R. M. Hardisty

Publication List Details

Period

1964 - 1987

Number

61

Co-Authors

Effect of oral contraceptives on factor VIII clotting activity and factor VIII related antigen in normal women.

Stableforth, P, Montgomery, D C, Wilson, E, Churchill, W G, Dormandy, K M, Hardisty, R M

The factor VIII clotting activity (VIIIc1 and factor VIII related antigen (VIIIRAg) were determined repeatedly in 24 pairs of age-matched normal women, one of each pair being on oral contraceptives....

Acute lymphoblastic leukaemia: four-year survivals old and new.

Hardisty, R M, Till, M M, Peto, J

Two groups of four-year survivors with acute lymphoblastic leukaemia (ALL) are compared: an 'old' series consisting of 83 patients diagnosed before 1968, and a 'new' series of 366 patients included...

First trimester prenatal diagnosis and detection of carriers of haemophilia A using the linked DNA probe DX13.

Winter, R M, Harper, K, Goldman, E, Mibashan, R S, Warren, R C, Rodeck, C H, ...

Although the use of a gene specific deoxyribonucleic acid (DNA) probe is the method of choice for detecting carriers of genes for rare genetic disorders, there will always be families in which such...

Hereditary Giant Platelet Syndrome: A Disorder of a New Aspect of Platelet Function

Howard, Margaret A., Hutton, R. A., Hardisty, R. M.

The platelets of three patients with the hereditary giant platelet syndrome of Bernard and Soulier failed to aggregate in response to either ristocetin or bovine fibrinogen. The results of...

Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis.

Secker-Walker, L M, Lawler, S D, Hardisty, R M

Chromosomes were studied on diagnostic bone-marrow samples from 39 children with acute lymphoblastic leukaemia (ALL). The patients were classified, according to the chromosomal characteristics of the...

Myelosuppressive Effect of Colaspase (L-Asparaginase) in Initial Treatment of Acute Lymphoblastic Leukaemia

Johnston, P. G. B., Hardisty, R. M., Kay, H. E. M., Smith, P. G.

Analysis of the remission induction phase in three Medical Research Council trials of treatment of acute lymphoblastic leukaemia has provided evidence of the adverse effect of the combination of...

Remission induction with cytosine arabinoside and L-Asparaginase in acute lymphoblastic leukaemia

McElwain, T. J., Hardisty, R. M.

Nine patients with acute lymphoblastic leukaemia in relapse were treated with a course of cytosine arabinoside followed immediately by a course of L-asparaginase. Eight patients achieved complete...

Survival and the HL-A System in Acute Lymphoblastic Leukaemia

Lawler, Sylvia D., Klouda, P. T., Smith, P. G., Till, Morwenna M., Hardisty, R. M.

The relation between the HL-A antigens and survival has been studied in 58 patients with acute lymphoblastic leukaemia. Patients with the HL-A9 antigen had the best estimated median survival times,...

Effect of oral contraceptives on factor VIII clotting activity and factor VIII related antigen in normal women.

Stableforth, P, Montgomery, D C, Wilson, E, Churchill, W G, Dormandy, K M, Hardisty, R M

The factor VIII clotting activity (VIIIc1 and factor VIII related antigen (VIIIRAg) were determined repeatedly in 24 pairs of age-matched normal women, one of each pair being on oral contraceptives....

Acute lymphoblastic leukaemia: four-year survivals old and new.

Hardisty, R M, Till, M M, Peto, J

Two groups of four-year survivors with acute lymphoblastic leukaemia (ALL) are compared: an 'old' series consisting of 83 patients diagnosed before 1968, and a 'new' series of 366 patients included...

First trimester prenatal diagnosis and detection of carriers of haemophilia A using the linked DNA probe DX13.

Winter, R M, Harper, K, Goldman, E, Mibashan, R S, Warren, R C, Rodeck, C H, ...

Although the use of a gene specific deoxyribonucleic acid (DNA) probe is the method of choice for detecting carriers of genes for rare genetic disorders, there will always be families in which such...

Hereditary Giant Platelet Syndrome: A Disorder of a New Aspect of Platelet Function

Howard, Margaret A., Hutton, R. A., Hardisty, R. M.

