Modulation of ATM gene expression in a murine mammary epithelial cell line (2000)
Vutskits, GV, Salmon, P, Soriano, JV, Cudre-Mauroux, C, Trono, D, Montesano, R, ...
No abstract available.
Workshop on DNA repair. (1992)
Lehmann, A.R., Hoeijmakers, J.H.J., Zeeland, A.A. Van, Backendorf, C.M.P., Bridges, B.A., Collins, A., ...
A workshop on DNA repair with emphasis on eukaryotic systems was held, under the auspices of the EC Concerted Action on DNA Repair and Cancer, at Noordwijkerhout (The Netherlands) 14-19 April 1991....
Genistein, a dietary-derived inhibitor of in vitro angiogenesis.
Fotsis, T, Pepper, M, Adlercreutz, H, Fleischmann, G, Hase, T, Montesano, R, ...
Consumption of a plant-based diet can prevent the development and progression of chronic diseases that are associated with extensive neovascularization; however, little is known about the mechanisms....
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.
Jiang, W, Zhang, Y J, Kahn, S M, Hollstein, M C, Santella, R M, Lu, S H, ...
We have examined DNA from four human esophageal carcinoma cell lines and 50 primary esophageal carcinomas obtained from China, Italy, and France for amplification of the cyclin D1 gene. We also...
Frequent mutation of the p53 gene in human esophageal cancer.
Hollstein, M C, Metcalf, R A, Welsh, J A, Montesano, R, Harris, C C
Sequence alterations in the p53 gene have been detected in human tumors of the brain, breast, lung, and colon, and it has been proposed that p53 mutations spanning a major portion of the coding...
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation.
Hollstein, M, Shomer, B, Greenblatt, M, Soussi, T, Hovig, E, Montesano, R, ...
In 1994 we described a list of approximately 2500 point mutations in the p53 gene of human tumors and cell lines which we had compiled from the published literature and made available electronically...
Hainaut, P, Soussi, T, Shomer, B, Hollstein, M, Greenblatt, M, Hovig, E, ...
In recent years, there has been an exponential increase in the number of p53 mutations identified in human cancers. The p53 mutation database consists of a list of point mutations in thep53 gene of...
Hainaut, P, Hernandez, T, Robinson, A, Rodriguez-Tome, P, Flores, T, Hollstein, M, ...
Since 1989, about 570 different p53 mutations have been identified in more than 8000 human cancers. A database of these mutations was initiated by M. Hollstein and C. C. Harris in 1990. This database...
Repair of O-alkylpyrimidines in mammalian cells: a present consensus.
Brent, T P, Dolan, M E, Fraenkel-Conrat, H, Hall, J, Karran, P, Laval, L, ...
Enzymatic repair of the O-alkylpyrimidines (O2- and O4-alkylthymine, O2-alkylcytosine) and alkyl phosphotriesters has been studied in Escherichia coli, and the two proteins involved, a glycosylase...
An important event during wound healing is the contraction of newly formed connective tissue (granulation tissue) by fibroblasts. The role of polypeptide growth factors in the process of wound...
Database of p53 gene somatic mutations in human tumors and cell lines.
Hollstein, M, Rice, K, Greenblatt, M S, Soussi, T, Fuchs, R, Sørlie, T, ...
A data base is described in which over 2,500 mutations in the p53 gene of human tumors and tumor cell lines are compiled from a systematic search of reports published before 1 January 1994. Data from...
Orci, L, Montesano, R, Meda, P, Malaisse-Lagae, F, Brown, D, Perrelet, A, ...
The Golgi apparatus is a key element in the ordered movement of secretory polypeptides from the rough endoplasmic reticulum to the plasma membrane during secretion. It has been shown that cisternae...
Removal of O6-methylguanine from DNA by human liver fractions.
Pegg, A E, Roberfroid, M, Von Bahr, C, Foote, R S, Mitra, S, Bresil, H, ...
In in vitro assays using methylated DNAs as substrates, human liver fractions were shown to be able to catalyze the removal of O6-methylguanine. The amount of removal was proportional to the amount...
Basic fibroblast growth factor induces angiogenesis in vitro.
Montesano, R, Vassalli, J D, Baird, A, Guillemin, R, Orci, L
Fibroblast growth factors (FGFs) are potent mitogens for vascular and capillary endothelial cells in vitro and can stimulate the formation of blood capillaries (angiogenesis) in vivo. A crucial event...
