Lymphatic endothelial differentiation: start out with Sox - carry on with Prox (2008)
Kiefer, Friedemann, Adams, Ralf H
Abstract The transcription factor Prox1 is the master regulator of lymphatic endothelial cell differentiation and its expression initiates the morphogenesis of the lymphatic vasculature in the early...
Bixel, M. Gabriele, Adams, Ralf H.
Cell differentiation occurs mostly during a specific developmental time window and is irreversible. The homeobox-containing transcription factor Prox1 is a master regulator of lymphatic endothelial...
Regulation of vascular morphogenesis by Notch signaling (2007)
Roca, Cristina, Adams, Ralf H.
The Notch pathway is a versatile regulator of cell fate specification, growth, differentiation, and patterning processes in metazoan organisms. In the vertebrate cardiovascular system, multiple Notch...
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature (2005)
Mäkinen, Taija, Adams, Ralf H, Bailey, John, Lu, Qiang, Ziemiecki, Andrew, Alitalo, Kari, ...
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature (2005)
Mäkinen, Taija, Adams, Ralf H., Bailey, John, Lu, Qiang, Ziemiecki, Andrew, Alitalo, Kari, ...
The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of embryonic blood vascular morphogenesis. However, the molecular mechanisms required for...
Adams, Ralf H., Wilkinson, George A., Weiss, Cornelia, Diella, Francesca, Gale, Nicholas W., Deutsch, Urban, ...
Otto, Diana M. E., Henderson, Colin J., Carrie, Dianne, Davey, Megan, Gundersen, Thomas E., Blomhoff, Rune, ...
The cytochrome P450-dependent monooxygenase system catalyzes the metabolism of xenobiotics and endogenous compounds, including hormones and retinoic acid. In order to establish the role of these...
Adams, Ralf H., Wilkinson, George A., Weiss, Cornelia, Diella, Francesca, Gale, Nicholas W., Deutsch, Urban, ...
Eph receptor tyrosine kinases and their cell-surface-bound ligands, the ephrins, regulate axon guidance and bundling in the developing brain, control cell migration and adhesion, and help patterning...
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
Mäkinen, Taija, Adams, Ralf H., Bailey, John, Lu, Qiang, Ziemiecki, Andrew, Alitalo, Kari, ...
The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of embryonic blood vascular morphogenesis. However, the molecular mechanisms required for...
Molecular control of arterial–venous blood vessel identity
Recent research has demonstrated that not only haemodynamic factors but also genetic programmes control arterial–venous cell fate and blood vessel identity. The identification of arteries and veins...
Otto, Diana M. E., Henderson, Colin J., Carrie, Dianne, Davey, Megan, Gundersen, Thomas E., Blomhoff, Rune, ...
The cytochrome P450-dependent monooxygenase system catalyzes the metabolism of xenobiotics and endogenous compounds, including hormones and retinoic acid. In order to establish the role of these...
Adams, Ralf H., Wilkinson, George A., Weiss, Cornelia, Diella, Francesca, Gale, Nicholas W., Deutsch, Urban, ...
Eph receptor tyrosine kinases and their cell-surface-bound ligands, the ephrins, regulate axon guidance and bundling in the developing brain, control cell migration and adhesion, and help patterning...
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
Mäkinen, Taija, Adams, Ralf H., Bailey, John, Lu, Qiang, Ziemiecki, Andrew, Alitalo, Kari, ...
The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of embryonic blood vascular morphogenesis. However, the molecular mechanisms required for...
Mutations of the Ephrin-B1 Gene Cause Craniofrontonasal Syndrome
Wieland, Ilse, Jakubiczka, Sibylle, Muschke, Petra, Cohen, Monika, Thiele, Hannelore, Gerlach, Klaus L., ...
Craniofrontonasal syndrome (CFNS) is an X-linked craniofacial disorder with an unusual manifestation pattern, in which affected females show multiple skeletal malformations, whereas the genetic...
Molecular control of arterial–venous blood vessel identity
Recent research has demonstrated that not only haemodynamic factors but also genetic programmes control arterial–venous cell fate and blood vessel identity. The identification of arteries and veins...
ERK activation causes epilepsy by stimulating NMDA receptor activity
Nateri, Abdolrahman S, Raivich, Gennadij, Gebhardt, Christine, Da Costa, Clive, Naumann, Heike, Vreugdenhil, Martin, ...
The ERK MAPK signalling pathway is a highly conserved kinase cascade linking transmembrane receptors to downstream effector mechanisms. To investigate the function of ERK in neurons, a constitutively...
Lymphatic endothelial differentiation: start out with Sox - carry on with Prox
Kiefer, Friedemann, Adams, Ralf H
Lymphatic system development comes into sharper focus.