R. Hardy

Publication List Details

Period

1980 - 2009

Number

78

Co-Authors

A Spine Approach to Branching Diffusions with Applications to L-p-convergence of Martingales (2009)

Hardy, R, Harris, Simon C

We present a modified formalization of the 'spine' change of measure approach for branching diffusions in the spirit, of those found in Kyprianou [40] and Lyons et al. [44, 437 41]. We use our...

Effectiveness of a social support intervention on infant feeding practices: randomised controlled trial (2009)

Watt, R. G., Tull, K. I., Hardy, R., Wiggins, M., Kelly, Y., ...

Background: To assess whether monthly home visits from trained volunteers could improve infant feeding practices at age 12 months, a randomised controlled trial was carried out in two disadvantaged...

Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics (2008)

Antoniou, A.C., Hardy, R., Walker, L., Evans, D.G., Shenton, A., Eeles, R., ...

Objectives: Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 has important implications for the clinical management of people found to carry a mutation. However,...

Is adiposity across life associated with subsequent hysterectomy risk? Findings from the 1946 British birth cohort study (2008)

Cooper, R., Hardy, R., Kuh, D.

Objective To examine the associations between adiposity at time points from early life onwards and subsequent hysterectomy risk. Design Prospective birth cohort study. Setting England, Scotland and...

The prevalence and severity of dental pain in 14-15 year old Brazilian schoolchildren (2007)

Goes, P.S.A., Watt, R.G., Hardy, R., Sheiham, A.

Objective: To assess the prevalence and severity of dental pain and it's associated factors in Brazilian schoolchildren. Methods: The study was a cross-sectional survey conducted in Recife, Brazil....

Is there an association between hysterectomy and subsequent adiposity? (2007)

Cooper, R., Kuh, D., Hardy, R., Power, C.

Objectives To examine the associations between hysterectomy and subsequent adiposity and to investigate whether these associations vary by characteristics of hysterectomy and are independent of...

Validity of age at menarche self-reported in adulthood (2006)

Cooper, R., Blell, M., Hardy, R., Black, S., Pollard, T.M., Wadsworth, M.E.J., ...

Objective: To test the validity of age at menarche self-reported in adulthood and examine whether socioeconomic position, education, experience of gynaecological events and psychological symptoms...

Developmental origins of midlife physical performance: evidence from a British birth cohort (2006)

Kuh, D., Hardy, R., Butterworth, S., Okell, L., Richards, M., Wadsworth, M., ...

The authors hypothesized that 1) physical growth, as a marker of the early development of muscle fibers, and 2) advanced childhood motor and cognitive abilities, as markers of central nervous system...

Statistical issues in life course epidemiology (2006)

De Stavola, B.L., Nitsch, D., McCormack, V., Hardy, R., Mann, V., ...

There is growing recognition that the risk of many diseases in later life, such as type 2 diabetes or breast cancer, is affected by adult as well as early-life variables, including those operating...

Age at puberty and adult blood pressure and body size in a British birth cohort study. (2006)

Hardy, R., Kuh, D., Whincup, P.H., Wadsworth, M.E.

Objective: To investigate the association between age at puberty and blood pressure at age 53 years. Design: A prospective birth cohort study with regular contacts through childhood and adulthood...

Developmental origins of midlife physical performance: evidence from a British birth cohort (2006)

Kuh, D., Hardy, R., Butterworth, S., Okell, L., Richards, M., Wadsworth, M., ...

The authors hypothesized that 1) physical growth, as a marker of the early development of muscle fibers, and 2) advanced childhood motor and cognitive abilities, as markers of central nervous system...

Developmental origins of midlife grip strength: findings from a birth cohort study (2006)

Kuh, D., Hardy, R., Butterworth, S., Okell, L., Wadsworth, M., Cooper, C., ...

BACKGROUND: There is growing evidence that the prenatal environment has long-term effects on adult grip strength, but little is known about the effects of the postnatal environment. We tested whether...

