How Does Cross-Reactive Stimulation Affect the Longevity of CD8þ T Cell Memory? (2009)
Vitaly V. Ganusov, Sergei S. Pilyugin, Rafi Ahmed, Rustom Antia
Immunological memory—the ability to ‘‘remember’ ’ previously encountered pathogens and respond faster upon reexposure is a central feature of the immune response in vertebrates. The...
Correction: How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory? (2006)
Vitaly V. Ganusov, Sergei S. Pilyugin, Rafi Ahmed, Rustom Antia
How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory? (2006)
Vitaly V. Ganusov, Sergei S. Pilyugin, Rafi Ahmed, Rustom Antia
Immunological memory—the ability to “remember” previously encountered pathogens and respond faster upon re-exposure is a central feature of the immune response in vertebrates. The...
How does cross-reactive stimulation affect the longevity of CD8+ T cell memory? (2006)
Vitaly V. Ganusov, Sergei Pilyugin, Rafi Ahmed, Rustom Antia
Immunological memory --- the ability to ``remember' previously encountered pathogens and respond faster upon re-exposure is a central feature of the immune response in vertebrates. The cross-reactive...
Enhanced Expression of Cell Cycle Regulatory Genes in Virus-Specific (2004)
Memory Cd, T Cells, Donald R. Latner, Susan M. Kaech, Rafi Ahmed
Unlike naive CD8 � T cells, antigen-experienced memory CD8 � T cells persist over time due to their unique ability to homeostatically proliferate. It was hypothesized that memory cells might...
Murali-Krishna, Kaja, Ahmed, Rafi
Dengue virus infection in the central nervous system (CNS) of immunized mice results in a strong influx of CD8 T cells into the brain. Whereas the kinetics of the splenic antiviral response are...
Mihaela Oprea, Rustom Antia, Kaja Murali-krishna, Rafi Ahmed, Alan S. Perelson
The specific CD8 � T-cell response during acute lymphocytic choriomeningitis virus (LCMV) infection of mice is characterized by a rapid proliferation phase, followed by a rapid death phase and...
Van Der Most, Robbert G., Murali-Krishna, Kaja, Ahmed, Rafi, Strauss, James H.
We have constructed a chimeric yellow fever/dengue (YF/DEN) virus, which expresses the premembrane (prM) and envelope (E) genes from DEN type 2 (DEN-2) virus in a YF virus (YFV-17D) genetic...
Standardization of the thermal stability test used in diesel fuel testing /--by Rafi Ahmed. (1994)
Typescript (photocopy).
Automatic Importation of Relational Schemas in Pegasus (1993)
Joseph Albert Rafi, Joseph Albert, Rafi Ahmed, Mohammed Ketabchi, William Kent, Ming-chien Shan
This paper describes a technique for importing automatically an external relational schema into Pegasus, a heterogeneous, multidatabase system. The Pegasus data model is a functional object model...
Object identification in multidatabase systems (1993)
William Kent, Rafi Ahmed, Joseph Albert, Mohammad Ketabchi, Ming-chien Shan
In the Pegasus prototype multidatabase system, the key to the problem of object identity is a differentiation between the view of a data administrator, capturing all the underlying discrepancies and...
Object Identification in Multidatabase Systems (1992)
William Kent, Rafi Ahmed, Joseph Albert, Mohammad Ketabchi, Ming-Chien Shan
this paper is unrelated to their usage in deductive database theory
Molecular basis of organ-specific selection of viral variants during chronic infection (1991)
Ahmed, Rafi, Hahn, Chang S., Somasundaram, T., Villarete, Lorelie, Matloubian, Mehrdad, Strauss, James H.
Viral variants of different phenotypes are present in the central nervous system (CNS) and lymphoid tissues of carrier mice infected at birth with the Armstrong strain of lymphocytic choriomeningitis...
Finite amplitude wave phenomena in two-phase flow : transition to slug flow / (1983)
Thesis (M.S.)--University of California, Santa Barbara, 1983.
The lactose system in Thermus sp. T2. (1974)
Thesis (M.S.)--Idaho State University, 1974.
Antia, Rustom, Pilyugin, Sergei S., Ahmed, Rafi
There has been much debate on the contribution of processes such as the persistence of antigens, cross-reactive stimulation, homeostasis, competition between different lineages of lymphocytes, and...
Czar, Michael J., Kersh, Ellen N., Mijares, Lilia A., Lanier, Gibson, Lewis, Jennifer, Yap, George, ...
