Combined microPET/CT for imaging of hepatocellular carcinoma in mice (2009)
Falck, C. Von, Rodt, T., Halter, R., Spanel, R., Galanski, M., Borlak, J.
The EGF-transgenic mouse is a genetic model of hepatocellular carcinoma that allows for a comprehensive study of signal pathways, molecular interactions and the evaluation of novel therapeutic...
In vivo microCT quantification of lung tumor growth in SPC-raf transgenic mice (2009)
Rodt, T., Falck, C. Von, Halter, R., Ringe, K., Shin, H.O., Galanski, M., ...
Lung cancer is the most common cancer worldwide. Early detection might reduce morbidity. In this study we evaluate a microCT imaging algorithm to assess in-vivo tumour load and quantification of...
Halter, R., Hansen, T., Seidel, A., Ziemann, C., Borlak, J.
The equivocal experimental and epidemiological evidence of bitumen fumes and the possible mechanisms of toxicity remain uncertain. This study therefore aimed at investigating the genotoxicity of...
Doppelt transgenes nicht menschliches Saeugetier (2007)
(A1) Die Erfindung betrifft transgene nicht menschliche Saeugetiere, die zwei Transgene in ihrem Genom tragen, ein Verfahren zu deren Herstellung, deren Verwendung und Zellgewebe daraus....
Towards a lung adenocarcinoma proteome map: Studies with SP-C/c-raf transgenic mice (2006)
Rütters, H., Zürbig, P., Halter, R., Borlak, J.
We report mapping of proteins of adenocarcinomas of the lung as a result of overexpression of the oncogenically activated N-terminal deletion mutant c-raf-1 BxB through usage of the human SP-C...
Jacobs, T., Andra, J., Gaworski, I., Graefe, S., Mellenthin, K., Kromer, M., ...
To elucidate the role of complement-mediated uptake in Leishmania major infection in vivo, transgenic BALB/c mice that express the cobra venom factor (CVF) under control of the 1-antitrypsin promoter...
Borlak, J., Meier, T., Halter, R., Spanel, R., Spanel-Borowski, K.
Epidermal growth factor is an important mitogen for hepatocytes. Its overexpression promotes hepatocellular carcinogenesis. To identify the network of genes regulated through EGF, we investigated the...
An "omics" approach to study lung carcinogenesis (2004)
Borlak, J., Meier, T., Rütters, H., Zürbig, P., Halter, R.
Lung cancer is the most common cancer in the world and smoking is the major risk factor, accounting for about 90% of the cases. In 1996, an estimated 1.3 million new cases were diagnosed worldwide,...
Isolation and identification of Cyclin E1 isoforms in murine hepatocellular carcinomas (HCC) (2003)
Liedtke, C., Halter, R., Borlak, J., Manns, M.P., Trautwein, C.
Cyclin E1 is involved in controlling G1/S-phase progression during the cell cycle. Earlier results indicated that Cyclin E1 misregulation correlates with tumor progression in some types of human...
Expression of active human blood clotting VIII in mammary gland of transgenic rabbits (2003)
Hiripi, L., Makovics, F., Halter, R., Baranyi, M., Paul, D., Carnwath, J., ...
Human clotting factor VIII is probably the largest protein to be expressed to date in the mammary gland of a transgenic animal, and it requires extensive posttranslational modification to achieve...
Ehrhardt, A., Bartels, T., Klocke, R., Paul, D., Halter, R.
PURPOSE: As previously described, SPC/myc transgenic mice developed bronchioloalveolar adenocarcinomas derived from alveolar type II (AT II) cells within 10-14 months, whereas SPC/IgEGF transgenic...
Application of cDNA arrays to monitor mRNA profiles in single preimplantation mouse embryos (2002)
Brambrink, T., Wabnitz, P., Halter, R., Klocke, R., Carnwath, J., Kues, W., ...
Array technology is a widely used tool for gene expression profiling in various biological systems. However, the application of this method to mammalian preimplantation embryos is limited by the...
Generation and characterization of transgenic mice expressing cobra venom factor (2002)
Andrä, J., Halter, R., Kock, M.A., Niemann, H., Paul, D.
Cobra venom factor (CVF), the anticomplementary protein in cobra venom, activates the alternative complement pathway, eventually leading to complement consumption. Here, we describe the development...
