Metabolomics Technologies applied to the Identification of Compounds in Plants (2008)
Sofia Moço, Prof Dr, R. J. Bino, Senior Onderzoeker, Sofia Isabel, Abraúl Viana Moço, ...
Dit onderzoek is uitgevoerd binnen de onderzoeksschool Voeding, Levensmiddelentechnologie, Agrobiotechnologie en Gezondheid. Metabolomics Technologies applied to the
Susceptibility of the Tomato Mutant High Pigment-2dg (hp-2dg) to Orobanche spp. Infection (2008)
Lopez Raez, J.A., Charnikhova, T., Mulder, P.P.J., Kohlen, W., Bino, R.J., Levin, I., ...
The consumption of natural products with potential health benefits has been continuously growing, and enhanced pigmentation is of major economic importance in fruits and vegetables. The tomato hp-2dg...
Lamers, P.P., Janssen, M.G.J., Bino, R.J., Wijffels, R.H.
The unicellular alga Dunaliella salina is the most interesting cell factory for the commercial production of ß-carotene because this species accumulates carotenoids to high concentrations....
Lamers, P.P., Janssen, M., Bino, R.J., Wijffels, R.H.
The unicellular alga Dunaliella salina is the most interesting cell factory for the commercial production of [beta]-carotene because this species accumulates carotenoids to high concentrations....
Moco, S.I.A., Forshed, J., Bino, R.J., Vervoort, J.J.M.
Nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LCMS) are frequently used as technological platforms for metabolomics applications. In this study, the metabolic profiles...
Roeleveld, J., Mooibroek, H., Sijtsma, L., Bino, R.J., Bosch, H.J., ...
Polyunsaturated fatty acid (PUFA) rich micro-algal oil was tested in vitro and compared with fish oil for antiproliferative properties on cancer cells in vitro. Oils derived from Crypthecodinium...
Moco, S.I.A., Lommen, A., Keurentjes, J.J.B., Bino, R.J., Hall, R.D.
Untargeted metabolomics aims to gather information on as many metabolites as possible in biological systems by taking into account all information present in the data sets. Here we describe a...
Metabolomics technologies and metabolite identification (2007)
Moco, S.I.A., Bino, R.J., Vervoort, J.J.M.
Metabolomics studies rely on the analysis of the multitude of small molecules (metabolites) present in a biological system. Most commonly, metabolomics is heavily supported by mass spectrometry (MS)...
Alink, G.M., Bino, R.J., Bosch, H.J., ...
Moco, S.I.A., Capanoglu, E., Tikunov, Y.M.., Bino, R.J., Vervoort, J.J.M.
Fruit maturation and tissue differentiation are important topics in plant physiology. These biological phenomena are accompanied by specific alterations in the biological system, such as differences...
Iridoids from Pentas lanceolata (Forssk.) Deflers (2007)
Schripsema, J., Caprini, C.P., Bino, R.J., Dagnino, D.
From the aerial parts of Pentas lanceolata, belonging to the family Rubiaceae, a series of iridoid glucosides was isolated by preparative HPLC. Seven iridoid glucosides were identified. Besides...
America, A.H.P., Cordewener, J.H.G., Lommen, A., Vissers, J.P.C., Bino, R.J., ...
A method for high-resolution proteomics analyses of complex protein mixtures is presented using multidimensional HPLC coupled to MS (MDLC-MS). The method was applied to identify proteins that are...
Genetics meets metabolomics: Unraveling plant metabolism (2006)
Keurentjes, J.J.B., Fu, Y., Lommen, A., Hall, R.D., Bino, R.J., ...
Variation for metabolite composition and content is often observed in plants. However, it is poorly understood to what extent this variation has a genetic basis. Here, we describe the genetic...
A liquid chromatography-mass spectrometry-based metabolome database for tomato (2006)
Moco, S.I.A., Bino, R.J., Vorst, O.F.J., Verhoeven, H.A., ...
For the description of the metabolome of an organism, the development of common metabolite databases is of utmost importance. Here we present the Metabolome Tomato Database (MoTo DB), a metabolite...
A liquid chromatography-mass spectrometry-based metabolome database for tomato (2006)
Moco, S.I.A., Bino, R.J., Vorst, O.F.J., Verhoeven, H.A., ...
