Soong, R., Shah, N., Salto-Tellez, M., Tai, B. C., Soo, R. A., Han, H. C., ...
Background: Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal...
Nomenclature for human DPYD alleles (1998)
McLeod, H.L., Johnson, M.R., Wei, X., Sapone, A., Diasio, R.B., ...
Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora.
Harris, B E, Manning, B W, Federle, T W, Diasio, R B
The mechanism of toxicity from 5-fluorocytosine chemotherapy is unclear. However, recent evidence suggests that the generation of 5-fluorouracil by a host may play an important role in the...
Kerkering, T M, Schwartz, P M, Espinel-Ingroff, A, Turek, P J, Diasio, R B
The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 microM) or oxypurinol (100 microM). Since allopurinol at this...
Sweeny, D J, Barnes, S, Heggie, G D, Diasio, R B
Recently we demonstrated clinically significant levels of a previously unrecognized metabolite of the anticancer drug 5-fluorouracil (FUra) in bile of cancer patients. In the present study,...
Rapid determination of serum 5-fluorocytosine levels by high-performance liquid chromatography.
Diasio, R B, Wilburn, M E, Shadomy, S, Espinel-Ingroff, A
A method for the rapid, quantitative determination of 5-fluorocytosine (5-FC) in serum by high-performance liquid chromatography (HPLC) has been developed. After initially ultrafiltrating the serum,...
Diasio, R B, Beavers, T L, Carpenter, J T
Severe neurotoxicity due to 5-fluorouracil (FUra) has previously been described in a patient with familial pyrimidinemia. We now report the biochemical basis for both the pyrimidinemia and...
Identification of bile acid-CoA: amino acid N-acyltransferase in rat kidney.
Kwakye, J B, Johnson, M R, Barnes, S, Grizzle, W E, Diasio, R B
A novel location of the bile-acid-conjugating enzyme bile acid-CoA:amino acid N-acyltransferase (BAT) has been discovered in the cytosolic fraction of rat kidney. Both taurine and glycine were...
Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora.
Harris, B E, Manning, B W, Federle, T W, Diasio, R B
The mechanism of toxicity from 5-fluorocytosine chemotherapy is unclear. However, recent evidence suggests that the generation of 5-fluorouracil by a host may play an important role in the...
Kerkering, T M, Schwartz, P M, Espinel-Ingroff, A, Turek, P J, Diasio, R B
The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 microM) or oxypurinol (100 microM). Since allopurinol at this...
Sweeny, D J, Barnes, S, Heggie, G D, Diasio, R B
Recently we demonstrated clinically significant levels of a previously unrecognized metabolite of the anticancer drug 5-fluorouracil (FUra) in bile of cancer patients. In the present study,...
Rapid determination of serum 5-fluorocytosine levels by high-performance liquid chromatography.
Diasio, R B, Wilburn, M E, Shadomy, S, Espinel-Ingroff, A
A method for the rapid, quantitative determination of 5-fluorocytosine (5-FC) in serum by high-performance liquid chromatography (HPLC) has been developed. After initially ultrafiltrating the serum,...
Diasio, R B, Beavers, T L, Carpenter, J T
Severe neurotoxicity due to 5-fluorouracil (FUra) has previously been described in a patient with familial pyrimidinemia. We now report the biochemical basis for both the pyrimidinemia and...
Identification of bile acid-CoA: amino acid N-acyltransferase in rat kidney.
Kwakye, J B, Johnson, M R, Barnes, S, Grizzle, W E, Diasio, R B
A novel location of the bile-acid-conjugating enzyme bile acid-CoA:amino acid N-acyltransferase (BAT) has been discovered in the cytosolic fraction of rat kidney. Both taurine and glycine were...