Design and Calibration of Microarrays as Universal Transcriptomic Environmental Biosensors (2006)
J. S. Almeida, D. J. McKillen, Y. A. Chen, P. S. Gross, R. W. Chapman, G. Warr
Design and Calibration of Microarrays as Universal Transcriptomic Environmental Biosensors (2005)
J. S. Almeida, D. J. McKillen, Y. A. Chen, P. S. Gross, R. W. Chapman, G. Warr
A Decision Support Methodology for Space Technology Advocacy. (2002)
In this thesis a decision support methodology for space technology advocacy was developed. Decision models inadequately address the risk and uncertainty inherent in R&D. A decision support...
Risk factors for biliary tract carcinogenesis (1999)
Cholangiocarcinoma has a worldwide distribution which accounts for about 10–15% of all cases of primary hepatobiliary malignancy. Although, in the majority of cases, no aetiological factor can be...
Pulmonary Biology Of Anti-interleukin 5 Antibodies (1997)
Egan, R.W., Athwahl, D., Chou, C-C., Chapman, R.W., Emtage, S., Jenh, C-H., ...
Interleukin 5 (IL-5) is a critical cytokine for the maturation of eosinophil precursors to eosinophils in the bone marrow and those eosinophils then accumulate in the lungs during asthma. We have...
How Often is Barium Enena Useful After Flexible Fibresigmoidoscopy (1990)
Fowlie, S., Jones, H. W., Hignett, C., Rosenberg, W, Chapman, R. W.
Chapman, R W, Gorman, A, Laulicht, M, Hussain, M A, Sherlock, S, Hoffbrand, A V
Total serum ferritin and the proportion of serum ferritin binding to concanavalin A (glycosylated ferritin) was measured in 18 healthy volunteers and in 84 patients, eight with primary...
Chapman, R W, Hussain, M A, Gorman, A, Laulicht, M, Politis, D, Flynn, D M, ...
The incidence of ascorbic acid (AA) deficiency and its effect on serum ferritin concentration relative to body iron stores was studied in 61 unchelated patients with beta-thalassaemia major....
Histological features of sclerosing cholangitis in patients with chronic ulcerative colitis.
Barbatis, C, Grases, P, Shepherd, H A, Chapman, R W, Trowell, J, Jewell, D P, ...
Primary sclerosing cholangitis was diagnosed radiologically in 16 of 681 patients (2.2%) with chronic ulcerative colitis in a follow up study at the gastroenterology unit in Oxford. On the basis of...
Tissue distribution of autoantigen specific for primary sclerosing cholangitis.
Lo, S K, Chapman, R W, Fleming, K A
AIM: To investigate the tissue distribution of the autoantigen specific for primary sclerosing cholangitis. METHODS: A range of normal frozen tissues including nervous system, muscle, uterus, ovary,...
Detection of reactivation and size variation in the regulatory region of JC virus in brain tissue.
Mehal, W Z, Esiri, M M, Lo, Y M, Chapman, R W, Fleming, K A
AIMS--To develop a sensitive and specific polymerase chain reaction (PCR) based system for detecting genomic variation in JC virus. To apply this system to formalin fixed, paraffin wax embedded brain...
Martins, E B, Chapman, R W, Marron, K, Fleming, K A
AIM: To analyse the expression of heat shock protein (HSP) 60 in biliary epithelium in auto-immune liver conditions and also in chronic cholestatic and other liver diseases. METHODS: Hepatic...
Mitochondrial and Nuclear Gene Dynamics of Introduced Populations of Lepomis Macrochirus
A population of bluegill sunfish, Lepomis macrochirus, was introduced into three man-made ponds in 1966. Analyses of these ponds in 1984 and 1985 found significant mtDNA divergence without nuclear...
Computed tomography for determining liver iron content in primary haemochromatosis.
