Tolerance to appetite suppression induced by peptidoglycan.
Biberstine, K J, Darr, D S, Rosenthal, R S
Physiologically realistic peptidoglycan (PG) fragments, derived from Neisseria gonorrhoeae, were shown previously to dose-dependently suppress food consumption and body weight gain in rats following...
The effect of penicillin G (penG) on the turnover and release of peptidoglycan (PG) by Neisseria gonorrhoeae RD5 was investigated. We previously showed that exponentially growing gonococci (labeled...
Structure of Bordetella pertussis peptidoglycan.
Folkening, W J, Nogami, W, Martin, S A, Rosenthal, R S
Bordetella pertussis Tohama phases I and III were grown to the late-exponential phase in liquid medium containing [3H]diaminopimelic acid and treated by a hot (96 degrees C) sodium dodecyl sulfate...
Newhall, W J, Kleinhans, F W, Rosenthal, R S, Sawyer, W D, Haak, R A
Spin-label electron spin resonance was used to characterize the microenvironment around spin probes which localize (i) in membranes, (ii) at the membrane surface, or (iii) in the cytoplasm of living...
Rosenthal, R S, Jungkind, D, Daneo-Moore, L, Shockman, G D
Growing protoplasts of Streptococcus faecalis 9790 were found to synthesize and excrete soluble peptidoglycan fragments. The presence of soluble peptidoglycan derivatives in culture supernatants was...
Protoplasts of Streptococcus faecalis ATCC 9790 were produced with the aid of lysozyme, and the ability of these bodies to synthesize soluble, peptide cross-linked peptidoglycan (PG) fragments was...
Protoplasts (autoplasts) of Streptococcus faecalis were produced by the action of native autolytic N-acetylmuramidase in the absence of added peptidoglycan hydrolases and were grown in osmotically...
Effect of Peptone on Azotobacter Morphology
Pleomorphism in cultures of Azotobacter vinelandii was induced by addition of Difco peptone to the growth medium. Under the conditions of the study, 5% peptone gave rise to transient forms described...
Striker, R, Kline, M E, Haak, R A, Rest, R F, Rosenthal, R S
The degradation of purified Neisseria gonorrhoeae peptidoglycan (PG) by granule extract derived from normal human polymorphonuclear leukocytes was examined. Hen egg lysozyme-resistant, extensively...
Rosenthal, R S, Nogami, W, Cookson, B T, Goldman, W E, Folkening, W J
Bordetella pertussis is known to release a factor which promotes the loss of ciliated respiratory epithelium and copurifies with a soluble peptidoglycan (PG) fragment termed tracheal cytotoxin (TCT)....
Fleming, T J, Wallsmith, D E, Rosenthal, R S
We examined the arthropathic activity of purified peptidoglycan (PG) fragments derived from (i) lysozyme-resistant, extensively O-acetylated PG from Neisseria gonorrhoeae FA19 (O-PG), and (ii)...
Rosenthal, R S, Gfell, M A, Folkening, W J
The effects of protein synthesis inhibitors on the extent of O-acetylation of Neisseria gonorrhoeae peptidoglycan (PG) and on the resistance of PG to degradation by human PG hydrolases were examined....
Swim, S C, Gfell, M A, Wilde, C E, Rosenthal, R S
The extent of lysozyme resistance and O-acetylation of purified peptidoglycan (PG) from 20 strains of Neisseria gonorrhoeae was examined to determine how widespread these properties are among various...
Peptidoglycan fragments decrease food intake and body weight gain in rats.
Biberstine, K J, Rosenthal, R S
We hypothesized that peptidoglycan (PG) fragments decrease appetite in rats. Male Lewis rats (150 g; n > or = 7) received intraperitoneal (i.p.) injections of purified soluble PG fragments that had...
Somnogenic activity of O-acetylated and dimeric muramyl peptides.
Johannsen, L, Rosenthal, R S, Martin, S A, Cady, A B, Obal, F, Guinand, M, ...
Slow-wave sleep-promoting factors in brain and urine were identified as muramyl peptides (MPs), the building blocks of bacterial cell wall peptidoglycan. In this study, structural variations of MPs...
Rosenthal, R S, Blundell, J K, Perkins, H R
Peptidoglycan from Neisseria gonorrhoeae RD5 was completely degraded by hen egg white lysozyme and was not extensively O-acetylated. In contrast, peptidoglycans from gonococcal strains FA19 and FA102...
Resistance of O-acetylated gonococcal peptidoglycan to human peptidoglycan-degrading enzymes.
