Li, Li, Dutra, Amalia, Pak, Evgenia, Labrie, Joseph E., Gerstein, Rachel M., Pandolfi, Pier Paolo, ...
Glioblastomas often show activation of epidermal growth factor receptor (EGFR) and loss of PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor, but it is not known if...
Coles, Andrew H., Marfella, Concetta G. A., Imbalzano, Anthony N., Steinman, Heather Anne, Garlick, David S., Gerstein, Rachel M., ...
The Inhibitor of Growth (ING) gene family encodes structurally related proteins that alter chromatin to regulate gene expression and cell growth. The initial member, ING1, has also been proposed to...
Kuo, Ya-Huei, Gerstein, Rachel M., Castilla, Lucio H.
The core-binding factor (CBF)-associated leukemia fusion protein CBFbeta-SMMHC impairs myeloid and lymphoid differentiation. By inhibiting RUNX function, the fusion oncoprotein predisposes...
Labrie, Joseph E., Borghesi, Lisa A., Gerstein, Rachel M.
B cell generation and immunoglobulin (Ig) diversity in mice is compromised with aging. Our recent work sought to understand mechanism(s) that contribute to reduced B cell production in aged mice....
Labrie, Joseph E., Sah, Alex P., Allman, David M., Cancro, Michael P., Gerstein, Rachel M.
During aging, adaptive immunity is severely compromised, due in part to decreased production of B lymphocytes and loss of immunoglobulin (Ig) diversity. However, the molecular mechanisms that...
Borghesi, Lisa A., Gerstein, Rachel M.
In B lineage progenitors, V(D)J recombination occurs only during distinct stages of development and is restricted to immunoglobulin loci. This process is thought to be controlled by both regulated...
Borghesi, Lisa A., Hsu, Lih-Yun, Miller, Juli P., Anderson, Michael, Herzenberg, Leonard A., Herzenberg, Leonore A., ...
Expression of V(D)J recombinase activity in developing lymphocytes is absolutely required for initiation of V(D)J recombination at antigen receptor loci. However, little is known about when during...
Liang, Huiling, Chen, Qin, Coles, Andrew H., Anderson, Stephen J., Pihan, German A., Bradley, Allan, ...
Wnt5a is a member of the Wnt family of secreted glycoproteins that play essential organizing roles in development. Similar to other Wnt members, Wnt5a can upregulate cell proliferation and has been...
Alugupalli, Kishore R., Gerstein, Rachel M., Chen, Jianzhu, Szomolanyi-Tsuda, Eva, Woodland, Robert T., Leong, John M.
The rate of pathogen clearance is a critical determinant of morbidity and mortality. We sought to characterize the immune response responsible for the remarkably rapid clearance of individual...
Borghesi, Lisa, Gerstein, Rachel M.
In B lineage progenitors, V(D)J recombination occurs only during distinct stages of development and is restricted to immunoglobulin loci. This process is thought to be controlled by both regulated...
Borghesi, Lisa, Hsu, Lih-Yun, Miller, Juli P., Anderson, Michael, Herzenberg, Leonard, Herzenberg, Leonore, ...
Expression of V(D)J recombinase activity in developing lymphocytes is absolutely required for initiation of V(D)J recombination at antigen receptor loci. However, little is known about when during...
Labrie, Joseph E., Sah, Alex P., Allman, David M., Cancro, Michael P., Gerstein, Rachel M.
During aging, adaptive immunity is severely compromised, due in part to decreased production of B lymphocytes and loss of immunoglobulin (Ig) diversity. However, the molecular mechanisms that...
Kuo, Ya-Huei, Gerstein, Rachel M., Castilla, Lucio H.
The core-binding factor (CBF)–associated leukemia fusion protein CBFβ-SMMHC impairs myeloid and lymphoid differentiation. By inhibiting RUNX function, the fusion oncoprotein predisposes...