Chapman, R W, Williams, G, Bydder, G, Dick, R, Sherlock, S, Kreel, L
Dual-energy computed tomography (CT) was used to estimate hepatic iron concentration in eight patients with primary haemochromatosis with varying degrees of iron overload. The values corresponded...
Increased prevalence of epilepsy in coeliac disease.
Chapman, R W, Laidlow, J M, Colin-Jones, D, Eade, O E, Smith, C L
Raised gamma-glutamyltransferase activity and the need for liver biopsy.
Ireland, A, Hartley, L, Ryley, N, McGee, J O, Trowell, J M, Chapman, R W
Chapman, R W, Gorman, A, Laulicht, M, Hussain, M A, Sherlock, S, Hoffbrand, A V
Total serum ferritin and the proportion of serum ferritin binding to concanavalin A (glycosylated ferritin) was measured in 18 healthy volunteers and in 84 patients, eight with primary...
Chapman, R W, Hussain, M A, Gorman, A, Laulicht, M, Politis, D, Flynn, D M, ...
The incidence of ascorbic acid (AA) deficiency and its effect on serum ferritin concentration relative to body iron stores was studied in 61 unchelated patients with beta-thalassaemia major....
Histological features of sclerosing cholangitis in patients with chronic ulcerative colitis.
Barbatis, C, Grases, P, Shepherd, H A, Chapman, R W, Trowell, J, Jewell, D P, ...
Primary sclerosing cholangitis was diagnosed radiologically in 16 of 681 patients (2.2%) with chronic ulcerative colitis in a follow up study at the gastroenterology unit in Oxford. On the basis of...
Tissue distribution of autoantigen specific for primary sclerosing cholangitis.
Lo, S K, Chapman, R W, Fleming, K A
AIM: To investigate the tissue distribution of the autoantigen specific for primary sclerosing cholangitis. METHODS: A range of normal frozen tissues including nervous system, muscle, uterus, ovary,...
Detection of reactivation and size variation in the regulatory region of JC virus in brain tissue.
Mehal, W Z, Esiri, M M, Lo, Y M, Chapman, R W, Fleming, K A
AIMS--To develop a sensitive and specific polymerase chain reaction (PCR) based system for detecting genomic variation in JC virus. To apply this system to formalin fixed, paraffin wax embedded brain...
Martins, E B, Chapman, R W, Marron, K, Fleming, K A
AIM: To analyse the expression of heat shock protein (HSP) 60 in biliary epithelium in auto-immune liver conditions and also in chronic cholestatic and other liver diseases. METHODS: Hepatic...
Mitochondrial and Nuclear Gene Dynamics of Introduced Populations of Lepomis Macrochirus
A population of bluegill sunfish, Lepomis macrochirus, was introduced into three man-made ponds in 1966. Analyses of these ponds in 1984 and 1985 found significant mtDNA divergence without nuclear...
Computed tomography for determining liver iron content in primary haemochromatosis.
Chapman, R W, Williams, G, Bydder, G, Dick, R, Sherlock, S, Kreel, L
Dual-energy computed tomography (CT) was used to estimate hepatic iron concentration in eight patients with primary haemochromatosis with varying degrees of iron overload. The values corresponded...
Increased prevalence of epilepsy in coeliac disease.
Chapman, R W, Laidlow, J M, Colin-Jones, D, Eade, O E, Smith, C L
Raised gamma-glutamyltransferase activity and the need for liver biopsy.
Ireland, A, Hartley, L, Ryley, N, McGee, J O, Trowell, J M, Chapman, R W
Accuracy of computed tomography in diagnosis of fatty liver.
Bydder, G M, Kreel, L, Chapman, R W, Harry, D, Sherlock, S, Bassan, L
Antineutrophil antibody: a test for autoimmune primary sclerosing cholangitis in childhood?
Lo, S K, Chapman, R W, Cheeseman, P, Charlton, C P, Walker-Smith, J A, Mieli-Vergani, G, ...
The detection of an antineutrophil antibody which is highly sensitive and specific for adult primary sclerosing cholangitis using indirect immunoalkaline phosphatase has been previously described. In...