Rosenthal, R S, Folkening, W J, Miller, D R, Swim, S C
Two naturally occurring forms of gonococcal peptidoglycan (PG) were tested for their susceptibility to human PG hydrolases. Purified 3H-labeled PG substituted extensively with O-acetyl derivatives...
Complement consumption gonococcal peptidoglycan.
Purified peptidoglycan (PG) obtained from Neisseria gonorrhoeae was tested for the ability to consume complement in normal human sera. Sonicated PG (S-PG), a heterogeneous mixture of soluble...
Release of soluble peptidoglycan from growing gonococci: hexaminidase and amidase activities.
Peptidoglycan (PG) turnover in exponentially growing Neisseria gonorrhoeae RD5 type 4 was accompanied by release of soluble PG fragments into the medium. Turnover of the D-[14C]glucosamine-labeled...
Ethylenediaminetetraacetic acid-sensitive antiphagocytic activity of Neisseria gonorrhoeae.
Rosenthal, R S, Fulbright, R S, Eads, M E, Sawyer, W D
Colonial types of Neisseria gonorrhoeae were examined for the presence of pilus-independent antiphagocytic activity. Type 3 and depiliated type 1 gonococci had a shearing- and protease-resistant...
Extent of Peptide Cross-Linking in the Peptidoglycan of Neisseria gonorrhoeae
Rosenthal, R. S., Wright, R. M., Sinha, R. K.
The extent of peptide cross-linking in peptidoglycan (PG) isolated from various strains of Neisseria gonorrhoeae was examined. Purified PG, specifically labeled in the peptide moiety with...
Previous analysis of soluble peptidoglycan (PG) fragments released by exponentially growing gonococci implicated the combined action of both hexosaminidase and amidase activities in PG turnover....
Impaired bacterial clearance and trapping in obstructive jaundice.
Katz, S, Grosfeld, J L, Gross, K, Plager, D A, Ross, D, Rosenthal, R S, ...
Sepsis is a major cause of mortality in patients with common bile duct obstruction. To define possible contributing factors to this phenomenon, this study evaluates the effect of biliary obstruction...
Tolerance to appetite suppression induced by peptidoglycan.
Biberstine, K J, Darr, D S, Rosenthal, R S
Physiologically realistic peptidoglycan (PG) fragments, derived from Neisseria gonorrhoeae, were shown previously to dose-dependently suppress food consumption and body weight gain in rats following...
The effect of penicillin G (penG) on the turnover and release of peptidoglycan (PG) by Neisseria gonorrhoeae RD5 was investigated. We previously showed that exponentially growing gonococci (labeled...
Structure of Bordetella pertussis peptidoglycan.
Folkening, W J, Nogami, W, Martin, S A, Rosenthal, R S
Bordetella pertussis Tohama phases I and III were grown to the late-exponential phase in liquid medium containing [3H]diaminopimelic acid and treated by a hot (96 degrees C) sodium dodecyl sulfate...
Newhall, W J, Kleinhans, F W, Rosenthal, R S, Sawyer, W D, Haak, R A
Spin-label electron spin resonance was used to characterize the microenvironment around spin probes which localize (i) in membranes, (ii) at the membrane surface, or (iii) in the cytoplasm of living...
Rosenthal, R S, Jungkind, D, Daneo-Moore, L, Shockman, G D
Growing protoplasts of Streptococcus faecalis 9790 were found to synthesize and excrete soluble peptidoglycan fragments. The presence of soluble peptidoglycan derivatives in culture supernatants was...
Protoplasts of Streptococcus faecalis ATCC 9790 were produced with the aid of lysozyme, and the ability of these bodies to synthesize soluble, peptide cross-linked peptidoglycan (PG) fragments was...
Protoplasts (autoplasts) of Streptococcus faecalis were produced by the action of native autolytic N-acetylmuramidase in the absence of added peptidoglycan hydrolases and were grown in osmotically...
Effect of Peptone on Azotobacter Morphology
Pleomorphism in cultures of Azotobacter vinelandii was induced by addition of Difco peptone to the growth medium. Under the conditions of the study, 5% peptone gave rise to transient forms described...
Striker, R, Kline, M E, Haak, R A, Rest, R F, Rosenthal, R S
The degradation of purified Neisseria gonorrhoeae peptidoglycan (PG) by granule extract derived from normal human polymorphonuclear leukocytes was examined. Hen egg lysozyme-resistant, extensively...
