Siang, Ang, Doley, Robin, Vonk, Freek J, Kini, R Manjunatha
Abstract Background The Red-headed krait ( Bungarus flaviceps , Squamata: Serpentes: Elapidae) is a medically important venomous snake that inhabits South-East Asia. Although the venoms of most...
Doley, Robin, Mackessy, Stephen P, Kini, R Manjunatha
Abstract Background Snake venom toxins evolve more rapidly than other proteins through accelerated changes in the protein coding regions. Previously we have shown that accelerated segment switch in...
BMC Evolutionary Biology BioMed Central (2009)
Robin Doley, Stephen P Mackessy, R Manjunatha Kini
Research article Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins
Doley, Robin, Pahari, Susanta, Mackessy, Stephen P, Kini, R Manjunatha
Abstract Background Snake venoms consist primarily of proteins and peptides showing a myriad of potent biological activities which have been shaped by both adaptive and neutral selective forces....
Doley, Robin, Tram, Nguyen, Reza, Md Abu, Kini, R Manjunatha
Abstract Background Toxin profiling helps in cataloguing the toxin present in the venom as well as in searching for novel toxins. The former helps in understanding potential pharmacological profile...
Zhou, Xingding, Sun, Qingxiang, Kini, R. Manjunatha, Sivaraman, J.
The most challenging tasks in biology include the identification of (1) the orphan receptor for a ligand, (2) the ligand for an orphan receptor protein, and (3) the target protein(s) for a given drug...
Pahari, Susanta, Mackessy, Stephen P, Kini, R Manjunatha
Abstract Background Snake venoms are complex mixtures of pharmacologically active proteins and peptides which belong to a small number of superfamilies. Global cataloguing of the venom transcriptome...
Pahari, Susanta, Bickford, David, Fry, Bryan G, Kini, R Manjunatha
Abstract Background Snake venom composition varies widely both among closely related species and within the same species, based on ecological variables. In terrestrial snakes, such variation has been...
BMC Molecular Biology 2007, 8:115 doi:10.1186/1471-2199-8-115 (2007)
Susanta Pahari, Stephen P Mackessy, Manjunatha R Kini, Susanta Pahari, Stephen P. Mackessy, R. Manjunatha Kini
PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. The venom gland transcriptome of the Desert Massasauga...
Lumsden, Natalie G., Banerjee, Yajnavalka, Kini, R. Manjunatha, Kuruppu, Sanjaya, Hodgson, Wayne C.
Colubrid snake venoms potentially represent a vast source of novel biological actives and structural motifs owing to their diverse phylogeny. The present study describes the identification of...
Li, Min, Fry, Bryan G., Kini, R. Manjunatha
Accelerated evolution of toxins is a unique feature of venoms, with the toxins evolving via the birth-and-death mode of molecular evolution. The venoms of sea snakes, however, are remarkably simple...
Li, Min, Fry, Bryan G., Kini, R. Manjunatha
Accelerated evolution of toxins is a unique feature of venoms, with the toxins evolving via the birth-and-death mode of molecular evolution. The venoms of sea snakes, however, are remarkably simple...
Li, Min, Fry, Bryan G., Kini, R. Manjunatha
Accelerated evolution of toxins is a unique feature of venoms, with the toxins evolving via the birth-and-death mode of molecular evolution. The venoms of sea snakes, however, are remarkably simple...
Ajikumar, Parayil Kumaran, Lakshminarayanan, Rajamani, Valiyaveettil, Suresh, Kini, R. Manjunatha
Model peptides were designed, synthesized and conducted a detailed structure-property study to unravel the molecular mechanism of goose eggshell calcification. The peptides were designed based on the...
Ajikumar, Parayil Kumaran, Lakshminarayanan, Rajamani, Valiyaveettil, Suresh, Kini, R. Manjunatha
Model peptides were designed, synthesized and conducted a detailed structure-property study to unravel the molecular mechanism of goose eggshell calcification. The peptides were designed based on the...
