Anson, R. Michael, Guo, Zhihong, De Cabo, Rafael, Iyun, Titilola, Rios, Michelle, Hagepanos, Adrienne, ...
Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains...
Anson, R. Michael, Guo, Zhihong, De Cabo, Rafael, Iyun, Titilola, Rios, Michelle, Hagepanos, Adrienne, ...
Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains...
Hyun, Dong-Hoon, Emerson, Scott S., Jo, Dong-Gyu, Mattson, Mark P., De Cabo, Rafael
The plasma membrane (PM) contains redox enzymes that provide electrons for energy metabolism and recycling of antioxidants such as coenzyme Q and α-tocopherol. Brain aging and neurodegenerative...
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Firestein, Ron, Blander, Gil, Michan, Shaday, Oberdoerffer, Philipp, Ogino, Shuji, Campbell, Jennifer, ...
Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from...
Martin, Bronwen, Pearson, Michele, Brenneman, Randall, Golden, Erin, Keselman, Alex, Iyun, Titilola, ...
The level of dietary energy intake influences metabolism, reproductive function, the development of age-related diseases, and even cognitive behavior. Because males and females typically play...
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
Pearson, Kevin J., Lewis, Kaitlyn N., Price, Nathan L., Chang, Joy W., Perez, Evelyn, Cascajo, Maria Victoria, ...
Caloric restriction (CR) is the most potent intervention known to both protect against carcinogenesis and extend lifespan in laboratory animals. A variety of anticarcinogens and CR mimetics induce...
Allard, Joanne S., Heilbronn, Leonie K., Smith, Carolina, Hunt, Nicole D., Ingram, Donald K., Ravussin, Eric, ...
Calorie restriction (CR) produces several health benefits and increases lifespan in many species. Studies suggest that alternate-day fasting (ADF) and exercise can also provide these benefits....