Pozsgay, Vince, Chu, Chiayung, Pannell, Lewis, Wolfe, Jennifer, Robbins, John B., Schneerson, Rachel
Our development of vaccines to prevent shigellosis is based on the hypothesis that a critical (protective) level of serum IgG to the O-specific polysaccharide (O-SP) domain of Shigella...
Trollfors, Birger, Lagergård, Teresa, Taranger, John, Bergfors, Elisabet, Schneerson, Rachel, Robbins, John B.
Serum immunoglobulin G (IgG) antibodies against the lipooligosaccharide (LOS) of Bordetella pertussis and the lipopolysaccharide (LPS) of Bordetella parapertussis were measured by enzyme-linked...
Pavliakova, Danka, Chu, Chiayung, Bystricky, Slavomir, Tolson, Nathaniel W., Shiloach, Joseph, Kaufman, Jeanne B., ...
Seroepidemiological data and a clinical trial with a Shigella sonnei O-specific polysaccharide (O-SP)–Pseudomonas aeruginosa recombinant exoprotein A (rEPA) conjugate provide evidence that a...
Kossaczka, Zuzana, Lin, Feng-Ying C., Ho, Vô Anh, Thuy, Nguyen Thi Thanh, Bay, Phan Van, Thanh, Tran Cong, ...
The capsular polysaccharide of Salmonella typhi, Vi, is an essential virulence factor and a protective vaccine for people older than 5 years. The safety and immunogenicity of two investigational Vi...
Pavliakova, Danka, Moncrief, J. Scott, Lyerly, David M., Schiffman, Gerald, Bryla, Dolores A., Robbins, John B., ...
Unlike the native protein, a nontoxic peptide (repeating unit of the native toxin designated rARU) from Clostridium difficile toxin A (CDTA) afforded an antigen that could be bound covalently to the...
Passwell, Justen H., Harlev, Efrat, Ashkenazi, Shai, Chu, Chiayung, Miron, Dan, Ramon, Reut, ...
Data suggest that the O-specific polysaccharide (O-SP) domain of the lipopolysaccharide (LPS) of Shigella species is both an essential virulence factor and a protective antigen and that a critical...
Expression of a Mycobacterium tuberculosis Arabinomannan Antigen In Vitro and In Vivo
Schwebach, J. Reid, Casadevall, Arturo, Schneerson, Rachel, Dai, Zhongdong, Wang, Xiaojuan, Robbins, John B., ...
The outermost layer of Mycobacterium tuberculosis contains two major polysaccharides, arabinomannan (AM) and glucan (GC). We studied the in vitro and in vivo expression of an M. tuberculosis AM...
Vidarsson, Gestur, Sigurdardottir, Sigurveig T., Gudnason, Thorolfur, Kjartansson, Sveinn, Kristinsson, Karl G., Ingolfsdottir, Gunnhildur, ...
Streptococcus pneumoniae is a major respiratory pathogen of infants, children, and the elderly. Polysaccharide vaccines have been useful in adult populations but do not elicit protective immunity in...
Schwebach, J. Reid, Glatman-Freedman, Aharona, Gunther-Cummins, Leslie, Dai, Zhongdong, Robbins, John B., Schneerson, Rachel, ...
The outermost layer of Mycobacterium tuberculosis is composed primarily of two polysaccharides, glucan (GC) and arabinomannan. To analyze the surface polysaccharide composition of M. tuberculosis, we...
Specificity and Diversity of Antibodies to Mycobacterium tuberculosis Arabinomannan
Navoa, Josephine Anne D., Laal, Suman, Pirofski, Liise-Anne, McLean, Gary R., Dai, Zhongdong, Robbins, John B., ...
Arabinomannan (AM) is a polysaccharide antigen of the mycobacterial capsule. However, it is uncertain whether AM constitutes an immunologically distinct fraction of Mycobacterium tuberculosis. In...
