Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma (2006)
Hoefnagel, J.J., Mulder, M.M.S., Dreef, E., Jansen, P.M., Pals, S.T., ...
Expression patterns of eight transcription factors involved in different stages of B-cell development were investigated in a large group of primary cutaneous B-cell lymphomas and compared with...
Jehn, U., Suciu, S., Thomas, X., Lefrère, F., Muus, P., Berneman, Zwi, ...
Hematology patterns of migrating European eels and the role of EVEX virus (2005)
Ballieux, B., Willemze, R., Coldenhoff, K., Lentjes, E., Antonissen, E., ...
We show that European eels infected with the rhabdovirus EVEX (Eel Virus European X) virus, developed hemorrhage and anemia during simulated migration in large swim tunnels, and died after 1000-1500...
Presence of virus infections in Eel species from various geographic regions (2004)
Haenen, O.L.M., Coldenhoff, K., Willemze, R., Antonissen, E., ...
EVEX (Eel-Virus-European-X), HVA (Herpesvirus anguillae), and EVE (Eel Virus European) were detected in wild and farmed European eels (Anguilla anguilla L.) from the Netherlands, EVEX and EVE from...
Raaphorst, F.M., Vermeer, J.E.M., Fieret, E., Blokzijl, T., ...
Polycomb-group (PcG) genes preserve cell identity by gene silencing, and contribute to regulation of lymphopoiesis and malignant transformation. We show that primary nodal large B-cell lymphomas...
Monoclonal proteinaemia and solid tumours (2004)
Schaar, C.G., Snijder, S., Oostindier, M.J., Rosendaal, F.R., Willemze, R., Kluin-Nelemans, J.C.
Monoclonal proteinaemia and solid tumours (2004)
Schaar, C.G., Snijder, S., Oostindier, M.J., Rosendaal, F.R., Willemze, R., Kluin-Nelemans, J.C.
Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma (2004)
Ferreri, A. J. M., Campo, E., Ambrosetti, A., Ilariucci, F., Seymour, J. F., Willemze, R., ...
Background: Optimal therapeutic management of intravascular lymphoma (IVL) lacks precise guidelines. Patients and methods: The clinico-pathological features of 38 HIV-negative patients with IVL were...
Bekkenk, M. W., Jansen, P. M., Willemze, R.
Background: The aim of this study was to define prognostic parameters and guidelines for diagnosis and treatment for CD56+ hematological neoplasms with first presentation in the skin. Patients and...
Suciu, S, Labar, B, Belhabri, A, Aul, C, ...
This report used the framework of a large European study to investigate the outcome of patients with and without an HLA-identical sibling donor on an intention-to-treat basis. After a common...
Keating, S, Suciu, S, De Witte, T, Zittoun, R, Mandelli, F, Belhabri, A, ...
Variable numbers of CD34(+) cells can be harvested from the blood of AML patients in CR after G-CSF supported mobilization following consolidation chemotherapy. We hypothesized that a decreased...
Muus, P, Suciu, S, Koller, C, Labar, B, ...
Comparisons of the effectiveness of chemotherapy and transplantation in AML in first complete remission (CR) have focused almost exclusively on patients with de novo disease. Here we used Cox...
Suciu, S, Labar, B, Archimbaud, E, Aul, C, ...
This study investigated the feasibility of allogeneic (alloSCT) and autologous stem cell transplantation (ASCT) as postconsolidation therapy for patients with myelodysplastic syndromes (MDSs) or...
Pruijt, J F, Van Kooyk, Y, Figdor, C G, Willemze, R
The chemokine interleukin-8 (IL-8) is a potent chemoattractant and activator of neutrophils. Upon systemic injection, IL-8 induces an immediate neutropenia followed by a rebound granulocytosis. In...
Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients (2000)
Doorn, R. Van, Haselen, C.W. Van, Geerts, M.L., Heule, F., Rie, M.A. De, ...
Mycosis fungoides - Disease evolution and prognosis of 309 Dutch patients. (2000)
VAN DOORN, R, VAN HASELEN, CW, VADER, PCV, Geerts, Maria, HEULE, F, DE RIE, M, ...
Primary cutaneous lymphomas differ significantly from their nodal equivalents in clinical behaviour and prognosis, and often require a different therapeutic approach. Since currently used...
Fibbe, W E, Laterveer, L, Pieters, R A, Lindley, I J, Paemen, L, ...
