Drusano, G. L., Preston, S. L., Smee, D., Bush, K., Bailey, K., Sidwell, R. W.
We examined RWJ-270201 in a lethal model of influenza in BALB/c mice. The aim was to delineate the pharmacodynamically linked variable for the drug. Challenge was performed with influenza virus...
Selective cytotoxicity of ricin A chain immunotoxins towards murine cytomegalovirus-infected cells.
Barnett, B B, Smee, D F, Malek, S M, Sidwell, R W
Immunotoxins were constructed by linking immunoglobulins specific for murine cytomegalovirus (MCMV) to deglycosylated ricin A chain. Toxicities toward MCMV-infected and uninfected cells were...
Sidwell, R W, Huffman, J H, Bailey, K W, Wong, M H, Nimrod, A, Panet, A
The oxygen free-radical scavenger recombinant human manganese superoxide dismutase (MnSOD) was studied for its effects on influenza virus infections in mice when used alone and in combination with...
In vivo anti-influenza virus activity of a zinc finger peptide.
Judd, A K, Sanchez, A, Bucher, D J, Huffman, J H, Bailey, K, Sidwell, R W
Matrix protein (M1) is a major structural protein of influenza virus, and it inhibits its own polymerase. A 19-amino-acid peptide, corresponding to a zinc finger region of the M1 sequence of...
In vitro and in vivo Phlebovirus inhibition by ribavirin.
Sidwell, R W, Huffman, J H, Barnett, B B, Pifat, D Y
Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) was markedly inhibitory in vitro to Adames and Balliet strains of Punta Toro virus (PTV), a Phlebovirus related to Rift Valley fever...
Sidwell, R W, Huffman, J H, Call, E W, Warren, R P, Radov, L A, Murray, R J
PR-879-317A (2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxy-imidazo [1,2a]pyridine) has been found to be a T-cell-selective immunomodulating agent. In the current studies, a series of experiments was...
Activity of selenazofurin against influenza A and B viruses in vitro.
Sidwell, R W, Huffman, J H, Call, E W, Alaghamandan, H, Cook, P D, Robins, R K
Activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza A and B viruses. In experiments with Madin Darby canine...
Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances.
Smee, D F, Sidwell, R W, Clark, S M, Barnett, B B, Spendlove, R S
The effects of four ribonucleic acid virus inhibitors were evaluated in cell cultures and in mice to determine inhibitory effects against bluetongue virus and Colorado tick fever virus (CTFV). Test...
Smee, D F, Sidwell, R W, Clark, S M, Barnett, B B, Spendlove, R S
Several RNA virus inhibitors were evaluated against simian (SA11) rotavirus infections in vitro and murine rotavirus gastroenteritis in vivo. Test compounds included...
Sidwell, R W, Huffman, J H, Gilbert, J, Moscon, B, Pedersen, G, Burger, R, ...
Pulmonary disease in mice induced by influenza virus was monitored by measurement of oxygen saturation (SaO2) in blood with a pulse oximeter. The SaO2 declined in inverse proportion to the viral...
Smee, D F, Morris, J L, Leonhardt, J A, Mead, J R, Holy, A, Sidwell, R W
Severe combined immunodeficient (SCID) mice were found to be highly susceptible to murine cytomegalovirus (MCMV) infection. Treatment of infected mice with ganciclovir (12.5, 25, and 50 mg/kg of body...
Morrey, J D, Bourn, S M, Bunch, T D, Jackson, M K, Sidwell, R W, Barrows, L R, ...
UV irradiation has been shown to activate the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in cell culture; however, only limited studies have been described in vivo. UV...
Barnard, D. L., Hubbard, V. D., Smee, D. F., Sidwell, R. W., Watson, K. G. W., Tucker, S. P. T., ...
Picornaviruses (PV) include human rhinovirus (HRV), the primary cause of the common cold, and the enteroviruses (EV), which cause serious diseases such as poliomyelitis, meningoencephalitis, and...
