R. L. Atmar

Detection of Norwalk virus and hepatitis A virus in shellfish tissues with the PCR.

Atmar, R L, Neill, F H, Romalde, J L, Le Guyader, F, Woodley, C M, Metcalf, T G, ...

A method for the detection of Norwalk virus and hepatitis A virus from shellfish tissues by PCR was developed. Virus was added to the stomach and hepatopancreatic tissues of oysters or hard-shell...

Collaborative evaluation of a method for the detection of Norwalk virus in shellfish tissues by PCR.

Atmar, R L, Neill, F H, Woodley, C M, Manger, R, Fout, G S, Burkhardt, W, ...

A multicenter, collaborative trial was performed to evaluate the reliability and reproducibility of a previously described method for the detection of Norwalk virus in shellfish tissues with the PCR...

Detection and analysis of a small round-structured virus strain in oysters implicated in an outbreak of acute gastroenteritis.

Le Guyader, F, Neill, F H, Estes, M K, Monroe, S S, Ando, T, Atmar, R L

Outbreaks of shellfish-transmitted viral disease occur periodically, but frequently the causative agent is not identified. In November 1993, during investigation of a multistate outbreak of acute...

Increasing doses of purified influenza virus hemagglutinin and subvirion vaccines enhance antibody responses in the elderly.

Keitel, W A, Cate, T R, Atmar, R L, Turner, C S, Nino, D, Dukes, C M, ...

The reactogenicities and immunogenicities of two influenza virus vaccines were compared in a placebo-controlled clinical trial among healthy ambulatory persons > or = 65 years old (mean age, 72...

Safety and pharmacokinetics of rimantadine small-particle aerosol.

Atmar, R L, Greenberg, S B, Quarles, J M, Wilson, S Z, Tyler, B, Feldman, S, ...

The safety and pharmacokinetics of rimantadine administered by small-particle aerosol were assessed in healthy adults and adults with acute influenza virus infection. Aerosolized rimantadine...

Granuloma cytokines in murine cysticercosis.

Robinson, P, Atmar, R L, Lewis, D E, White, A C

Neurocysticercosis, caused by Taenia solium, is one of the most common causes of seizures worldwide. The symptoms result from granulomatous inflammation associated with dying cyst forms of the...

In situ detection of hepatitis A virus in cell cultures and shellfish tissues.

Romalde, J L, Estes, M K, Szücs, G, Atmar, R L, Woodley, C M, Metcalf, T G

An in situ transcription method was developed to detect hepatitis A virus RNA in both cell cultures and shellfish tissues. Radiolabeled cDNA copies were synthesized in situ by reverse...

Detection of enteric viruses in oysters by using the polymerase chain reaction.

Atmar, R L, Metcalf, T G, Neill, F H, Estes, M K

A procedure for the detection of enteric viral nucleic acid in oysters by the polymerase chain reaction was developed. Known quantities of poliovirus type 1 were seeded into oysters. Virus was...

Comparison of reverse transcription-PCR with tissue culture and other rapid diagnostic assays for detection of type A influenza virus.

Atmar, R L, Baxter, B D, Dominguez, E A, Taber, L H

We applied a reverse transcription (RT)-PCR assay for influenza A virus to combined nasal wash-throat swab specimens previously obtained from an outpatient pediatric population with acute respiratory...

Use of heat release and an internal RNA standard control in reverse transcription-PCR detection of Norwalk virus from stool samples.

Schwab, K J, Estes, M K, Neill, F H, Atmar, R L

Norwalk virus (NV) and the Norwalk-like viruses are important human pathogens that cause epidemic acute viral gastroenteritis. Current techniques used to recover NV from clinical samples involve...

Development and application of an enzyme immunoassay for coronavirus OC43 antibody in acute respiratory illness.

Gill, E P, Dominguez, E A, Greenberg, S B, Atmar, R L, Hogue, B G, Baxter, B D, ...

Study of coronavirus OC43 infections has been limited because of the lack of sensitive cell culture systems and serologic assays. To improve this circumstance, we developed an indirect enzyme...

High doses of purified influenza A virus hemagglutinin significantly augment serum and nasal secretion antibody responses in healthy young adults.

Keitel, W A, Couch, R B, Cate, T R, Hess, K R, Baxter, B, Quarles, J M, ...

The reactogenicity and immunogenicity of purified influenza virus hemagglutinin (HA) vaccines administered intramuscularly were evaluated in two placebo-controlled clinical trials. A total of 139...

Classification of respiratory tract picornavirus isolates as enteroviruses or rhinoviruses by using reverse transcription-polymerase chain reaction.

Atmar, R L, Georghiou, P R

The classification of picornaviruses isolated from respiratory secretions as human rhinoviruses (HRVs) or enteroviruses (EVs) by using reverse transcription-polymerase chain reaction was compared to...

Detection of Norwalk virus and hepatitis A virus in shellfish tissues with the PCR.

Atmar, R L, Neill, F H, Romalde, J L, Le Guyader, F, Woodley, C M, Metcalf, T G, ...

A method for the detection of Norwalk virus and hepatitis A virus from shellfish tissues by PCR was developed. Virus was added to the stomach and hepatopancreatic tissues of oysters or hard-shell...

Collaborative evaluation of a method for the detection of Norwalk virus in shellfish tissues by PCR.

Atmar, R L, Neill, F H, Woodley, C M, Manger, R, Fout, G S, Burkhardt, W, ...

A multicenter, collaborative trial was performed to evaluate the reliability and reproducibility of a previously described method for the detection of Norwalk virus in shellfish tissues with the PCR...

Detection and analysis of a small round-structured virus strain in oysters implicated in an outbreak of acute gastroenteritis.

Le Guyader, F, Neill, F H, Estes, M K, Monroe, S S, Ando, T, Atmar, R L

Outbreaks of shellfish-transmitted viral disease occur periodically, but frequently the causative agent is not identified. In November 1993, during investigation of a multistate outbreak of acute...

Increasing doses of purified influenza virus hemagglutinin and subvirion vaccines enhance antibody responses in the elderly.

Keitel, W A, Cate, T R, Atmar, R L, Turner, C S, Nino, D, Dukes, C M, ...

The reactogenicities and immunogenicities of two influenza virus vaccines were compared in a placebo-controlled clinical trial among healthy ambulatory persons > or = 65 years old (mean age, 72...

Safety and pharmacokinetics of rimantadine small-particle aerosol.

Atmar, R L, Greenberg, S B, Quarles, J M, Wilson, S Z, Tyler, B, Feldman, S, ...

The safety and pharmacokinetics of rimantadine administered by small-particle aerosol were assessed in healthy adults and adults with acute influenza virus infection. Aerosolized rimantadine...

Granuloma cytokines in murine cysticercosis.

Robinson, P, Atmar, R L, Lewis, D E, White, A C

Neurocysticercosis, caused by Taenia solium, is one of the most common causes of seizures worldwide. The symptoms result from granulomatous inflammation associated with dying cyst forms of the...

In situ detection of hepatitis A virus in cell cultures and shellfish tissues.

Romalde, J L, Estes, M K, Szücs, G, Atmar, R L, Woodley, C M, Metcalf, T G

An in situ transcription method was developed to detect hepatitis A virus RNA in both cell cultures and shellfish tissues. Radiolabeled cDNA copies were synthesized in situ by reverse...

Detection of enteric viruses in oysters by using the polymerase chain reaction.

Atmar, R L, Metcalf, T G, Neill, F H, Estes, M K

A procedure for the detection of enteric viral nucleic acid in oysters by the polymerase chain reaction was developed. Known quantities of poliovirus type 1 were seeded into oysters. Virus was...

Comparison of reverse transcription-PCR with tissue culture and other rapid diagnostic assays for detection of type A influenza virus.

Atmar, R L, Baxter, B D, Dominguez, E A, Taber, L H

We applied a reverse transcription (RT)-PCR assay for influenza A virus to combined nasal wash-throat swab specimens previously obtained from an outpatient pediatric population with acute respiratory...

Use of heat release and an internal RNA standard control in reverse transcription-PCR detection of Norwalk virus from stool samples.

Schwab, K J, Estes, M K, Neill, F H, Atmar, R L

Norwalk virus (NV) and the Norwalk-like viruses are important human pathogens that cause epidemic acute viral gastroenteritis. Current techniques used to recover NV from clinical samples involve...

Development and application of an enzyme immunoassay for coronavirus OC43 antibody in acute respiratory illness.

Gill, E P, Dominguez, E A, Greenberg, S B, Atmar, R L, Hogue, B G, Baxter, B D, ...

Study of coronavirus OC43 infections has been limited because of the lack of sensitive cell culture systems and serologic assays. To improve this circumstance, we developed an indirect enzyme...

High doses of purified influenza A virus hemagglutinin significantly augment serum and nasal secretion antibody responses in healthy young adults.

Keitel, W A, Couch, R B, Cate, T R, Hess, K R, Baxter, B, Quarles, J M, ...

The reactogenicity and immunogenicity of purified influenza virus hemagglutinin (HA) vaccines administered intramuscularly were evaluated in two placebo-controlled clinical trials. A total of 139...

Classification of respiratory tract picornavirus isolates as enteroviruses or rhinoviruses by using reverse transcription-polymerase chain reaction.

Atmar, R L, Georghiou, P R

The classification of picornaviruses isolated from respiratory secretions as human rhinoviruses (HRVs) or enteroviruses (EVs) by using reverse transcription-polymerase chain reaction was compared to...