Socio-economic position across the life course and hysterectomy in three British cohorts: a cross-cohort comparative study (2005)

Cooper, R., Lawlor, D.A., Hardy, R., Ebrahim, S., Leon, D.A., Wadsworth, M.E., ...

Objective: To examine the association between indicators of lifetime socio-economic position and rates of hysterectomy in three British cohorts. Design: Cross-cohort comparative study. Setting: Two...

Life course social roles and women’s health in mid-life: causation or selection? (2005)

McMunn, A., Bartley, M., Hardy, R., Kuh, D.

Study objective: To investigate whether relationships between social roles and health are explained by health selection into employment and parenthood by examining the influence of early health on...

Social outcomes in adulthood of children with intellectual impairment: evidence from a birth cohort (2005)

Hall, I., Strydom, A., Richards, M., Hardy, R., Bernal, J., Wadsworth, M.

Background: Social Policy for people with intellectual disabilities (ID) continues to evolve, but little is known about the lives to which such policies are applied. We aimed to use a prospective...

Childhood cognitive ability and deaths up until middle age: a post-war birth cohort study (2004)

Kuh, D., Richards, M., Hardy, R., Butterworth, S., Wadsworth, M.E.J.

Background: Childhood IQ has been related to mortality in later life in four studies. Cognitive ability may be a mediator between early disadvantage and mortality, a marker of the efficiency of...

Birthweight, childhood growth, and blood pressure at 43 years in a British birth cohort (2004)

Hardy, R., Wadsworth, M.E.J., Langenberg, C., Kuh, D.

Background Low birthweight is associated with high blood pressure in later life, but it is unclear whether the association is confounded with or modified by maternal and socioeconomic factors or...

Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort (2003)

Hardy, R., Wadsworth, M.E.J., Langenberg, C., Kuh, D.

Summary: Background: The negative effect of birthweight on systolic blood pressure has been suggested to be initiated in utero and amplified with age. We aimed to investigate this hypothesis....

Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis (2003)

Aihie-Sayer, A., Poole, J., Cox, V., Kuh, D., Hardy, R., Wadsworth, M., ...

Objective To determine the influence of body weight throughout the life course on the development of clinical hand osteoarthritis (OA). Methods A British national survey was used to perform a...

Birth weight, osteoarthritis of the hand, and cardiovascular disease in men (2003)

Poole, J., Aihie-Sayer, A., Cox, V., Cooper, C., Kuh, D., Hardy, R., ...

Haara et al reported recently that the presence of osteoarthritis (OA) in at least one hand joint significantly predicted cardiovascular mortality in a sample of 1560 Finnish men aged 30 or over.1 OA...

Randomized crossover comparison of the ProSealTM laryngeal mask airway with the Laryngeal Tube(R) during anaesthesia with controlled ventilation (2003)

Cook, T. M., McKinstry, C., Hardy, R., Twigg, S.

Background. The Laryngeal Tube (LT®) performs similarly to the classic laryngeal mask airway during controlled ventilation but with an improved airway seal. We compared the laryngeal tube with the...

Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study (2002)

Kuh, D., Bassey, J., Hardy, R., Sayer, A.A., Wadsworth, M., Cooper, C.

Environmental influences during gestation may have long-term effects on adult muscle strength. It is not known how early in adult life such effects are manifest and whether they are modified by...

Does early growth influence timing of the menopause? Evidence from a British birth cohort (2002)

Hardy, R., Kuh, D.

Summary: Background: The negative effect of birthweight on systolic blood pressure has been suggested to be initiated in utero and amplified with age. We aimed to investigate this hypothesis....

Mortality in adults aged 26-54 years related to socioeconomic conditions in childhood and adulthood: post war birth cohort study (2002)

Kuh, D., Hardy, R., Langenberg, C., Richards, M., Wadsworth, M.E.J.

Objective: To examine premature mortality in adults in relation to socioeconomic conditions in childhood and adulthood. Design: Nationally representative birth cohort study with prospective...

Does early growth influence timing of the menopause? Evidence from a British birth cohort (2002)

Hardy, R., Kuh, D.