Designer peptides to understand the mineralization of calcium salts (2003)
Ajikumar, Parayil Kumaran, Lakshminarayanan, Rajamani, Valiyaveettil, Suresh, Kini, R. Manjunatha
Recently, we reported the extraction, purification and amino acid sequence of ansocalcin, the major goose eggshell matrix protein. In vitro studies showed that ansocalcin induces spherical calcite...
Designer peptides to understand the mineralization of calcium salts (2003)
Ajikumar, Parayil Kumaran, Lakshminarayanan, Rajamani, Valiyaveettil, Suresh, Kini, R. Manjunatha
Recently, we reported the extraction, purification and amino acid sequence of ansocalcin, the major goose eggshell matrix protein. In vitro studies showed that ansocalcin induces spherical calcite...
Sivaraja, Vaithiyalingam, Sasaki, Toru, Cheng, Betty, Kumar, Thallampuranam Krishnaswamy S, ...
An important and exciting challenge in the postgenomic era is to understand the functions of newly discovered proteins based on their structures. The main thrust is to find the common structural...
Investigation of the role of ansocalcin in the biomineralization in goose eggshell matrix
Lakshminarayanan, Rajamani, Kini, R. Manjunatha, Valiyaveettil, Suresh
The role of proteins in biomineralization and the mechanism of eggshell formation are not well understood. We have isolated and purified the major protein, ansocalcin from goose eggshell matrix. The...
Rao, Veena S, Joseph, Jeremiah S, Kini, R Manjunatha
Procoagulant venoms of several Australian elapids contain proteinases that specifically activate prothrombin; among these, Group D activators are functionally similar to coagulation factor Xa (FXa)....
Investigation of the role of ansocalcin in the biomineralization in goose eggshell matrix
Lakshminarayanan, Rajamani, Kini, R. Manjunatha, Valiyaveettil, Suresh
The role of proteins in biomineralization and the mechanism of eggshell formation are not well understood. We have isolated and purified the major protein, ansocalcin from goose eggshell matrix. The...
Rao, Veena S, Joseph, Jeremiah S, Kini, R Manjunatha
Procoagulant venoms of several Australian elapids contain proteinases that specifically activate prothrombin; among these, Group D activators are functionally similar to coagulation factor Xa (FXa)....
Wickramaratna, Janith C, Fry, Bryan G, Aguilar, Marie-Isabel, Kini, R Manjunatha, Hodgson, Wayne C
It has long been thought that death adder venoms are devoid of myotoxic activity based on studies done on Acanthophis antarcticus (Common death adder) venom. However, a recent clinical study reported...
Banerjee, Yajnavalka, Lakshminarayanan, Rajamani, Vivekanandan, Subramanian, Anand, Ganesh Srinivasan, Valiyaveettil, Suresh, Kini, R. Manjunatha
Hemextin AB complex from the venom of Hemachatus haemachatus is the first known natural anticoagulant that specifically inhibits the enzymatic activity of blood coagulation factor VIIa in the absence...
Banerjee, Yajnavalka, Kumar, Sundramurthy, Jobichen, Chacko, Kini, R. Manjunatha
Crystals of hemextin A, a three-finger toxin isolated and purified from African Ringhals cobra (H. haemachatus), are orthorhombic, space group P212121, with unit-cell parameters a = 49.27, b = 49.51,...
Structural Characterization of Myotoxic Ecarpholin S From Echis carinatus Venom
Zhou, Xingding, Tan, Tien-Chye, Valiyaveettil, S., Go, Mei Lin, Kini, R. Manjunatha, Velazquez-Campoy, Adrian, ...
Phospholipase A2 (PLA2), a common toxic component of snake venom, has been implicated in various pharmacological effects. Ecarpholin S, isolated from the venom of the snake Echis carinatus sochureki,...
Zhou, Xingding, Sun, Qingxiang, Kini, R. Manjunatha, Sivaraman, J.
The most challenging tasks in biology include the identification of (1) the orphan receptor for a ligand, (2) the ligand for an orphan receptor protein, and (3) the target protein(s) for a given drug...