R. J. Simes

The value of N-terminal fragment of brain natiuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study (2008)

West, M. J., Nestel, P.J., Kirby, A.C., Schnabel, R., Sullivan, D., Simes, R.J., ...

Variations in the use of emergency PCI for the treatment of re-infarction following intravenous fibrinolytic therapy: impact on outcomes in HERO-2 (2007)

Edmond, J.J., French, J.K., Aylward, P.E.G., Wong, C.K., Stewart, R.A.H., Williams, B.F., ...

Background Patients who suffer re-infarction during initial hospitalization for ST-elevation myocardial infarction (STEMI) have decreased survival compared to patients without re-infarction, so...

Effect of sertraline on symptoms and survival in patients with advanced cancer, but without major depression: a placebo-controlled double-blind randomised trial (2007)

Stockler, M.R., O'Connell, R., Nowak, A.K., Goldstein, D., Turner, J., Wilcken, N.R.C., ...

Effect of fenofi brate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial (2007)

Keech, A. C., Mitchell, P., O'Day, J., Davis, T .M. E., Moffitt, M. S., ...

Laser treatment for diabetic retinopathy is often associated with visual field reduction and other ocular side-effects. Our aim was to assess whether long-term lipid-lowering therapy with fenofibrate...

Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial (2007)

Keech, A C, Mitchell, P, Summanen, P A, O'Day, J, Davis, T M E, Moffitt, M S, ...

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial (2005)

Keech, A., Simes, R. J., Barter, P., Best, J., Scott, R., Taskinen, M. R., ...

Background Patients with type 2 diabetes mellitus are at increased risk of cardiovascular disease, partly owing to dyslipidaemia, which can be amenable to fibrate therapy. We designed the Fenofibrate...

Patients' preferences for adjuvant chemotherapy in early breast cancer: what makes AC and CMF worthwhile now? (2005)

Duric, V. M., Stockler, M. R., Heritier, S., Boyle, F., Beith, J., Sullivan, A., ...

Background: Studies of women who had adjuvant chemotherapy for early breast cancer 10–20 years ago showed that many judged small benefits sufficient to make it worthwhile. Indications, regimens and...

Patients' preferences for adjuvant chemotherapy in early breast cancer: what makes AC and CMF worthwhile now? (2005)

Duric, V. M., Stockler, M. R., Heritier, S., Boyle, F., Beith, J., Sullivan, A., ...

Background: Studies of women who had adjuvant chemotherapy for early breast cancer 10-20 years ago showed that many judged small benefits sufficient to make it worthwhile. Indications, regimens and...

Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart6 disease and average cholesterol concentrations: the LIPID trial follow-up P Thompson, M West, H White (2002)

Simes, R. J., Hunt, D., Kirby, A., Tonkin, A., Keech, A., Aylward, P., ...

Background The Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID) study showed that pravastatin therapy over 6 years reduced mortality and cardiovascular events in patients with...

Cholesterol-lowering therapy with pravastatin in patients with average cholesterol levels and established ischaemic heart disease: is it cost-effective? (2002)

Glasziou, P. P., Eckermann, S. D., Mulray, S. E., Simes, R. J., Martin, A. J., Kirby, A. C., ...

Objective: To measure the cost-effectiveness of cholesterol-lowering therapy with pravastatin in patients with established ischaemic heart disease and average baseline cholesterol levels. Design:...

Clinical characteristics and outcome of patients with early (4h) presentation treated by primary coronary angioplasty or thrombolytic therapy for acute myocardial infarction (2002)

Zijlstra, F, Patel, A, Jones, M, Grines, C.L, Ellis, S, Garcia, E, ...

Aims We examined the clinical characteristics and outcome of patients with early (4h) presentation treated by primary angioplasty or thrombolytic therapy for acute myocardial infarction. Methods and...

Randomised comparison of two standard chemotherapy regimens for good prognosis germ cell tumours: Superior survival with more dose-intensive regimen (2001)

Toner, G. C., Stockler, M. R., Boyer, M. J., Jones, M., Thomson, D. B., Harvey, V. J., ...

