R. Seifert

New Flight Deck Design in the Light of the Operational Capabilities, (9999)

Seifert,R., Brauser,K.

The classification of human errors (H.E.) by category and conditions of occurrence is presented. According to the conditions and causes of H.E. occurrence different means of preventing H.E.'s by...

Item-Level RFid in the Retail Supply Chain (9999)

Gaukler, G., Seifert, R, Hausman, W.H

Euphotic zone bacterioplankton sources major sedimentary bacteriohopanepolyols in the Holocene Black Sea (2009)

Blumenberg, M., Seifert, R., Kasten, S., Bahlmann, E., Michaelis, W.

Synthesis and pharmacological properties of new tetracyclic forskolin analogues (2009)

Egger, M., Maity, P., Hübner, M., Seifert, R., König, B.

Chemical analysis with tin oxide gas sensors: choice of additives, method of operation and analysis of numerical signal. (2009)

Frank, K., Magapu, V., Schindler, V., Kohler, H., Keller, H.B., Seifert, R.

Sensor Letters, 6(2008) S.908-11

Efficient calibration and recalibration of metal oxide gas sensors by a new mathematical procedure. (2009)

Seifert, R., Keller, H.B., Frank, K., Kohler, H.

Sensor and Test 2009 : 14th Internat.Conf.on Sensors, Technologies, Electronics and Applications, Nürnberg, May 26-28, 2009

Synthesis and Cannabinoid Receptor Activity of Ketoalkenes from Echinacea pallida and Non-natural Analogues (2008)

Egger, M., Pellett, P., Nickl, K., Geiger, S., Graetz, S., Seifert, R., ...

Understanding macrophysical outcomes of microphysical choices in simulations of shallow cumulus convection (2008)

Stevens, B., Seifert, R.

The sensitivity of simulations of shallow cumulus convection to their microphysical representation is explored, with a focus on the parameter space spanned by two common bulk schemes (Seifert and...

Mathematisches Verfahren zur Analyse von N-Stoff-Gemischen bei periodischer Variation der Arbeitstemperatur. (2008)

Keller, H.B., Seifert, R., Frank, K., Kohler, H.

Multigassensoren und Life Sciences : 5.Workshop, Berlin, 4.Dezember 2008

Chemische Analyse mit Zinnoxid-Multigassensoren: Betriebsweise, Wahl der Additive und Numerisches Auswerteverfahren. (2008)

Frank, K., Kohler, H., Keller, H.B., Seifert, R.

Multigassensoren und Life Sciences : 5.Workshop, Berlin, 4.Dezember 2008

The female body as political body: Rape, War and the Nation (2007)

Seifert, R.

What are the causes of rape? Is it an act of social supremacy, an instrument of war or an uncontrollable sexual “need” ? The author of this article examines the subject from a typically...

Il corpo femminile come corpo politico: lo stupro, la guerra e la nazione (2007)

Seifert, R.

Quali sono le cause dello stupro? È un atto di supremazia sociale, uno strumento di guerra, oppure un irrefrenabile “bisogno” sessuale? L’autrice di questo articolo esamina l’argomento da un...

A novel, multi-layered methanotrophic microbial mat system growing on the sediment of the Black Sea (2007)

Krüger, M., Blumenberg, M., Kasten, S., Wieland, A., Känel, L., ...

Neoimmun versus Neoral: a bioequivalence study in healthy volunteers and influence of a fat-rich meal on the bioavailability of Neoimmun (2007)

Kees, F., Bucher, M., Schweda, F., Gschaidmeier, H., Faerber, L., Seifert, R.

In two crossover studies with 12 (6 males/6 females) healthy young volunteers each, we compared the bioavailability of Neoimmun capsules with the microemulsion Neoral and the influence of a fat-rich...

Verfahren zur Bestimmung/Analyse der Einzelkonzentrationen eines mehrkomponentigen gasförmigen Stoffgemisches bestehend aus einem Kalibrier- und Auswertteil. (2007)

Keller, H., Seifert, R., Kohler, H., Hetznecker, A., Schindler, V., Schoenauer, U.