We have introduced a targeted mutation in SH2D1A/DSHP/SAP, the gene responsible for the human genetic disorder X-linked lymphoproliferative disease (XLP). SLAM-associated protein (SAP)-deficient mice...
A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection
Matloubian, Mehrdad, Suresh, M., Glass, Alison, Galvan, Marisa, Chow, Kit, Whitmire, Jason K., ...
Cytotoxic T cells secrete perforin to kill virus-infected cells. In this study we show that perforin also plays a role in immune regulation. Perforin-deficient (perf −/−) mice chronically...
Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection
Whitmire, Jason K., Asano, Mary S., Murali-Krishna, Kaja, Suresh, M., Ahmed, Rafi
CD4 T cells play a central role in viral immunity. They provide help for B cells and CD8 T cells and can act as effectors themselves. Despite their importance, relatively little is known about the...
Van Der Most, Robbert G., Murali-Krishna, Kaja, Ahmed, Rafi, Strauss, James H.
We have constructed a chimeric yellow fever/dengue (YF/DEN) virus, which expresses the premembrane (prM) and envelope (E) genes from DEN type 2 (DEN-2) virus in a YF virus (YFV-17D) genetic...
Gupta, Manisha, Mahanty, Siddhartha, Bray, Mike, Ahmed, Rafi, Rollin, Pierre E.
Ebola hemorrhagic fever is a severe, usually fatal illness caused by Ebola virus, a member of the filovirus family. The use of nonhomologous immune serum in animal studies and blood from survivors in...
De Boer, Rob J., Oprea, Mihaela, Antia, Rustom, Murali-Krishna, Kaja, Ahmed, Rafi, Perelson, Alan S.
The specific CD8+ T-cell response during acute lymphocytic choriomeningitis virus (LCMV) infection of mice is characterized by a rapid proliferation phase, followed by a rapid death phase and...
Puglielli, Maryann T., Zajac, Allan J., Van Der Most, Robbert G., Dzuris, John L., Sette, Alessandro, Altman, John D., ...
CD8 T cells drive the protective immune response to lymphocytic choriomeningitis virus (LCMV) infection and are thus a determining force in the selection of viral variants. To examine how escape...
Cytotoxic T-Lymphocyte Epitopes Fused to Anthrax Toxin Induce Protective Antiviral Immunity
Doling, Amy M., Ballard, Jimmy D., Shen, Hao, Krishna, Kaja Murali, Ahmed, Rafi, Collier, R. John, ...
We have investigated the use of the protective antigen (PA) and lethal factor (LF) components of anthrax toxin as a system for in vivo delivery of cytotoxic T-lymphocyte (CTL) epitopes. During...
Harrington, Laurie E., Most, Robbert Van Der, Whitton, J. Lindsay, Ahmed, Rafi
Recombinant vaccinia viruses (rVV) have been extensively used as vaccines, but there is little information about the total magnitude of the VV-specific T-cell response and how this compares to the...
Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection
Suresh, M., Lanier, Gibson, Large, Mary Katherine, Whitmire, Jason K., Altman, John D., Ruddle, Nancy H., ...
The importance of lymphotoxin α (LTα) in lymphoid organogenesis is well established. Although LTα has been implicated in the pathogenesis of T-cell-mediated immunopathologies, the requirement for...
Villinger, Francois, Mayne, Ann E., Bostik, Pavel, Mori, Kazuyasu, Jensen, Peter E., Ahmed, Rafi, ...
By using the dominant simian immunodeficiency virus (SIV) Gag Mamu-A01 restricted major histocompatibility complex (MHC) class I epitope p11CM, we demonstrate antibody-mediated enhanced MHC class I...
Wherry, E. John, Blattman, Joseph N., Murali-Krishna, Kaja, Van Der Most, Robbert, Ahmed, Rafi
Chronic viral infections often result in ineffective CD8 T-cell responses due to functional exhaustion or physical deletion of virus-specific T cells. However, how persisting virus impacts various...
Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, Andrew B., Williams, Matthew A., Jones, Thomas R., Shirasugi, Nozomu, Durham, Megan M., Kaech, Susan M., ...
Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We...
Ahmed, Rafi, Chakraborty, P. R., Graham, A. F., Ramig, R. F., Fields, B. N.
Persistent reovirus infection of L cells was established with a serially passaged stock of temperature-sensitive (ts) mutant C(447) containing greater than 90% defective interfering particles. Within...