Development of an improved vaccine for anthrax
Leppla, Stephen H., Robbins, John B., Schneerson, Rachel, Shiloach, Joseph
A newly discovered cholesteryl galactoside from Borrelia burgdorferi
Ben-Menachem, Gil, Kubler-Kielb, Joanna, Coxon, Bruce, Yergey, Alfred, Schneerson, Rachel
Two major glycolipids, which comprise ≈36% of the total lipid mass from Borrelia burgdorferi, the etiological agent of Lyme disease, were investigated. We determined the fatty acid type, sugar...
Schneerson, Rachel, Kubler-Kielb, Joanna, Liu, Teh-Yung, Dai, Zhong-Dong, Leppla, Stephen H., Yergey, Alfred, ...
Both the protective antigen (PA) and the poly(γ-d-glutamic acid) capsule (γdPGA) are essential for the virulence of Bacillus anthracis. A critical level of vaccine-induced IgG anti-PA confers...
Jin, Zhigang, Chu, Chiayung, Robbins, John B., Schneerson, Rachel
Epidemic and endemic meningitis caused by group A Neisseria meningitidis remains a problem in sub-Saharan Africa. Although group A meningococcal capsular polysaccharide (GAMP) vaccine confers...
Chu, Chiayung, Schneerson, Rachel, Robbins, John B., Rastogi, Suresh C.
Conjugates were prepared by carbodiimide-mediated coupling of adipic acid hydrazide derivatives of Haemophilus influenzae type b (Hib), Escherichia coli K100, and pneumococcal 6A (Pn6A)...
Differential Complement Resistance Mediates Virulence of Haemophilus influenzae Type b
Sutton, Ann, Schneerson, Rachel, Kendall-Morris, Saundra, Robbins, John B.
Studies were undertaken to gain insight into the virulence of type b in contrast to the other Haemophilus influenzae capsular types. A relationship was found between the comparative virulence of H....
Age-Related Susceptibility to Haemophilus influenzae Type b Disease in Rabbits
Schneerson, Rachel, Robbins, John B.
Anti-type b antibodies were detected in newborns and in most 6- to 8-week-old rabbits, similar to those observed in humans. Culture of the pharynx and rectum of rabbits at varied ages failed to yield...
Robbins, John B., Myerowitz, Richard L., Whisnant, John K., Argaman, Meir, Schneerson, Rachel, Handzel, Zeev T., ...
Enteric bacteria of 1,335 individual strains were studied for serological cross-reactions with Neisseria meningitidis groups A and C and Diplococcus pneumoniae types I and III. Enterobacterial...
Myerowitz, Richard L., Handzel, Zeev T., Schneerson, Rachel, Robbins, John B.
In two separate experiments, newborn rabbits were fed a live suspension of either of two Escherichia coli strains which possess a “K” antigen cross-reactive with the capsular polysaccharide of...
Antigenic Evidence of Prevalence and Diversity of Mycobacterium tuberculosis Arabinomannan
Glatman-Freedman, Aharona, Casadevall, Arturo, Dai, Zongdong, Jacobs, William R., Li, Anping, Morris, Sheldon L., ...
Arabinomannan (AM) is a polysaccharide of the mycobacterial capsule. The capsular polysaccharides of various microorganisms are diverse, and this diversity is important for classification of...
Kubler-Kielb, Joanna, Coxon, Bruce, Schneerson, Rachel
Bacillus pumilus strain Sh18 cell wall polysaccharide (CWP), cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b, was purified and its chemical structure was elucidated...
Canh, Do Gia, Lin, Feng-ying (Kimi), Thiem, Vu Dinh, Trach, Dang Duc, Trong, Nguyen Dinh, Mao, Nguyen Duc, ...
In a double-blind, randomized, and placebo-controlled previous trial, the efficacy of Vi-rEPA for typhoid fever in 2- to 5-year-olds was 89.0% for 46 months. Vi-rEPA contained 25 μg of Vi and...