Geick, A., Redecker, P., Ehrhardt, A., Klocke, R., Paul, D., Halter, R.
To investigate the influence of the proto-oncogene c-MYC on tumor development in different epithelial tissues which secrete Clara Cell Secretory Protein (uteroglobin, UG), transgenic mouse lines were...
M-CSF transgenic mice: Role of M-CSF in infection and autoimmunity (2001)
Bernier, T., Halter, R., Paul, D., Rittinghausen, S., Emmendörffer, A.
In this study, transgenic CD2F1 mouse lines (C-1.1-C-1.11) bearing a transgene encoding the murine growth factor M-CSF under the control of the liver specific alpha-1-antitrypsin gene promoter were...
Niemann, H., Verhoeyen, E., Wonigeit, K., Lorenz, R., Hecker, J., Schwinzer, R., ...
The critical shortage of human donor organs has generated growing interest for porcine to human xenotransplantation. The major immunological barrier to xenotransplantation is the hyperacute rejection...
Klocke, R., Bartels, T., Jennings, G., Brand, K., Halter, R., Strauss, M., ...
The role of the tumor suppressor function of p53 in the process of hepatocellular carcinoma (HCC) development is still enigmatic in view of uncertainties with respect to the phenotype of most p53...
Ehrhardt, A., Bartels, T., Geick, A., Klocke, R., Paul, D., Halter, R.
Transgenic mouse models were established to study tumorigenesis of bronchiolo-alveolar adenocarcinomas derived from alveolar type IIpneumocytes (AT-II cells). Transgenic lines expressing the...
Expression of human blood clotting factor VIII in the mammary gland of transgenetic sheep (1999)
Niemann, H., Halter, R., Carnwath, J.W., Herrmann, D., Lemme, E., Paul, D.
By targeting the expression of sequences encoding non-milk proteins to the mammary gland of transgenic farm animals, the organ could serve as a 'bioreactor' for producing pharmacologically active...
A transgenic mouse model for lung adenocarcinoma (1995)
Sandmöller, A., Halter, R., Suske, G., Paul, D., Beato, M.
Lung cancer is a leading cause of tumor-related deaths in humans but its origin and development are poorly understood. To study the biology of these tumors, appropriate animal and cell culture models...
Sandmöller, A., Halter, R., Suske, G., Paul, D., ...
Adenocarcinomas derived from the lining epithelia of various organs are the most common malignant tumors in human pathology and about 50% are hormone dependent. The tissue-specific and hormally...
Jacobs, E, Gerstenecker, B, Mader, B, Huang, C H, Hu, P C, Halter, R, ...
The adherence protein (P1 protein) of Mycoplasma pneumoniae was purified by electroelution and cleaved with cyanogen bromide. The resulting peptides were separated by two-dimensional electrophoresis....
Halter, R, Pohlner, J, Meyer, T F
IgA protease is a putative virulence factor that exists in several allelic forms in Neisseria gonorrhoeae. However, extracellular secretion of these variant IgA proteases occurs by the same pathway...
Halter, R, Pohlner, J, Meyer, T F
Gonococcal virulence is thought to rely on multiple characteristics including the production of an extracellular protease specific for human IgA1. Using a sensitive filter assay we have isolated an...
Jacobs, E, Gerstenecker, B, Mader, B, Huang, C H, Hu, P C, Halter, R, ...
The adherence protein (P1 protein) of Mycoplasma pneumoniae was purified by electroelution and cleaved with cyanogen bromide. The resulting peptides were separated by two-dimensional electrophoresis....
Halter, R, Pohlner, J, Meyer, T F
IgA protease is a putative virulence factor that exists in several allelic forms in Neisseria gonorrhoeae. However, extracellular secretion of these variant IgA proteases occurs by the same pathway...
Halter, R, Pohlner, J, Meyer, T F
Gonococcal virulence is thought to rely on multiple characteristics including the production of an extracellular protease specific for human IgA1. Using a sensitive filter assay we have isolated an...
Ehrhardt, A, Bartels, T, Geick, A, Klocke, R, Paul, D, Halter, R
Transgenic mouse models were established to study tumorigenesis of bronchiolo-alveolar adenocarcinomas derived from alveolar type II pneumocytes (AT-II cells). Transgenic lines expressing the murine...