For the description of the metabolome of an organism, the development of common metabolite databases is of utmost importance. Here we present the Metabolome Tomato Database (MoTo DB), a metabolite...
The genetics of plant metabolism (2006)
Keurentjes, J. J. B., Fu, J. Y., Lommen, A., Hall, R. D., Bino, R. J., ...
Metabolomics of tomato fruit volatiles during fruit development (2006)
Tikunov, Y.M.., Lommen, A., Verhoeven, H.A., Bino, R.J., Hall, R.D., ...
Metabolomics meets genetics: linking metabolite profiles to QTLs (2006)
Keurentjes, J.J.B., Fu, J., Lommen, A., Bino, R.J., Jansen, R., ...
The genetics of plant metabolism (2006)
Keurentjes, J.J.B., Fu, J., Lommen, A., Hall, R.D., Bino, R.J., ...
Variation for metabolite composition and content is often observed in plants. However, it is poorly understood to what extent this variation has a genetic basis. Here, we describe the genetic...
NMR database of flavonoids (2006)
Moco, S.I.A., Chen, Y., Spraul, M., Tseng, L., Bino, R.J., Vervoort, J.J.M.
High pigment tomato mutants - more than just lycopene (a review) (2006)
Levin, I., Tadmor, Y., Bovy, A.G., Lieberman, M., Oren-Shamir, M., ...
Fruit constitutes a major component of our diet, providing fiber, vitamins, minerals, and many phytonutrients that promote good health. Fleshy fruits such as tomatoes already contain high levels of...
Soeda, Y., Vorst, O.F.J., Stoopen, G.M., Maliepaard, C.A., ...
During seed maturation and germination, major changes in physiological status, gene expression, and metabolic events take place. Using chlorophyll sorting, osmopriming, and different drying regimes,...
Vorst, O.F.J., Lommen, A., Staps, R.V., Visser, R.G.F., Bino, R.J., ...
An essential element of any strategy for non-targeted metabolomics analysis of complex biological extracts is the capacity to perform comparisons between large numbers of samples. As the most widely...
Tikunov, Y., Lommen, A., Verhoeven, H.A., Bino, R.J., Hall, R.D., ...
To take full advantage of the power of functional genomics technologies and in particular those for metabolomics, both the analytical approach and the strategy chosen for data analysis need to be as...
Tikunov, Y.M.., Lommen, A., Verhoeven, H.A., Bino, R.J., Hall, R.D., ...
To take full advantage of the power of functional genomics technologies and in particular those for metabolomics, both the analytical approach and the strategy chosen for data analysis need to be as...
Tikunov, Y., Lommen, A., Verhoeven, H.A., Bino, R.J., Hall, R.D., ...
To take full advantage of the power of functional genomics technologies and in particular those for metabolomics, both the analytical approach and the strategy chosen for data analysis need to be as...
Potential of metabolomics as a functional genomics tool (2004)
Bino, R. J., Hall, R. D., Fiehn, O., Kopka, J., Saito, K., Draper, John, ...
Metabolomics is developing as an important functional genomics tool; however, there is still room for technical improvements in both the large-scale determination of metabolites from complex plant...
Potential of metabolomics as a functional genomics tool (2004)
Bino, R.J., Hall, R.D., Fiehn, O., Kopka, J., Saito, K., Draper, J., ...
Metabolomics is developing as an important functional genomics tool; however, there is still room for technical improvements in both the large-scale determination of metabolites from complex plant...
Pawlowski, T.A., Bergervoet, J.H.W., Bino, R.J., Groot, S.P.C.
Cell cycle events in embryo axes of Norway maple (Acer platanoides L.) seeds were studied during dormancy breaking by flow cytometric analyses of the nuclear DNA content and by immunodetection of...
A proposed framework for the description of plant metabolomics experiments and their results (2004)
Jenkens, H., Hardy, N., Beckmann, M., Draper, J., Smith, A.R., Taylor, J., ...
The study of the metabolite complement of biological samples, known as metabolomics, is creating large amounts of data, and support for handling these data sets is required to facilitate meaningful...
Metabolomics research on potato and tomato (2004)
Hall, R.D., Verhoeven, H., Tikunov, Y.M.., Bouwmeester, H.J., Verstappen, F.W.A., ...
