Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1.
Levy, D N, Refaeli, Y, MacGregor, R R, Weiner, D B
In human immunodeficiency virus (HIV)-positive individuals, the vast majority of infected peripheral blood cells and lymph node cells may be latently or nonproductively infected. The vpr open reading...
Dewey, S L, Smith, G S, Logan, J, Brodie, J D, Simkowitz, P, MacGregor, R R, ...
Previously we demonstrated that positron emission tomography (PET) can be used to measure changes in the concentrations of synaptic dopamine and acetylcholine. Whether induced directly or indirectly...
Biliary excretion of imipenem-cilastatin in hospitalized patients.
Graziani, A L, Gibson, G A, MacGregor, R R
Imipenem-cilastatin concentrations in bile were measured in 12 cholecystectomy patients (group 1) and 12 patients with common duct drainage (group 2). Six patients in each group received 0.5 g, and...
Vancomycin concentrations in infected and noninfected human bone.
Graziani, A L, Lawson, L A, Gibson, G A, Steinberg, M A, MacGregor, R R
Concentrations of vancomycin in bones of 14 patients undergoing total hip arthroplasty (group 1) and 5 patients with osteomyelitis (group 2) were studied. Group 1 received vancomycin, 15 mg/kg...
MacGregor, R R, Gibson, G A, Bland, J A
Serum, urine, tissue, and body fluids were collected from 40 adult patients who were receiving imipenem/cilastatin treatment for serious infections. Thirty-two patients were given 1 g every 6 h (4...
Multiple-dose pharmacokinetics of imipenem-cilastatin.
Drusano, G L, Standiford, H C, Bustamante, C, Forrest, A, Rivera, G, Leslie, J, ...
We characterized the pharmacokinetic profile of imipenem-cilastatin administered intravenously to six normal volunteers in a dose of 1,000 mg of each drug every 6 h for 40 doses. The plasma...
Safety and efficacy of high-dose treatment with imipenem-cilastatin in seriously ill patients.
Zajac, B A, Fisher, M A, Gibson, G A, MacGregor, R R
Imipenem-cilastatin was given in doses of 1 g intravenously every 6 h to 31 patients. Twenty-five patients, with 27 infections, were clinically evaluable and received 20 to 210 g of imipenem for a...
Pietroski, N A, Graziani, A L, Lawson, L A, Bland, J A, Rogers, J D, MacGregor, R R
We studied the concentrations in plasma and pharmacokinetics of imipenem and cilastatin in elderly patients (greater than 65 years old) who had various degrees of renal function and who were...
Niacin-positive Mycobacterium kansasii isolated from immunocompromised patients.
Nachamkin, I, MacGregor, R R, Staneck, J L, Tsang, A Y, Denner, J C, Willner, M, ...
Niacin-positive Mycobacterium kansasii was isolated from three patients, two with respiratory infections and one with a perirectal abscess. The isolates were phenotypically similar to other strains...
Nachamkin, I, Axelrod, P, Talbot, G H, Fischer, S H, Wennersten, C B, Moellering, R C, ...
Enterococci isolated from different body sites were tested for high-level gentamicin resistance. A total of 259 enterococcal isolates were screened for resistance (MIC, greater than 2,000...
Secretion of parathyroid hormone (PTH) is regulated in part by a classical "stimulus-secretion" pathway responsive to catecholamines. The primary physiological modulator of PTH exocytosis in...
Comparative adherence of granulocytes to endothelial monolayers and nylon fiber.
MacGregor, R R, Macarak, E J, Kefalides, N A
Adherence of granulocytes to tissue culture monolayers of endothelium averaged 26.2 +/- 1.3% SEM, which was similar to their adherence on 50-mg nylon fiber columns (27.7 +/- 3.6%). In contrast,...
The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor.
Lentnek, A L, Schreiber, A D, MacGregor, R R
The adherence of granylocytes to surfaces, measured in vitro in nylon fiber columns, is inhibited by in vivo administration of anti-inflammatory agents. Therefore, the effect of inflammation itself...
Ampicillin and Tetracycline in the Treatment and Prophylaxis of Chronic Bronchitis
Hahn, H. H., MacGregor, R. R., Avent, C. K., Counts, G. W., Smith, H. E., Beaty, H. N.
Ampicillin and tetracycline, in doses of 2 g a day, were compared in the treatment of acute exacerbations of chronic bronchitis. Seventy-nine patients were followed for 3 to 29 months and were...
Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1.
Levy, D N, Refaeli, Y, MacGregor, R R, Weiner, D B
In human immunodeficiency virus (HIV)-positive individuals, the vast majority of infected peripheral blood cells and lymph node cells may be latently or nonproductively infected. The vpr open reading...
