R. Frederick Westbrook

Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear (2008)

Laurent, Vincent, Westbrook, R. Frederick

We studied the roles of the basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) in learning and relearning to inhibit context conditioned fear (freezing) in extinction. In Experiment...

Contextual and temporal modulation of extinction: behavioral and biological mechanisms (2006)

Bouton, Mark E., Westbrook, R. Frederick, Corcoran, Kevin A., Maren, Stephen

Extinction depends, at least partly, on new learning that is specific to the context in which it is learned. Several behavioral phenomena (renewal, reinstatement, spontaneous recovery, and rapid...

Predicting danger: The nature, consequences, and neural mechanisms of predictive fear learning (2006)

McNally, Gavan P., Westbrook, R. Frederick

The ability to detect and learn about the predictive relations existing between events in the world is essential for adaptive behavior. It allows us to use past events to predict the future and to...

The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear

Laurent, Vincent, Marchand, Alain R., Westbrook, R. Frederick

Extinction of conditioned fear involves new learning that inhibits but does not eliminate the original fear memory. This inhibitory learning is thought to require activation of NMDA receptors (NMDAr)...