Defense and coping in relation to subjective health and immunology (1995)
Olff, M., Brosschot, J.F., Godaert, G.L.R., Benschop, R.J., Ballieux, R.E., Heijnen, C.J., ...
Relationships between cardiovascular and immunologic changes in an experimental stress model (1995)
Benschop, R.J., Godaert, G.L.R., Geenen, R., Brosschot, J.F., Olff, M., ...
Influence of life stress on immunological reactivity to mild psychological stress (1994)
Brosschot, J.F., Benschop, R.J., Godaert, G.L.R., Olff, M., Heijnen, C.J., ...
Modulation of the immune response by POMC-derived peptides (1987)
Heijnen, C.J., Zijlstra, J., Kavelaars, A., Croiset, G., Ballieux, R.E.
The POMC-derived peptides β-endorphin and ACTH are capable of modulating an immune response in physiological concentrations. These neuropeptides can either enhance or inhibit the proliferative...
Prognostic significance of pretreatment variables in patients with invasive cervical cancer (1987)
Velde, E.R. Te, Habbema, J.D.F., Gelpke, G.J., Ballieux, R.E.
In 119 consecutive patients with invasive cervical cancer 92 variables of potential significance in predicting recurrence were determined before treatment. In 49 patients recurrent disease was...
WGA activates human T lymphocytes by stimulation of phosphoinositide hydrolysis (1986)
Clevers, J.C., Bresser, A. De, Kleinveld, H., Ballieux, R.E.
Ligands of surface Ig raise cytoplasmic free Ca++ in human B cells (1985)
Clevers, J.C., Bloem, A.C., Gmelig-Meyling, F., Ballieux, R.E.
Calcium ionophore A23187 induces Il2 reactivity in human T cells (1985)
Clevers, J.C., Hoeksema, M., Gmelig-Meyling, F., Ballieux, R.E.
Synergistic action of A23187 and phorbol ester on human B cell activation (1985)
Clevers, J.C., Versteegen, J.M.T., Logtenberg, T., Ballieux, R.E.
Demel, R.A., Heijnen, C.J., Ballieux, R.E.
An immune response to the peripheral nerve basic protein P2 may be operative in the pathogenesis of the Guillain-Barré syndrome (GBS). A method is described for the purification of P2 of human...
A crude factor isolated from bovine thymus was partially purified using ion exchange chromatography. The resulting fraction was tested for inhibitory properties towards the proliferation of various...
Velde, E.R. Te, Berrens, L., Zegers, B.J.M., Ballieux, R.E.
Twenty patients with invasive cervical cancer of the squamous cell type were treated by radiotherapy and/or radical hysterectomy. During a follow-up period of approximately 2 yr in 10 of these...
Heijnen, C.J., UytdeHaag, F., Ballieux, R.E.
Distinct human T-cell subpopulations were isolated and cultured in the presence of B-cells and antigens. After an incubation period of 6 days cells were tested for their capacity to secrete...
Zegers, B.J.M., Stoop, J.W., Reerink-Brongers, E.E., Sander, P.C., Aalberse, R.C., Ballieux, R.E.
Serum levels of IgM, IgG, IgA, IgD, and IgE were determined in serum samples of 270 healthy Dutch children (aged 4–13 years) and of 30 healthy Dutch adults, the amounts being expressed in...
Zegers, Ben J.M., Poen, H., Stoop, J.W., Ballieux, R.E.
A comparative study was made of the results of immunoglobulin determination in sera using immunoelectrophoresis and the radial diffusion method of Mancini. The results indicated that, except for...
Pathology of immunoglobulins some aspects of monoclonal gammopathy (1968)
Ballieux, R.E., Imhof, J.W., Mul, N.A.J., Zegers, Ben J.M., Stoop, J.W.
Studies on the antigenic properties of the Fd-fragment of a human G-myeloma protein (Daw) (1967)
Zegers, Ben J.M., Ballieux, R.E.
The present investigation deals with an immunochemical approach in studies on the structure of Fd-fragments of human immunoglobulins. Rabbits were immunized with a preparation of Fd-fragment of a...
Bakker, H.D., Imhof, J.W., Mul, N.A.J., Ballieux, R.E.
A disbalance of immunoglobulin-A (IgA), immunoglobulin-G (IgG) and immunoglobulin-M (IgM) concentrations—i.e., increased IgA and IgG fractions and a normal or diminished IgM concentration—is not...
With a summary in English.
Ultracentrifuge investigation of the serum proteins in Waldenström's macroglobulinaemia (1960)
Imhof, J.W., Ballieux, R.E., Mijnlieff, P.F.
Data on 90 cases of WaldenstrÖm's macroglobulinaemia collected from the literature, and personal observations on 75 cases, showed that the sedimentation constant of the pathological macroglobulin...