Persistent Infection with Ebola Virus under Conditions of Partial Immunity
Gupta, Manisha, Mahanty, Siddhartha, Greer, Patricia, Towner, Jonathan S., Shieh, Wun-Ju, Zaki, Sherif R., ...
Ebola hemorrhagic fever in humans is associated with high mortality; however, some infected hosts clear the virus and recover. The mechanisms by which this occurs and the correlates of protective...
Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus
Derjuga, Anna, Gourley, Tania S., Holm, Teresa M., Heng, Henry H. Q., Shivdasani, Ramesh A., Ahmed, Rafi, ...
Cap'n'collar (CNC) family basic leucine zipper transcription factors play crucial roles in the regulation of mammalian gene expression and development. To determine the in vivo function of the CNC...
Enhanced Expression of Cell Cycle Regulatory Genes in Virus-Specific Memory CD8+ T Cells
Latner, Donald R., Kaech, Susan M., Ahmed, Rafi
Unlike naive CD8+ T cells, antigen-experienced memory CD8+ T cells persist over time due to their unique ability to homeostatically proliferate. It was hypothesized that memory cells might...
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
Wherry, E. John, Barber, Daniel L., Kaech, Susan M., Blattman, Joseph N., Ahmed, Rafi
Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting...
Kitchen, Scott G., Whitmire, Jason K., Jones, Nicole R., Galic, Zoran, Kitchen, Christina M. R., Ahmed, Rafi, ...
CD8+ T lymphocytes play a major role in cellular-mediated immune responses to foreign antigen. We have previously demonstrated that costimulation of purified human CD8+ T cells induces de novo...
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes
Manders, Peter M., Hunter, Patricia J., Telaranta, Aino I., Carr, James M., Marshall, Jennifer L., Carrasco, Marlene, ...
A characteristic of the secondary response of CD8+ T cells that distinguishes it from the primary response is the generation of greater numbers of effector cells. Because effector CD8+ T cells are...
Li, Zhu-Nan, Mueller, Scott N., Ye, Ling, Bu, Zhigao, Yang, Chinglai, Ahmed, Rafi, ...
Large polypeptides of the Bacillus anthracis protective antigen (PA) were inserted into an influenza A virus hemagglutinin glycoprotein (HA), and the chimeric proteins were functionally characterized...
Wherry, E. John, Blattman, Joseph N., Ahmed, Rafi
Therapeutic vaccination has the potential to boost immune responses and enhance viral control during chronic infections. However, many therapeutic vaccination approaches have fallen short of...
How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?
Ganusov, Vitaly V, Pilyugin, Sergei S, Ahmed, Rafi, Antia, Rustom
Immunological memory—the ability to “remember” previously encountered pathogens and respond faster upon re-exposure is a central feature of the immune response in vertebrates. The...
Correction: How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?
Ganusov, Vitaly V, Pilyugin, Sergei S, Ahmed, Rafi, Antia, Rustom
Antia, Rustom, Pilyugin, Sergei S., Ahmed, Rafi
There has been much debate on the contribution of processes such as the persistence of antigens, cross-reactive stimulation, homeostasis, competition between different lineages of lymphocytes, and...
Czar, Michael J., Kersh, Ellen N., Mijares, Lilia A., Lanier, Gibson, Lewis, Jennifer, Yap, George, ...
We have introduced a targeted mutation in SH2D1A/DSHP/SAP, the gene responsible for the human genetic disorder X-linked lymphoproliferative disease (XLP). SLAM-associated protein (SAP)-deficient mice...
A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection
Matloubian, Mehrdad, Suresh, M., Glass, Alison, Galvan, Marisa, Chow, Kit, Whitmire, Jason K., ...
Cytotoxic T cells secrete perforin to kill virus-infected cells. In this study we show that perforin also plays a role in immune regulation. Perforin-deficient (perf −/−) mice chronically...
Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection
Whitmire, Jason K., Asano, Mary S., Murali-Krishna, Kaja, Suresh, M., Ahmed, Rafi
CD4 T cells play a central role in viral immunity. They provide help for B cells and CD8 T cells and can act as effectors themselves. Despite their importance, relatively little is known about the...
Van Der Most, Robbert G., Murali-Krishna, Kaja, Ahmed, Rafi, Strauss, James H.
We have constructed a chimeric yellow fever/dengue (YF/DEN) virus, which expresses the premembrane (prM) and envelope (E) genes from DEN type 2 (DEN-2) virus in a YF virus (YFV-17D) genetic...