Jin, Zhigang, Bohach, Gregory A., Shiloach, Joseph, Norris, Scott E., Freedberg, Darón I., Deobald, Claudia, ...
Neisseria meningitidis groups A (GAM) and W135 capsular polysaccharides (CPs) were bound to recombinant Staphylococcus aureus enterotoxin C1 (rSEC). The CPs were activated with...
Kubler-Kielb, Joanna, Liu, Teh-Yung, Mocca, Christopher, Majadly, Fathy, Robbins, John B., Schneerson, Rachel
The capsule of Bacillus anthracis, composed of poly-γ-d-glutamic acid (γDPGA), is an essential virulence factor of B. anthracis. The capsule inhibits innate host defense through its antiphagocytic...
Pozsgay, Vince, Chu, Chiayung, Pannell, Lewis, Wolfe, Jennifer, Robbins, John B., Schneerson, Rachel
Our development of vaccines to prevent shigellosis is based on the hypothesis that a critical (protective) level of serum IgG to the O-specific polysaccharide (O-SP) domain of Shigella...
Trollfors, Birger, Lagergård, Teresa, Taranger, John, Bergfors, Elisabet, Schneerson, Rachel, Robbins, John B.
Serum immunoglobulin G (IgG) antibodies against the lipooligosaccharide (LOS) of Bordetella pertussis and the lipopolysaccharide (LPS) of Bordetella parapertussis were measured by enzyme-linked...
Pavliakova, Danka, Chu, Chiayung, Bystricky, Slavomir, Tolson, Nathaniel W., Shiloach, Joseph, Kaufman, Jeanne B., ...
Seroepidemiological data and a clinical trial with a Shigella sonnei O-specific polysaccharide (O-SP)–Pseudomonas aeruginosa recombinant exoprotein A (rEPA) conjugate provide evidence that a...
Kossaczka, Zuzana, Lin, Feng-Ying C., Ho, Vô Anh, Thuy, Nguyen Thi Thanh, Bay, Phan Van, Thanh, Tran Cong, ...
The capsular polysaccharide of Salmonella typhi, Vi, is an essential virulence factor and a protective vaccine for people older than 5 years. The safety and immunogenicity of two investigational Vi...
Pavliakova, Danka, Moncrief, J. Scott, Lyerly, David M., Schiffman, Gerald, Bryla, Dolores A., Robbins, John B., ...
Unlike the native protein, a nontoxic peptide (repeating unit of the native toxin designated rARU) from Clostridium difficile toxin A (CDTA) afforded an antigen that could be bound covalently to the...
Passwell, Justen H., Harlev, Efrat, Ashkenazi, Shai, Chu, Chiayung, Miron, Dan, Ramon, Reut, ...
Data suggest that the O-specific polysaccharide (O-SP) domain of the lipopolysaccharide (LPS) of Shigella species is both an essential virulence factor and a protective antigen and that a critical...
Expression of a Mycobacterium tuberculosis Arabinomannan Antigen In Vitro and In Vivo
Schwebach, J. Reid, Casadevall, Arturo, Schneerson, Rachel, Dai, Zhongdong, Wang, Xiaojuan, Robbins, John B., ...
The outermost layer of Mycobacterium tuberculosis contains two major polysaccharides, arabinomannan (AM) and glucan (GC). We studied the in vitro and in vivo expression of an M. tuberculosis AM...
Vidarsson, Gestur, Sigurdardottir, Sigurveig T., Gudnason, Thorolfur, Kjartansson, Sveinn, Kristinsson, Karl G., Ingolfsdottir, Gunnhildur, ...
Streptococcus pneumoniae is a major respiratory pathogen of infants, children, and the elderly. Polysaccharide vaccines have been useful in adult populations but do not elicit protective immunity in...
Schwebach, J. Reid, Glatman-Freedman, Aharona, Gunther-Cummins, Leslie, Dai, Zhongdong, Robbins, John B., Schneerson, Rachel, ...