Verfahren zur Klassifikation und zur Bestimmung der Einzelkonzentrationen eines Stoffgemisches. (2007)

Seifert, R., Keller, H., Hetznecker, A., Schindler, V., Kohler, H., Schoenauer, U., ...

Improving the analysis capability of tin oxide gas sensors by dynamic operation, appropriate additives and an advanced evaluation procedure. (2007)

Frank, K., Magapu, V., Schindler, V., Arnanthigo, Y., Kohler, H., Keller, H.B., ...

Sensor 2007 : 13th Internat.Conf., Nürnberg, May 22-24, 2007

Metal oxide gas sensors for chemical analysis? (2007)

Kohler, H., Frank, K., Seifert, R., Hetznecker, A., Guth, U., Keller, H.B.

Raina, J.P. [Hrsg.]

Chemical analysis with thin oxide gas sensors: choice of additives, method of operation and analysis of numerical signal. (2007)

Frank, K., Magapu, V., Schindler, V., Kohler, H., Keller, H.B., Seifert, R.

7th East Asian Conf.on Chemical Sensors, Singapore, SGP, December 3-5, 2007

Metalloxid-Gassensoren: Mit neuen Sensormaterialien und einem neuartigen Betriebs- und Kalibrierverfahren wird eine Lücke der Feldanalytik geschlossen. (2006)

Kohler, H., Frank, K., Hetznecker, A., Seifert, R., Keller, H.B.

Forschung aktuell

Neue Wege der In-situ-Analyse von in Wasser gelösten, flüchtigen Kohlenwasserstoffen (VOC): Kombination einer Trägergassonde mit periodisch beheizten Metalloxid Gassensoren. (2006)

Kohler, H., Frank, K., Hetznecker, A., Seifert, R., Keller, H.B.

GVC/DECHEMA Jahrestagungen 2005, Wiesbaden, 6.-8.September 2005

Mathematical procedure for gas analysis with dynamically operated sensor arrays. (2006)

Keller, H.B., Seifert, R., Frank, K., Schindler, V., Kohler, H.

11th Internat.Meeting on Chemical Sensors (ICMS-11), Brescia, I, July 16-19, 2006

Metal oxide gas sensors: a new approach for high quality field analysis applications using a dynamically operated sensor array. (2006)

Frank, K., Hetznecker, A., Schindler, V., Kohler, H., Schönauer, U., Keller, H.B., ...

11th Internat.Meeting on Chemical Sensors (ICMS-11), Brescia, I, July 16-19, 2006

Preliminary results of RV Poseidon cruise P317/2 to the Black Sea – Geochemical processes at AOM-induced sulfidization fronts (2005)

Kasten, S., Jørgensen, B. B., Blumenberg, M., Pape, T., SEifert, R.

The Task Taxonomy Method: A Basis for an Expert System on Human Reliability, (2005)

Seifert,R., Brauser,K.

A survey of human error (HE), its definition, nature of HE and the categorization of HE's, causes and prevention measures is described. Then a HE rating scale is introduced, which allows the...

Subsurface microbial methanotrophic mats in the Black Sea (2005)

Treude, T., Knittel, K., Blumenberg, M., Seifert, R., Boetius, A.

Cell-transistor coupling: Investigation of potassium currents recorded with p- and n-channel FETs (2005)

Wrobel, G., Seifert, R., Ingebrandt, S., Enderlein, J., Ecken, H., Baumann, A., ...

This version is available at the following Publisher URL: http://www.biophysj.org/

Gasanalysegerät und Verfahren. (2005)

Becker, F., Keller, H., Seifert, R., Jerger, A., Kohler, H.

Metal oxide gas sensors for field analysis: Novel SnO§2/La§2O§3 sensor element for analysis of dissolved toluene/ethanol binary mixtures. (2005)

Frank, K., Hetznecker, A., Kohler, H., Schindler, V., Schönauer, U., Arnanthigo, Y., ...

Sensor 2005 : 12th Internat.Conf., Nürnberg, May 10-12, 2005

Feldanalyse mit Metalloxid Gassensoren durch periodische Variation der Arbeitstemperatur und numerische Signalanalyse. (2004)

Jerger, A., Kohler, H., König, S., Vogt, A., Keller, H.B., Seifert, R.