Metabolomics of tomato fruit volatile compounds (2004)
Tikunov, Y.M.., Lommen, A., Bino, R.J., Hall, R.D., Bovy, A.G.
Metabolomics of tomato fruit volatile compounds (2004)
Tikunov, Y.M.., Lommen, A., Bino, R.J., Hall, R.D., Bovy, A.G.
Volatile compounds are important contributors to the tomato fruit flavour. In this study, ripe fruits of 96 tomato cultivars of three types (cherry, round and beef tomatoes) have been used. These...
Bino, R.J., Lommen, A., Hall, R.D., Sumner, L.W., ...
Medicago truncatula is the model plant for molecular and genetic studies of legumes, which are important agricultural protein crops. Furthermore, legumes synthesize several unique (pharmaceutical...
Screening tomato fruit for flavour and health using integrated metabolomics approaches (2004)
Lommen, A., Jonker, H.H., Verstappen, F.W.A., Bouwmeester, H.J., Bino, R.J., ...
For the consumer, the most important tomato fruit quality traits are their flavour and their positive health impact. Breeding for these traits is nowadays a major goal of tomato seed companies. By...
Vorst, O.F.J., Lommen, A., Staps, R.V., Visser, R.G.F., Bino, R.J., ...
The success of non-targetted metabolic fingerprinting of large numbers of plant samples, as will be required for population screening, biodiversity studies etc, is dependant both on the accuracy and...
The further development of metabolomics as a functional genomics tool (2004)
Bino, R.J., Hall, R.D., Fiehn, O., Saito, K., Draper, J., Nikolau, B.J., ...
The further development of metabolomics as a functional genomics tool (2004)
Bino, R.J., Hall, R.D., Fiehn, O., Saito, K., Draper, J., Nikolau, B.J., ...
Our goal is to promote plant metabolomics as a true functional genomics tool that provides a comprehensive characterization of the biochemical phenotype of a plant. The realization of this goal will...
Integrated metabolomics approaches as a complement to genomics tools in tomato and potato (2004)
Bovy, A.G., Lommen, A., Tikunov, Y.M.., Bouwmeester, H.J., ...
Screening tomato fruit for flavour and health using integrated metabolomics approaches (2004)
Lommen, A., Jonker, H.H., Verstappen, F.W.A., Bouwmeester, H.J., Bino, R.J., ...
For the consumer, the most important tomato fruit quality traits are their flavour and their positive health impact. Breeding for these traits is nowadays a major goal of tomato seed companies. By...
Metabolomics research on potato and tomato (2004)
Hall, R.D., Verhoeven, H.A., Tikunov, Y., Bouwmeester, H.J., Verstappen, F.W.A., ...
Metabolomics of tomato fruit volatile compounds (2004)
Tikunov, Y.M.., Lommen, A., Bino, R.J., Hall, R.D., Bovy, A.G.
Volatile compounds are important contributors to the tomato fruit flavour. In this study, ripe fruits of 96 tomato cultivars of three types (cherry, round and beef tomatoes) have been used. These...
Metabolomics of tomato fruit volatile compounds (2004)
Tikunov, Y.M.., Lommen, A., Bino, R.J., Hall, R.D., Bovy, A.G.
Volatile compounds are important contributors to the tomato fruit flavour. In this study, ripe fruits of 96 tomato cultivars of three types (cherry, round and beef tomatoes) have been used. These...
Bino, R.J., Lommen, A., Hall, R.D., Sumner, L.W., ...
Medicago truncatula is the model plant for molecular and genetic studies of legumes, which are important agricultural protein crops. Furthermore, legumes synthesize several unique (pharmaceutical...
Vorst, O.F.J., Lommen, A., Staps, R.V., Visser, R.G.F., Bino, R.J., ...
The success of non-targetted metabolic fingerprinting of large numbers of plant samples, as will be required for population screening, biodiversity studies etc, is dependant both on the accuracy and...
The further development of metabolomics as a functional genomics tool (2004)
Bino, R.J., Hall, R.D., Fiehn, O., Saito, K., Draper, J., Nikolau, B.J., ...
A proposed framework for the description of plant metabolomics experiments and their results (2004)
Jenkins, H., Hardy, N., Beckmann, M., Draper, J., Smith, A. R., Taylor, J., ...