Rosenthal, R S, Nogami, W, Cookson, B T, Goldman, W E, Folkening, W J
Bordetella pertussis is known to release a factor which promotes the loss of ciliated respiratory epithelium and copurifies with a soluble peptidoglycan (PG) fragment termed tracheal cytotoxin (TCT)....
Fleming, T J, Wallsmith, D E, Rosenthal, R S
We examined the arthropathic activity of purified peptidoglycan (PG) fragments derived from (i) lysozyme-resistant, extensively O-acetylated PG from Neisseria gonorrhoeae FA19 (O-PG), and (ii)...
Rosenthal, R S, Gfell, M A, Folkening, W J
The effects of protein synthesis inhibitors on the extent of O-acetylation of Neisseria gonorrhoeae peptidoglycan (PG) and on the resistance of PG to degradation by human PG hydrolases were examined....
Swim, S C, Gfell, M A, Wilde, C E, Rosenthal, R S
The extent of lysozyme resistance and O-acetylation of purified peptidoglycan (PG) from 20 strains of Neisseria gonorrhoeae was examined to determine how widespread these properties are among various...
Peptidoglycan fragments decrease food intake and body weight gain in rats.
Biberstine, K J, Rosenthal, R S
We hypothesized that peptidoglycan (PG) fragments decrease appetite in rats. Male Lewis rats (150 g; n > or = 7) received intraperitoneal (i.p.) injections of purified soluble PG fragments that had...
Somnogenic activity of O-acetylated and dimeric muramyl peptides.
Johannsen, L, Rosenthal, R S, Martin, S A, Cady, A B, Obal, F, Guinand, M, ...
Slow-wave sleep-promoting factors in brain and urine were identified as muramyl peptides (MPs), the building blocks of bacterial cell wall peptidoglycan. In this study, structural variations of MPs...
Rosenthal, R S, Blundell, J K, Perkins, H R
Peptidoglycan from Neisseria gonorrhoeae RD5 was completely degraded by hen egg white lysozyme and was not extensively O-acetylated. In contrast, peptidoglycans from gonococcal strains FA19 and FA102...
Resistance of O-acetylated gonococcal peptidoglycan to human peptidoglycan-degrading enzymes.
Rosenthal, R S, Folkening, W J, Miller, D R, Swim, S C
Two naturally occurring forms of gonococcal peptidoglycan (PG) were tested for their susceptibility to human PG hydrolases. Purified 3H-labeled PG substituted extensively with O-acetyl derivatives...
Complement consumption gonococcal peptidoglycan.
Purified peptidoglycan (PG) obtained from Neisseria gonorrhoeae was tested for the ability to consume complement in normal human sera. Sonicated PG (S-PG), a heterogeneous mixture of soluble...
Release of soluble peptidoglycan from growing gonococci: hexaminidase and amidase activities.
Peptidoglycan (PG) turnover in exponentially growing Neisseria gonorrhoeae RD5 type 4 was accompanied by release of soluble PG fragments into the medium. Turnover of the D-[14C]glucosamine-labeled...
Ethylenediaminetetraacetic acid-sensitive antiphagocytic activity of Neisseria gonorrhoeae.
Rosenthal, R S, Fulbright, R S, Eads, M E, Sawyer, W D
Colonial types of Neisseria gonorrhoeae were examined for the presence of pilus-independent antiphagocytic activity. Type 3 and depiliated type 1 gonococci had a shearing- and protease-resistant...
Extent of Peptide Cross-Linking in the Peptidoglycan of Neisseria gonorrhoeae
Rosenthal, R. S., Wright, R. M., Sinha, R. K.
The extent of peptide cross-linking in peptidoglycan (PG) isolated from various strains of Neisseria gonorrhoeae was examined. Purified PG, specifically labeled in the peptide moiety with...
Previous analysis of soluble peptidoglycan (PG) fragments released by exponentially growing gonococci implicated the combined action of both hexosaminidase and amidase activities in PG turnover....
Impaired bacterial clearance and trapping in obstructive jaundice.
Katz, S, Grosfeld, J L, Gross, K, Plager, D A, Ross, D, Rosenthal, R S, ...
Sepsis is a major cause of mortality in patients with common bile duct obstruction. To define possible contributing factors to this phenomenon, this study evaluates the effect of biliary obstruction...
Rosenthal, R. S., Rodwell, V. W.
The mvaAB operon of Pseudomonas mevalonii encodes HMG-CoA reductase (EC 1.1.1.88) and HMG-CoA lyase (EC 4.1.3.4), enzymes that catalyze the initial reactions of mevalonate catabolism in this...