Bloom, S, Heryet, A, Fleming, K, Chapman, R W
The distribution of carbohydrate antigens of the ABO, Lewis, and Kell systems was examined in biliary and colonic epithelial of 11 patients with primary sclerosing cholangitis (PSC) using a panel of...
Cap polyposis--an unusual cause of diarrhoea.
Campbell, A P, Cobb, C A, Chapman, R W, Kettlewell, M, Hoang, P, Haot, B J, ...
'Cap polyposis' is a poorly recognised condition with distinct clinical, sigmoidoscopic, and pathological features that may be confused with other inflammatory conditions of the large intestine...
Snook, J A, Kelly, P, Chapman, R W, Jewell, D P
This case report describes the previously undocumented association between fibrolamellar hepatocellular carcinoma and ulcerative colitis complicated by primary sclerosing cholangitis.
Lo, S K, Fleming, K A, Chapman, R W
The detection of a nuclear anti-neutrophil antibody in patients with primary sclerosing cholangitis (PSC), using an immunoperoxidase technique, was recently reported by us. Subsequently, detection of...
Acute hepatitis C infection after sexual exposure.
Healey, C J, Smith, D B, Walker, J L, Holmes, E C, Fleming, K A, Chapman, R W, ...
A case is described of a woman with acute hepatitis C infection whose partner had chronic hepatitis C infection and where heterosexual contact was the only major risk factor. Infection of both...
Healey, C J, Chapman, R W, Fleming, K A
Forty two cases of confirmed hepatitis C virus (HCV) infection with available liver histology were studied. Most patients, 23 of 42 (55%) had abnormal liver function tests but 19 of 42 (45%) had...
Bansi, D S, Fleming, K A, Chapman, R W
Antineutrophil cytoplasmic antibodies (ANCA) have been reported in up to 87% of patients with primary sclerosing cholangitis with or without ulcerative colitis (PSC +/- UC) and in 68% of those with...
Chapman, R W, Arborgh, B A, Rhodes, J M, Summerfield, J A, Dick, R, Scheuer, P J, ...
Twenty-nine patients with primary sclerosing cholangitis were reviewed. Males predominated (2:1). Seventy-six per cent presented with cholestasis and cholangitis, 17% with cirrhosis and portal...
Association of primary sclerosing cholangitis with HLA-B8.
Chapman, R W, Varghese, Z, Gaul, R, Patel, G, Kokinon, N, Sherlock, S
The frequency of HLA antigens was studied in 25 patients with primary sclerosing cholangitis and compared with a control group of 562 kidney donors. Fourteen patients also had ulcerative colitis. A...
Serum autoantibodies, ulcerative colitis and primary sclerosing cholangitis.
Chapman, R W, Cottone, M, Selby, W S, Shepherd, H A, Sherlock, S, Jewell, D P
The aetiology of primary sclerosing cholangitis is unknown, but it is closely associated with ulcerative colitis. Serum anticolon antibodies, crossreacting with portal tracts, have been reported in...
Carcinoid tumour of the ampulla of Vater presenting as acute pancreatitis.
Dixon, J M, Chapman, R W, Berry, A R
The first report of a carcinoid tumour of the ampulla of Vater causing acute pancreatitis is presented. The pancreatitis resulted from ampullary obstruction and diversion of the bile through the...
Expression of HLA-DR antigens on bile duct epithelium in primary sclerosing cholangitis.
Chapman, R W, Kelly, P M, Heryet, A, Jewell, D P, Fleming, K A
The expression of HLA class I (HLA-A, B, C) and class II (HLA-DR) antigens on the biliary epithelium of 10 patients (nine men) with primary sclerosing cholangitis (PSC) was investigated using an...
Chapman, R W, Selby, W S, Jewell, D P
A prospective double blind controlled trial was undertaken to examine the role of metronidazole as an adjunct to corticosteroids in the management of severe ulcerative colitis. Thirty nine patients...