Absence of filipin-sterol complexes from large coated pits on the surface of culture cells.
Montesano, R, Perrelet, A, Vassalli, P, Orci, L
Monolayer cultures of normal or transformed fibroblasts and of liver cells fixed in a glutaraldehyde solution containing 300 microM filipin, a sterol-specific polyene antibiotic, were...
Seelentag, W K, Mermod, J J, Montesano, R, Vassalli, P
The control of haematopoietic colony-stimulating factors (CSF) gene expression by interleukin 1 (IL-1) and tumour necrosis factor alpha (TNF-alpha) in cultured endothelial cells was studied by RNA...
Margison, G P, Margison, J M, Montesano, R
1. DNA was extracted from livers, kidneys and lungs of Syrian golden hamsters at various times (up to 96h) after injection of a hepatocarcinogenic dose of [14C]dimethylnitrosamine. Purine bases were...
Margison, G P, Margison, J M, Montesano, R
1. BD-IV rats were given labelled dimethylnitrosamine (2 mg/kg) by stomach tube on weekdays (Monday to Friday) for up to 24 weeks. The rats killed after 2, 4, 8, 16 and 24 weeks of treatment (72 h...
Margison, G P, Margison, J M, Montesano, R
1. Syrian golden hamster liver ribosomal RNA was isolated up to 96 h after administration of [14C]dimethylnitrosamine at 25 mg/kg or 2.5 mg/kg body weight. 2. The chemical alkyation products,...
Mutagenicity and metabolism of vinyl chloride and related compounds.
Bartsch, H, Malaveille, C, Barbin, A, Bresil, H, Tomatis, L, Montesano, R
The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites. The metabolism of vinyl chloride...
Wild, C P, Jansen, L A, Cova, L, Montesano, R
Aflatoxin exposure and hepatitis B virus infection have been implicated as major risk factors for primary hepatocellular carcinoma (PHC) in high-incidence regions of the world. Investigations using...
An overview of phthalate ester carcinogenicity testing results: the past.
This paper presents a short review of the available carcinogenicity tests which have been carried out on various phthalate esters prior to the availability of the National Cancer Institute bioassay...
Genistein, a dietary-derived inhibitor of in vitro angiogenesis.
Fotsis, T, Pepper, M, Adlercreutz, H, Fleischmann, G, Hase, T, Montesano, R, ...
Consumption of a plant-based diet can prevent the development and progression of chronic diseases that are associated with extensive neovascularization; however, little is known about the mechanisms....
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.
Jiang, W, Zhang, Y J, Kahn, S M, Hollstein, M C, Santella, R M, Lu, S H, ...
We have examined DNA from four human esophageal carcinoma cell lines and 50 primary esophageal carcinomas obtained from China, Italy, and France for amplification of the cyclin D1 gene. We also...
Frequent mutation of the p53 gene in human esophageal cancer.
Hollstein, M C, Metcalf, R A, Welsh, J A, Montesano, R, Harris, C C
Sequence alterations in the p53 gene have been detected in human tumors of the brain, breast, lung, and colon, and it has been proposed that p53 mutations spanning a major portion of the coding...
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation.
Hollstein, M, Shomer, B, Greenblatt, M, Soussi, T, Hovig, E, Montesano, R, ...
In 1994 we described a list of approximately 2500 point mutations in the p53 gene of human tumors and cell lines which we had compiled from the published literature and made available electronically...
Hainaut, P, Soussi, T, Shomer, B, Hollstein, M, Greenblatt, M, Hovig, E, ...
In recent years, there has been an exponential increase in the number of p53 mutations identified in human cancers. The p53 mutation database consists of a list of point mutations in thep53 gene of...
Hainaut, P, Hernandez, T, Robinson, A, Rodriguez-Tome, P, Flores, T, Hollstein, M, ...
Since 1989, about 570 different p53 mutations have been identified in more than 8000 human cancers. A database of these mutations was initiated by M. Hollstein and C. C. Harris in 1990. This database...
Repair of O-alkylpyrimidines in mammalian cells: a present consensus.
Brent, T P, Dolan, M E, Fraenkel-Conrat, H, Hall, J, Karran, P, Laval, L, ...
Enzymatic repair of the O-alkylpyrimidines (O2- and O4-alkylthymine, O2-alkylcytosine) and alkyl phosphotriesters has been studied in Escherichia coli, and the two proteins involved, a glycosylase...
An important event during wound healing is the contraction of newly formed connective tissue (granulation tissue) by fibroblasts. The role of polypeptide growth factors in the process of wound...
Database of p53 gene somatic mutations in human tumors and cell lines.
Hollstein, M, Rice, K, Greenblatt, M S, Soussi, T, Fuchs, R, Sørlie, T, ...
A data base is described in which over 2,500 mutations in the p53 gene of human tumors and tumor cell lines are compiled from a systematic search of reports published before 1 January 1994. Data from...
Orci, L, Montesano, R, Meda, P, Malaisse-Lagae, F, Brown, D, Perrelet, A, ...
The Golgi apparatus is a key element in the ordered movement of secretory polypeptides from the rough endoplasmic reticulum to the plasma membrane during secretion. It has been shown that cisternae...
Removal of O6-methylguanine from DNA by human liver fractions.
Pegg, A E, Roberfroid, M, Von Bahr, C, Foote, R S, Mitra, S, Bresil, H, ...
In in vitro assays using methylated DNAs as substrates, human liver fractions were shown to be able to catalyze the removal of O6-methylguanine. The amount of removal was proportional to the amount...
Basic fibroblast growth factor induces angiogenesis in vitro.
Montesano, R, Vassalli, J D, Baird, A, Guillemin, R, Orci, L
Fibroblast growth factors (FGFs) are potent mitogens for vascular and capillary endothelial cells in vitro and can stimulate the formation of blood capillaries (angiogenesis) in vivo. A crucial event...
Absence of filipin-sterol complexes from large coated pits on the surface of culture cells.
Montesano, R, Perrelet, A, Vassalli, P, Orci, L
Monolayer cultures of normal or transformed fibroblasts and of liver cells fixed in a glutaraldehyde solution containing 300 microM filipin, a sterol-specific polyene antibiotic, were...
Seelentag, W K, Mermod, J J, Montesano, R, Vassalli, P
The control of haematopoietic colony-stimulating factors (CSF) gene expression by interleukin 1 (IL-1) and tumour necrosis factor alpha (TNF-alpha) in cultured endothelial cells was studied by RNA...
Margison, G P, Margison, J M, Montesano, R
1. DNA was extracted from livers, kidneys and lungs of Syrian golden hamsters at various times (up to 96h) after injection of a hepatocarcinogenic dose of [14C]dimethylnitrosamine. Purine bases were...
Margison, G P, Margison, J M, Montesano, R
1. BD-IV rats were given labelled dimethylnitrosamine (2 mg/kg) by stomach tube on weekdays (Monday to Friday) for up to 24 weeks. The rats killed after 2, 4, 8, 16 and 24 weeks of treatment (72 h...
Margison, G P, Margison, J M, Montesano, R
1. Syrian golden hamster liver ribosomal RNA was isolated up to 96 h after administration of [14C]dimethylnitrosamine at 25 mg/kg or 2.5 mg/kg body weight. 2. The chemical alkyation products,...
Mutagenicity and metabolism of vinyl chloride and related compounds.
Bartsch, H, Malaveille, C, Barbin, A, Bresil, H, Tomatis, L, Montesano, R
The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites. The metabolism of vinyl chloride...
Wild, C P, Jansen, L A, Cova, L, Montesano, R
Aflatoxin exposure and hepatitis B virus infection have been implicated as major risk factors for primary hepatocellular carcinoma (PHC) in high-incidence regions of the world. Investigations using...
An overview of phthalate ester carcinogenicity testing results: the past.
This paper presents a short review of the available carcinogenicity tests which have been carried out on various phthalate esters prior to the availability of the National Cancer Institute bioassay...
Takahashi, S., Hall, J., Montesano, R.
The intercellular distribution of O6-methylguanine-DNA methyltransferase (MGMT) mRNA expression has been investigated at the individual cell level in the liver of rats treated with...
In vivo assembly of tight junctions in fetal rat liver
Montesano, R., Friend, D. S., Perrelet, A., Orci, L.
Examination of glutaraldehyde-fixed, freeze-fractured livers from 14-15-day rat fetuses provided the basis for the following observations. Membrane particles align in otherwise poorly particulated...