Drusano, G. L., Preston, S. L., Smee, D., Bush, K., Bailey, K., Sidwell, R. W.
We examined RWJ-270201 in a lethal model of influenza in BALB/c mice. The aim was to delineate the pharmacodynamically linked variable for the drug. Challenge was performed with influenza virus...
Selective cytotoxicity of ricin A chain immunotoxins towards murine cytomegalovirus-infected cells.
Barnett, B B, Smee, D F, Malek, S M, Sidwell, R W
Immunotoxins were constructed by linking immunoglobulins specific for murine cytomegalovirus (MCMV) to deglycosylated ricin A chain. Toxicities toward MCMV-infected and uninfected cells were...
Sidwell, R W, Huffman, J H, Bailey, K W, Wong, M H, Nimrod, A, Panet, A
The oxygen free-radical scavenger recombinant human manganese superoxide dismutase (MnSOD) was studied for its effects on influenza virus infections in mice when used alone and in combination with...
In vivo anti-influenza virus activity of a zinc finger peptide.
Judd, A K, Sanchez, A, Bucher, D J, Huffman, J H, Bailey, K, Sidwell, R W
Matrix protein (M1) is a major structural protein of influenza virus, and it inhibits its own polymerase. A 19-amino-acid peptide, corresponding to a zinc finger region of the M1 sequence of...
In vitro and in vivo Phlebovirus inhibition by ribavirin.
Sidwell, R W, Huffman, J H, Barnett, B B, Pifat, D Y
Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) was markedly inhibitory in vitro to Adames and Balliet strains of Punta Toro virus (PTV), a Phlebovirus related to Rift Valley fever...
Sidwell, R W, Huffman, J H, Call, E W, Warren, R P, Radov, L A, Murray, R J
PR-879-317A (2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxy-imidazo [1,2a]pyridine) has been found to be a T-cell-selective immunomodulating agent. In the current studies, a series of experiments was...
Activity of selenazofurin against influenza A and B viruses in vitro.
Sidwell, R W, Huffman, J H, Call, E W, Alaghamandan, H, Cook, P D, Robins, R K
Activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza A and B viruses. In experiments with Madin Darby canine...
Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances.
Smee, D F, Sidwell, R W, Clark, S M, Barnett, B B, Spendlove, R S
The effects of four ribonucleic acid virus inhibitors were evaluated in cell cultures and in mice to determine inhibitory effects against bluetongue virus and Colorado tick fever virus (CTFV). Test...
Smee, D F, Sidwell, R W, Clark, S M, Barnett, B B, Spendlove, R S
Several RNA virus inhibitors were evaluated against simian (SA11) rotavirus infections in vitro and murine rotavirus gastroenteritis in vivo. Test compounds included...
Sidwell, R W, Huffman, J H, Gilbert, J, Moscon, B, Pedersen, G, Burger, R, ...
Pulmonary disease in mice induced by influenza virus was monitored by measurement of oxygen saturation (SaO2) in blood with a pulse oximeter. The SaO2 declined in inverse proportion to the viral...
Smee, D F, Morris, J L, Leonhardt, J A, Mead, J R, Holy, A, Sidwell, R W
Severe combined immunodeficient (SCID) mice were found to be highly susceptible to murine cytomegalovirus (MCMV) infection. Treatment of infected mice with ganciclovir (12.5, 25, and 50 mg/kg of body...
Morrey, J D, Bourn, S M, Bunch, T D, Jackson, M K, Sidwell, R W, Barrows, L R, ...
UV irradiation has been shown to activate the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in cell culture; however, only limited studies have been described in vivo. UV...
Barnard, D. L., Hubbard, V. D., Smee, D. F., Sidwell, R. W., Watson, K. G. W., Tucker, S. P. T., ...
Picornaviruses (PV) include human rhinovirus (HRV), the primary cause of the common cold, and the enteroviruses (EV), which cause serious diseases such as poliomyelitis, meningoencephalitis, and...