Rainer Saffrich

The Many Facets of SDF-1α, CXCR4 Agonists and Antagonists on Hematopoietic Progenitor Cells (2007)

Anne Faber, Christoph Roderburg, Frederik Wein, Rainer Saffrich, Anja Seckinger, Kerstin Horsch, ...

Stromal cell-derived factor-1alpha (SDF-1α) has pleiotropic effects on hematopoietic progenitor cells (HPCs). We have monitored podia formation, migration, proliferation, and cell-cell...

The Many Facets of SDF-1α, CXCR4 Agonists and Antagonists on Hematopoietic Progenitor Cells (2007)

Anne Faber, Christoph Roderburg, Frederik Wein, Rainer Saffrich, Anja Seckinger, Kerstin Horsch, ...

Stromal cell-derived factor-1alpha (SDF-1α) has pleiotropic effects on hematopoietic progenitor cells (HPCs). We have monitored podia formation, migration, proliferation, and cell-cell adhesion of...

MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation (2006)

Yang, Ying, Marcello, Marco, Endris, Volker, Saffrich, Rainer, Fischer, Roger, Trendelenburg, Michael, ...

Over the past several years, it has become clear that the Rho family of GTPases plays an important role in various aspects of neuronal development including cytoskeleton dynamics and cell adhesion...

Complex Functions of AP-1 Transcription Factors in Differentiation and Survival of PC12 Cells

Leppä, Sirpa, Eriksson, Minna, Saffrich, Rainer, Ansorge, Wilhelm, Bohmann, Dirk

c-Jun activation by mitogen-activated protein kinases has been implicated in various cellular signal responses. We investigated how JNK and c-Jun contribute to neuronal differentiation, cell...

The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription

Westermarck, Jukka, Weiss, Carsten, Saffrich, Rainer, Kast, Jürgen, Musti, Anna-Maria, Wessely, Matthias, ...

Tandem affinity purification (TAP) and mass spectrometric peptide sequencing showed that the DEAD-box RNA helicase RHII/Gu is a functional interaction partner of c-Jun in human cells. The N-terminal...

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

Bohnsack, Markus T., Regener, Kathrin, Schwappach, Blanche, Saffrich, Rainer, Paraskeva, Efrosyni, Hartmann, Enno, ...

Importin β-type transport receptors mediate the vast majority of transport pathways between cell nucleus and cytoplasm. We identify here the translation elongation factor 1A (eEF1A) as the...

Induction of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

Beier, Rudolf, Bürgin, Andrea, Kiermaier, Astrid, Fero, Matthew, Karsunky, Holger, Saffrich, Rainer, ...

The c-myc gene has been implicated in three distinct genetic programs regulating cell proliferation: control of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth. We have...

Nuclear Export of the Nonenveloped Parvovirus Virion Is Directed by an Unordered Protein Signal Exposed on the Capsid Surface

Maroto, Beatriz, Valle, Noelia, Saffrich, Rainer, Almendral, José M.

It is uncertain whether nonenveloped karyophilic virus particles may actively traffic from the nucleus outward. The unordered amino-terminal domain of the VP2 major structural protein (2Nt) of the...

Complex Functions of AP-1 Transcription Factors in Differentiation and Survival of PC12 Cells

Leppä, Sirpa, Eriksson, Minna, Saffrich, Rainer, Ansorge, Wilhelm, Bohmann, Dirk

c-Jun activation by mitogen-activated protein kinases has been implicated in various cellular signal responses. We investigated how JNK and c-Jun contribute to neuronal differentiation, cell...

The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription

Westermarck, Jukka, Weiss, Carsten, Saffrich, Rainer, Kast, Jürgen, Musti, Anna-Maria, Wessely, Matthias, ...

Tandem affinity purification (TAP) and mass spectrometric peptide sequencing showed that the DEAD-box RNA helicase RHII/Gu is a functional interaction partner of c-Jun in human cells. The N-terminal...

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

Bohnsack, Markus T., Regener, Kathrin, Schwappach, Blanche, Saffrich, Rainer, Paraskeva, Efrosyni, Hartmann, Enno, ...

Importin β-type transport receptors mediate the vast majority of transport pathways between cell nucleus and cytoplasm. We identify here the translation elongation factor 1A (eEF1A) as the...

Induction of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

Beier, Rudolf, Bürgin, Andrea, Kiermaier, Astrid, Fero, Matthew, Karsunky, Holger, Saffrich, Rainer, ...

The c-myc gene has been implicated in three distinct genetic programs regulating cell proliferation: control of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth. We have...

Nuclear Export of the Nonenveloped Parvovirus Virion Is Directed by an Unordered Protein Signal Exposed on the Capsid Surface

Maroto, Beatriz, Valle, Noelia, Saffrich, Rainer, Almendral, José M.

It is uncertain whether nonenveloped karyophilic virus particles may actively traffic from the nucleus outward. The unordered amino-terminal domain of the VP2 major structural protein (2Nt) of the...

The Many Facets of SDF-1α, CXCR4 Agonists and Antagonists on Hematopoietic Progenitor Cells

Faber, Anne, Roderburg, Christoph, Wein, Frederik, Saffrich, Rainer, Seckinger, Anja, Horsch, Kerstin, ...

Stromal cell-derived factor-1alpha (SDF-1α) has pleiotropic effects on hematopoietic progenitor cells (HPCs). We have monitored podia formation, migration, proliferation, and cell-cell adhesion of...

Microinjection of Anti-coilin Antibodies Affects the Structure of Coiled Bodies

Almeida, Fátima, Saffrich, Rainer, Ansorge, Wilhelm, Carmo-Fonseca, Maria

The coiled body is a distinct subnuclear domain enriched in small nuclear ribonucleoprotein particles (snRNPs) involved in processing of pre-mRNA. Although the function of the coiled body is still...

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

Wagner, Wolfgang, Horn, Patrick, Castoldi, Mirco, Diehlmann, Anke, Bork, Simone, Saffrich, Rainer, ...

Mesenchymal stem cells (MSC) comprise a promising tool for cellular therapy. These cells are usually culture expanded prior to their application. However, a precise molecular definition of MSC and...