Gupta, Manisha, Mahanty, Siddhartha, Bray, Mike, Ahmed, Rafi, Rollin, Pierre E.
Ebola hemorrhagic fever is a severe, usually fatal illness caused by Ebola virus, a member of the filovirus family. The use of nonhomologous immune serum in animal studies and blood from survivors in...
De Boer, Rob J., Oprea, Mihaela, Antia, Rustom, Murali-Krishna, Kaja, Ahmed, Rafi, Perelson, Alan S.
The specific CD8+ T-cell response during acute lymphocytic choriomeningitis virus (LCMV) infection of mice is characterized by a rapid proliferation phase, followed by a rapid death phase and...
Puglielli, Maryann T., Zajac, Allan J., Van Der Most, Robbert G., Dzuris, John L., Sette, Alessandro, Altman, John D., ...
CD8 T cells drive the protective immune response to lymphocytic choriomeningitis virus (LCMV) infection and are thus a determining force in the selection of viral variants. To examine how escape...
Cytotoxic T-Lymphocyte Epitopes Fused to Anthrax Toxin Induce Protective Antiviral Immunity
Doling, Amy M., Ballard, Jimmy D., Shen, Hao, Krishna, Kaja Murali, Ahmed, Rafi, Collier, R. John, ...
We have investigated the use of the protective antigen (PA) and lethal factor (LF) components of anthrax toxin as a system for in vivo delivery of cytotoxic T-lymphocyte (CTL) epitopes. During...
Harrington, Laurie E., Most, Robbert Van Der, Whitton, J. Lindsay, Ahmed, Rafi
Recombinant vaccinia viruses (rVV) have been extensively used as vaccines, but there is little information about the total magnitude of the VV-specific T-cell response and how this compares to the...
Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection
Suresh, M., Lanier, Gibson, Large, Mary Katherine, Whitmire, Jason K., Altman, John D., Ruddle, Nancy H., ...
The importance of lymphotoxin α (LTα) in lymphoid organogenesis is well established. Although LTα has been implicated in the pathogenesis of T-cell-mediated immunopathologies, the requirement for...
Villinger, Francois, Mayne, Ann E., Bostik, Pavel, Mori, Kazuyasu, Jensen, Peter E., Ahmed, Rafi, ...
By using the dominant simian immunodeficiency virus (SIV) Gag Mamu-A01 restricted major histocompatibility complex (MHC) class I epitope p11CM, we demonstrate antibody-mediated enhanced MHC class I...
Wherry, E. John, Blattman, Joseph N., Murali-Krishna, Kaja, Van Der Most, Robbert, Ahmed, Rafi
Chronic viral infections often result in ineffective CD8 T-cell responses due to functional exhaustion or physical deletion of virus-specific T cells. However, how persisting virus impacts various...
Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, Andrew B., Williams, Matthew A., Jones, Thomas R., Shirasugi, Nozomu, Durham, Megan M., Kaech, Susan M., ...
Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We...
Ahmed, Rafi, Chakraborty, P. R., Graham, A. F., Ramig, R. F., Fields, B. N.
Persistent reovirus infection of L cells was established with a serially passaged stock of temperature-sensitive (ts) mutant C(447) containing greater than 90% defective interfering particles. Within...
Persistent Infection with Ebola Virus under Conditions of Partial Immunity
Gupta, Manisha, Mahanty, Siddhartha, Greer, Patricia, Towner, Jonathan S., Shieh, Wun-Ju, Zaki, Sherif R., ...
Ebola hemorrhagic fever in humans is associated with high mortality; however, some infected hosts clear the virus and recover. The mechanisms by which this occurs and the correlates of protective...
Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus
Derjuga, Anna, Gourley, Tania S., Holm, Teresa M., Heng, Henry H. Q., Shivdasani, Ramesh A., Ahmed, Rafi, ...
Cap'n'collar (CNC) family basic leucine zipper transcription factors play crucial roles in the regulation of mammalian gene expression and development. To determine the in vivo function of the CNC...
Enhanced Expression of Cell Cycle Regulatory Genes in Virus-Specific Memory CD8+ T Cells
Latner, Donald R., Kaech, Susan M., Ahmed, Rafi
Unlike naive CD8+ T cells, antigen-experienced memory CD8+ T cells persist over time due to their unique ability to homeostatically proliferate. It was hypothesized that memory cells might...
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
Wherry, E. John, Barber, Daniel L., Kaech, Susan M., Blattman, Joseph N., Ahmed, Rafi
Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting...