6.Dresdner Sensor-Symp. : Sensoren für zukünftige Hochtechnologien und Neuentwicklungen für die Verfahrenstechnik, Dresden, 8.-10.Dezember 2003

On-line fähige Sensorsysteme zur in-situ Analytik von Gasen und flüchtigen Kohlenwasserstoffen. (2004)

Kohler, H., Seifert, R., Keller, H.B.

Abschlussbericht

Numerische Analyse von Leitwert-Zeit-Profilen zur Stoffidentifikation und Analyse. (2003)

Keller, H., Seifert, R.

4.Statusseminar des DBU-Förderprojektes 'On-line fähige Sensorsysteme zur in-situ Analytik von Gasen und flüchtigen Kohlenwasserstoffen', Fachhochschule Karlsruhe, 23.Januar 2003

Entwurf eines Auswerteverfahrens zur mehrkomponentigen Gasanalyse. (2003)

Seifert, R., Keller, H.B.

On-line fähige Sensorsysteme zur in-situ Analytik von Gasen und flüchtigen Kohlenwasserstoffen, DBU Statuskolloquium, Fachhochschule Karlsruhe, 7.Februar 2002

Feldanalyse mit Metalloxid Gassensoren durch periodische Variation der Arbeitstemperatur und numerische Signalanalyse. (2003)

Jerger, A., Kohler, H., König, S., Vogt, A., Keller, H., Seifert, R.

Baselt, J.P. [Hrsg.]

Microbial Reefs in the Black Sea Fueled by Anaerobic Oxidation of Methane (2002)

Michaelis, W., Seifert, R., Nauhaus, K., Treude, T., Thiel, V., Blumenberg, M., ...

Molecular evidence for microorganisms in recent and ancient methane-related settings (2002)

Michaelis, W., Seifert, R., Nauhaus, K., Treude, T., Blumenberg, M., Knittel, K., ...

Microbial reefs in the Black Sea fueled by anaerobic oxidation of methane (2002)

Michaelis, W., Seifert, R., Nauhaus, K., Treude, T., Thiel, V., Blumenberg, M., ...

Massive microbial mats covering up to 4-meter-high carbonate buildups prosper at methane seeps in anoxic waters of the northwestern Black Sea shelf. Strong C-13 depletions indicate an incorporation...

A novel and economic sensor system for monitoring of ammonia. (2002)

Jerger, A., Kohler, H., Keller, H.B., Seifert, R.

Field Screening Europe 2001 : Proc.of the 2nd Internat.Conf.on Strategies and Techniques for the Investigation and Monitoring of Contaminated Sites, Karlsruhe, May 14-16, 2001

New applications of tin oxide gas sensors. II. Intelligent sensor system for reliable monitoring of ammonia leakages. (2002)

Jerger, A., Kohler, H., Becker, F., Keller, H.B., Seifert, R.

Sensors and Actuators B, 81(2002) S.301-07

Intelligenter Sensorkopf zur Alarmierung von Gasleckagen. (2002)

Kohler, H., Jerger, A., Keller, H.B., Seifert, R.

Horizonte : Forschung an Fachhochschulen in Baden-Württemberg, (2002) Nr.20 S.27-29

Untersuchungen zur Ankopplung von gentechnisch modifizierten HEK293-Zellen an siliziumbasierte Transducer-Materialien (2001)

Ecken, H., Baumann, A., Yoshinobu, T., Seifert, R., Kaupp, U. B., Schöning, M. J., ...

Um die elektrische Signalübertragung zwischen biologischen Systemen und Halbleitermaterialien zu untersuchen, beschäftigt sich die aktuelle Forschung in jüngster Zeit mit der direkten Ankopplung...

Intelligent monitoring of ammonia. (2001)

Seifert, R., Keller, H., Kohler, H., Kunze, S.

The Big 5 Meeting, Dubai, October 27-31, 2001 (Poster)

Anwendungen der industriellen 3D-Computertomographie (2000)

Maisl, M., Reiter, H., Purschke, M., Seifert, R., Zabler, E., Rosenberger-Koch, M.

