Traducción de: Clinical pharmacology in dentistry
Rogers, H.J., Bradbrook, I.D., Morrison, P.J., Spector, R.G., Cox, D.A., Lees, L.J.
Sultamicillin is an orally absorbed double ester of sulbactam (penicillanic acid sulphone, a semisynthetic inhibitor of the &eegr;-lactamases of many Gram-positive and Gram-negative species) and...
Medically Qualified Preclinical Teachers
Quilliam, J. P., Bowden, Ruth M., Downham, C. B. B., Gillespie, J. S., Glenister, T. W. A., Paton, W. D. M., ...
Medically Qualified Preclinical Teachers
Quilliam, J. P., Bowden, Ruth M., Downham, C. B. B., Gillespie, J. S., Glenister, T. W. A., Paton, W. D. M., ...
ORG 10172: a low molecular weight heparinoid anticoagulant with a long half-life in man.
Bradbrook, I D, Magnani, H N, Moelker, H C, Morrison, P J, Robinson, J, Rogers, H J, ...
ORG 10172 is a heparinoid with mean molecular weight 6500 daltons. Intravenous bolus injections of ORG 10172 were compared with placebo and heparin injections in 91 separate studies in 83 healthy...
Effects of single and multiple doses of ketoconazole on adrenal function in normal subjects.
Bradbrook, I D, Gillies, H C, Morrison, P J, Robinson, J, Rogers, H J, Spector, R G
The plasma cortisol response to 0.25 mg tetracosactrin given by intramuscular injection was suppressed by nine oral doses of 200 mg ketoconazole given 12 hourly to nine normal female subjects. No...
Pharmacokinetics of single doses of sulphinpyrazone and its major metabolites in plasma and urine.
Bradbrook, I D, John, V A, Morrison, P J, Rogers, H J, Spector, R G
1 High pressure liquid chromatographic assays for the estimation of sulphinpyrazone and its sulphide, sulphone and p-hydroxy metabolites in plasma and urine are described. 2 Five normal volunteers...
Effect of pirprofen on glibenclamide kinetics and response.
Morrison, P J, Rogers, H J, Spector, R G, Bradbrook, I D, John, V A
Pirprofen (a new non-steroidal anti-inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose...
Bradbrook, I. D., John, V. A., Morrison, P. J., Rogers, H. J., Spector, R. G.
1 The absorption kinetics of oxprenolol have been investigated in eight healthy volunteers after single dosing with 16/260 Oros drug delivery systems. Oxprenolol disposition kinetics in individual...
Effect of aldosterone and cortisol on leptazol-induced seizures in rats
Leptazol B.P. (0.2 ml./kg) produced convulsions in 65% of normal adult rats with no fatalities. The same dose of leptazol in animals which had previously been given 0.125 mg/kg aldosterone resulted...
1. The respiration of a mitochondrial and synaptasome fraction of rat cerebral cortex was measured using an oxygen electrode.
Influence of pH on aggregation and protein binding of barbituric acid and amylobarbitone
Mikikits, W., Skinner, A., Spector, R. G., Watts, D. C.
1. Cryoscopic methods indicated that barbituric acid exists in aqueous solution as a monomer. Amylobarbitone is a monomer at pH 8, but appears to be polymerized at pH 2. The size of the oligomers...
The effect of chlorpromazine on cerebral glucose, ATP, ADP, AMP and ATPase in the mouse
Chowdhury, A. K., Skinner, Annette, Spector, R. G.
1. Administration of chlorpromazine 10 mg/kg intraperitoneally to mice produced no alteration in cerebral adenosine triphosphate (ATP), adenosine diphosphate (ADP) or adenosine monophosphate (AMP)....
Chowdhury, A. K., Rogers, H., Skinner, A., Spector, R. G., Watts, D. C.
1. The experiment investigated the effects of psychotropic drugs on enzymes in vitro.