The study of the metabolite complement of biological samples, known as metabolomics, is creating large amounts of data, and support for handling these data sets is required to facilitate meaningful...
Potential of metabolomics as a functional genomics tool (2004)
Bino, R. J., Hall, R. D., Fiehn, O., Saito, K., Draper, J., ...
Metabolomics is developing as an important functional genomics tool; however, there is still room for technical improvements in both the large-scale determination of metabolites from complex plant...
Plant enzymes for bioconversion (2004)
Franssen, M.C.R., Bino, R.J., Schurink, M., Bouwmeester, H.J.
Metabormatics for MS and development ideas (2003)
Lommen, A., Laue, G., Verhoeven, H.A., Nielen, M., Bouwmeester, H.J., ...
Metabolomic profiling of activation-tagged Arabidopsis mutants using QTOF-MS (2003)
Verhoeven, H.A., Aharoni, A., Pereira, A.B., Bino, R.J., Hall, R.D.
Increased production of nutriments by genetically engineered crops (2002)
Sevenier, R.E., Bino, R.J., Koops, A.J.
Plants are the basis of human nutrition and have been selected and improved to assure this purpose. Nowadays, new technologies such as genetic engineering and genomics approaches allow further...
Nontargeted metabolome analysis by use of Fourier transform ion cyclotron mass spectrometry (2002)
Aharoni, A., Maliepaard, C.A., Kruppa, G, Bino, R.J., Goodenough, D
Advanced functional genomic tools now allow the parallel and high-throughput analyses of gene and protein expression. Although this information is crucial to our understanding of gene function, it...
Bino, R.J., Jing, H.C., Hilhorst, H.W.M.
Cell cycle activities are initiated following imbibition of non-dormant seeds. However, it is not known whether cell cycle related events other than DNA replication also remain suppressed in imbibed...
Groot, S.P.C., Bino, R.J., Hilhorst, H.W.M.
Cell cycle activities are initiated following imbibition of non-dormant seeds. However, it is not known whether cell cycle related events other than DNA replication also remain suppressed in imbibed...
Molecular genetic analysis of arabidopsis seed quality (2000)
Groot, S.P.C., Tesnier, K., Alonso-Blanco, C., Bentsink, L., Donkers, H., ...
Molecular genetic analysis of Arabidopsis seed quality (2000)
Groot, S.P.C., Tesnier, K.J.Y., Alonso-Blanco, C., Bentsink, L., Donkers, H., ...
Cucumber (Cucumis sativus L.) seed performance as influenced by ovary and ovule position (2000)
Jing, H.C., Jalink, H., Bergervoet, J.W., Klooster, M., Du, S.L., Bino, R.J., ...
The performance of cucumber (Cucumis sativus L.) seeds in relation to ovary and ovule position was monitored during seed production. Seeds from three (first, seventh and tenth nodes) fruit positions...
Groot, S.P.C., Bino, R.J., Hilhorst, H.W.M.
We studied cell cycle events in embryos of tomato (Lycopersicon esculentum Mill. cv Moneymaker) seeds during imbibition in water and during osmoconditioning ("priming") using both quantitative and...
Cucumber (Cucumis sativus L.) seed performance as influenced by ovary and ovule position (2000)
Bergervoet, J.H.W., Jalink, H., Klooster, M., Bino, R.J., ...
Molecular genetic analysis of Arabidopsis seed quality (2000)
Groot, S.P.C., Tesnier, K., Alonso-Blanco, C., Bentsink, L., Donkers, H., ...
Bergervoet, J.H.W., Jing, H., Bino, R.J., ...
Effect of harvest time and soaking treatment on cell cycle activity in sugar-beet seeds (1999)
Elwira, S., Jing, H., Job, C., Job, D., Bergervoet, J.H.W., Bino, R.J., ...
ÖZBINGÖL, N., CORBINEAU, F., GROOT, S. P. C., BINO, R. J., CÔME, D.
Using flow cytometric analyses of the nuclear DNA content, we studied the effects of various conditions of osmopriming on the activation of the cell cycle in embryo root tips of tomato (Lycopersicon...
Seed technology training in the year 2000 (1998)
McDonald,M.B., Marcos-Filho,J., Bino,R.J.
Seed quality will remain the centerpiece of successful agricultural programs in the year 2000. As new changes occur in agriculture driven by advancements in biotechnology, seed enhancement...