Die dreidimensionale Computertomographie (3D-CT) ist ein schnelles Verfahren zur 3D-Prüfung, Charakterisierung und Vermessung von Bauteilen. Einsatz findet das Verfahren insbesondere im...

Einsatz von Sensormeßnetzen zur Umweltüberwachung. (2000)

Fick, A., Seifert, R., Guo, F., Keller, H.B.

Visser, U. [Hrsg.]

Intelligent sensor system for reliable monitoring of ammonia leakages. (2000)

Jerger, A., Kohler, H., Becker, F., Seifert, R., Keller, H.B.

8th Internat.Meeting on Chemical Sensors, Basel, CH, July 2-5, 2000

Ethylene and methane in the upper water column of the subtropical Atlantic (1999)

Seifert, R., Delling, N., Richnow, H. H., Kempe, S., Hefter, J., Michaelis, W.

Organic pollutants associated with macromolecular soil organic matter: Mode of binding (1997)

Richnow, H. H., Seifert, R., Hefter, J., Link, M., Francke, W., Schaefer, G., ...

Bildungsmechanismen von Bound Residues bei der biologischen Behandlung kontaminierter Böden (1996)

Richnow, H. H., Eschenbach, A., Hefter, J., Kästner, M., Mahro, B., Seifert, R., ...

Erfassung geeigneter Plasmakenngrößen und deren Nutzung zur Steuerung des Laser-Arc-Beschichtungsprozesses (1996)

Seifert, R.

Statistische Materialbilanzierungsverfahren zur on-line Meßinstrumentüberwachung. (1996)

Seifert, R.

Wissenschaftliche Berichte, FZKA-5699 (Februar 96)

Lernen ohne Hilfestellung. Entwurf eines neuen Klassifikationsverfahrens und seine Anwendung zur Klassifikation von Kongenerenverteilungen. (1996)

Seifert, R.

Wissenschaftliche Berichte, FZKA-5703 (Februar 96)

FZK-Seminarreihe 'Aktuelle Forschungsgebiete in der Mathematik'. Seminarbeiträge 1995. (1996)

Hugelmann, C.P., Seifert, R., Westermann, T., [Hrsg.]

Wissenschaftliche Berichte, FZKA-5765 (Mai 96)

Bilanzierung der Verbrennungsluft der TAMARA-Anlage zur Messinstrumentüberwachung. (1996)

Ganter, F., Seifert, R.

Interner Bericht 21.01.03/P11 X (April 95)

Statistische Materialbilanzierungsverfahren zur on-line Meßinstrumentüberwachung. (1996)

Seifert, R.

Interner Bericht 21.01.03/18A (Juli 95)

Erste Auswertungen von Screening-Experimenten im Bereich Aufbau- und Verbindungstechnik für die Mikrosystemtechnik. (1996)

Seifert, R.

Interner Bericht 41.05.01/13A (Oktober 95)

n-Alkanoic compounds in sulphur-rich macromolecular substances: A detailed investigation of sulphur incorporation and cross-linking (1995)

Hefter, J., Richnow, H. H., Seifert, R., Michaelis, W.

KfK-Seminarreihe - Aktuelle Forschungsgebiete in der Mathematik, Seminarbeiträge 1994. (1995)

Hugelmann, C.P., Seifert, R., Westermann, T., [Hrsg.]

Wissenschaftliche Berichte, FZKA-5560 (April 95)

HCl-Bilanzierung am ersten Wäscher der TAMARA-Anlage zur Meßinstrumentüberwachung. (1995)

Ganter, F., Golly, W., Seifert, R.

Interner Bericht 21.01.03/11C (Januar 95)

Metabolites of xenobiotica and mineral oil constituents linked to macromolecular organic matter in polluted environments (1994)

Richnow, H. H., Seifert, R., Hefter, J., Kästner, M., Mahro, B., Michaelis, W.

KfK-Seminarreihe - Aktuelle Forschungsgebiete in der Mathematik, Seminarbeiträge 1993. (1994)

Seifert, R., Westermann, T.