Mitchell, S A, Thyssen, M, Orchard, T R, Jewell, D P, Fleming, K A, Chapman, R W
Background and aims: The strong clinical association between primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) suggests common factors in their pathogenesis. Smoking, previous...
Patients with small duct primary sclerosing cholangitis have a favourable long term prognosis
Björnsson, E, Boberg, K M, Cullen, S, Fleming, K, Clausen, O P, Fausa, O, ...
Background: Patients with cholestatic liver function tests and histological features of primary sclerosing cholangitis (PSC) but a normal cholangiogram are considered to have small duct PSC. The...
Rupture of right coronary artery aneurysm into the right atrium.
A 63-year-old man presented with acute congestive heart failure and was found to have a continuous murmur. Two years earlier, he had an inferior myocardial infarct, when no murmurs were heard....
Snook, J A, Chapman, R W, Fleming, K, Jewell, D P
We have previously described circulating autoantibodies to a portal tract antigen in patients with primary sclerosing cholangitis. In this study the antigen has been shown by double-labelling studies...
Respiratory effects of baclofen and 3-aminopropylphosphinic acid in guinea-pigs.
Hey, J A, Mingo, G, Bolser, D C, Kreutner, W, Krobatsch, D, Chapman, R W
1. The effects of the GABAB receptor agonists, baclofen and 3-aminopropylphosphinic acid (3-APPi) given by the subcutaneous or intracerebroventricular (i.c.v.) route were examined on minute...
Bolser, D C, DeGennaro, F C, O'Reilly, S, Chapman, R W, Kreutner, W, Egan, R W, ...
1. The GABA-B receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APPi) have antitussive activity in the cat and guinea pig. The purpose of this study was to investigate the sites of...
Kung, T T, Crawley, Y, Luo, B, Young, S, Kreutner, W, Chapman, R W
This study investigates the role of adrenal-derived catecholamines and corticosterone on the inhibition by rolipram, a phosphodiesterase (PDE)-4 inhibitor, of pulmonary eosinophilia and airway...
Hey, J. A., Del Prado, M., Egan, R. W., Kreutner, W., Chapman, R. W.
1. The effect of (R)-alpha-methylhistamine, a selective H3-histamine receptor agonist, was examined on the neurogenic hypertension and tachycardia that is induced by stimulation of areas in the...
Antitussive effects of GABAB agonists in the cat and guinea-pig.
Bolser, D. C., Aziz, S. M., DeGennaro, F. C., Kreutner, W., Egan, R. W., Siegel, M. I., ...
1. GABAB agonists inhibit neuronal processes which are important in the pathogenesis of airway disease, such as bronchospasm. Cough is a prominent symptom of pulmonary disease, but the effects of...
Design and Calibration of Microarrays as Universal Transcriptomic Environmental Biosensors
Almeida, J. S., McKillen, D. J., Chen, Y. A., Gross, P. S., Chapman, R. W., Warr, G.
Early postoperative endoscopic sphincterotomy for retained biliary stones.
Bickerstaff, K. I., Berry, A. R., Chapman, R. W., Britton, J.
Endoscopic sphincterotomy was attempted on 18 patients with retained biliary stones. Endoscopy was performed within 2 weeks of the operation in 13 patients and within 3 weeks in 5 patients. A T-tube...
Endoscopic sphincterotomy for bile duct stones: an institutional review of 272 patients.
Bickerstaff, K. I., Berry, A. R., Chapman, R. W., Britton, J.
The results of the first 283 endoscopic sphincterotomies (ES) attempted in Oxford for bile duct stones are described. Endoscopic sphincterotomy was achieved in 272 patients (96%) and complete duct...
Mahida, Y. R., Chapman, R. W., Jewell, D. P.
Three cases of chronic pancreatitis occurring in patients with small intestinal diverticulosis and bacterial overgrowth are reported. In two of the cases, pancreatic supplements were therapeutically...