The outermost layer of Mycobacterium tuberculosis is composed primarily of two polysaccharides, glucan (GC) and arabinomannan. To analyze the surface polysaccharide composition of M. tuberculosis, we...
Specificity and Diversity of Antibodies to Mycobacterium tuberculosis Arabinomannan
Navoa, Josephine Anne D., Laal, Suman, Pirofski, Liise-Anne, McLean, Gary R., Dai, Zhongdong, Robbins, John B., ...
Arabinomannan (AM) is a polysaccharide antigen of the mycobacterial capsule. However, it is uncertain whether AM constitutes an immunologically distinct fraction of Mycobacterium tuberculosis. In...
Development of an improved vaccine for anthrax
Leppla, Stephen H., Robbins, John B., Schneerson, Rachel, Shiloach, Joseph
A newly discovered cholesteryl galactoside from Borrelia burgdorferi
Ben-Menachem, Gil, Kubler-Kielb, Joanna, Coxon, Bruce, Yergey, Alfred, Schneerson, Rachel
Two major glycolipids, which comprise ≈36% of the total lipid mass from Borrelia burgdorferi, the etiological agent of Lyme disease, were investigated. We determined the fatty acid type, sugar...
Schneerson, Rachel, Kubler-Kielb, Joanna, Liu, Teh-Yung, Dai, Zhong-Dong, Leppla, Stephen H., Yergey, Alfred, ...
Both the protective antigen (PA) and the poly(γ-d-glutamic acid) capsule (γdPGA) are essential for the virulence of Bacillus anthracis. A critical level of vaccine-induced IgG anti-PA confers...
Jin, Zhigang, Chu, Chiayung, Robbins, John B., Schneerson, Rachel
Epidemic and endemic meningitis caused by group A Neisseria meningitidis remains a problem in sub-Saharan Africa. Although group A meningococcal capsular polysaccharide (GAMP) vaccine confers...
Chu, Chiayung, Schneerson, Rachel, Robbins, John B., Rastogi, Suresh C.
Conjugates were prepared by carbodiimide-mediated coupling of adipic acid hydrazide derivatives of Haemophilus influenzae type b (Hib), Escherichia coli K100, and pneumococcal 6A (Pn6A)...
Differential Complement Resistance Mediates Virulence of Haemophilus influenzae Type b
Sutton, Ann, Schneerson, Rachel, Kendall-Morris, Saundra, Robbins, John B.
Studies were undertaken to gain insight into the virulence of type b in contrast to the other Haemophilus influenzae capsular types. A relationship was found between the comparative virulence of H....
Age-Related Susceptibility to Haemophilus influenzae Type b Disease in Rabbits
Schneerson, Rachel, Robbins, John B.
Anti-type b antibodies were detected in newborns and in most 6- to 8-week-old rabbits, similar to those observed in humans. Culture of the pharynx and rectum of rabbits at varied ages failed to yield...
Robbins, John B., Myerowitz, Richard L., Whisnant, John K., Argaman, Meir, Schneerson, Rachel, Handzel, Zeev T., ...
Enteric bacteria of 1,335 individual strains were studied for serological cross-reactions with Neisseria meningitidis groups A and C and Diplococcus pneumoniae types I and III. Enterobacterial...
Myerowitz, Richard L., Handzel, Zeev T., Schneerson, Rachel, Robbins, John B.
In two separate experiments, newborn rabbits were fed a live suspension of either of two Escherichia coli strains which possess a “K” antigen cross-reactive with the capsular polysaccharide of...
Antigenic Evidence of Prevalence and Diversity of Mycobacterium tuberculosis Arabinomannan
Glatman-Freedman, Aharona, Casadevall, Arturo, Dai, Zongdong, Jacobs, William R., Li, Anping, Morris, Sheldon L., ...