Previously, we demonstrated that IL-8 induces rapid mobilization of hematopoietic progenitor cells (HPC) from the bone marrow of rhesus monkeys. Because activation of neutrophils by IL-8 induces the...
Biology of IL-8-induced stem cell mobilization (1999)
Pruijt, J F, Velders, G A, Van Kooyk, Y, Figdor, C G, ...
The CXC chemokine interleukin-8 (IL-8) has profound hematopoietic activities following systemic administration. It induces the rapid mobilization of cells with lymphomyeloid repopulating ability in...
Biology of IL-8-induced stem cell mobilization (1999)
Willemze, R., Figdor, C.G., Kooyk, Y. Van, Opdenakker, G., Velders, G.A., Pruijt, J.F.M., ...
Pentostatin in T-cell malignancies - a phase II trial of the EORTC (1999)
Ho, A. D., Suciu, S., Stryckmans, P., De Cataldo, F., Willemze, R., Thaler, J., ...
Purpose: Within this phase II EORTC trial, we have investigated the safety and efficacy of pentostatin in lymphoid malignancies. We have previously reported the results in T-and B-cell prolymphocytic...
Enhancement of G-CSF-induced stem cell mobilization by antibodies to the beta2-integrin LFA-1 (1998)
Fibbe, W.E., Willemze, R., Figdor, C.G., Kooyk, Y. Van, Pruijt, J.F.M., Velders, G.A.
Murine hematopoietic progenitor cells do not express LFA-1 (1998)
Fibbe, W.E., Willemze, R., Kooyk, Y. Van, Figdor, C.G., Pruijt, J.F.M.
Zittoun, R., Dardenne, M., Jaksic, B., Labar, B., Jehn, U., Dohner, H., ...
Mechanisms of stem cell mobilization in mice (1997)
Willemze, R., Opdenakker, G., Figdor, C.G., Laterveer, L., Pruijt, J.F.M., Fibbe, W.E.
WILLEMZE, R, KERL, H, STERRY, W, BERTI, E, CERRONI, L, CHIMENTI, S, ...
Hiemstra, PS, Stolk, J, Fibbe, WE, ...
Serum contains many growth factors and nutrients that stimulate colony formation of hematopoietic progenitor cells (HPC) in semisolid cultures. In the absence of serum, no proliferation of HPCs could...
Autologous stem cell transplantations in elderly AML patients (1996)
Archimbaud, E., Jehn, U., De Cataldo, F., Fillet, Georges, Amadori, S., Willemze, R.
Cutaneous immunocytomas : a clinicopathologic study of 26 cases. (1993)
RIJLAARSDAM, JU, VANDERPUTTE, SCJ, BERTI, E, KERL, H, RIEGER, E, TOONSTRA, J, ...
Interleukin-6 (IL-6) is a pleiotropic cytokine that enhances the maturation of megakaryocytes. In mice, in vivo treatment with IL-6 results in elevated platelet counts both in untreated animals and...
Raaij, E. M. H., Bruynzeel, I., Nickoloff, Brian J., Stoof, T. J., Willemze, R., Boorsma, D. M.
Peer Reviewed
Kluin-Nelemans, J C, Willemze, R, Fibbe, WE
Since monocytes and macrophages that arise during the culture of bone marrow progenitor cells are potential sources of interleukin 6 (IL-6), we investigated whether auto- or paracrine production of...
Fibbe, W E, Ralph, P, Den Ottolander, G J, ...
In patients with hairy cell leukemia (HCL), we measured serum levels of monocyte colony-stimulating factor (M-CSF), interleukin-6 (IL-6), and erythropoietin during various degrees of pancytopenia...
Fibbe, W E, Landegent, J E, Willemze, R, ...
On normal monocytes, interleukin 4 (IL-4) down-regulates the production of several proteins that are produced in response to bacterial cell wall lipopolysaccharides (LPS), among others IL-6. In...
Fibbe, W E, Duinkerken, N, Ralph, P, Kaushansky, K, ...
Goselink, H M, Van Eeden, G, Voogt, P J, ...
To study the effect of interleukin-1 (IL-1) beta on the proliferation of hematopoietic progenitor cells (HPC) in long-term bone marrow cultures (LTBMC), stromal cell layers were established from...
Duinkerken, N, Lurvink, E, Ralph, P, ...
