Irinotecan pathway genotype analysis to predict pharmacokinetics (2003)
Mathijssen, R.H., Marsh, S., Karlsson, M.O., Xie, R., Baker, S.D., Verweij, J., ...
PURPOSE: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of...
Effects of St. John's wort on irinotecan metabolism (2002)
Mathijssen, R.H., Verweij, J., Bruijn, P. De, Loos, W.J., Sparreboom, A.
St. John's wort (SJW), a widely used herbal product, has been implicated in drug interactions resulting from the induced expression of the cytochrome P450 CYP3A4 isoform. In this study, we determined...
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11) (2001)
Mathijssen, R.H., Alphen, R.J. Van, Verweij, J., Loos, W.J., Nooter, K., Stoter, G., ...
CPT-11 belongs to the class of topoisomerase I inhibitors, and it acts as a prodrug of SN-38, which is approximately 100-1000-fold more cytotoxic than the parent drug. CPT-11 has shown a broad...