Dewey, S L, Smith, G S, Logan, J, Brodie, J D, Simkowitz, P, MacGregor, R R, ...
Previously we demonstrated that positron emission tomography (PET) can be used to measure changes in the concentrations of synaptic dopamine and acetylcholine. Whether induced directly or indirectly...
Biliary excretion of imipenem-cilastatin in hospitalized patients.
Graziani, A L, Gibson, G A, MacGregor, R R
Imipenem-cilastatin concentrations in bile were measured in 12 cholecystectomy patients (group 1) and 12 patients with common duct drainage (group 2). Six patients in each group received 0.5 g, and...
Vancomycin concentrations in infected and noninfected human bone.
Graziani, A L, Lawson, L A, Gibson, G A, Steinberg, M A, MacGregor, R R
Concentrations of vancomycin in bones of 14 patients undergoing total hip arthroplasty (group 1) and 5 patients with osteomyelitis (group 2) were studied. Group 1 received vancomycin, 15 mg/kg...
MacGregor, R R, Gibson, G A, Bland, J A
Serum, urine, tissue, and body fluids were collected from 40 adult patients who were receiving imipenem/cilastatin treatment for serious infections. Thirty-two patients were given 1 g every 6 h (4...
Multiple-dose pharmacokinetics of imipenem-cilastatin.
Drusano, G L, Standiford, H C, Bustamante, C, Forrest, A, Rivera, G, Leslie, J, ...
We characterized the pharmacokinetic profile of imipenem-cilastatin administered intravenously to six normal volunteers in a dose of 1,000 mg of each drug every 6 h for 40 doses. The plasma...
Safety and efficacy of high-dose treatment with imipenem-cilastatin in seriously ill patients.
Zajac, B A, Fisher, M A, Gibson, G A, MacGregor, R R
Imipenem-cilastatin was given in doses of 1 g intravenously every 6 h to 31 patients. Twenty-five patients, with 27 infections, were clinically evaluable and received 20 to 210 g of imipenem for a...
Pietroski, N A, Graziani, A L, Lawson, L A, Bland, J A, Rogers, J D, MacGregor, R R
We studied the concentrations in plasma and pharmacokinetics of imipenem and cilastatin in elderly patients (greater than 65 years old) who had various degrees of renal function and who were...
Niacin-positive Mycobacterium kansasii isolated from immunocompromised patients.
Nachamkin, I, MacGregor, R R, Staneck, J L, Tsang, A Y, Denner, J C, Willner, M, ...
Niacin-positive Mycobacterium kansasii was isolated from three patients, two with respiratory infections and one with a perirectal abscess. The isolates were phenotypically similar to other strains...
Nachamkin, I, Axelrod, P, Talbot, G H, Fischer, S H, Wennersten, C B, Moellering, R C, ...
Enterococci isolated from different body sites were tested for high-level gentamicin resistance. A total of 259 enterococcal isolates were screened for resistance (MIC, greater than 2,000...
Secretion of parathyroid hormone (PTH) is regulated in part by a classical "stimulus-secretion" pathway responsive to catecholamines. The primary physiological modulator of PTH exocytosis in...
Comparative adherence of granulocytes to endothelial monolayers and nylon fiber.
MacGregor, R R, Macarak, E J, Kefalides, N A
Adherence of granulocytes to tissue culture monolayers of endothelium averaged 26.2 +/- 1.3% SEM, which was similar to their adherence on 50-mg nylon fiber columns (27.7 +/- 3.6%). In contrast,...
The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor.
Lentnek, A L, Schreiber, A D, MacGregor, R R
The adherence of granylocytes to surfaces, measured in vitro in nylon fiber columns, is inhibited by in vivo administration of anti-inflammatory agents. Therefore, the effect of inflammation itself...
Ampicillin and Tetracycline in the Treatment and Prophylaxis of Chronic Bronchitis
Hahn, H. H., MacGregor, R. R., Avent, C. K., Counts, G. W., Smith, H. E., Beaty, H. N.
Ampicillin and tetracycline, in doses of 2 g a day, were compared in the treatment of acute exacerbations of chronic bronchitis. Seventy-nine patients were followed for 3 to 29 months and were...
McGregor, D. H., Chu, L. L., MacGregor, R. R., Cohn, D. V.
Tris(hydroxymethyl)aminomethane (Tris, Tromethamine, THAM) and other non-amphoteric amines were previously reported to inhibit the conversion of proparathyroid hormone to parathyroid hormone in...