Electrophoretically pure human interleukin-1 (IL-1) beta was found to stimulate human fibroblasts in a monolayer culture to elaborate colony-stimulating activity (CSA). Supernatant fluids from...
Zijlmans, J M, Visser, J W, Kleiverda, K, Kluin, P M, Willemze, R, Fibbe, W E
We have developed a modified rhodamine (Rho) staining procedure to study uptake and efflux in murine hematopoietic stem cells. Distinct populations of Rho++ (bright), Rho+ (dull), and Rho- (negative)...
Faber, L M, Goulmy, E, Willemze, R, ...
We investigated whether minor histocompatibility (mH) antigen-specific cytotoxic T lymphocytes (CTL) can discriminate between leukemic hematopoietic progenitor cells (leukemic-HPC) from AML or CML...
Studies on clonality by PCR analysis of the PGK-1 gene.
Van Kamp, H, Jansen, R, Willemze, R, Fibbe, W E, Landegent, J E
Miedema, F, Van Oostveen, J W, Terpstra, F G, Willemze, R, Rauws, E A, ...
The neoplastic T cells of a series of seven patients with chronic T-cell neoplasia were tested for helper activity on pokeweed mitogen (PWM)-induced and interleukin 2 (IL-2)-induced Ig synthesis. The...
Bakels, V, Van Oostveen, J W, Preesman, A H, Meijer, C J, Willemze, R
AIMS: Differentiation between actinic reticuloid and cutaneous T cell lymphoma can be extremely difficult. Demonstration of clonal T cell receptor (TCR) gene rearrangements has been suggested as a...
A cytotoxic phenotype does not predict clinical outcome in anaplastic large cell lymphomas.
Dukers, D F, Ten Berge, R L, Oudejans, J J, Pulford, K, Hayes, D, Miseré, J F, ...
AIM: To investigate whether anaplastic large cell lymphomas (ALCL) expressing cytotoxic proteins have a relatively worse clinical outcome compared with ALCL lacking a cytotoxic phenotype. METHODS: 59...
Zijlmans, J M, Visser, J W, Kleiverda, K, Kluin, P M, Willemze, R, Fibbe, W E
We have developed a modified rhodamine (Rho) staining procedure to study uptake and efflux in murine hematopoietic stem cells. Distinct populations of Rho++ (bright), Rho+ (dull), and Rho- (negative)...
Faber, L M, Goulmy, E, Willemze, R, ...
We investigated whether minor histocompatibility (mH) antigen-specific cytotoxic T lymphocytes (CTL) can discriminate between leukemic hematopoietic progenitor cells (leukemic-HPC) from AML or CML...
Studies on clonality by PCR analysis of the PGK-1 gene.
Van Kamp, H, Jansen, R, Willemze, R, Fibbe, W E, Landegent, J E
Miedema, F, Van Oostveen, J W, Terpstra, F G, Willemze, R, Rauws, E A, ...
The neoplastic T cells of a series of seven patients with chronic T-cell neoplasia were tested for helper activity on pokeweed mitogen (PWM)-induced and interleukin 2 (IL-2)-induced Ig synthesis. The...
Bakels, V, Van Oostveen, J W, Preesman, A H, Meijer, C J, Willemze, R
AIMS: Differentiation between actinic reticuloid and cutaneous T cell lymphoma can be extremely difficult. Demonstration of clonal T cell receptor (TCR) gene rearrangements has been suggested as a...
A cytotoxic phenotype does not predict clinical outcome in anaplastic large cell lymphomas.
Dukers, D F, Ten Berge, R L, Oudejans, J J, Pulford, K, Hayes, D, Miseré, J F, ...
AIM: To investigate whether anaplastic large cell lymphomas (ALCL) expressing cytotoxic proteins have a relatively worse clinical outcome compared with ALCL lacking a cytotoxic phenotype. METHODS: 59...
Bijl, J. J., Rieger, E., Van Oostveen, J. W., Walboomers, J. M., Kreike, M., Willemze, R., ...
Homeobox (HOX) genes are involved in the lineage-specific differentiation of bone marrow stem cells. Recently, we reported a largely similar expression pattern of HOXC4 and HOXC6 in normal and...
Bakels, V., Van Oostveen, J. W., Van Der Putte, S. C., Meijer, C. J., Willemze, R.