Lokhorst, H M, Boom, S E, Bast, B J, Peters, P J, Tedder, T F, Gerdes, J, ...
We examined bone marrow from myeloma patients for the presence of cells with the characteristics of the clonogenic cell in the myeloma stem cell assay. We identified a novel type of cell that...
Bloem, A C, Van Hooff, C O, Bast, E J, Ballieux, R E
This study provides evidence that leukaemic B cells are able to proliferate and differentiate into plasmablasts. The Ig produced was monoclonal in nature and this was shown by gel electrophoresis.
Idiotypic peripheral blood lymphocytes in monoclonal gammopathy
Van Camp, B., Reynaert, Philippine, Wiringa, G., Ballieux, R. E.
Using two sets of anti-idiotypic antibody reagents (from guinea-pig and rabbit origin), idiotypic peripheral blood lymphocytes (PBL) could be shown in multiple myeloma (MM) patients in relapse, but...
Heijnen, C J, Pot, K H, Kater, L, Kluin-Nelemans, H C, Uytdehaag, F, Ballieux, R E
The investigation described here is concerned with the T cell regulation of the antigen-specific antibody response which has been studied in patients suffering from systemic lupus erythematosus...
Bloem, A C, Bast, E J, Gmelig Meyling, F H, DeGast, G C, Ballieux, R E
Peripheral blood lymphocytes (PBL) from 14 patients with chronic lymphocytic leukaemia (CLL) were stimulated with pokeweed mitogen (PWM), formalinized Staphylococcus aureus (Sta) and a combination of...
Differentiation between benign and malignant monoclonal gammopathy by the presence of the J chain.
Bast, E J, Van Camp, B, Boom, S E, Jaspers, F C, Ballieux, R E
Malignant monoclonal gammopathy (MMG) cannot easily be distinguished from the benign (BMG) form in a number of cases. Using two different anti-J chain reagents it could be shown in the present study...
Hart, L A, Heijnen, C J, Zijlstra, J, Ballieux, R E
Human peripheral blood B lymphocytes, when cultured for 6 days with ovalbumin in the presence of T cells and monocytes, can differentiate into plaque-forming cells (PFC) secreting small amounts of...
Bloem, A C, Clevers, J C, Bast, E J, Ballieux, R E
A reverse T cell plaque assay was employed to study the ability of purified T cells isolated from the blood of seven patients with B cell chronic lymphocytic leukaemia (B-CLL) to secrete...
Bloem, A C, Chand, M A, Van Camp, B, Bast, E J, Ballieux, R E
The monoclonal B cells present in the blood of three patients with Waldenstrøm's macroglobulinaemia were analysed according to phenotype and function. As a marker for the monoclonal nature of the...
Serum immunoglobulin levels in healthy children and adults
Stoop, J. W., Zegers, B. J. M., Sander, P. C., Ballieux, R. E.
Serum levels of IgM, IgG and IgA were determined in 270 healthy children, 4–12 years old, and in thirty healthy adults by the radial immunodiffusion method of Mancini. There were nine 1-year age...
Classification of immunoglobulins in the dermo-epidermal junction in lupus erythematosus
Cormane, R. H., Ballieux, R. E., Kalsbeek, G. L., Hymans, W.
Immunofluorescence studies of skin lesions of discoid and systemic lupus erythematosus and also of the unaffected skin in systemic lupus erythematosus, revealed γ-globulin (IgG) apparently always...
Pneumococcal antibodies in IgA of serum and external secretions
Mouton, R. P., Stoop, J. W., Ballieux, R. E., Mul, N. A. J.
An indirect immuno-fluorescent method is described for the detection of group and type specific antibodies against pneumococci. The localization of these antibodies in the various immunoglobulin...
Alpha-chain disease with involvement of the respiratory tract in a Dutch child
Stoop, J. W., Ballieux, R. E., Hijmans, W., Zegers, B. J. W.
A description is given of an 8-year-old girl of pure Dutch extraction who, since age 4, has shown unclassifiable skin changes, marked eosinophilia and diffuse infiltrative pulmonary changes with...
Benschop, R J, Nijkamp, F P, Ballieux, R E, Heijnen, C J
1. The circulation of natural killer (NK) cells in vivo is influenced by physical exercise, mental stress, and infusion of beta-adrenoceptor agonists. We have previously presented in vitro data,...
HEAVY CHAIN SUBCLASSES OF HUMAN γG-GLOBULIN : SERUM DISTRIBUTION AND CELLULAR LOCALIZATION
Bernier, G. M., Ballieux, R. E., Tominaga, K. T., Putnam, F. W.
Two antigenic types of naturally occurring proteins related to the papain produced Fc fragment of γG-globulin have been studied. Most normal and myeloma γG-globulins are related to one or the other...