Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.
Jiang, W, Zhang, Y J, Kahn, S M, Hollstein, M C, Santella, R M, Lu, S H, ...
We have examined DNA from four human esophageal carcinoma cell lines and 50 primary esophageal carcinomas obtained from China, Italy, and France for amplification of the cyclin D1 gene. We also...
Carothers, A M, Zhen, W, Mucha, J, Zhang, Y J, Santella, R M, Grunberger, D, ...
We evaluated the formation and removal of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene (BcPHDE)-DNA adducts in two Chinese hamster ovary (CHO) cell...
Santella, R M, Grunberger, D, Weinstein, I B, Rich, A
Poly(dG-dC).poly(dG-dC) and poly(dG).poly(dC) were modified by treatment with N-acetoxy-N-2-acetylaminofluorene, and their conformations were examined by circular dichroism and susceptibility to...
Ushay, H M, Santella, R M, Caradonna, J P, Grunberger, D, Lippard, S J
Chlorodiethylenetriamineplatinum(II) chloride, [(dien)PtCl]Cl, bound to less than or equal to 10% of the nucleotide bases of poly(dG-dC) . poly(dG-dC) reduces the amount of ethanol necessary to bring...
Santella, R M, Grunberger, D, Broyde, S, Hingerty, B E
The conformation of poly(dG-dC).poly(dG-dC), poly(dG).poly(dC), and calf thymus DNA modified with N-acetoxy-N-2-acetylaminofluorene (N-acetoxy-AAF) was examined by extent of reaction with anti...
Monoclonal antibodies to DNA modified by 8-methoxypsoralen and ultraviolet A light.
Santella, R M, Dharmaraja, N, Gasparro, F P, Edelson, R L
A panel of monoclonal antibodies have been developed which specifically recognize DNA modified by 8-methoxypsoralen (8-MOP) and ultraviolet A light (320-400 nm) (UVA). These antibodies have been...
Reconstitution of rods from tobacco mosaic virus protein and RNA modified with bulky carcinogens.
Fraenkel-Conrat, H, Singer, B, Takanami, Y, Santella, R M, Grunberger, D
Tobacco mosaic virus (TMV) RNA was treated with radioactive N-acetoxy-2-acetylaminofluorene (N-acetoxy-AAF) and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10...
Poirier, M C, Lippard, S J, Zwelling, L A, Ushay, H M, Kerrigan, D, Thill, C C, ...
Rabbit antiserum elicited against calf thymus DNA modified to 4.4% (Pt drug/nucleotide ratio = 0.044) with the antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) contains antibodies specific...
Ahsan, H, Wang, L Y, Chen, C J, Tsai, W Y, Santella, R M
Exposure to aflatoxin B1 (AFB1), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the...
Molecular epidemiology in environmental carcinogenesis.
Perera, F P, Mooney, L A, Dickey, C P, Santella, R M, Bell, D, Blaner, W, ...
Molecular epidemiology has significant potential in preventing cancer and other diseases caused by environmental exposures (related to lifestyle, occupation, or ambient pollution). This approach...
Biologic markers in risk assessment for environmental carcinogens
Perera, F., Mayer, J., Santella, R. M., Brenner, D., Jeffrey, A., Latriano, L., ...
The potential of biologic markers to provide more timely and precise risk assessments for environmental carcinogens is viewed against the current state-of-the-art in biological monitoring/molecular...
Diesel exhaust exposure among adolescents in Harlem: a community-driven study.
Northridge, M E, Yankura, J, Kinney, P L, Santella, R M, Shepard, P, Riojas, Y, ...
OBJECTIVES: This study sought individual-level data on diesel exhaust exposure and lung function among adolescents in Harlem as part of a community-driven research agenda. METHODS: High school...
Relationship between ambient air pollution and DNA damage in Polish mothers and newborns.
Whyatt, R M, Santella, R M, Jedrychowski, W, Garte, S J, Bell, D A, Ottman, R, ...
