WYKE, R. J., AW, T. C., ALLAN, R. N., HARRINGTON, J. M.
The attitude of 126 occupational physicians to the employment problems of patients with intestinal stomas were assessed by a postal questionnaire. Heavy work and work in hot places were commonly (65...
Mortality in Crohn's Disease -- A Clinical Analysis (1989)
ANDREWS, H. A., LEWIS, P., ALLAN, R. N.
SUMMARY We have examined the causes of death and the changing pattern of mortality over time among 769 patients with Crohn's disease under long-term review between 1944 and 1984. One hundred and...
Clustering of Crohn's Disease in a Cotswold Village (1986)
ALLAN, R. N., PEASE, P., IBBOTSON, J. P.
The first large cluster of patients with Crohn's disease, identified in the parish of Blockley, Gloucestershire is reported. Twelve patients with Crohn's disease have been identified of whom only two...
Ulcerative Colitis: Why is the Mortality from Cardiovascular Disease Reduced? (1984)
GYDE, S. N., PRIOR, P., ALEXANDER, F., EVANS, S., TAYLOR, K., JOHN, W. G., ...
A recent mortality study of patients with ulcerative colitis showed significant deficits in deaths from cardiovascular disease and from respiratory disease in males. The reasons for the observed...
Crohn's Disease: Course, Treatment and Long Term Prognosis (1980)
COOKE, W. T., MALLAS, E., PRIOR, P., ALLAN, R. N.
The course, treatment and outcome of Crohn's disease affecting 174 patients diagnosed more than 20 years ago and followed for 20 to 45 years are reported. Fifty patients died, 23 related to Crohn's...
The Spectrum of Hepatic Dysfunction in Inflammatory Bowel Disease (1979)
DEW, M. J., THOMPSON, H., ALLAN, R. N.
The spectrum and incidence of liver disease is described among a large series of patients with inflammatory bowel disease. The incidence of significant liver disease identified by the presence of...
Biliary Tract Carcinoma Associated with Ulcerative Colitis (1974)
RITCHIE, JEAN K., ALLAN, R. N., MACARTNEY, J., THOMPSON, H., HAWLEY, P. R., COOKE, W. T.
This paper reports 15 well-documented cases in which a biliary tract tumour has developed in a patient with ulcerative colitis. Most patients had both a long history of colitis and total involvement...
A sex difference in the leucocyte count
Allan, R. N., Alexander, M. K.
In a study of a group of 325 blood donors between the ages of 18 and 65 years, the total leucocyte and polymorph counts of the females aged 50 to 65 years were found to be significantly lower than...
Coeliac disease and disseminated lymphomatosis.
Kulshrestha, M K, Honan, W P, Aluwihare, N, Carey, M, Allan, R N
Impact of preoperative weight loss on postoperative morbidity1
Higgens, C S, Keighley, M R B, Allan, R N
Clinical observations in developing countries and experimental studies in animals suggest that preoperative weight loss adversely affects postoperative morbidity. Since it is not clear whether these...
Colonic Crohn's disease and use of oral contraception.
Rhodes, J M, Cockel, R, Allan, R N, Hawker, P C, Dawson, J, Elias, E
The prevalence of use of oral contraception before the onset of disease was established in 100 consecutive women attending follow up clinics for inflammatory bowel disease. A significant excess of...
Comparison of surgical and medical management of bleeding peptic ulcers
Morris, D L, Hawker, P C, Dykes, P W, Allan, R N, Keighley, M R B
Management of gastrointestinal bleeding
Keighley, M R B, Allan, R N, Alexander-Williams, John, Dykes, P W
Finger clubbing in inflammatory bowel disease: its prevalence and pathogenesis.
Kitis, G, Thompson, H, Allan, R N
Finger clubbing, measured objectively by using the hyponychial angle, was present in 75 out of 200 (38%) patients with Crohn's disease, 15 out of 103 (15%) with ulcerative colitis, and two out of 24...
A sex difference in the leucocyte count
Allan, R. N., Alexander, M. K.