Differentiation between cutaneous pseudo-T-cell lymphomas and cutaneous T-cell lymphomas (CTCLs) may be extremely difficult. In this study, it was investigated whether demonstration of an aberrant...
Beljaards, R. C., Meijer, C. J., Scheffer, E., Toonstra, J., Van Vloten, W. A., Van Der Putte, S. C., ...
The histologic and immunophenotypical features of 20 primary cutaneous large-cell lymphomas of T-cell origin were investigated and correlated with clinical data to obtain prognostically relevant...
Experimental myelocytic leukemia in the Brown-Norway rat as a model for pulmonary leukostasis.
Van Buchem, M. A., Colly, L. P., Hogendoorn, P. C., Kluin, P. M., Willemze, R.
Willemze, R., Scheffer, E., Meijer, C. J.
Using an indirect immunoperoxidase technique and a panel of monoclonal antibodies with well-defined specificities, the authors studied the distribution of lymphoid and nonlymphoid cells in the T-cell...
Willemze, R., Cornelisse, C. J., Hermans, J., Pardoel, V. P., Van Vloten, W. A., Meijer, C. J.
Previous studies have demonstrated that quantitative analysis of nuclear convolution of lymphoid cells in electron micrographs is a valuable method of differentiation between well-established...
Willemze, R., Meijer, C. J., Scheffer, E., Kluin, P. M., Van Vloten, W. A., Toonstra, J., ...
This report describes the clinical, histologic, and immunologic characteristics of 16 diffuse large cell lymphomas of follicular center cell origin with only skin lesions at presentation. These...
Berge, R., Oudejans, J., Ossenkoppele, G., Pulford, K., Willemze, R., Falini, B., ...
Aims—In anaplastic large cell lymphoma (ALCL), the site of origin has been described as an important prognostic factor. Recently, a fusion protein containing anaplastic lymphoma kinase (ALK) was...
Ten, B, Snijdewint, F, Poort-Keesom, R, Oudejans, J, Meijer, J, ...
Aims—To investigate whether MUC1 mucin, a high molecular weight transmembrane glycoprotein, also known as epithelial membrane antigen (EMA), differs in its expression and degree of glycosylation...
Dukers, D, Vermeer, M, Jaspars, L, Sander, C, Flaig, M, Vos, W, ...
Background/Aims—Killer inhibitory receptors (KIR) have a modulating effect on the cytotoxic functions of natural killer (NK) cells and T cells. Because lymphoma cells often have the same receptors...
Chromosome abnormalities in cutaneous B-cell lymphomas
BUSSCHOTS, AM, Geerts, Maria, BAKELS, V, VAN OOSTVEEN, JW, MEUER, CJLM, WILLEMZE, R
A comparison of two culture techniques: an in vitro & an in vivo tumour colony-forming assay.
Slee, P. H., Willemze, R., Van Oosterom, A. T., Lurvink, E.
Twenty-one identical tumour specimens were cultured both in the Plasma-Clot Diffusion Chamber (PCDC) Technique and the Human Tumour Colony-forming Assay (HTCA). The culture results achieved in the...
Richel, D. J., Colly, L. P., Kluin-Nelemans, J. C., Willemze, R.
In the present study we demonstrate that Aza-dC in combination with Amsacrine has major antileukaemic properties in patients who have not already received extensive Ara-C therapy. Eight out of 11...
B-cell colony growth of malignant and normal B-cells.
Kluin-Nelemans, J. C., Hakvoort, H. W., Van Dierendonck, J. H., Beverstock, G. C., Fibbe, W. E., Willemze, R., ...
B-cell colony growth of malignant and normal B-cells has been studied in a double layer (agar-fluid) colony assay. Stimulatory factors consisted of irradiated blood leukocytes, phytohaemagglutinin...
Richel, D. J., Colly, L. P., Lurvink, E., Willemze, R.
Using a Brown Norway rat leukaemia model (BNML), which is a realistic model of human myelocytic leukaemia, we compared the antileukaemic activity, influence on cell cycle kinetics and effect on...
Primary gastrointestinal non-Hodgkin's lymphoma in a population-based registry.
Otter, R., Bieger, R., Kluin, P. M., Hermans, J., Willemze, R.
In a population-based registry of 580 patients with non-Hodgkin's lymphoma (NHL) 54 patients had a primary gastric lymphoma, 42 an intestinal, 113 a primary extranodal lymphoma localised elsewhere...