BACKGROUND: Few adult environmental or behavioural factors have been consistently associated with age at menopause. The peak number of follicles attained in utero or lost before ovulation begins may...

Using CFD in a GLUE framework to model the flow and dispersion characteristics of a natural fluvial dead zone. (2001)

Hankin, B. G., Hardy, R., Kettle, H., Beven, Keith J.

Monte Carlo simulations of a two-dimensional depth-averaged distributed bed-roughness flow model, TELEMAC-2D, are used to model a detailed tracer dispersion test in a complex reach of the River...

Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study (2001)

Richards, M., Hardy, R., Kuh, D., Wadsworth, M.E.J.

Objective: To examine the association between birth weight and cognitive function in the normal population. Design: A longitudinal, population based, birth cohort study. Participants: 3900 males and...

Long-term affective disorder in people with mild learning disability (2001)

Richards, M., Maughan, B., Hardy, R., Hall, I., Strydom, A., Wadsworth, M.

Background: Increased risk of affective disorder in learning disability has been reported, although the extent to which this is due to adverse social and material circumstances is uncertain and there...

Report on Alternative Devices to Pyrotechnics on Spacecraft, (1997)

Lucy, M., Hardy, R., Kist, E., Watson, J., Wise, S.

Pyrotechnics accomplish many functions on today's spacecraft, possessing minimum volume/weight, providing instantaneous operation on demand, and requiring little input energy. However, functional...

Synthesis related to the mikrolin structure. (1984)

Hardy, R.

Thesis (Ph. D.)--University of Nottingham, 1984.

Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers.

Rowe, M, Peng-Pilon, M, Huen, D S, Hardy, R, Croom-Carter, D, Lundgren, E, ...

An ability of the Epstein-Barr virus latent membrane protein LMP1 to enhance the survival of infected B cells through upregulation of the bcl-2 oncogene was first suggested by experiments involving...

Expression of cell surface markers after human B lymphocyte activation.

Stashenko, P, Nadler, L M, Hardy, R, Schlossman, S F

The fate of two recently described human B lymphocyte-specific antigens (B1 and B2) was studied after B-cell activation in vivo and in vitro. Whereas both B1 and B2 were present on virtually all B...

A unique cell surface antigen identifying lymphoid malignancies of B cell origin.

Nadler, L M, Ritz, J, Hardy, R, Pesando, J M, Schlossman, S F, Stashenko, P

A monoclonal antibody (anti-B1) specific for a unique B cell surface differentiation antigen was used to characterize the malignant cells from patients with leukemias or lymphomas. All tumor cells...

Cadherin adhesion in the intestinal crypt regulates morphogenesis, mitogenesis, motogenesis, and metaplasia formation.

Perry, I, Hardy, R, Tselepis, C, Jankowski, J A

The topographical organisation of the epithelium lining mucous membranes has been an intense point of research. One of the fundamental biological issues underpinning this and associated issues...

A colorectal cell line with alterations in E-cadherin and epithelial biology may be an in vitro model of colitis.

Perry, I, Hardy, R, Jones, T, Jankowski, J

BACKGROUND: It has been shown previously in ulcerative colitis tissue that E-cadherin can occasionally be mutated in the extracellular domain early in neoplastic progression. E-cadherin is known to...

Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis.

Frolov, I, Hardy, R, Rice, C M

Alphavirus genome replication is a multistep asymmetric process. Several lines of evidence suggest that the template preference of the RNA replicase is regulated by proteolytic cleavage of the viral...

Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers.

Rowe, M, Peng-Pilon, M, Huen, D S, Hardy, R, Croom-Carter, D, Lundgren, E, ...

An ability of the Epstein-Barr virus latent membrane protein LMP1 to enhance the survival of infected B cells through upregulation of the bcl-2 oncogene was first suggested by experiments involving...

Expression of cell surface markers after human B lymphocyte activation.

Stashenko, P, Nadler, L M, Hardy, R, Schlossman, S F

The fate of two recently described human B lymphocyte-specific antigens (B1 and B2) was studied after B-cell activation in vivo and in vitro. Whereas both B1 and B2 were present on virtually all B...

