Ciprofloxacin therapy for methicillin-resistant Staphylococcus aureus infections or colonizations.
Smith, S M, Eng, R H, Tecson-Tumang, F
Thirty patients were treated for colonization or for skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus. Three treatment regimens were evaluated, each progressively...
Inoculum effect of beta-lactam antibiotics on Enterobacteriaceae.
Eng, R H, Cherubin, C, Smith, S M, Buccini, F
Seven beta-lactam antibiotics were studied for both their antimicrobial activity and the degree to which they produced inoculum effect on Escherichia coli, Klebsiella pneumoniae, and Salmonella...
Inoculum effect of new beta-lactam antibiotics on Pseudomonas aeruginosa.
Eng, R H, Smith, S M, Cherubin, C
The degree of the inoculum effect shown by the new beta-lactam antibiotics with Pseudomonas aeruginosa was investigated, and the antibiotics were divided into three groups based upon the...
Eng, R H, Cherubin, C, Smith, S M, Buccini, F
One Salmonella and four Escherichia coli isolates from patients with bacterial meningitis who had responded slowly, relapsed, or failed to respond to monotherapy with moxalactam were examined. For...
Activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus.
Ciprofloxacin, a carboxy quinolone antibiotic with a broad spectrum of activity, was tested against 54 strains of methicillin-resistant Staphylococcus aureus. The ciprofloxacin MICs for 50 and 90% of...
Eng, R H, Smith, S M, Goldstein, E J, Miyasaki, K T, Quah, S E, Buccini, F
Reported is a case of Actinobacillus actinomycetemcomitans endocarditis which developed after dental prophylaxis with vancomycin and erythromycin. In vitro results indicated that this isolate and 20...
Susceptibility of zygomycetes to amphotericin B, miconazole, and ketoconazole.
Eng, R H, Person, A, Mangura, C, Chmel, H, Corrado, M
Susceptibility to amphotericin B, miconazole, and ketoconazole was determined for 25 clinical isolates of zygomycetes in yeast nitrogen base broth and human serum. In yeast nitrogen base broth, 7 of...
Effect of rifampin on ampicillin killing of group B streptococci.
Smith, S M, Eng, R H, Landesman, S
The activity of rifampin against group B streptococci as a single agent and in combination with ampicillin was examined. The minimum concentration of rifampin required to inhibit 90% of the isolates...
Antifungal activity in human urine and serum after ingestion of garlic (Allium sativum).
Caporaso, N, Smith, S M, Eng, R H
A fresh extract of garlic (Allium sativum) was administered orally to human volunteers. At intervals, serum and urine were collected and assayed for antifungal activity. The maximum tolerable dose...
Cefmenoxime therapy of serious bacterial infections.
Gombert, M E, Glasser, L A, Eng, R H
The efficacy and safety of cefmenoxime was evaluated in 50 patients with serious bacterial infections. These included 26 pneumonias, 18 urinary tract infections, 2 soft tissue infections, 2...
Vancomycin-dependent Enterococcus faecium isolated from stool following oral vancomycin therapy.
Dever, L L, Smith, S M, Handwerger, S, Eng, R H
The isolation of clinical strains of enterococci requiring vancomycin for growth has only recently been reported. We describe the isolation of Enterococcus faecium requiring vancomycin for growth...
Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria.
Eng, R H, Padberg, F T, Smith, S M, Tan, E N, Cherubin, C E
Antimicrobial agents are most often tested against bacteria in the log phase of multiplication to produce the maximum bactericidal effect. In an infection, bacteria may multiply less optimally. We...
Development of resistance in candida isolates from patients receiving prolonged antifungal therapy.
Fan-Havard, P, Capano, D, Smith, S M, Mangia, A, Eng, R H
The impact of prolonged antifungal therapy on the development of resistance was examined in 61 patients with oropharyngeal thrush. Fifty-nine patients had symptomatic human immunodeficiency virus...
Involvement of Gardnerella vaginalis in urinary tract infections in men.
Smith, S M, Ogbara, T, Eng, R H
Fifteen male patients from whose urine samples Gardnerella vaginalis was isolated (clinical incidence of 0.1%) were evaluated for clinical signs and symptoms of urinary tract infection and modality...
D-lactic acid measurements in the diagnosis of bacterial infections.
Smith, S M, Eng, R H, Campos, J M, Chmel, H
Body fluids suspected of bacterial infection were cultured and examined for the presence of D-lactic acid, a specific bacterial metabolite. We examined 206 patients and 264 specimens. D-Lactic acid...
