R. B. Nagle

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer (2007)

Gatenby, R A, Smallbone, K, Maini, P K, Rose, F, Averill, J, Nagle, R B, ...

Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are...

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer (2007)

Gatenby, R. A., Smallbone, K., Maini, P. K., Rose, F., Averill, J., Nagle, R. B., ...

Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are...

Chlorotrifluoroethylene Nephrotoxicity in Rats: A Subacute Study (1982)

BUCKLEY, L.A., CLAYTON, J.W., NAGLE, R.B., GANDOLFI, A.J.

Chlorotrifluoroethylene Nephrotoxicity in Rats: A Sub-acute Study. Buckley, L.A., Clayton, J.W., Nagle, R.B. and Gandolfi, A.J. (1982). Fundam. Appl. Toxicol. 2:181-186. Male Fischer-344 rats were...

Activation of gelatinase-tissue-inhibitors-of-metalloproteinase complexes by matrilysin.

Von Bredow, D C, Cress, A E, Howard, E W, Bowden, G T, Nagle, R B

Matrilysin, gelatinase A and gelatinase B are matrix metalloproteinases (MMPs) implicated in normal and pathological processes that require remodelling of the extracellular matrix. In human prostate...

Activation of gelatinase-tissue-inhibitors-of-metalloproteinase complexes by matrilysin.

Von Bredow, D C, Cress, A E, Howard, E W, Bowden, G T, Nagle, R B

Matrilysin, gelatinase A and gelatinase B are matrix metalloproteinases (MMPs) implicated in normal and pathological processes that require remodelling of the extracellular matrix. In human prostate...

Differential expression of cytokeratin mRNA and protein in normal prostate, prostatic intraepithelial neoplasia, and invasive carcinoma.

Yang, Y., Hao, J., Liu, X., Dalkin, B., Nagle, R. B.

The expression of cytokeratin (CK) mRNA for CK5, -8, -14, -16, and -19 was investigated in normal prostate, prostatic intraepithelial neoplasia (PIN) lesions, and invasive carcinoma using in situ...

Differential expression of laminin 5 (alpha 3 beta 3 gamma 2) by human malignant and normal prostate.

Hao, J., Yang, Y., McDaniel, K. M., Dalkin, B. L., Cress, A. E., Nagle, R. B.

Laminin 5 is an extracellular matrix protein integral to the formation of the hemidesmosomes that attach normal basal cells to the underlying basal lamina. We have shown that these hemidesmosomal...

Expression of hemidesmosomal and extracellular matrix proteins by normal and malignant human prostate tissue.

Nagle, R. B., Hao, J., Knox, J. D., Dalkin, B. L., Clark, V., Cress, A. E.

The progression of prostate carcinoma may be influenced by the biochemical nature of the basal lamina surrounding the primary carcinoma cells. As a first step toward understanding this process, the...

Coexpression patterns of vimentin and glial filament protein with cytokeratins in the normal, hyperplastic, and neoplastic breast.

Gould, V. E., Koukoulis, G. K., Jansson, D. S., Nagle, R. B., Franke, W. W., Moll, R.

The authors studied by immunohistochemistry the intermediate filament (IF) protein profile of 66 frozen samples of breast tissue, including normal parenchyma, all variants of fibrocystic disease...

Phenotypic relationships of prostatic intraepithelial neoplasia to invasive prostatic carcinoma.

Nagle, R. B., Brawer, M. K., Kittelson, J., Clark, V.

Thirty-one snap-frozen human prostate specimens containing examples of benign hyperplasia, prostatic intraepithelial neoplasia (PIN), and invasive carcinoma were analyzed using a panel of 24...

Differential expression of extracellular matrix molecules and the alpha 6-integrins in the normal and neoplastic prostate.

Knox, J. D., Cress, A. E., Clark, V., Manriquez, L., Affinito, K. S., Dalkin, B. L., ...

The epithelial basal lamina composition and integrin expression profile of normal and neoplastic human prostate was characterized using immunohistochemical analysis of frozen samples. The major...

Complement receptors on normal human lymphocytes containing parallel tubular arrays.

Payne, C. M., Nagle, R. B.

Membrane complement receptors have been identified on a subpopulation of normal lymphocytes containing cytoplasmic inclusions called parallel tubular arrays (PTA) using two different rosetting...

A quantitative light- and electron-microscopic study of type IV nuclear bodies in crescentic glomerulonephritis.

Graham, A. R., Payne, C. M., Nagle, R. B.

Type IV nuclear bodies were found in all renal biopsies obtained from 14 patients with crescentic glomerulonephritis (CGN) and in 8 of 43 control patients studied by light and electron microscopy....

Structural and functional changes in rat kidney during CCl4 intoxication.

Striker, G. E., Smuckler, E. A., Kohnen, P. W., Nagle, R. B.

Alteration of the structure and function of guinea pig peritoneal macrophages by a soybean oil emulsion.

Strunk, R. C., Payne, C. M., Nagle, R. B., Kunke, K.

Studies in humans who have received Intralipid (IL) have demonstrated the presence of a fat pigment and fat droplets in reticuloendothelial phagocytic cells. Clinical data and in vitro studies...

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer

Gatenby, R A, Smallbone, K, Maini, P K, Rose, F, Averill, J, Nagle, R B, ...

Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are...