Rachel L. Brumbaugh

Notch1 promotes survival of E2A-deficient T cell lymphomas through pre–T cell receptor–dependent and –independent mechanisms

Reschly, Erica J., Spaulding, Christina, Vilimas, Tomas, Graham, W. Vallen, Brumbaugh, Rachel L., Aifantis, Iannis, ...

Loss of E2A transcription factor activity or activation of the intracellular form of Notch1 (ICN) leads to the development of leukemia or lymphoma in humans or mice, respectively. Current models...

Early B Cell Factor Promotes B Lymphopoiesis with Reduced Interleukin 7 Responsiveness in the Absence of E2A

Seet, Christopher S., Brumbaugh, Rachel L., Kee, Barbara L.

The basic helix-loop-helix transcription factors encoded by the E2A gene function at the apex of a transcriptional hierarchy involving E2A, early B cell factor (EBF), and Pax5, which is essential for...