KfK-5276 (März 94)

Untersuchungen zur Bestimmung der Meßfelder bei der HCl-Konzentrationsbestimmung im Absalzstrom des 1.Wäschers der Versuchsbrennanlage TAMARA. (1994)

Ganter, F., Seifert, R.

Interner Bericht 21.01.03/11B (Dezember 94)

Einsatz von statistischer Versuchsmethodik im Bereich Aufbau- und Verbindungstechnik für die Mikrosystemtechnik. (1994)

Peter, N., Seifert, R., Maas, D., Pschibl, S.

Interner Bericht 41.05.01/11A (Dezember 94)

Das Rechenprogramm MESA zur Meßinstrumentüberwachung. Stand und zukünftige Entwicklungen. (1994)

Bicking, U., Linn, C., Seifert, R.

Interner Bericht 21.01.03/11A (Dezember 94)

The PC program MEMO - a useful tool to calculate the statistical measurement model for NRTA test procedures. (1993)

Seifert, R., Golly, W., Bicking, U., Bahm, W.

ESARDA Bulletin, (1992) Nr. 21, S.11-13

Practical results in establishing statistical measurement models of real sequential balance data. (1993)

Seifert, R., Golly, W., Bahm, W., Lausch, J., Schmidt, D.

ESARDA Bulletin, (1992) Nr. 21, S.14

Theoretical framework for sequential D/MUF-D analysis. (1993)

Picard, R.R., Seifert, R., Sellinschegg, W.D.

LA-12253-MS (March 93)

Experience in establishing detailed measurement models for real NRTA balance data. (1992)

Golly, W., Seifert, R., Lausch, J., Schmidt, D.

3rd NRTA Workshop, Los Alamos, N.M., September 24-29, 1991

MEMO - A PC program to establish measurement models for NRTA evaluation procedures. (1992)

Bicking, U., Golly, W., Seifert, R.

3rd NRTA Workshop, Los Alamos, N.M., September 24-29, 1991

Aspekte der Modellierung und statistische Auswerteverfahren bei sequentiellen Bilanzierungsproblemen. (1992)

Seifert, R.

Vortr.: Universitaet Freiburg, 21.Februar 1992

The DoD method. (1992)

Bicking, U., Golly, W., Peter, N., Seifert, R.

Vortr.: Commission of the European Communities, Geel, B, 11.Februar 1992

DoD manual. (1992)

Bicking, U., Golly, W., Seifert, R.

KfK-5074 (August 92)

MEMO version 2.0 manual. (1992)

Bicking, U., Golly, W., Seifert, R.

KfK-5077 (August 92)

PROSA - an advanced computer package for sequential evaluation of nuclear materials balance data. (1991)

Seifert, R., Bicking, U., Golly, W.

Annual Meeting of the Institute of Nuclear Materials Management : 31st, Los Angeles, Calif., July 15-18, 1990 ; Proc.

The computer program MEMO - a tool to establish detailed measurement models for NRTA test procedures. (1991)

Bicking, U., Golly, W., Seifert, R.

Proc.of the 13th Annual Symp.on Safeguards and Nuclear Material Management, Avignon, F, May 14-16, 1991

PROSA Version 4.0. Manual. (1991)

Bicking, U., Golly, W., Peter, N., Seifert, R.

KfK-4866 (Mai 91)

Real sequential evaluation of material balance data with the computer program PROSA. (1991)

Bicking, U., Golly, W., Seifert, R.

3rd Internat.Conf.on Nuclear Fuel Reprocessing and Waste Management (RECOD '91), Sendai, J, April 14-18, 1991 Proc. Vol. I S.516-23

Application of near real time accountancy to nuclear material balance data. (1990)

Seifert, R.

KfK-4680 (Februar 90)

The DoD method. (1990)

Beyrich, W., Golly, W., Peter, N., Seifert, R.

KfK-4721 (Mai 90)

Fortgeschrittene Bilanzierungsmethoden zur internationalen Kernmaterialueberwachung. (1990)

Bahm, W., Baumgaertel, G., Seifert, R.