Industrialized regions in Poland are characterized by high ambient pollution, including polycyclic aromatic hydrocarbons (PAHs) from coal burning for industry and home heating. In experimental...
Calderón-Garcidueñas, L, Wen-Wang, L, Zhang, Y J, Rodriguez-Alcaraz, A, Osnaya, N, Villarreal-Calderón, A, ...
Southwest metropolitan Mexico City children are repeatedly exposed to high levels of a complex mixture of air pollutants, including ozone, particulate matter, aldehydes, metals, and nitrogen oxides....
Detection of polycyclic aromatic hydrocarbon-DNA adducts in human lung.
Weston, A, Bowman, E D, Shields, P G, Trivers, G E, Poirier, M C, Santella, R M, ...
Synchronous fluorescence spectroscopy has been combined with immunoaffinity chromatography (IAC) and HPLC to detect polycyclic aromatic hydrocarbon (PAH)-DNA adducts and measure...
Santella, R M, Zhang, Y J, Chen, C J, Hsieh, L L, Lee, C S, Haghighi, B, ...
Monoclonal antibodies recognizing the stable imidazole ring-opened form of the major N7-guanine aflatoxin B1-DNA adduct have been used in competitive enzyme-linked immunosorbent assays (ELISA) and...
Mumford, J L, Lee, X, Lewtas, J, Young, T L, Santella, R M
The high lung cancer rate in Xuan Wei, China, is associated with smoky coal use in unvented homes, but not with wood or smokeless coal use. Smoky coal combustion emits higher polycyclic aromatic...
Quantitation of exposure to benzo[a]pyrene with monoclonal antibodies.
Santella, R M, Hsieh, L L, Lin, C D, Viet, S, Weinstein, I B
It is now possible to quantitate carcinogen adducts on DNA by highly sensitive immunoassays. These techniques are particularly useful for screening human populations for exposure to potential...
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.
Jiang, W, Zhang, Y J, Kahn, S M, Hollstein, M C, Santella, R M, Lu, S H, ...
We have examined DNA from four human esophageal carcinoma cell lines and 50 primary esophageal carcinomas obtained from China, Italy, and France for amplification of the cyclin D1 gene. We also...
Carothers, A M, Zhen, W, Mucha, J, Zhang, Y J, Santella, R M, Grunberger, D, ...
We evaluated the formation and removal of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene (BcPHDE)-DNA adducts in two Chinese hamster ovary (CHO) cell...
Santella, R M, Grunberger, D, Weinstein, I B, Rich, A
Poly(dG-dC).poly(dG-dC) and poly(dG).poly(dC) were modified by treatment with N-acetoxy-N-2-acetylaminofluorene, and their conformations were examined by circular dichroism and susceptibility to...
Ushay, H M, Santella, R M, Caradonna, J P, Grunberger, D, Lippard, S J
Chlorodiethylenetriamineplatinum(II) chloride, [(dien)PtCl]Cl, bound to less than or equal to 10% of the nucleotide bases of poly(dG-dC) . poly(dG-dC) reduces the amount of ethanol necessary to bring...
Santella, R M, Grunberger, D, Broyde, S, Hingerty, B E
The conformation of poly(dG-dC).poly(dG-dC), poly(dG).poly(dC), and calf thymus DNA modified with N-acetoxy-N-2-acetylaminofluorene (N-acetoxy-AAF) was examined by extent of reaction with anti...
Monoclonal antibodies to DNA modified by 8-methoxypsoralen and ultraviolet A light.
Santella, R M, Dharmaraja, N, Gasparro, F P, Edelson, R L
A panel of monoclonal antibodies have been developed which specifically recognize DNA modified by 8-methoxypsoralen (8-MOP) and ultraviolet A light (320-400 nm) (UVA). These antibodies have been...
Reconstitution of rods from tobacco mosaic virus protein and RNA modified with bulky carcinogens.
Fraenkel-Conrat, H, Singer, B, Takanami, Y, Santella, R M, Grunberger, D
Tobacco mosaic virus (TMV) RNA was treated with radioactive N-acetoxy-2-acetylaminofluorene (N-acetoxy-AAF) and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10...