Seed research for improved technologies (1998)
Bino,R.J., Jalink,H., Oluoch,M.O., Groot,S.P.C.
The production of high-quality seed is the basis for a durable a profitable agriculture. After production, seed is processed, conditioned, stored, shipped and germinated. For quality assurance, seed...
Dihaploid embryo production via microspore-embryogenesis in Brassica napus. (1998)
Xuhan, X., Jing, H., Iwanowska, A., Bergervoet, J.H.W., Groot, S.P.C., ...
Bino, R.J., Groot, S.P.C., Liu, Y.
Production of high quality seed is the basis for a durable and profitable agriculture. After production, seed is processed, conditioned, stored, shipped and used throughout the world. Seed quality,...
FINCH-SAVAGE, W. E., BERGERVOET, J. H. W., BINO, R. J., CLAY, H. A., GROOT, S. P. C.
Flow cytometric analyses of nuclear DNA levels were carried out during development, stratification and germination of dormant seeds from three tree species with contrasting characteristics. Norway...
High amounts of nuclear DNA in tomato (Lycopersicon esculentum Mill.) pericarp (1996)
Bergervoet, J.H.W., Verhoeven, H.A., Gilissen, L.J.W., Bino, R.J.
High amounts of nuclear DNA in tomato (Lycopersicon esculentum) pericarp (1996)
Bergervoet, J.H.W., Verhoeven, H.A., Gilissen, L.J.W., Bino, R.J.
Effect of ABA and slow drying on DNA replication in carrot (Daucus carota) embryoids. (1995)
Tetteroo, F.A.A., Bino, R.J., Bergervoet, J.H.W., Hasenack, B.
Non-destructive seed evaluation with impact measurements and X-ray analysis (1995)
Jalink, H., Aartse, J.W., Bino, R.J.
Non-destructive testing is important in the search for seed characteristics that relate to quality. It provides a means for consecutive testing on a seed by seed basis. If the tests are fast and can...
BINO, R. J., VRIES, J. N. DE, KRAAK, H. L., PIJLEN, J. G. VAN
Flow cytometric determination of DNA levels in embryos of fully matured dry tomato (Lycopersicon esculenium) seeds revealed large amounts of 2C DNA signals, indicating that most cells had arrested in...
BINO, R J, TUYL, J M VAN, DE VRIES, J N
Nuclear DNA content in mature pollen was measured with a flow cytometer Pollen of Lilium longiflorum, Dendranthema grandiflora (syn Chrysanthemum monfolium) and Zea mays was chopped and stained with...
Effects of Alternaria alternata f.sp. lycopersici toxins on pollen (1988)
Bino, R.J., Franken, J., Witsenboer, H.M.A., Hille, J., Dons, J.J.M.
Effects of the phytotoxic compounds (AAL-toxins) isolated from cell-free culture filtrates of Alternaria alternata f.sp. lycopersici on in vitro pollen development were studied. AAL-toxins inhibited...
Kanamycin resistance during in vitro development of pollen from transgenic tomato plants (1987)
Bino, R.J., Hille, J., Franken, J.
Effects of kanamycin on pollen germination and tube growth of pollen from non-transformed plants and from transgenic tomato plants containing a chimaeric kanamycin resistance gene were determined....
Cytoplasmic male sterility in Petunia hybrida. A structural and histochemical analysis. (1986)
http://library.wur.nl/wda/abstracts/ab1079.html
[beta]-Tubulin Accumulation and DNA Replication in Imbibing Tomato Seeds.
De Castro, R. D., Zheng, X., Bergervoet, JHW., De Vos, CHR., Bino, R. J.
The activation of the cell cycle in embryo root tips of imbibing tomato (Lycopersicon esculentum Mill. cv Lerica) seeds was studied by flow cytometric analyses of the nuclear DNA content and by...
[beta]-Tubulin Accumulation and DNA Replication in Imbibing Tomato Seeds.
De Castro, R. D., Zheng, X., Bergervoet, JHW., De Vos, CHR., Bino, R. J.
The activation of the cell cycle in embryo root tips of imbibing tomato (Lycopersicon esculentum Mill. cv Lerica) seeds was studied by flow cytometric analyses of the nuclear DNA content and by...