Atomwirtschaft-Atomtechnik, 35(1990) S.461-64

DIDI-Programm zur Berechnung eines Messmodells einer Wiederaufarbeitungsanlage. (1989)

Bicking, U., Seifert, R.

KfK-4518 (Maerz 89)

Establishing of a detailed measurement model for NRTA procedures. (1989)

Bicking, U., Golly, W., Seifert, R.

Proc.of the 11th Annual Symp.of the European Safeguards Research and Development Association (ESARDA), Luxembourg, L, May 29 - June 1, 1989

The new PROSA version, an advanced computer program for near-real-time accountancy. (1989)

Bicking, U., Golly, W., Seifert, R.

Proc.of the 11th Annual Symp.of the European Safeguards Research and Development Association (ESARDA), Luxembourg, L, May 29 - June 1, 1989

Evaluation of real balance data using a detailed realistic measurement model. (1989)

Bicking, U., Golly, W., Seifert, R.

30th Annual Meeting of the Institute of Nuclear Materials Management, Orlando, Fla., July 9-12, 1989

Developments and tests of an advanced method for nuclear materials safeguards. (1989)

Bahm, W., Seifert, R., [KfK-Mitarb.]

enis75 (June 89)

Statistical methods for verification of measurement models. (1988)

Beedgen, R., Seifert, R.

Internat.Conf.of the American Society of Mechanical Engineers (ASME) on Modelling and Simulation, Karlsruhe, July 20-22, 1987

Concepts of establishing measurement models for NRTA procedures. (1988)

Beedgen, R., Golly, W., Seifert, R.

Proc.of the 29th Annual Meeting of the Institute of Nuclear Material Management, Northbrook, Ill., June 26-29, 1988

Nationale und internationale Kernmaterialueberwachung in Wiederaufarbeitungsanlagen. (1988)

Bahm, W., Beedgen, R., Seifert, R.

Grupe, H. [Hrsg.]

Application of near real time accountancy to nuclear material balance data. (1988)

Seifert, R.

Symp.on Computerized Nuclear Material Accountancy and Information Systems, Harwell, November 22-23, 1988

The GEMUF test: a new sequential test for detecting loss of material in a sequence of accounting periods. (1987)

Seifert, R.

Nuclear Safeguards Technology 1986

Problems in establishing a measurement model for reprocessing facilities and its use in applying sequential statistical tests. (1987)

Beedgen, R., Golly, W., Seifert, R.

Internat.Conf.on Nuclear Fuel Reprocessing and Waste Management (RECOD 87), Paris, F, August 23-27, 1987 Proc. Vol. 2 S.939

Der GEMUF-Test und Fragen zur near-real-time accountancy. (1987)

Seifert, R.

KfK-4326 (November 87)

Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat.

Iida, H, Seifert, R, Alpers, C E, Gronwald, R G, Phillips, P E, Pritzl, P, ...

We investigated whether platelet-derived growth factor (PDGF), or its receptor (PDGF-R), was upregulated in a rat model of mesangial proliferative glomerulonephritis. A marked increase in both PDGF...

Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae.

Baumann, A, Frings, S, Godde, M, Seifert, R, Kaupp, U B

Cyclic nucleotide-gated (CNG) ion channels serve as downstream targets of signalling pathways in vertebrate photoreceptors and olfactory sensory neurons. Whether CNG channels subserve similar...

Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils.

Norgauer, J, Kownatzki, E, Seifert, R, Aktories, K

The binary botulinum C2 toxin ADP-ribosylated the actin of human neutrophils. Treatment of human neutrophils with botulinum C2 toxin for 45 min increased FMLP-stimulated superoxide anion (O2-)...

Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts.

Kazlauskas, A, Bowen-Pope, D, Seifert, R, Hart, C E, Cooper, J A

Binding sites for platelet-derived growth factor (PDGF) differ in their selectivity for the AA, AB and BB forms of PDGF. Human fibroblasts bind BB well and AA poorly, whereas Swiss 3T3 cells bind...

Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways.