Poirier, M C, Lippard, S J, Zwelling, L A, Ushay, H M, Kerrigan, D, Thill, C C, ...
Rabbit antiserum elicited against calf thymus DNA modified to 4.4% (Pt drug/nucleotide ratio = 0.044) with the antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) contains antibodies specific...
Ahsan, H, Wang, L Y, Chen, C J, Tsai, W Y, Santella, R M
Exposure to aflatoxin B1 (AFB1), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the...
Molecular epidemiology in environmental carcinogenesis.
Perera, F P, Mooney, L A, Dickey, C P, Santella, R M, Bell, D, Blaner, W, ...
Molecular epidemiology has significant potential in preventing cancer and other diseases caused by environmental exposures (related to lifestyle, occupation, or ambient pollution). This approach...
Diesel exhaust exposure among adolescents in Harlem: a community-driven study.
Northridge, M E, Yankura, J, Kinney, P L, Santella, R M, Shepard, P, Riojas, Y, ...
OBJECTIVES: This study sought individual-level data on diesel exhaust exposure and lung function among adolescents in Harlem as part of a community-driven research agenda. METHODS: High school...
Biologic markers in risk assessment for environmental carcinogens
Perera, F., Mayer, J., Santella, R. M., Brenner, D., Jeffrey, A., Latriano, L., ...
The potential of biologic markers to provide more timely and precise risk assessments for environmental carcinogens is viewed against the current state-of-the-art in biological monitoring/molecular...
Relationship between ambient air pollution and DNA damage in Polish mothers and newborns.
Whyatt, R M, Santella, R M, Jedrychowski, W, Garte, S J, Bell, D A, Ottman, R, ...
Industrialized regions in Poland are characterized by high ambient pollution, including polycyclic aromatic hydrocarbons (PAHs) from coal burning for industry and home heating. In experimental...
Calderón-Garcidueñas, L, Wen-Wang, L, Zhang, Y J, Rodriguez-Alcaraz, A, Osnaya, N, Villarreal-Calderón, A, ...
Southwest metropolitan Mexico City children are repeatedly exposed to high levels of a complex mixture of air pollutants, including ozone, particulate matter, aldehydes, metals, and nitrogen oxides....
Detection of polycyclic aromatic hydrocarbon-DNA adducts in human lung.
Weston, A, Bowman, E D, Shields, P G, Trivers, G E, Poirier, M C, Santella, R M, ...
Synchronous fluorescence spectroscopy has been combined with immunoaffinity chromatography (IAC) and HPLC to detect polycyclic aromatic hydrocarbon (PAH)-DNA adducts and measure...
Santella, R M, Zhang, Y J, Chen, C J, Hsieh, L L, Lee, C S, Haghighi, B, ...
Monoclonal antibodies recognizing the stable imidazole ring-opened form of the major N7-guanine aflatoxin B1-DNA adduct have been used in competitive enzyme-linked immunosorbent assays (ELISA) and...
Mumford, J L, Lee, X, Lewtas, J, Young, T L, Santella, R M
The high lung cancer rate in Xuan Wei, China, is associated with smoky coal use in unvented homes, but not with wood or smokeless coal use. Smoky coal combustion emits higher polycyclic aromatic...
Quantitation of exposure to benzo[a]pyrene with monoclonal antibodies.
Santella, R M, Hsieh, L L, Lin, C D, Viet, S, Weinstein, I B
It is now possible to quantitate carcinogen adducts on DNA by highly sensitive immunoassays. These techniques are particularly useful for screening human populations for exposure to potential...
Chen, C. J., Yu, M. W., Liaw, Y. F., Wang, L. W., Chiamprasert, S., Matin, F., ...
This study was carried out to elucidate the effect of glutathione S-transferase (GST) Ml and Tl polymorphisms on the aflatoxin-related hepatocarcinogenesis among chronic carriers of hepatitis B...