Radu Dobrin

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease (2009)

Dobrin, Radu, Zhu, Jun, Molony, Cliona, Argman, Carmen, Parrish, Mark L, Carlson, Sonia, ...

Abstract Background Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus and several...

Maximizing the Fault Tolerance Capability of Fixed Priority Schedules ∗ (2009)

Radu Dobrin, Hüseyin Aysan, Sasikumar Punnekkat

Real-time systems typically have to satisfy complex requirements, mapped to the task attributes, eventually guaranteed by the underlying scheduler. These systems consist of a mix of hard and soft...

Additional files for “Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease” (2009)

Dobrin, Radu, Zhu, Jun, Molony, Cliona, Argman, Carmen, Parrish, Mark L, Carlson, Sonia, ...

Figure S1 shows the connectivity distribution P(k) for GGC networks. Figure S2 shows FDR curves for each tissue in the analysis. Figure S3 shows modules in single tissue GGC networks as detected by...

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease (2009)

Dobrin, Radu, Zhu, Jun, Molony, Cliona, Argman, Carmen, Parish, Mark L, Carlson, Sonia, ...

Background: Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus and several metabolic...

Common body mass index-associated variants confer risk of extreme obesity (2009)

Cotsapas, Chris, Speliotes, Elizabeth K., Hatoum, Ida J., Greenawalt, Danielle M., Dobrin, Radu, Lum, Pek Y., ...

To investigate the genetic architecture of severe obesity, we performed a genome-wide association study of 775 cases and 3197 unascertained controls at ∼550 000 markers across the autosomal genome....

HANDLING NON-PERIODIC EVENTS TOGETHER WITH COMPLEX CONSTRAINED TASKS IN DISTRIBUTED REAL-TIME SYSTEMS (2008)

Radu Dobrin, Gerhard Fohler

Abstract: In this paper we show how off-line scheduling and fixed priority scheduling (FPS) can be combined to get the advantages of both- the capability to cope with complex timing constraints while...

FT-Feasibility in Fixed Priority Real-Time Scheduling (2008)

Hüseyin Aysan, Radu Dobrin, Sasikumar Punnekkat

Real-time systems typically have to satisfy complex requirements mapped to the timing attributes of the tasks that are eventually guaranteed by the underlying scheduler. These systems consist of a...

Attribute Assignment for the Integration of Off-line and Fixed Priority Scheduling (2007)

Radu Dobrin, Gerhard Fohler

In this paper we present work to combine fixed priority scheduling with off-line schedule construction.It assumes a schedule has been constructed off-line for a set of tasks to meet their complex...

Reducing the Number of Preemptions in Standard Fixed Priority Scheduling (2007)

Radu Dobrin, Gerhard Fohler

Preemptive xed priority scheduling (FPS) has been widely studied and used in a number of industrial applications, mostly due to its exibility and simple runtime mechanism. However, preemption related...

Implementing Off-Line Message Scheduling (2007)

Radu Dobrin, Gerhard Fohler

Abstract- Controller Area Network (CAN) is widely used in a number of industrial applications. The message scheduling on CAN is based on identifiers (ID) assigned to the messages according to their...

Reducing the Number of Preemptions in Fixed Priority Scheduling (2007)

Radu Dobrin, Gerhard Fohler

Fixed priority scheduling (FPS) has been widely studied and used in a number of applications, mostly due to its flexibility, simple run-time mechanism and small overhead. However, preemption related...

No.18 Combining Off-line Schedule Construction and Fixed Priority Scheduling in Real-Time Computer Systems (2005)

Radu Dobrin

Off-line scheduling and fixed priority scheduling (FPS) are often considered as complementing and incompatible paradigms. A number of industrial applications demand temporal properties...

Aggregation of topological motifs in the Escherichia colitranscriptional regulatory network (2004)

Dobrin, Radu, Beg, Qasim, Barabási, Albert-László, Oltvai, Zoltán

Abstract Background Transcriptional regulation of cellular functions is carried out through a complex network of interactions among transcription factors and the promoter regions of genes and operons...

BMC Bioinformatics BioMed Central Research article Aggregation of topological motifs in the Escherichia coli transcriptional regulatory network (2004)

Radu Dobrin, Qasim K Beg, Albert-lászló Barabási, Zoltán N Oltvai, Zoltán N Oltvai

Background: Transcriptional regulation of cellular functions is carried out through a complex network of interactions among transcription factors and the promoter regions of genes and operons...

Attaining flexible real-time systems by bringing together component technologies and real-time systems theory (2003)

Johan Fredriksson, Kristian S, Radu Dobrin

In this paper we propose a component model and run-time mechanisms, gathering benefits provided by both Real Time Systems (RTS) and Component Based Software Engineering (CBSE). In particular, we show...

No.11 Transformation Methods for Off-line Schedules to Attributes for Fixed Priority Scheduling (2003)

Radu Dobrin

Off-line scheduling and fixed priority scheduling (FPS) are often considered as complementing and incompatible paradigms. A number of industrial applications demand temporal properties...

Trees, paths and avalanches on random networks [microform] / (2002)

Dobrin, Radu.

Thesis (Ph. D.)--Michigan State University. Dept. of Physics and Astronomy, 2002.

Trees, paths and avalanches on random networks / (2002)

Dobrin, Radu.

Thesis (Ph. D.)--Michigan State University. Dept. of Physics and Astronomy, 2002.

Translating off-line schedules into task attributes for fixed priority scheduling (2001)

Radu Dobrin, Gerhard Fohler, Peter Puschner

Off-line scheduling and fixed priority scheduling (FPS) are often considered as complementing and incompatible paradigms. A number of industrial applications demand temporal properties...

Task Attribute Assignment of Fixed Priority Scheduled Tasks to Reenact Off-Line Schedules (2000)

Radu Dobrin, Yusuf Zdemir, Gerhard Fohler

A number of industrial applications advocate the use of time triggered approaches for reasons of predictability, distribution, and particular constraints such as jitter or end-to-end deadlines. The...

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease

Dobrin, Radu, Zhu, Jun, Molony, Cliona, Argman, Carmen, Parrish, Mark L, Carlson, Sonia, ...

Tissue-to-tissue coexpression networks between genes in hypothalamus, liver or adipose tissue enable identification of obesity-specific genes.