A unique cell surface antigen identifying lymphoid malignancies of B cell origin.

Nadler, L M, Ritz, J, Hardy, R, Pesando, J M, Schlossman, S F, Stashenko, P

A monoclonal antibody (anti-B1) specific for a unique B cell surface differentiation antigen was used to characterize the malignant cells from patients with leukemias or lymphomas. All tumor cells...

Cadherin adhesion in the intestinal crypt regulates morphogenesis, mitogenesis, motogenesis, and metaplasia formation.

Perry, I, Hardy, R, Tselepis, C, Jankowski, J A

The topographical organisation of the epithelium lining mucous membranes has been an intense point of research. One of the fundamental biological issues underpinning this and associated issues...

A colorectal cell line with alterations in E-cadherin and epithelial biology may be an in vitro model of colitis.

Perry, I, Hardy, R, Jones, T, Jankowski, J

BACKGROUND: It has been shown previously in ulcerative colitis tissue that E-cadherin can occasionally be mutated in the extracellular domain early in neoplastic progression. E-cadherin is known to...

Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis.

Frolov, I, Hardy, R, Rice, C M

Alphavirus genome replication is a multistep asymmetric process. Several lines of evidence suggest that the template preference of the RNA replicase is regulated by proteolytic cleavage of the viral...

Upregulation of the oncogene c-myc in Barrett’s adenocarcinoma: induction of c-myc by acidified bile acid in vitro

Tselepis, C, Morris, C D, Wakelin, D, Hardy, R, Perry, I, Luong, Q T, ...

Background and aims: C-myc over expression is implicated in malignancy although to date this has not been studied in Barrett’s metaplasia. We sought to determine c-myc expression in the malignant...

Mortality from infective endocarditis: clinical predictors of outcome

Wallace, S M, Walton, B I, Kharbanda, R K, Hardy, R, Wilson, A P, Swanton, R H

Objective: To identify clinical markers available within the first 48 hours of admission that are associated with poor outcome in infective endocarditis.

Development of a scale to measure symptoms of anxiety and depression in the general UK population: the psychiatric symptom frequency scale.

Lindelow, M, Hardy, R, Rodgers, B

OBJECTIVES: The psychiatric symptom frequency (PSF) scale was developed to assess symptoms of anxiety and depression (i.e. affective symptoms) experienced over the past year in the general...

Central and total obesity in middle aged men and women in relation to lifetime socioeconomic status: evidence from a national birth cohort

Langenberg, C, Hardy, R, Kuh, D, Brunner, E, Wadsworth, M

Study objective: To investigate the influence of social class in childhood, young adulthood and middle age, and intergenerational mobility, on adult central and total obesity.

Urinary incontinence in middle aged women: childhood enuresis and other lifetime risk factors in a British prospective cohort

Kuh, D., Cardozo, L., Hardy, R.

STUDY OBJECTIVE: To investigate the prevalence and lifetime risk factors for urinary incontinence in middle aged women. DESIGN: Nationally representative birth cohort study with prospective data on...

Desmocollin switching in colorectal cancer

Khan, K, Hardy, R, Haq, A, Ogunbiyi, O, Morton, D, Chidgey, M

The desmocollins are members of the desmosomal cadherin family of cell–cell adhesion molecules. They are essential constituents of desmosomes, intercellular junctions that play a critical role in...

Birthweight, childhood growth and risk of breast cancer in a British cohort

Stavola, B L De, Hardy, R, Kuh, D, Silva, I Dos Santos, Wadsworth, M, Swerdlow, A J

We have examined the relationship between birthweight and risk of breast cancer, taking into account growth in childhood, using data on a total of 2221 women born in 1946 and followed up to 1997....

Dietary calcium and vitamin D intakes in childhood and throughout adulthood and mammographic density in a British birth cohort

Mishra, G, McCormack, V, Kuh, D, Hardy, R, Stephen, A

We examined the role of dietary calcium and vitamin D intakes in childhood and throughout adulthood in relation to mammographic density using data from a nationally representative cohort of 1161...