Background Most patients with metastatic germ-cell tumours are cured with chemotherapy. However, the optimum chemotherapy regimen is uncertain, and there is variation in international practice. We...

Long-term risk stratification for survivors of acute coronary syndromes - Results from the long-term intervention with pravastatin in ischemic disease (LIPID) study (2001)

Marschner, I. C., Colquhoun, D., Simes, R. J., Glasziou, P., Harris, P., Singh, B. B., ...

OBJECTIVES We developed a prognostic strategy for quantifying the long-term risk of coronary heart disease (CHD) events in survivors of acute coronary syndromes (ACS). BACKGROUND Strategies for...

Prediction of 1-year survival after thrombolysis for acute myocardial infarction in the global utilization of streptokinase and TPA for occluded coronary arteries trial (2000)

Pieper, K S, Lee, K L, Simes, R J, Armstrong, P W, ...

BACKGROUND: When a patient survives thrombolysis for acute myocardial infarction, little information from large studies exists from which to estimate prognosis during follow-up visits. METHODS AND...

A comparison of standard gamble, time trade-off and adjusted time trade-off scores (2000)

Martin, A., Glasziou, P. P., Simes, R. J., Lumley, T.

Pravastatin therapy and the risk of stroke (2000)

White, H., Simes, R. J., Anderson, N. E., Hankey, G. J., Watson, J. D., Hunt, D., ...

A cardiovascular extension of the Health Measurement Questionnaire (1999)

Martin, A. J., Glasziou, P. P., Simes, R. J.

Improved quality of life with megestrol acetate in patients with endocrine-insensitive advanced cancer: A randomised placebo-controlled trial (1997)

Beller, E., Tattersall, M., Lumley, T., Levi, J., Dalley, D., Olver, I., ...

Purpose: To investigate the effect of two doses of megestrol acetate (MA) compared with placebo on quality of life (QoL) and nutritional status (NS) in patients with advanced endo crine-insensitive...

One-year results from the Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries (GUSTO-I) trial. GUSTO-I Investigators (1996)

White, H D, Sadowski, Z, Armstrong, P W, Vahanian, A, ...

BACKGROUND: In the randomized Global Utilization of t-PA and Streptokinase for Occluded Coronary Arteries (GUSTO-I) trial, 41021 patients received one of four thrombolytic regimens. Patients treated...

Variations in patient management and outcomes for acute myocardial infarction in the United States and other countries. Results from the GUSTO trial. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (1995)

Topol, E J, Lee, K L, Woodlief, L H, Granger, C B, Armstrong, P W, ...

OBJECTIVE--To examine differences in outcomes and patient management between patients in the United States and outside the United States undergoing thrombolysis for acute myocardial infarction....

High-Frequency Electrooptic Fabry-Perot Modulators (1991)

Simes, R. J., Yan, R. H., Barron, C. C., Derickson, Dennis J., Lishan, D. G., Karin, Judy R., ...

Electrooptic modulators built from GaAs/AlxGa1-xAs Fabry-Perot cavities operating up to 6.5 GHz are reported. The measured frequency response agrees well with the one predicted using an equivalent...

Editorial: Improving cancer care: Transferring clinical research into practice through treatment guidelines (1990)

Simes, R.J., Tattersall, M.H.N.

An improved Bonferroni procedure for multiple tests of significance (1986)

SIMES, R. J.

A modification of the Bonferroni procedure for testing multiple hypotheses is presented. The method, based on the ordered p-values of the individual tests, is less conservative than the classical...

Disarming the guarded prognosis: predicting survival in newly referred patients with incurable cancer

Stockler, M R, Tattersall, M H N, Boyer, M J, Clarke, S J, Beale, P J, Simes, R J

People affected by cancer want information about their prognosis but clinicians have trouble estimating and talking about it. We sought to determine the nature and accuracy of medical oncologists'...

A systematic review of taxane-containing regimens for metastatic breast cancer

Ghersi, D, Wilcken, N, Simes, R J

We compared the results of randomised trials comparing taxane-containing chemotherapy regimens with regimens not containing a taxane in women with metastatic breast cancer. The specialised register...