Arabinomannan (AM) is a polysaccharide of the mycobacterial capsule. The capsular polysaccharides of various microorganisms are diverse, and this diversity is important for classification of...
Kubler-Kielb, Joanna, Coxon, Bruce, Schneerson, Rachel
Bacillus pumilus strain Sh18 cell wall polysaccharide (CWP), cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b, was purified and its chemical structure was elucidated...
Canh, Do Gia, Lin, Feng-ying (Kimi), Thiem, Vu Dinh, Trach, Dang Duc, Trong, Nguyen Dinh, Mao, Nguyen Duc, ...
In a double-blind, randomized, and placebo-controlled previous trial, the efficacy of Vi-rEPA for typhoid fever in 2- to 5-year-olds was 89.0% for 46 months. Vi-rEPA contained 25 μg of Vi and...
Jin, Zhigang, Bohach, Gregory A., Shiloach, Joseph, Norris, Scott E., Freedberg, Darón I., Deobald, Claudia, ...
Neisseria meningitidis groups A (GAM) and W135 capsular polysaccharides (CPs) were bound to recombinant Staphylococcus aureus enterotoxin C1 (rSEC). The CPs were activated with...
Kubler-Kielb, Joanna, Liu, Teh-Yung, Mocca, Christopher, Majadly, Fathy, Robbins, John B., Schneerson, Rachel
The capsule of Bacillus anthracis, composed of poly-γ-d-glutamic acid (γDPGA), is an essential virulence factor of B. anthracis. The capsule inhibits innate host defense through its antiphagocytic...
Kubler-Kielb, Joanna, Majadly, Fathy, Wu, Yimin, Narum, David L., Guo, Chunyan, Miller, Louis H., ...
Malaria is a leading cause of morbidity and mortality, estimated to cause >1 million childhood deaths annually. Plasmodium falciparum causes the most severe form of the disease. There is as yet no...
Chowers, Yehuda, Kirschner, Joachim, Keller, Nathan, Barshack, Iris, Bar-Meir, Simon, Ashkenazi, Shai, ...
The O-specific polysaccharide (O-SP) domain of Shigella LPS is both an essential virulence factor and a protective antigen for this genus. A critical level of serum IgG anti-O-SP was shown to confer...
Haemophilus influenzae Type a Infection and Its Prevention▿
Jin, Zhigang, Romero-Steiner, Sandra, Carlone, George M., Robbins, John B., Schneerson, Rachel
Haemoglobin O in An Arab Family
Ramot, Bracha, Fisher, Sharon, Remez, Dina, Schneerson, Rachel, Kahane, D., Ager, J. A. M., ...
Pozsgay, Vince, Kubler-Kielb, Joanna, Schneerson, Rachel, Robbins, John B.
Endemic and epidemic shigellosis, an acute invasive disease of the lower intestines, afflicts millions of people worldwide with an estimated one million fatalities per annum at a low infectious dose....
Kubler-Kielb, Joanna, Vinogradov, Evgeny, Hu, Haijing, Leppla, Stephen H., Robbins, John B., Schneerson, Rachel
Bacillus anthracis is a spore-forming bacterium that causes anthrax in humans and in other mammals. The glycoprotein BclA (Bacillus collagen-like protein of anthracis) is a major constituent of the...
Robbins, John B., Schneerson, Rachel, Gotschlich, Emil C., Mohammed, Idris, Nasidi, Abdulsalami, Chippaux, Jean-Philippe, ...
Endemic and epidemic group A meningococcal meningitis remains a major cause of morbidity and mortality in sub-Saharan Africa, despite the availability of the safe and inexpensive group A...
Robbins, John B., Kubler-Kielb, Joanna, Vinogradov, Evguenii, Mocca, Christopher, Pozsgay, Vince, Shiloach, Joseph, ...
Shigellosis, an enteric disease, is on the World Health Organization's priority prevention list. In one study, the Shigella sonnei O-specific polysaccharide (O-SP)-protein conjugate showed 72%...