In a study of a group of 325 blood donors between the ages of 18 and 65 years, the total leucocyte and polymorph counts of the females aged 50 to 65 years were found to be significantly lower than...
Coeliac disease and disseminated lymphomatosis.
Kulshrestha, M K, Honan, W P, Aluwihare, N, Carey, M, Allan, R N
Impact of preoperative weight loss on postoperative morbidity1
Higgens, C S, Keighley, M R B, Allan, R N
Clinical observations in developing countries and experimental studies in animals suggest that preoperative weight loss adversely affects postoperative morbidity. Since it is not clear whether these...
Colonic Crohn's disease and use of oral contraception.
Rhodes, J M, Cockel, R, Allan, R N, Hawker, P C, Dawson, J, Elias, E
The prevalence of use of oral contraception before the onset of disease was established in 100 consecutive women attending follow up clinics for inflammatory bowel disease. A significant excess of...
Comparison of surgical and medical management of bleeding peptic ulcers
Morris, D L, Hawker, P C, Dykes, P W, Allan, R N, Keighley, M R B
Management of gastrointestinal bleeding
Keighley, M R B, Allan, R N, Alexander-Williams, John, Dykes, P W
Finger clubbing in inflammatory bowel disease: its prevalence and pathogenesis.
Kitis, G, Thompson, H, Allan, R N
Finger clubbing, measured objectively by using the hyponychial angle, was present in 75 out of 200 (38%) patients with Crohn's disease, 15 out of 103 (15%) with ulcerative colitis, and two out of 24...
Diagnostic Accuracy of Early Radiology in Acute Gastrointestinal Haemorrhage
Allan, R. N., Dykes, P. W., Toye, D. K. M.
The accuracy of early radiology in patients with acute gastrointestinal haemorrhage has been studied by a comparison of the radiological opinion with the established diagnosis. A full examination has...
Further observations upon HLA-B27, Yersinia enterocolitica, and ankylosing spondylitis.
Pease, P E, Balmer, S E, Tallack, J E, Chahal, H, Ibbotson, J, Bartlett, L R, ...
Stainsby, K J, Lowes, J R, Allan, R N, Ibbotson, J P
Cultural and serological studies have provided limited, often conflicting, evidence of a role for mycobacteria in the pathogenesis of Crohn's disease. Interest has focussed on Mycobacterium...
Surgical resections in parous patients with distal ileal and colonic Crohn's disease.
Nwokolo, C U, Tan, W C, Andrews, H A, Allan, R N
The surgical resection rates among parous women with distal ileal and colonic Crohn's disease have been compared with resection rates among distal ileal (n = 197) and colonic (n = 332) Crohn's...
Diffuse jejunoileitis of Crohn's disease.
Diffuse jejunoileitis is an uncommon, but important manifestation of Crohn's disease because of the associated high morbidity and challenges in medical management. Despite this there have been no...
Pathogenesis of gall stones in Crohn's disease: an alternative explanation.
Hutchinson, R, Tyrrell, P N, Kumar, D, Dunn, J A, Li, J K, Allan, R N
The increased prevalence of gall stones in Crohn's disease is thought to be related to depletion of the bile salt pool due either to terminal ileal disease or after ileal resection. This study was...
Crohn's disease and colorectal cancer.
Gillen, C D, Andrews, H A, Prior, P, Allan, R N
The colorectal cancer risk in Crohn's disease eliminating all known biases was assessed in a cohort of 281 patients with Crohn's disease who resided in the West Midlands at the time of diagnosis, and...
Interrelation of strongyloidiasis and tuberculosis.
Dwarakanath, A D, Welton, M, Ellis, C J, Allan, R N
A 31 year old man from Gambia, resident in the United Kingdom for two years, presented with a two month history of unproductive cough, malaise, weight loss, non-specific abdominal pain, and episodic...
Gillen, C D, Walmsley, R S, Prior, P, Andrews, H A, Allan, R N
The risk of developing colorectal cancer has been compared in two identically selected cohorts of patients with extensive Crohn's colitis (n = 125) and extensive ulcerative colitis (n = 486). In both...
