Immune challenge induces differential corticosterone and interleukin-6 responsiveness in rats bred for extremes in anxiety-related behavior (2008)
Salome, N.,
Tasiemski, A.,
Dutriez, I.,
Wigger, A.,
Landgraf, R.,
Viltart, O.
Expressing emotions: Avp and Crh are involved in the phenotype of mice bred for extremes in anxiety-related behavior (2007)
Bunck, M.,
Czibere, L.,
Schmidt, M. V.,
Rafael, J.,
Muigg, P.,
Panhuysen, M.,
...
The role of tachykinin 1 in a mouse model of trait anxiety (2007)
Czibere, L.,
Baur-Jaronowski, L. A.,
Weber, P.,
Pütz, B.,
Panhuysen, M.,
Deussing, J. M.,
...
Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment (2007)
Jochum, T.,
Boettger, M. K.,
Wigger, A.,
Beiderbeck, D.,
Neumann, I. D.,
Landgraf, R.,
...
15N metabolic labeling of high and low anxiety-related behavior HAB/LAB mice (2007)
Kessler, M. S.,
Frank, E.,
Filiou, M. D.,
Zhang, Y. Y.,
Haegler, K.,
Maccarrone, G.,
...
Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice (2007)
Kessler, M. S.,
Murgatroyd, C.,
Bunck, M.,
Czibere, L.,
Frank, E.,
Jacob, W.,
...
Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: Focus on vasopressin and glyoxalase-I (2007)
Landgraf, R.,
Kessler, M. S.,
Bunck, M.,
Murgatroyd, C.,
Spengler, D.,
Zimbelmann, M.,
...
Neural nitric oxide gene inactivation affects the release profile of oxytocin into the blood in response to forced swimming (2007)
Orlando, G. F.,
Langnaese, K.,
Landgraf, R.,
Spina, M. G.,
Wolf, G.,
Engelmann, M.
Linking cognitive abilities and stress reactivity: insights from the HR/IR/LR mouse model (2007)
Wolferstätter, M.,
Glasl, L.,
Marwedel, A. L.,
Bunck, M.,
Landgraf, R.,
Touma, C.
Neuropetide Y, calcitonin gene-related peptide and CRH in brain of rats bred for high anxiety-related behaviors (2007)
Gruber, S. H. M.,
Beiderbeck, D. I.,
Khoury, A. E.,
Södergren, A.,
Landgraf, R.,
Neumann, I. D.,
...
Brain biochemistry markers differentiate between animal models of anxiety and depression (2007)
Mathe, A. A.,
Gruber, S. H. M.,
El Khoury, A.,
Beiderbeck, D.,
Neumann, I. D.,
Landgraf, R.
Protein biomarkers in a mouse model of extremes in trait anxiety (2006)
Ditzen, C.,
Jastorff, A. M.,
Kessler, M. S.,
Bunck, M.,
Teplytska, L.,
Erhardt, A.,
...
Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat (2006)
Frank, E.,
Salchner, P.,
Aldag, J. M.,
Salomé, N.,
Singewald, N.,
Landgraf, R.,
...
Neurobiological correlates of pathological anxiety studied in psychopathological rodent models (2006)
Singewald, N.,
Salchner, P.,
Muigg, P.,
Sartori, S.,
Kessler, M.,
Bunck, M.,
...
Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: Novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress (2006)
Welt, T.,
Engelmann, M.,
Renner, U.,
Erhardt, A.,
Müller, M. B.,
Landgraf, R.,
...
Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior (2006)
Salchner, P.,
Sartori, S. B.,
Sinner, C.,
Wigger, A.,
Frank, E.,
Landgraf, R.,
...
Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates (2006)
Salome, N.,
Viltart, O.,
Lesage, J.,
Landgraf, R.,
Vieau, D.,
Laborie, C.
Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment (2005)
Keck, M. E.,
Sartori, S. B.,
Welt, T.,
Müller, M. B.,
Ohl, F.,
Holsboer, F.,
...
Regulation of activity-dependent dendritic vasopressin release from rat supraoptic neurones (2005)
Ludwig, M.,
Bull, P. M.,
Tobin, V. A.,
Sabatier, N.,
Landgraf, R.,
Dayanithi, G.,
...
Glyoxalase I: Implications for an enzyme involved in trait anxiety (2005)
Czibere, L.,
Kessler, M. S.,
Birg, I.,
Panhuysen, M.,
Pütz, B.,
Deussing, J. M.,
...
Nitric oxide is not involved in the control of vasopressin release during acute forced swimming in rats (2004)
Engelmann, M.,
Wolf, G.,
Putzke, J.,
Bloom, F. E.,
Raber, J.,
Landgraf, R.,
...
GABA selectively controls the secretory activity of oxytocin neurons in the rat supraoptic nucleus (2004)
Engelmann, M.,
Bull, P. M.,
Brown, C. H.,
Landgraf, R.,
Horn, T. F. W.,
Singewald, N.,
...
High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats (2004)
Kalisch, R.,
Salome, N.,
Platzer, S.,
Wigger, A.,
Czisch, M.,
Sommer, W.,
...
Hypothalamic neuropeptide release after experimental subarachnoid hemorrhage: in vivo microdialysis study (2004)
Kleindienst, A.,
Hildebrandt, G.,
Kroemer, S. A.,
Franke, G.,
Gaab, M. R.,
Landgraf, R.
Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety (2004)
Murgatroyd, C.,
Wigger, A.,
Frank, E.,
Singewald, N.,
Bunck, M.,
Holsboer, F.,
...
Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers (2004)
Zimmermann, U.,
Spring, K.,
Wittchen, H. U.,
Himmerich, H.,
Landgraf, R.,
Uhr, M.,
...
