Rainer Wittig

Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides (2008)

Otto, Christoph, Kaemmerer, Ulrike, Illert, Bertram, Muehling, Bettina, Pfetzer, Nadja, Wittig, Rainer, ...

Abstract Background Among the most prominent metabolic alterations in cancer cells are the increase in glucose consumption and the conversion of glucose to lactic acid via the reduction of pyruvate...

DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease (2007)

Renner, Marcus, Bergmann, Gaby, Krebs, Inge, End, Caroline, Lyer, Stefan, Hilberg, Frank, ...

BACKGROUND & AIMS: Impaired mucosal defense plays an important role in the pathogenesis of Crohn's disease (CD), one of the main subtypes of inflammatory bowel disease (IBD). Deleted in malignant...

The Role of Glucose Metabolism and Glucose-Associated Signalling in Cancer (2007)

Rainer Wittig, Johannes F. Coy

Aggressive carcinomas ferment glucose to lactate even in the presence of oxygen. This particular metabolism, termed aerobic glycolysis, the glycolytic phenotype, or the Warburg effect, was discovered...

Thioredoxin, a regulator of gene expression (2004)

Kontou,Maria, Will,Rainer D., Adelfalk,Caroline, Wittig,Rainer, Poustka,Annemarie, Hirsch-Kauffmann,Monica, ...

Cancer cells have high levels of thioredoxin (Trx) and of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Cells from patients with the cancer-prone disease Fanconi anemia (FA) exhibit reduced Trx...

Thioredoxin, a regulator of gene expression (2004)

Kontou, Maria, Will, Rainer D., Adelfalk, Caroline, Wittig, Rainer, Poustka, Annemarie, Hirsch-Kauffmann, Monica, ...

Cancer cells have high levels of thioredoxin (Trx) and of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Cells from patients with the cancer-prone disease Fanconi anemia (FA) exhibit reduced Trx...

The Role of Glucose Metabolism and Glucose-Associated Signalling in Cancer

Wittig, Rainer, Coy, Johannes F.

Aggressive carcinomas ferment glucose to lactate even in the presence of oxygen. This particular metabolism, termed aerobic glycolysis, the glycolytic phenotype, or the Warburg effect, was discovered...