R. Ebstein

Replication of a rare protective allele in the noradrenaline transporter gene and ADHD (2008)

Xu, X., Hawi, Z., Brookes, K.J., Anney, R., Bellgrove, M., Franke, B., ...

Replication is a key to resolving whether a reported genetic association represents a false positive finding or an actual genetic risk factor. In a previous study screening 51 candidate genes for...

Association of ADHD with genetic variants in the 5'-region of the dopamine transporter gene: evidence for allelic heterogeneity (2008)

Brookes, K.J., Xu, X., Anney, R., Franke, B., Zhou, K., Chen, Wai, ...

Multiple studies have reported an association between attention deficit hyperactivity disorder (ADHD) and the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the...

Linkage to chromosome 1p36 for Attention Deficit Hyperactivity Disorder traits in school and home settings (2008)

Zhou, K., Asherson, P., Sham, P., Franke, B., Anney, R.J., Buitelaar, J., ...

Background Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype....

A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16 (2008)

Asherson, P., Zhou, K., Anney, R.J.L., Franke, B., Buitelaar, J., Ebstein, R., ...

As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth...

Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth (2008)

Brookes, K.J., Neale, B., Xu, X., Thapar, A., Gill, M., Langley, K., ...

Season of birth (SOB) has been associated with attention deficit hyperactivity disorder (ADHD) in two existing studies. One further study reported an interaction between SOB and genotypes of the...

Population differences in the international multi-centre ADHD gene project (2008)

Neale, B.M., Sham, P.C., Purcell, S., Banaschewski, T., Buitelaar, J., Franke, B., ...

The International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics...

DSM-IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage (2008)

Chen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., ...

Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments....

No association between two polymorphisms of the serotonin transporter gene and combined type attention deficit hyperactivity disorder (2008)

Xu, X., Aysimi, E., Anney, R., Brookes, K., Franke, B., Zhou, K., ...

Several independent studies have reported association between serotonin transporter gene (SLC6A4) polymorphisms and attention deficit hyperactivity disorder (ADHD). Five studies found evidence for...

Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD (2007)

Zhou, K., Chen, W., Buitelaar, J., Banaschewski, T., Oades, R.D., Franke, B., ...

Previous studies have found heterogeneous association between DAT1-3-UTR-VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their...

Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test (2007)

Lasky-Su, J., Banaschewski, T., Buitelaar, J., Franke, B., Brookes, K., Sonuga-Barke, E., ...

Background: Lisdexamfetamine dimesylate is a therapeutically inactive prodrug in which d-amphetamine is covalently bound to l-lysine, a naturally occurring amino acid. Pharmacologically active...

Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test (2007)

Lasky-Su, J., Banaschewski, T., Buitelaar, J., Franke, B., Brookes, K., Sonuga-Barke, E., ...

Background Previous research found an association between single nucleotide polymorphisms (SNPs) in the promoter region of DRD4 and statistically derived phenotypes generated from...

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes (2006)

Brookes, K, Xu, X, Chen, W, Zhou, K, Neale, B, Lowe, N, ...

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies...

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes (2006)

Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., ...

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies...