Martinez, D., Marburg, S., Tolman, R. L., Galloway, D. R.
For the preparation of greatly detoxified but highly immunogenic toxoids, two enzymatically active, low-toxicity derivatives of Pseudomonas aeruginosa exotoxin-A were further inactivated by...
Activation of PPARdelta alters lipid metabolism in db/db mice. (2000)
Leibowitz, M D, Fiévet, C, Hennuyer, N, Peinado-Onsurbe, J, Duez, H, Bergera, J, ...
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which heterodimerize with the retinoid X receptor and bind to peroxisome proliferator response elements in the promoters of...
Identification and selective inhibition of an isozyme of steroid 5 alpha-reductase in human scalp.
Harris, G, Azzolina, B, Baginsky, W, Cimis, G, Rasmusson, G H, Tolman, R L, ...
Steroid 5 alpha-reductase (EC 1.3.1.22) catalyzes the reduction of testosterone to dihydrotestosterone. The 5 alpha-reductase found in human scalp has been compared with the enzyme found in prostate....
Nsiah, Y A, Tolman, R L, Karkas, J D, Rapp, F
Latent herpes simplex virus type 1 (HSV-1) infection was induced in human embryonic lung cells in vitro by using a combination of viral replication inhibitors and elevated temperature. Under...
Effect of 2'-nor-cyclic GMP against guinea pig cytomegalovirus infection.
Yang, Z H, Lucia, H L, Tolman, R L, Colonno, R J, Hsiung, G D
Cyclic phosphate derivative of DHPG, 2'-nor-cGMP [9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl]-guani ne phosphate-oxide] was evaluated for activity against guinea pig cytomegalovirus (GPCMV)...
Germershausen, J, Bostedor, R, Liou, R, Field, A K, Wagner, A F, MacCoss, M, ...
The metabolisms of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (2'NDG) and its cyclic phosphate, 9-[(2-hydroxy-1,3,2-dioxophosphorinan-5-yl) oxymethyl]guanine P-oxide (2'-nor-cGMP), were compared in...
Bourne, N, Bravo, F J, Ashton, W T, Meurer, L C, Tolman, R L, Karkas, J D, ...
Herpes simplex virus (HSV)-coded thymidine kinase (TK) is important in efficient reactivation of latent infection. These studies were designed to investigate whether treatment of latently infected...
Vella, P P, Marburg, S, Staub, J M, Kniskern, P J, Miller, W, Hagopian, A, ...
In an effort to prepare pneumococcal (Pn) capsular polysaccharide (Ps) vaccines that would be immunogenic in infants, covalent conjugates were prepared for Pn types 6B, 14, 19F, and 23F. Each Ps type...
Callahan, L T, Martinez, D, Marburg, S, Tolman, R L, Galloway, D R
For the preparation of greatly detoxified but highly immunogenic toxoids, two enzymatically active, low-toxicity derivatives of Pseudomonas aeruginosa exotoxin-A were further inactivated by...
Pseudomonas exotoxin A: toxoid preparation by photoaffinity inactivation.
Marburg, S, Tolman, R L, Callahan, L T
A method for toxoid preparation has been developed in which toxins expressing enzymatic activity can be detoxified by photoaffinity labeling techniques. In the case of Pseudomonas aeruginosa exotoxin...
Field, A K, Davies, M E, DeWitt, C, Perry, H C, Liou, R, Germershausen, J, ...
9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (2'-nor-2'-deoxyguanosine; 2'NDG) selectively inhibits the replication of herpes group viruses. In cell culture studies 2'NDG was at least 10-fold...
Identification and selective inhibition of an isozyme of steroid 5 alpha-reductase in human scalp.
Harris, G, Azzolina, B, Baginsky, W, Cimis, G, Rasmusson, G H, Tolman, R L, ...
Steroid 5 alpha-reductase (EC 1.3.1.22) catalyzes the reduction of testosterone to dihydrotestosterone. The 5 alpha-reductase found in human scalp has been compared with the enzyme found in prostate....
Nsiah, Y A, Tolman, R L, Karkas, J D, Rapp, F
Latent herpes simplex virus type 1 (HSV-1) infection was induced in human embryonic lung cells in vitro by using a combination of viral replication inhibitors and elevated temperature. Under...
Effect of 2'-nor-cyclic GMP against guinea pig cytomegalovirus infection.
Yang, Z H, Lucia, H L, Tolman, R L, Colonno, R J, Hsiung, G D
Cyclic phosphate derivative of DHPG, 2'-nor-cGMP [9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl]-guani ne phosphate-oxide] was evaluated for activity against guinea pig cytomegalovirus (GPCMV)...
Germershausen, J, Bostedor, R, Liou, R, Field, A K, Wagner, A F, MacCoss, M, ...
The metabolisms of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (2'NDG) and its cyclic phosphate, 9-[(2-hydroxy-1,3,2-dioxophosphorinan-5-yl) oxymethyl]guanine P-oxide (2'-nor-cGMP), were compared in...
Bourne, N, Bravo, F J, Ashton, W T, Meurer, L C, Tolman, R L, Karkas, J D, ...
Herpes simplex virus (HSV)-coded thymidine kinase (TK) is important in efficient reactivation of latent infection. These studies were designed to investigate whether treatment of latently infected...
Vella, P P, Marburg, S, Staub, J M, Kniskern, P J, Miller, W, Hagopian, A, ...
In an effort to prepare pneumococcal (Pn) capsular polysaccharide (Ps) vaccines that would be immunogenic in infants, covalent conjugates were prepared for Pn types 6B, 14, 19F, and 23F. Each Ps type...
Callahan, L T, Martinez, D, Marburg, S, Tolman, R L, Galloway, D R
For the preparation of greatly detoxified but highly immunogenic toxoids, two enzymatically active, low-toxicity derivatives of Pseudomonas aeruginosa exotoxin-A were further inactivated by...
Pseudomonas exotoxin A: toxoid preparation by photoaffinity inactivation.
Marburg, S, Tolman, R L, Callahan, L T
A method for toxoid preparation has been developed in which toxins expressing enzymatic activity can be detoxified by photoaffinity labeling techniques. In the case of Pseudomonas aeruginosa exotoxin...
Field, A K, Davies, M E, DeWitt, C, Perry, H C, Liou, R, Germershausen, J, ...
9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (2'-nor-2'-deoxyguanosine; 2'NDG) selectively inhibits the replication of herpes group viruses. In cell culture studies 2'NDG was at least 10-fold...