Schwaner, I, Seifert, R, Schultz, G

The pluripotent human erythroleukaemia cell line, HEL, possesses erythrocytic, megakaryocytic and macrophage-like properties. With respect to signal transduction, HEL cells have been used as a model...

Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.

Offermanns, S, Seifert, R, Metzger, J W, Jung, G, Lieberknecht, A, Schmidt, U, ...

Synthetic lipopeptide analogues of the N-terminus of bacterial lipoprotein are effective activators of macrophages, neutrophils and lymphocytes. We studied the effect of the lipopeptide...

Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides.

Seifert, R, Schultz, G, Richter-Freund, M, Metzger, J, Wiesmüller, K H, Jung, G, ...

Upon exposure to the bacterial chemotactic peptide fMet-Leu-Phe, human neutrophils release lysozyme and generate superoxide anions (O2.-). The synthetic lipoamino acid...

Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production.

Krautwurst, D, Seifert, R, Hescheler, J, Schultz, G

In human neutrophils, the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) induces increases in the intracellular free Ca2+ concentration ([Ca2+]i) with subsequent activation...

Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells.

Musgrave, I F, Seifert, R, Schultz, G

We investigated whether maitotoxin activates non-selective cation channels, as was recently proposed [Soergel, Yasumoto, Daly and Gusovsky (1992) Mol. Pharmacol. 41, 487-493]. Stimulation of...

Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells.

Klinker, J F, Höer, A, Schwaner, I, Offermanns, S, Wenzel-Seifert, K, Seifert, R

Synthetic lipopeptides activate superoxide-anion (O2-) formation in human neutrophils in a pertussis-toxin (PTX)-sensitive manner, suggesting the involvement of G-proteins of the Gi family in the...

Some taste substances are direct activators of G-proteins.

Naim, M, Seifert, R, Nürnberg, B, Grünbaum, L, Schultz, G

Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine,...

Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides.

Seifert, R, Burde, R, Schultz, G

Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide,...

Molecular determinants of a Ca2+-binding site in the pore of cyclic nucleotide-gated channels: S5/S6 segments control affinity of intrapore glutamates.

Seifert, R, Eismann, E, Ludwig, J, Baumann, A, Kaupp, U B

Cyclic nucleotide-gated (CNG) channels play an important role in Ca2+ signaling in many cells. CNG channels from various tissues differ profoundly in their Ca2+ permeation properties. Using the...

Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway.

Wenzel-Seifert, K, Krautwurst, D, Musgrave, I, Seifert, R

The Ca2+-ATPase inhibitor thapsigargin (TG) activates bivalent-cation early in human neutrophils via depletion of intracellular Ca2+ stores bu little is known about the underlying mechanism and the...

Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity.

Wenzel-Seifert, K, Lee, T W, Seifert, R, Kobilka, B K

The beta2-adrenoceptor (beta2AR) activates the G-protein Gsalpha to stimulate adenylate cyclase (AC). Fusion of the beta2AR C-terminus to the N-terminus of Gsalpha (producing beta2ARGsalpha) markedly...

How should we talk to patients with acute leukaemia?

Greenberg, M, Cohen, Vivienne, Reggiori, Joan, Seifert, R

The avian prechordal head region: a morphological study.

Seifert, R, Jacob, M, Jacob, H J

The axial mesoderm of the anterior head region was investigated in young chick and quail embryos by light and electron microscopy. Semithin sections showed that the axial head mesoderm consists of...

Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat.

Iida, H, Seifert, R, Alpers, C E, Gronwald, R G, Phillips, P E, Pritzl, P, ...

We investigated whether platelet-derived growth factor (PDGF), or its receptor (PDGF-R), was upregulated in a rat model of mesangial proliferative glomerulonephritis. A marked increase in both PDGF...

Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae.

Baumann, A, Frings, S, Godde, M, Seifert, R, Kaupp, U B

Cyclic nucleotide-gated (CNG) ion channels serve as downstream targets of signalling pathways in vertebrate photoreceptors and olfactory sensory neurons. Whether CNG channels subserve similar...

Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils.