Malignancy in coeliac disease--effect of a gluten free diet.
Holmes, G K, Prior, P, Lane, M R, Pope, D, Allan, R N
Two hundred and ten patients with coeliac disease previously reported from this unit were reviewed at the end of 1985 after a further 11 years of follow up. The initial review at the end of 1974...
Superoxide production by Crohn's disease neutrophils.
Curran, F T, Allan, R N, Keighley, M R
Neutrophil superoxide anion production was measured in healthy subjects and in patients with quiescent and active Crohn's disease using superoxide dismutase inhibitable cytochrome C reduction. Three...
Candidacidal activity of Crohn's disease neutrophils.
Curran, F T, Youngs, D J, Allan, R N, Keighley, M R
The ability of normal and Crohn's disease neutrophils to kill Candida albicans has been studied using neutrophils isolated from peripheral blood and suspended in phosphate buffered saline at 5 x...
Sulphasalazine induced renal failure.
Dwarakanath, A D, Michael, J, Allan, R N
Two men with longstanding ulcerative colitis who were treated with sulphasalazine for several years and who developed chronic renal failure are reported. Renal biopsy specimens showed histological...
A national training programme for gastroenterology and hepatology.
Farthing, M J, Walt, R P, Allan, R N, Swan, C H, Gilmore, I T, Mallinson, C N, ...
Ferguson, R, Allan, R N, Cooke, W T
The cellular infiltrate of the proximal jejunum has been compared between 20 subjects without gastrointestinal disease, 20 subjects with ulcerative colitis, and 26 subjects with Crohn's disease. A...
Lithocholate metabolism during chemotherapy for gallstone dissolution. 2. Absorption and sulphation.
Allan, R N, Thistle, J L, Hofmann, A F
The amount of lithocholate input and the size of the total lithocholate exchangeable pool were measured using isotope dilution in three patients ingesting chenodeoxycholic acid for gallstone...
Allan, R N, Thistle, J L, Hofmann, A F, Carter, J A, Yu, P Y
Serum levels of total sulphated and total unsulphated lithocholates were each measured by a specific radioimmunoassay in 66 patients ingesting chenodeoxycholic (chenic) acid for gallstone dissoultion...
Dunne, W T, Cooke, W T, Allan, R N
Intestinal disaccharidase and dipeptidase activities were measured in mucosal biopsies from the proximal jejunum in 20 patients with Crohn's disease apparently confined to the distal ileum or large...
Influence of inflammatory bowel disease on intestinal microflora.
Keighley, M R, Arabi, Y, Dimock, F, Burdon, D W, Allan, R N, Alexander-Williams, J
The microflora of the jejunum, ileum, and colon has been studied from operative samples in Crohn's disease (n = 30), ulcerative colitis (n = 15), and controls (n = 40). There was no significant...
Clarke, R. J., Allan, R. N., Alexander-Williams, J.
The result of a prospective trial of 40 patients with duodenal ulcer treated either by proximal gastric vagotomy (antrum innervated) or by selective vagotomy (antrum denervated) shows that they are...
Steinberg, D. M., Allan, R. N., Thompson, H., Brooke, B. N., Alexander-Williams, J., Cooke, W. T.
This paper reports the indications for, and results of, excision of the large intestine with ileostomy in 73 patients with Crohn's colitis who have been followed for a mean of nine years since...
Crohn's disease of the distal ileum.
A clinical and statistical analysis has been undertaken in a consecutive series of 227 patients with Crohn's disease involving the distal ileum under long-term review between 1944 and 1978. We have...
Relationship of proctitis and rectal capacity in Crohn's disease.
Buchmann, P, Mogg, G A, Alexander-Williams, J, Allan, R N, Keighley, M R
In patients with Crohn's disease involving the rectum (n=25), there was an inverse relationship between rectal capacity and the degree of proctitis. However, in patients with Crohn's disease not...
Malignancy in Crohn's disease.