Kitchen, Scott G., Whitmire, Jason K., Jones, Nicole R., Galic, Zoran, Kitchen, Christina M. R., Ahmed, Rafi, ...
CD8+ T lymphocytes play a major role in cellular-mediated immune responses to foreign antigen. We have previously demonstrated that costimulation of purified human CD8+ T cells induces de novo...
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes
Manders, Peter M., Hunter, Patricia J., Telaranta, Aino I., Carr, James M., Marshall, Jennifer L., Carrasco, Marlene, ...
A characteristic of the secondary response of CD8+ T cells that distinguishes it from the primary response is the generation of greater numbers of effector cells. Because effector CD8+ T cells are...
Wherry, E. John, Blattman, Joseph N., Ahmed, Rafi
Therapeutic vaccination has the potential to boost immune responses and enhance viral control during chronic infections. However, many therapeutic vaccination approaches have fallen short of...
Li, Zhu-Nan, Mueller, Scott N., Ye, Ling, Bu, Zhigao, Yang, Chinglai, Ahmed, Rafi, ...
Large polypeptides of the Bacillus anthracis protective antigen (PA) were inserted into an influenza A virus hemagglutinin glycoprotein (HA), and the chimeric proteins were functionally characterized...
How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?
Ganusov, Vitaly V, Pilyugin, Sergei S, Ahmed, Rafi, Antia, Rustom
Immunological memory—the ability to “remember” previously encountered pathogens and respond faster upon re-exposure is a central feature of the immune response in vertebrates. The...
Correction: How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?
Ganusov, Vitaly V, Pilyugin, Sergei S, Ahmed, Rafi, Antia, Rustom
Masopust, David, Murali-Krishna, Kaja, Ahmed, Rafi
Measuring the magnitudes and specificities of antiviral CD8 T-cell responses is critical for understanding the dynamics and regulation of adaptive immunity. Despite many excellent studies, the...
Radziewicz, Henry, Ibegbu, Chris C., Fernandez, Marina L., Workowski, Kimberly A., Obideen, Kamil, Wehbi, Mohammad, ...
The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearance. Evidence from murine chronic viral infections shows that...
Estimation of the rate of killing by cytotoxic T lymphocytes in vivo
Regoes, Roland R., Barber, Daniel L., Ahmed, Rafi, Antia, Rustom
Cytotoxic T lymphocytes (CTL) help control virus infections by killing virus-infected (target) cells. How fast do CTL find and kill target cells in vivo? Experiments allow us to follow populations of...
Laughlin, Elsa M., Miller, Joseph D., James, Eddie, Fillos, Dimitri, Ibegbu, Chris C., Mittler, Robert S., ...
Detection of antigen-specific CD4+ T cells is facilitated by the use of fluorescently labeled soluble peptide-major histocompatibility complex (MHC) multimers which mirror the antigen specificity of...
Velu, Vijayakumar, Kannanganat, Sunil, Ibegbu, Chris, Chennareddi, Lakshmi, Villinger, Francois, Freeman, Gordon J., ...
Here, we study the temporal expression of the inhibitory receptor programmed death 1 (PD-1) on simian immunodeficiency virus (SIV) Gag-specific T cells following pathogenic SIV infection or following...
Zhang, Benyue, Maris, Charles H., Foell, Juergen, Whitmire, Jason, Niu, Liguo, Song, Jing, ...
CD137 is expressed on activated T cells and ligands to this costimulatory molecule have clinical potential for amplifying CD8 T cell immunity to tumors and viruses, while suppressing CD4 autoimmune T...
Revisiting Estimates of CTL Killing Rates In Vivo
Yates, Andrew, Graw, Frederik, Barber, Daniel L., Ahmed, Rafi, Regoes, Roland R., Antia, Rustom
Recent experimental advances have allowed the estimation of the in vivo rates of killing of infected target cells by cytotoxic T lymphocytes (CTL). We present several refinements to a method applied...
Laughlin, Elsa M., Miller, Joseph D., James, Eddie, Fillos, Dimitri, Ibegbu, Chris C., Mittler, Robert S., ...
Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade
Freeman, Gordon J., Wherry, E. John, Ahmed, Rafi, Sharpe, Arlene H.
The programmed death (PD)-1–PD-1 ligand (PD-L) pathway, which is part of the B7–CD28 family, consists of the PD-1 receptor and its two ligands PD-L1 and PD-L2. Engagement of PD-1 by its ligands...
Vezys, Vaiva, Masopust, David, Kemball, Christopher C., Barber, Daniel L., O'Mara, Leigh A., Larsen, Christian P., ...
Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T cell activation. Pathogen-specific T cells in chronically infected hosts are often phenotypically and...
Querec, Troy, Bennouna, Soumaya, Alkan, Sefik, Laouar, Yasmina, Gorden, Keith, Flavell, Richard, ...
The live attenuated yellow fever vaccine 17D (YF-17D) is one of the most effective vaccines available, with a 65-yr history of use in >400 million people globally. Despite this efficacy, there is...
Karem, Kevin L., Reynolds, Mary, Hughes, Christine, Braden, Zach, Nigam, Pragati, Crotty, Shane, ...
Following the U.S. monkeypox outbreak of 2003, blood specimens and clinical and epidemiologic data were collected from cases, defined by standard definition, and household contacts of cases to...
Mueller, Scott N., Matloubian, Mehrdad, Clemens, Daniel M., Sharpe, Arlene H., Freeman, Gordon J., Gangappa, Shivaprakash, ...
Many chronic viral infections are marked by pathogen persistence and a generalized immunosuppression. The exact mechanisms by which this occurs are still unknown. Using a mouse model of persistent...
Genetic studies of persistent reovirus infection in L cells /
Thesis (Ph. D.)--Harvard University, 1981.
Cousens, Leslie P., Peterson, Ron, Hsu, Sang, Dorner, Andrew, Altman, John D., Ahmed, Rafi, ...
Viral infections induce CD8 T cell expansion and interferon (IFN)-γ production for defense, but the innate cytokines shaping these responses have not been identified. Although interleukin (IL)-12...
Harrington, Laurie E., Galvan, Marisa, Baum, Linda G., Altman, John D., Ahmed, Rafi
Currently there are few reliable cell surface markers that can clearly discriminate effector from memory T cells. To determine if there are changes in O-glycosylation between these two cell types, we...
Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells
Becker, Todd C., Wherry, E. John, Boone, David, Murali-Krishna, Kaja, Antia, Rustom, Ma, Averil, ...
The generation and efficient maintenance of antigen-specific memory T cells is essential for long-lasting immunological protection. In this study, we examined the role of interleukin (IL)-15 in the...
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, Allan J., Blattman, Joseph N., Murali-Krishna, Kaja, Sourdive, David J.D., Suresh, M., Altman, John D., ...
We examined the regulation of virus-specific CD8 T cell responses during chronic lymphocytic choriomeningitis virus (LCMV) infection of mice. Our study shows that within the same persistently...
Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells
Blattman, Joseph N., Antia, Rustom, Sourdive, David J.D., Wang, Xiaochi, Kaech, Susan M., Murali-Krishna, Kaja, ...
The constraint of fitting a diverse repertoire of antigen specificities in a limited total population of lymphocytes results in the frequency of naive cells specific for any given antigen (defined as...
Sourdive, David J.D., Murali-Krishna, Kaja, Altman, John D., Zajac, Allan J., Whitmire, Jason K., Pannetier, Christophe, ...
Viral infections often induce potent CD8 T cell responses that play a key role in antiviral immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo apoptosis, leaving...
Ha, Sang-Jun, Mueller, Scott N., Wherry, E. John, Barber, Daniel L., Aubert, Rachael D., Sharpe, Arlene H., ...
Therapeutic vaccination is a potentially promising strategy to enhance T cell immunity and viral control in chronically infected individuals. However, therapeutic vaccination approaches have fallen...
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates
Sarkar, Surojit, Kalia, Vandana, Haining, W. Nicholas, Konieczny, Bogumila T., Subramaniam, Shruti, Ahmed, Rafi
An important question in memory development is understanding the differences between effector CD8 T cells that die versus effector cells that survive and give rise to memory cells. In this study, we...
Doria-Rose, Nicole A., Klein, Rachel M., Manion, Maura M., O'Dell, Sijy, Phogat, Adhuna, Chakrabarti, Bimal, ...
Induction of broadly cross-reactive neutralizing antibodies (NAb) is an important goal for a prophylactic human immunodeficiency virus type 1 (HIV-1) vaccine. Some HIV-infected patients make a NAb...
Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection▿
Blattman, Joseph N., Wherry, E. John, Ha, Sang-Jun, Van Der Most, Robbert G., Ahmed, Rafi
During some persistent viral infections, virus-specific T-cell responses wane due to the antigen-specific deletion or functional inactivation (i.e., exhaustion) of responding CD8 T cells. T-cell...