Schutter, M., Janse, M., Osinga, R., Janssen, M., Wijffels, R.H., ...
The relation between irradiance, skeletal growth and net photosynthesis was studied for the scleractinian coral Galaxea fascicularis to provide experimental evidence for mediation of light-enhanced...
Hypothesized kinetic models for describing the growth of globular and encrusting demosponges (2006)
Sipkema, D., Yosef, N.A.M., Adamczewski, M., Osinga, R., Mendola, D., Tramper, J., ...
The marine sponges Dysidea avara and Chondrosia reniformis (globular forms) were cultured in the laboratory on a diet of viable Phaeodactylum tricornutum cells and dissolved nutrients (algae and fish...
Large-scale production of pharmaceuticals by marine sponges: Sea, cell, or synthesis? (2005)
Sipkema, D., Osinga, R., Schatton, W., Mendola, D., Tramper, J., Wijffels, R.H.
Marine sponges are known to produce an overwhelming array of secondary metabolites with pharmaceutical potential. The technical and economical potential of using marine sponges for large-scale...
Marine sponges as pharmacy (2005)
Sipkema, D., Franssen, M.C.R., Osinga, R., Tramper, J., Wijffels, R.H.
Marine sponges have been considered as a gold mine during the past 50 years, with respect to the diversity of their secondary metabolites. The biological effects of new metabolites from sponges have...
Oxygen dynamics in choanosomal sponge explants (2005)
Hoffmann, F., Larsen, O., Rapp, H.T., Osinga, R.
Oxygen microprofiles were measured over the boundary layer and into the tissue of 10-day-old cultivated tissue fragments (explants of 2-4 cm 3) from the choanosome of the cold-water sponge Geodia...
Selenium affects biosilica formation in the demosponge Suberites domuncula (2005)
Mueller, W.E.G., Borejko, A., Brandt, D., Osinga, R., Ushijima, H., Hamer, B., ...
Selenium is a trace element found in freshwater and the marine environment. We show that it plays a major role in spicule formation in the demosponge Suberites domuncula. If added to primmorphs, an...
The life and death of sponge cells (2004)
Sipkema, D., Snijders, A.P.L., Osinga, R., Wijffels, R.H.
Cell viability is an essential touchstone in the study of the effect of medium components on cell physiology. We developed a flow-cytometric assay to determine sponge-cell viability, based on the...
Primmorphs from seven marine sponges : formation and structure (2003)
Sipkema, D., Tramper, J., Osinga, R., Wijffels, R.H.
Primmorphs were obtained from seven different marine sponges: Stylissa massa, Suberites domuncula, Pseudosuberites aff. andrewsi, Geodia cydonium, Axinella polypoides, Halichondria panicea and...
Preliminary study on the occurrence of brominated organic compounds in Dutch marine organisms (2003)
Kotterman, M.J.J., Leonards, P.E.G., Osinga, R.
The extracts of three marine organisms; the ascidian Ciona intestinalis, the brown seaweed Sargassum muticum and the sponge Halichondria panicea, all elicited a number of brominated compounds, some...
Preliminary study on the occurrence of brominated organic compounds in Dutch marine organisms (2003)
Kotterman, M.J.J., Leonards, P.E.G., Osinga, R.
The extracts of three marine organisms; the ascidian Ciona intestinalis, the brown seaweed Sargassum muticum and the sponge Halichondria panicea, all elicited a number of brominated compounds, some...
Sponge cell culture? A molecular identification method for sponge cells (2003)
Sipkema, D., Heilig, G.H.J., Akkermans, A.D.L., Osinga, R., Tramper, J., Wijffels, R.H.
Dissociated sponge cells are easily confused with unicellular organisms. This has been an obstacle in the development of sponge-cell lines. We developed a molecular detection method to identify cells...
What to do in marine biotechnology? (2003)
Tramper, J., Battershill, C., Brandenburg, W.A., Burgess, G., Hill, R., Luiten, E.E.M., ...
During the symposium "Marine Biotechnology: Basics and Applications", held 25 February¿1 March, 2003 in Matalascañas, Spain, a special brainstorm session was organized. Two questions were...
Osinga, R., Kleijn, R., Groenendijk, E., Niesink, P., Tramper, J., Wijffels, R.H.
The rate of food particle uptake of the tropical sponge Pseudosuberites aff. andrewsi was studied in relation to particle concentrations and particle size. A range of different concentrations of...
Cultivation of marine sponges (1999)
Osinga, R., Tramper, J., Wijffels, R.H.
There is increasing interest in biotechnological production of marine sponge biomass owing to the discovery of many commercially important secondary metabolites in this group of animals. In this...
Cultivation of marine sponges for metabolite production: applications for biotechnology? (1998)
Osinga, R., Tramper, J., Wijffels, R.H.
The world's oceans harbour a large diversity of living organisms. As tropical rainforests have been searched for natural drugs, these marine organisms are being screened for useful products, and a...
In vitro cultivation of four marine sponge species: determination of the nutritional demands. (1998)