The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats (2003)
Keck, M. E.,
Welt, T.,
Müller, M. B.,
Landgraf, R.,
Holsboer, F.
Validation of a genetic mouse model for anxiety and comorbid depression (2003)
Krömer, S. A.,
Milfay, D.,
Wigger, A.,
Jacob, W.,
Kessler, M.,
Bunck, M.,
...
High trait anxiety in a genetic rat model: association with altered diazepam response and gene expression in the medial prefrontal/anterior cingulate cortex (2003)
Sommer, W.,
Kalisch, R.,
Heilig, M.,
Arlinde, C.,
Platzer, S.,
Wigger, A.,
...
Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis (2002)
Salome, N,
Viltart, O,
Darnaudery, M,
Salchner, P,
Singewald, N,
Landgraf, R,
...
The reliability of behavioural data constitutes a major concern in the neuroscience field. Indeed, discrepancies in the behavioural patterns of mice or rats in the same anxiety tests performed in...
Vasopressin in CSF and plasma in depressed suicide attempters: preliminary results (2002)
Brunner, J,
Keck, ME,
Landgraf, R,
Uhr, M,
Namendorf, C,
Bronisch, T
Increased plasma arginine vasopressin (AVP) concentrations have been reported in depressed suicide attempters. Plasma AVP is primarily produced by the magnocellular system in response to increased...
High vs low anxiety-related behavior rats: An animal model of extremes in trait anxiety (2002)
Landgraf, R,
Wigger, A
In addition to their robust difference in trait anxiety, as illustrated by a variety of behavioral tests, HAB and LAB rats differ in their stress coping strategies, the former being more susceptible...
Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion (2002)
Wotjak, CT,
Ludwig, M,
Ebner, K,
Russell, JA,
Singewald, N,
Landgraf, R,
...
Magnocellular vasopressinergic and oxytocinergic neurons of the hypothalamic supraoptic (SON) and paraventricular nuclei comprise the hypothalamic-neurohypophysial system, which is crucially involved...
The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety (2002)
Lancel, M,
Müller-Preuß, P,
Wigger, A,
Landgraf, R,
Holsboer, F
Excessive corticotropin-releasing hormone (CRH) secretion in limbic and prefrontal brain areas has been postulated to underly stress-related clinical conditions. Studies in mice with deleted or...
Serotonin in brain regions of rats differing in their inborn locomotor activity (2002)
Umriukhin, AE,
Landgraf, R
Serotonin contents in the paraventricular hypothalamic nucleus (PVN) and dorsal hippocampis of rats with different levels of inborn motor activity were studied by microdialysis in basal and...
Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites (2002)
Ludwig, M,
Sabatier, N,
Bull, PM,
Landgraf, R,
Dayanithi, G,
Leng, G
Information in neurons flows from synapses, through the dendrites and cell body (soma), and, finally, along the axon as spikes of electrical activity that will ultimately release neurotransmitters...
Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior (2002)
Henniger, MSH,
Spanagel, R,
Wigger, A,
Landgraf, R,
Hölter, SM
According to the tension reduction hypothesis, individuals with art elevated anxiety level may be more sensitive to the anxiolytic effects of alcohol and may, therefore, have a higher predisposition...
Cognitive performance in rats differing in their inborn anxiety (2002)
Ohl, F,
Roedel, A,
Storch, C,
Holsboer, F,
Landgraf, R
There is profound evidence that cognitive processes and anxiety are interrelated, To team more about this interaction. the authors tested rats bred for either high (HABs) or low (LABs)...
Pharmacologic fMRI (phMRI) at 7 Tesla reveals candidate regions for pathological regulation of emotional behavior in an animal model of high innate anxiety (2002)
Kalisch, R,
Wigger, A,
Gössl, C,
Czisch, M,
Landgraf, R,
Auer, DP
Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats (2002)
Ebner, K,
Wotjak, CT,
Landgraf, R,
Engelmann, M
Previously, we have demonstrated that forced swimming triggers the release of arginine vasopressin (AVP) within the septum of rats, where AVP modulates stress-coping strategies. The present study was...
Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: Implications for pathogenesis of affective disorders (2002)
Keck, ME,
Wigger, A,
Welt, T,
Müller, MB,
Gesing, A,
Reul, JMHM,
...
To investigate the neuroendocrine alterations linked to inborn emotionality in two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior, we administered the...
Forced swimming stimulates the expression of vasopressin and oxytocin in magnocellular neurons of the rat hypothalamic paraventricular nucleus. (2001)
Wotjak, C. T.,
Naruo, T.,
Muraoka, S.,
Simchen, R.,
Landgraf, R.,
Engelmann, M.
The anxiolytic effect of the CRH1 receptor antagonist R121919 depends on innate emotionality in rats. (2001)
Keck, M. E.,
Welt, T.,
Wigger, A.,
Renner, U.,
Engelmann, M.,
Holsboer, F.,
...
Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects. (2001)
Keck, M. E.,
Welt, T.,
Post, A.,
Müller, M. B.,
Toschi, N.,
Wigger, A.,
...
Taurine selectively modulates the secretory activity of vasopressin neurons in conscious rats. (2001)
Engelmann, M.,
Ludwig, M.,
Singewald, N.,
Ebner, K.,
Sabatier, N.,
Lubec, G.,
...
Repetitive transcranial magnetic stimulation induces active coping strategies and attenuates the neuroendocrine stress response in rats. (2000)
Keck, M. E.,
Engelmann, M.,
Müller, M. B.,
Henniger, M. S. H.,
Hermann, B.,
Rupprecht, R.,
...