Norgauer, J, Kownatzki, E, Seifert, R, Aktories, K

The binary botulinum C2 toxin ADP-ribosylated the actin of human neutrophils. Treatment of human neutrophils with botulinum C2 toxin for 45 min increased FMLP-stimulated superoxide anion (O2-)...

Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts.

Kazlauskas, A, Bowen-Pope, D, Seifert, R, Hart, C E, Cooper, J A

Binding sites for platelet-derived growth factor (PDGF) differ in their selectivity for the AA, AB and BB forms of PDGF. Human fibroblasts bind BB well and AA poorly, whereas Swiss 3T3 cells bind...

Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways.

Schwaner, I, Seifert, R, Schultz, G

The pluripotent human erythroleukaemia cell line, HEL, possesses erythrocytic, megakaryocytic and macrophage-like properties. With respect to signal transduction, HEL cells have been used as a model...

Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.

Offermanns, S, Seifert, R, Metzger, J W, Jung, G, Lieberknecht, A, Schmidt, U, ...

Synthetic lipopeptide analogues of the N-terminus of bacterial lipoprotein are effective activators of macrophages, neutrophils and lymphocytes. We studied the effect of the lipopeptide...

Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides.

Seifert, R, Schultz, G, Richter-Freund, M, Metzger, J, Wiesmüller, K H, Jung, G, ...

Upon exposure to the bacterial chemotactic peptide fMet-Leu-Phe, human neutrophils release lysozyme and generate superoxide anions (O2.-). The synthetic lipoamino acid...

Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production.

Krautwurst, D, Seifert, R, Hescheler, J, Schultz, G

In human neutrophils, the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) induces increases in the intracellular free Ca2+ concentration ([Ca2+]i) with subsequent activation...

Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells.

Musgrave, I F, Seifert, R, Schultz, G

We investigated whether maitotoxin activates non-selective cation channels, as was recently proposed [Soergel, Yasumoto, Daly and Gusovsky (1992) Mol. Pharmacol. 41, 487-493]. Stimulation of...

Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells.

Klinker, J F, Höer, A, Schwaner, I, Offermanns, S, Wenzel-Seifert, K, Seifert, R

Synthetic lipopeptides activate superoxide-anion (O2-) formation in human neutrophils in a pertussis-toxin (PTX)-sensitive manner, suggesting the involvement of G-proteins of the Gi family in the...

Some taste substances are direct activators of G-proteins.

Naim, M, Seifert, R, Nürnberg, B, Grünbaum, L, Schultz, G

Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine,...

Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides.

Seifert, R, Burde, R, Schultz, G

Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide,...

Molecular determinants of a Ca2+-binding site in the pore of cyclic nucleotide-gated channels: S5/S6 segments control affinity of intrapore glutamates.

Seifert, R, Eismann, E, Ludwig, J, Baumann, A, Kaupp, U B

Cyclic nucleotide-gated (CNG) channels play an important role in Ca2+ signaling in many cells. CNG channels from various tissues differ profoundly in their Ca2+ permeation properties. Using the...

Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway.

Wenzel-Seifert, K, Krautwurst, D, Musgrave, I, Seifert, R

The Ca2+-ATPase inhibitor thapsigargin (TG) activates bivalent-cation early in human neutrophils via depletion of intracellular Ca2+ stores bu little is known about the underlying mechanism and the...

Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity.

Wenzel-Seifert, K, Lee, T W, Seifert, R, Kobilka, B K

The beta2-adrenoceptor (beta2AR) activates the G-protein Gsalpha to stimulate adenylate cyclase (AC). Fusion of the beta2AR C-terminus to the N-terminus of Gsalpha (producing beta2ARGsalpha) markedly...

The avian prechordal head region: a morphological study.

Seifert, R, Jacob, M, Jacob, H J

The axial mesoderm of the anterior head region was investigated in young chick and quail embryos by light and electron microscopy. Semithin sections showed that the axial head mesoderm consists of...

How should we talk to patients with acute leukaemia?

Greenberg, M, Cohen, Vivienne, Reggiori, Joan, Seifert, R

Supervised discharge is anachronistic.

Turner, T. H., Akuffo, E., Caviston, P., Dinan, T., Deahl, M., Kohen, D., ...