Gyde, S N, Prior, P, Macartney, J C, Thompson, H, Waterhouse, J A, Allan, R N
Cancer morbidity has been evaluated in a series of 513 patients with Crohn's disease under long-term review between 1944-76. In comparison with morbidity rates for cancer in the West Midlands Region...
Adenocarcinoma of the small intestine complicating Crohn's disease.
Hawker, P C, Gyde, S N, Thompson, H, Allan, R N
Adenocarcinoma of the small intestine is an uncommon complication of Crohn's disease. We report the clinical and pathological details of three cases diagnosed between 1968 and 1980 with a review of...
Clostridium difficile toxin in acute diarrhoea complicating inflammatory bowel disease.
Keighley, M R, Youngs, D, Johnson, M, Allan, R N, Burdon, D W
The incidence of Clostridium difficile cytotoxin has been studied in 69 consecutive patients with inflammatory bowel disease complicated by severe diarrhoea or ileostomy flux during 74 admissions to...
Cancer morbidity in ulcerative colitis.
Prior, P, Gyde, S N, Macartney, J C, Thompson, H, Waterhouse, J A, Allan, R N
Cancer morbidity at all sites has been studied in a series of 676 patients with ulcerative colitis under long-term review, of whom more than two-thirds had extensive disease, and the level and...
Association of coeliac disease and inflammatory bowel disease.
Kitis, G, Holmes, G K, Cooper, B T, Thompson, H, Allan, R N
The association of coeliac disease and inflammatory bowel disease is rare, as only three individual cases have been reported. Four additional cases of the association are described. A review of the...
Management of enterocutaneous fistulae in Crohn's disease.
Hawker, P C, Givel, J C, Keighley, M R, Alexander-Williams, J, Allan, R N
The outcome among 39 patients with enterocutaneous fistulae complicating Crohn's disease has been reviewed. The patients were considered in two groups: (1) no disease - all were early postoperative...
Survival of patients with colorectal cancer complicating ulcerative colitis.
Gyde, S N, Prior, P, Thompson, H, Waterhouse, J A, Allan, R N
The crude five year survival of patients with colorectal cancer complicating ulcerative colitis in a large series of patients under long term review has, for the first time, been compared with the...
Clinical impact of colectomy and ileorectal anastomosis in the management of Crohn's disease.
Ambrose, N S, Keighley, M R, Alexander-Williams, J, Allan, R N
We report the outcome of 63 consecutive patients with Crohn's colitis treated by colectomy and ileorectal anastomosis between 1951-1981. There were no operative deaths. Serious postoperative...
Long term prognosis of Crohn's disease with onset in childhood and adolescence.
Puntis, J, McNeish, A S, Allan, R N
The long term outcome has been determined in 67 children with Crohn's disease whose symptoms started at or before 16 years of age. The mean period of follow up was 15.0 years (range 1.5-47 years)....
Higgens, C S, Keighley, M R, Allan, R N
One hundred and twenty seven patients undergoing elective surgery for inflammatory bowel disease were divided into three groups according to their preoperative ideal body weight (less than 80%,...
Crohn's disease in the elderly.
Fabricius, P J, Gyde, S N, Shouler, P, Keighley, M R, Alexander-Williams, J, Allan, R N
The natural history of Crohn's disease in 47 patients, 60 years of age or older at the time of diagnosis has been defined, and their clinical management and long term prognosis reviewed. Distal...
Faecal mucus degrading glycosidases in ulcerative colitis and Crohn's disease.
Rhodes, J M, Gallimore, R, Elias, E, Allan, R N, Kennedy, J F
Because the normal faecal flora includes bacteria which can produce mucus-digesting glycosidases, it follows that increased digestion of colonic mucus by these bacterial enzymes could be important in...
Crohn's disease in two married couples.
Rhodes, J M, Marshall, T, Hamer, J D, Allan, R N
Only two examples of married couples where both partners have developed Crohn's disease have been reported previously from the United Kingdom. We describe two further examples; one where the index...
Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres.
Gyde, S N, Prior, P, Allan, R N, Stevens, A, Jewell, D P, Truelove, S C, ...