Eng, R H, Bishburg, E, Smith, S M, Mangia, A
Thirty acquired immunodeficiency syndrome patients with mycobacterial bacteremia documented by Du Pont Isolator (Du Pont Co., Wilmington, Del.) blood cultures underwent microscopic examination of...
Bishburg, E, Eng, R H, Smith, S M, Kapila, R
The yield in cultures of bone marrow aspirations or biopsies was determined in 50 patients with acquired immunodeficiency syndrome. Most patients were febrile and had no identifiable source of...
Pseudomonas mesophilica infections in humans.
Smith, S M, Eng, R H, Forrester, C
Reported here is the case of a patient with metastatic adenocarcinoma of the lung who had bacteremia involving Pseudomonas mesophilica. Of the common laboratory media tested at 35 degrees C, buffered...
Species identification of coagulase-negative staphylococcal isolates from blood cultures.
Eng, R H, Wang, C, Person, A, Kiehn, T E, Armstrong, D
Coagulase-negative staphylococci generally are not fully identified, are called Staphylococcus epidermidis, and are considered contaminants when isolated from blood cultures. In a cancer hospital...
Epidemiology of Klebsiella antibiotic resistance and serotypes.
Smith, S M, Digori, J T, Eng, R H
Because of the emergence of drug-resistant Klebsiella strains in many hospitals, the distribution of the serotypes was reexamined to determine whether there was any correlation between the serotype...
In vitro evaluation of the BACTEC resin-containing blood culture bottle.
The BACTEC resin-containing blood culture bottle (16B; Johnston Laboratories) was designed to bind antibiotics and to support bacterial growth. However, only modest increases in the recovery rates of...
Bactericidal screening test for late complement component deficiencies or defects.
Congenital complement deficiency has been described in disseminated Neisseria infections. Its occurrences in humans with other kinds of infections have not been described. In the past, CH50...
Serum cryptococcal antigen determination in the presence of rheumatoid factor.
Sera from nine patients with cryptococcal infections and from four with rheumatoid arthritis and positive rheumatoid factor were examined for the presence of cryptococcal capsular antigen by the...
Ciprofloxacin therapy for methicillin-resistant Staphylococcus aureus infections or colonizations.
Smith, S M, Eng, R H, Tecson-Tumang, F
Thirty patients were treated for colonization or for skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus. Three treatment regimens were evaluated, each progressively...
Inoculum effect of beta-lactam antibiotics on Enterobacteriaceae.
Eng, R H, Cherubin, C, Smith, S M, Buccini, F
Seven beta-lactam antibiotics were studied for both their antimicrobial activity and the degree to which they produced inoculum effect on Escherichia coli, Klebsiella pneumoniae, and Salmonella...
Inoculum effect of new beta-lactam antibiotics on Pseudomonas aeruginosa.
Eng, R H, Smith, S M, Cherubin, C
The degree of the inoculum effect shown by the new beta-lactam antibiotics with Pseudomonas aeruginosa was investigated, and the antibiotics were divided into three groups based upon the...
Eng, R H, Cherubin, C, Smith, S M, Buccini, F
One Salmonella and four Escherichia coli isolates from patients with bacterial meningitis who had responded slowly, relapsed, or failed to respond to monotherapy with moxalactam were examined. For...
Activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus.
Ciprofloxacin, a carboxy quinolone antibiotic with a broad spectrum of activity, was tested against 54 strains of methicillin-resistant Staphylococcus aureus. The ciprofloxacin MICs for 50 and 90% of...
Eng, R H, Smith, S M, Goldstein, E J, Miyasaki, K T, Quah, S E, Buccini, F
Reported is a case of Actinobacillus actinomycetemcomitans endocarditis which developed after dental prophylaxis with vancomycin and erythromycin. In vitro results indicated that this isolate and 20...
Susceptibility of zygomycetes to amphotericin B, miconazole, and ketoconazole.
Eng, R H, Person, A, Mangura, C, Chmel, H, Corrado, M
Susceptibility to amphotericin B, miconazole, and ketoconazole was determined for 25 clinical isolates of zygomycetes in yeast nitrogen base broth and human serum. In yeast nitrogen base broth, 7 of...
Effect of rifampin on ampicillin killing of group B streptococci.
Smith, S M, Eng, R H, Landesman, S
The activity of rifampin against group B streptococci as a single agent and in combination with ampicillin was examined. The minimum concentration of rifampin required to inhibit 90% of the isolates...
Antifungal activity in human urine and serum after ingestion of garlic (Allium sativum).
Caporaso, N, Smith, S M, Eng, R H
A fresh extract of garlic (Allium sativum) was administered orally to human volunteers. At intervals, serum and urine were collected and assayed for antifungal activity. The maximum tolerable dose...
Cefmenoxime therapy of serious bacterial infections.
Gombert, M E, Glasser, L A, Eng, R H
The efficacy and safety of cefmenoxime was evaluated in 50 patients with serious bacterial infections. These included 26 pneumonias, 18 urinary tract infections, 2 soft tissue infections, 2...
Vancomycin-dependent Enterococcus faecium isolated from stool following oral vancomycin therapy.
Dever, L L, Smith, S M, Handwerger, S, Eng, R H
The isolation of clinical strains of enterococci requiring vancomycin for growth has only recently been reported. We describe the isolation of Enterococcus faecium requiring vancomycin for growth...
Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria.
Eng, R H, Padberg, F T, Smith, S M, Tan, E N, Cherubin, C E
Antimicrobial agents are most often tested against bacteria in the log phase of multiplication to produce the maximum bactericidal effect. In an infection, bacteria may multiply less optimally. We...
Development of resistance in candida isolates from patients receiving prolonged antifungal therapy.
Fan-Havard, P, Capano, D, Smith, S M, Mangia, A, Eng, R H
The impact of prolonged antifungal therapy on the development of resistance was examined in 61 patients with oropharyngeal thrush. Fifty-nine patients had symptomatic human immunodeficiency virus...
Involvement of Gardnerella vaginalis in urinary tract infections in men.
Smith, S M, Ogbara, T, Eng, R H
Fifteen male patients from whose urine samples Gardnerella vaginalis was isolated (clinical incidence of 0.1%) were evaluated for clinical signs and symptoms of urinary tract infection and modality...
D-lactic acid measurements in the diagnosis of bacterial infections.
Smith, S M, Eng, R H, Campos, J M, Chmel, H
Body fluids suspected of bacterial infection were cultured and examined for the presence of D-lactic acid, a specific bacterial metabolite. We examined 206 patients and 264 specimens. D-Lactic acid...
Eng, R H, Bishburg, E, Smith, S M, Mangia, A
Thirty acquired immunodeficiency syndrome patients with mycobacterial bacteremia documented by Du Pont Isolator (Du Pont Co., Wilmington, Del.) blood cultures underwent microscopic examination of...
Bishburg, E, Eng, R H, Smith, S M, Kapila, R
The yield in cultures of bone marrow aspirations or biopsies was determined in 50 patients with acquired immunodeficiency syndrome. Most patients were febrile and had no identifiable source of...
Pseudomonas mesophilica infections in humans.
Smith, S M, Eng, R H, Forrester, C
Reported here is the case of a patient with metastatic adenocarcinoma of the lung who had bacteremia involving Pseudomonas mesophilica. Of the common laboratory media tested at 35 degrees C, buffered...
Species identification of coagulase-negative staphylococcal isolates from blood cultures.
Eng, R H, Wang, C, Person, A, Kiehn, T E, Armstrong, D
Coagulase-negative staphylococci generally are not fully identified, are called Staphylococcus epidermidis, and are considered contaminants when isolated from blood cultures. In a cancer hospital...
Epidemiology of Klebsiella antibiotic resistance and serotypes.
Smith, S M, Digori, J T, Eng, R H
Because of the emergence of drug-resistant Klebsiella strains in many hospitals, the distribution of the serotypes was reexamined to determine whether there was any correlation between the serotype...
In vitro evaluation of the BACTEC resin-containing blood culture bottle.
The BACTEC resin-containing blood culture bottle (16B; Johnston Laboratories) was designed to bind antibiotics and to support bacterial growth. However, only modest increases in the recovery rates of...
Bactericidal screening test for late complement component deficiencies or defects.
Congenital complement deficiency has been described in disseminated Neisseria infections. Its occurrences in humans with other kinds of infections have not been described. In the past, CH50...
Serum cryptococcal antigen determination in the presence of rheumatoid factor.
Sera from nine patients with cryptococcal infections and from four with rheumatoid arthritis and positive rheumatoid factor were examined for the presence of cryptococcal capsular antigen by the...