The platelets of three patients with the hereditary giant platelet syndrome of Bernard and Soulier failed to aggregate in response to either ristocetin or bovine fibrinogen. The results of...

Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis.

Secker-Walker, L M, Lawler, S D, Hardisty, R M

Chromosomes were studied on diagnostic bone-marrow samples from 39 children with acute lymphoblastic leukaemia (ALL). The patients were classified, according to the chromosomal characteristics of the...

Myelosuppressive Effect of Colaspase (L-Asparaginase) in Initial Treatment of Acute Lymphoblastic Leukaemia

Johnston, P. G. B., Hardisty, R. M., Kay, H. E. M., Smith, P. G.

Analysis of the remission induction phase in three Medical Research Council trials of treatment of acute lymphoblastic leukaemia has provided evidence of the adverse effect of the combination of...

Remission induction with cytosine arabinoside and L-Asparaginase in acute lymphoblastic leukaemia

McElwain, T. J., Hardisty, R. M.

Nine patients with acute lymphoblastic leukaemia in relapse were treated with a course of cytosine arabinoside followed immediately by a course of L-asparaginase. Eight patients achieved complete...

Survival and the HL-A System in Acute Lymphoblastic Leukaemia

Lawler, Sylvia D., Klouda, P. T., Smith, P. G., Till, Morwenna M., Hardisty, R. M.

The relation between the HL-A antigens and survival has been studied in 58 patients with acute lymphoblastic leukaemia. Patients with the HL-A9 antigen had the best estimated median survival times,...

Factors in Pathogenesis of Central-nervous-system Leukaemia

West, R. J., Graham-Pole, J., Hardisty, R. M., Pike, M. C.

Eighty-three (50%) of 165 children with acute lymphoblastic or acute stem-cell leukaemia presenting during 1958-70 developed leukaemia of the central nervous system (C.N.S.). The rate of incidence of...

Lymphocyte Transformation in Patients with Acute Lymphoblastic Leukaemia

Jones, Lindsay H., Hardisty, R. M., Wells, D. G., Kay, H. E. M.

The response of lymphocytes to phytohaemagglutinin was tested as an index of lymphocyte function in patients with acute lymphoblastic leukaemia in remission. No significant differences were found in...

Vincristine and Prednisone for the Induction of Remissions in Acute Childhood Leukaemia

Hardisty, R. M., McElwain, T. J., Darby, Caryl W.

A total of 65 children with acute lymphoblastic leukaemia and seven with other types of acute leukaemia received treatment with a combination of vincristine and prednisone. In all 122 courses of...

Long-term control of central nervous system leukaemia.

Gribbin, M A, Hardisty, R M, Chessells, J M

Seventy-four children with acute lymphoblastic leukaemia had one or more episodes of central nervous system (CNS) leukaemia. 5 children had CNS involvement at diagnosis; 4 survived for less than one...

Inhibitor of prostacyclin production in sporadic haemolytic uraemic syndrome.

Levin, M, Elkon, K B, Nokes, T J, Buckle, A M, Dillon, M J, Hardisty, R M, ...

Prostacyclin (PGI2) production was diminished when rat aortic rings were incubated with plasma from 5 of 6 patients with the sporadic form of haemolytic uraemic syndrome but was normal in the...

Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia.

Chessells, J M, Leiper, A D, Tiedemann, K, Hardisty, R M, Richards, S

It has been postulated that variations in methotrexate absorption may influence the outcome of treatment in lymphoblastic leukaemia. One hundred and forty four children with acute lymphoblastic...

Long survival in childhood lymphoblastic leukaemia.

Chessells, J. M., Hardisty, R. M., Richards, S.

Long term follow-up of 378 children with acute lymphoblastic leukaemia (ALL) treated at a single centre showed that at six years from diagnosis 202 (53%) were alive, of whom 140 (37%) remained in...

Epidemiology of childhood leukaemia in greater london: A search for evidence of transmission assuming a possibly long latent period.

Smith, P. G., Pike, M. C., Till, M. M., Hardisty, R. M.

Studies of space-time clustering of cases of childhood leukaemia have yielded equivocal results. This might be because the disease has a long and variable latent period, in which case the usual...