A retrospective cohort of 823 patients with ulcerative colitis who resided at the time of diagnosis in one of three defined geographical areas (West Midlands region, Oxford region, England and...
Prevalence of sexually transmitted disease among male patients presenting with proctitis.
Andrews, H, Wyke, J, Lane, M, Clay, J, Keighley, M R, Allan, R N
Fifty male patients with proctitis were examined and the clinical, microbiological, serological and proctological features compared with 51 known male homosexuals attending the genitourinary (GU)...
Psychiatric illness in patients with inflammatory bowel disease.
Andrews, H, Barczak, P, Allan, R N
One hundred and sixty two consecutive patients attending a clinic for inflammatory bowel disease (91 Crohn's, 71 ulcerative colitis) were assessed for the presence of anxiety and depression using a...
Plasma fibronectin in Crohn's disease.
Allan, A, Wyke, J, Allan, R N, Morel, P, Robinson, M, Scott, D L, ...
The hypothesis that abnormal fibronectin metabolism in Crohn's disease could be an important mechanism leading to stricture formation or postoperative infection was tested in three related studies....
Clements, D, Ellis, C J, Allan, R N
Shigella usually causes a self-limited infection which untreated lasts on average seven days (range one to 30 days). We report a patient who had persistent symptoms for 10 months caused by Shigella...
Employment problems and prospects for patients with inflammatory bowel disease.
Wyke, R J, Edwards, F C, Allan, R N
A random sample of 170 patients (88 men) with chronic inflammatory bowel disease (75 ulcerative colitis) were first interviewed in 1978 about their employment status, problems at work, and influence...
Ibbotson, J P, Lowes, J R, Chahal, H, Gaston, J S, Life, P, Kumararatne, D S, ...
Culture studies have suggested that Mycobacterium paratuberculosis may play a role in the aetiology of Crohn's disease. However, evidence of sensitization to mycobacterial antigens amongst patients...
The surgical treatment of gastroduodenal Crohn's disease.
Shepherd, A. F., Allan, R. N., Dykes, P. W., Keighley, M. R., Alexander-Williams, J.
Crohn's disease can affect any part of the gastrointestinal tract. Gastroduodenal involvement is uncommon and was not recognised until 1949 (1). Since then approximately 200 cases have been described...
Enterovesical fistulas in Crohn's disease.
Heyen, F., Ambrose, N. S., Allan, R. N., Dykes, P. W., Alexander-Williams, J., Keighley, M. R.
A total of 19 enterovesical fistulas were recorded in a series of 799 patients with Crohn's disease (2.4%). The origin of the fistulas was: ileum (9), colon (6) and four were complex involving the...
Occult small bowel adenocarcinoma complicating Crohn's disease: a report of three cases.
Gillen, C. D., Wilson, C. A., Walmsley, R. S., Sanders, D. S., O'Dwyer, S. T., Allan, R. N.
Three patients with Crohn's disease are described who were treated by ileal resection for intestinal obstruction. Histological examination of the resected specimen in each case established the...
Walmsley, R. S., David, D. B., Allan, R. N., Kirkby, G. R.
We report a case of bilateral endogenous Escherichia coli endophthalmitis in an insulin-dependent diabetic. This condition appears to occur almost exclusively in diabetics, and is invariably related...
Early onset high grade dysplasia in ulcerative colitis.
Clements, D., Suarez, V., Thompson, H., Alexander-Williams, J., Allan, R. N.
We report a patient with ulcerative colitis who underwent colectomy when aged 25 years for multifocal high grade dysplasia which had developed within 2 years of diagnosis, and only 5 1/2 years after...
Prognosis and management of Crohn's disease in the over-55 age group.
Walmsley, R. S., Gillen, C. D., Allan, R. N.
The course, prognosis and management of 62 patients with Crohn's disease aged 55 years or over at diagnosis has been reviewed. The distal ileus was the commonest site of disease in the older patient,...
Folate metabolism in man: the effect of malignant disease.
Saleh, A. M., Pheasant, A. E., Blair, J. A., Allan, R. N., Walters, J.
The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding...