-clamp techniques were used to study the voltage-dependent membrane conductances in parasympathetic neurones enzymatically isolated from the interatrial septum of bull-frog heart...
Muscarinic modulation of calcium current in neurones from the interatrial septum of bull-frog heart.
Tse, A, Clark, R B, Giles, W R
1. The effects of activation of muscarinic receptors on the voltage-dependent calcium current, ICa, in parasympathetic neurones were examined. 2. Neurones were enzymatically isolated from the...
Properties of the transient outward current in rabbit atrial cells.
Clark, R B, Giles, W R, Imaizumi, Y
1. Whole-cell and patch clamp techniques have been used to study the steady-state voltage dependence and the kinetics of a transient outward current, It, in single cells from rabbit atrium. 2. The...
Sodium current in single cells from bullfrog atrium: voltage dependence and ion transfer properties.
1. Whole-cell and patch-clamp techniques (Hamill, Marty, Neher, Sakmann & Sigworth, 1981) have been used to make quantitative measurements of the transient inward sodium current (INa) in single cells...
Influence of agonists on desensitization of glutamate receptors on locust muscle.
Anis, N A, Clark, R B, Gration, K A, Usherwood, P N
1. The desensitization, by ionophoretically and bath-applied L-glutamate and agonists, of excitatory post-junctional receptor populations on locust extensor tibiae muscle was investigated. 2. The...
Desensitization of glutamate receptors on innervated and denervated locust muscle fibres.
Clark, R B, Gration, K A, Usherwood, P N
Depolarizations to L-glutamate, applied locally by microinophoresis to the extrajunctional membrane of locust extensor tibiae muscle fibres and measured either in current clamp or voltage clamp,...
Sheng, J Z, Prinsen, C F, Clark, R B, Giles, W R, Schnetkamp, P P
The recently cloned retinal cone Na(+)-Ca(2+)-K(+) exchanger (NCKX) was expressed in cultured insect cells, and whole-cell patch clamp was used to measure transmembrane currents generated by this...
A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes.
Pandit, S V, Clark, R B, Giles, W R, Demir, S S
Mathematical models were developed to reconstruct the action potentials (AP) recorded in epicardial and endocardial myocytes isolated from the adult rat left ventricle. The main goal was to obtain...
Beddell, C R, Clark, R B, Lowe, L A, Wilkinson, S, Chang, K J, Cuatrecasas, P, ...
1. Leucine-enkephalin and some analogues were assayed for activity in vitro on the mouse vas deferens and for binding to opiate receptors from rat brain. 2. The experimental data were analysed in...
Quinidine-induced open channel block of K+ current in rat ventricle.
Clark, R. B., Sanchez-Chapula, J., Salinas-Stefanon, E., Duff, H. J., Giles, W. R.
1. The effects of quinidine on calcium-independent outward K+ currents in rat ventricular myocytes were studied using whole-cell patch clamp techniques. 2. Quinidine sulphate (6 microM) significantly...
Responses to DL-ibotenic acid at locust glutamatergic neuromuscular junctions
Clark, R.B., Gration, K.A.F., Usherwood, P.N.R.
1 The responses of excitatory junctions on locust skeletal muscle fibres to iontophoretically applied L-glutamic acid and DL-ibotenic acid, a rigidly extended analogue of glutamate, were recorded by...