Ralf Ignatius

Aetiology of community-acquired, acute gastroenteritis in hospitalised adults: a prospective cohort study (2008)

Jansen, Andreas, Stark, Klaus, Kunkel, Jan, Schreier, Eckart, Ignatius, Ralf, Liesenfeld, Oliver, ...

Abstract Background The aetiology of severe gastroenteritis leading to hospitalisation in adults frequently remains unclear. Our objective was to study the causes and characteristics of...

Aetiology of community-acquired, acute gastroenteritis in hospitalised adults: a prospective cohort study (2008)

Jansen, Andreas, Stark, Klaus, Kunkel, Jan, Schreier, Eckart, Ignatius, Ralf, Liesenfeld, Oliver, ...

Background The aetiology of severe gastroenteritis leading to hospitalisation in adults frequently remains unclear. Our objective was to study the causes and characteristics of community-acquired,...

The uraemic toxin phenylacetic acid impairs macrophage function (2008)

Schmidt, Sven, Westhoff, Timm H., Krauser, Philipp, Ignatius, Ralf, Jankowski, Joachim, Jankowski, Vera, ...

Background. Nitric oxide (NO) is known to be an important mediator of macrophage cytotoxicity. NO in macrophages is generated via the inducible nitric oxide synthases (iNOS). Macrophage dysfunction...

High rate of resistance to locally used antibiotics among enteric bacteria from children in Northern Ghana (2008)

Djie-Maletz, Andrea, Reither, Klaus, Danour, Stephen, Anyidoho, Louis, Saad, Eiman, Danikuu, Francis, ...

Objectives Information on antimicrobial susceptibility of bacterial pathogens is scarce in resource-poor settings. We determined the susceptibility of bacterial enteric pathogens and faecal...

Sexually transmitted infections, bacterial vaginosis, and candidiasis in women of reproductive age in rural Northeast Brazil: a population-based study (2007)

Oliveira, Fabíola Araújo, Pfleger, Viola, Lang, Katrin, Heukelbach, Jörg, Miralles, Iracema, Fraga, Francisco, ...

Population-based data on sexually transmitted infections (STI), bacterial vaginosis (BV), and candidiasis reflect the epidemiological situation more accurately than studies performed in specific...

Acute childhood diarrhoea in northern Ghana: epidemiological, clinical and microbiological characteristics (2007)

Reither, Klaus, Ignatius, Ralf, Weitzel, Thomas, Seidu-Korkor, Andrew, Anyidoho, Louis, Saad, Eiman, ...

Abstract Background Acute diarrhoea is a major cause of childhood morbidity and mortality in sub-Saharan Africa. Its microbiological causes and clinico-epidemiological aspects were examined during...

Acute childhood diarrhoea in northern Ghana: epidemiological, clinical and microbiological characteristics (2007)

Reither, Klaus, Ignatius, Ralf, Weitzel, Thomas, Seidu-Korkor, Andrew, Anyidoho, Louis, Saad, Eiman, ...

Background Acute diarrhoea is a major cause of childhood morbidity and mortality in sub-Saharan Africa. Its microbiological causes and clinico-epidemiological aspects were examined during the dry...

Sexually transmitted infections, bacterial vaginosis, and candidiasis in women of reproductive age in rural Northeast Brazil: a population-based study (2007)

Oliveira,Fabíola Araújo, Pfleger,Viola, Lang,Katrin, Heukelbach,Jörg, Miralles,Iracema, Fraga,Francisco, ...

Population-based data on sexually transmitted infections (STI), bacterial vaginosis (BV), and candidiasis reflect the epidemiological situation more accurately than studies performed in specific...

Bartonella henselae-Specific Cell-Mediated Immune Responses Display a Predominantly Th1 Phenotype in Experimentally Infected C57BL/6 Mice

Arvand, Mardjan, Ignatius, Ralf, Regnath, Thomas, Hahn, Helmut, Mielke, Martin E. A.

Immune responses of the immunocompetent host to Bartonella henselae infection were investigated in the murine infection model using C57BL/6 mice. Following intraperitoneal infection with...

The Decreased Replicative Capacity of Simian Immunodeficiency Virus SIVmac239Δnef Is Manifest in Cultures of Immature Dendritic Cells and T Cells

Messmer, Davorka, Ignatius, Ralf, Santisteban, Christine, Steinman, Ralph M., Pope, Melissa

Transmission of simian immunodeficiency virus SIVmac239Δnef (Δnef) to macaques results in attenuated replication of the virus in most animals and ultimately induces protection against challenge...

Canarypox Virus-Induced Maturation of Dendritic Cells Is Mediated by Apoptotic Cell Death and Tumor Necrosis Factor Alpha Secretion

Ignatius, Ralf, Marovich, Mary, Mehlhop, Erin, Villamide, Loreley, Mahnke, Karsten, Cox, William I., ...

Recombinant avipox viruses are being widely evaluated as vaccines. To address how these viruses, which replicate poorly in mammalian cells, might be immunogenic, we studied how canarypox virus...

Increased Macrophage Infection upon Subcutaneous Inoculation of Rhesus Macaques with Simian Immunodeficiency Virus-Loaded Dendritic Cells or T Cells but Not with Cell-Free Virus

Ignatius, Ralf, Tenner-Racz, Klara, Messmer, Davorka, Gettie, Agegnehu, Blanchard, James, Luckay, Amara, ...

Information on the establishment of immunodeficiency virus infection through transmission of infected cells is sparse. Dendritic cells (DCs) and T cells may be central to the onset and subsequent...

Susceptibilities of Campylobacter jejuni Isolates from Germany to Ciprofloxacin, Moxifloxacin, Erythromycin, Clindamycin, and Tetracycline

Wagner, Jutta, Jabbusch, Miriam, Eisenblätter, Martin, Hahn, Helmut, Wendt, Constanze, Ignatius, Ralf

To elucidate Campylobacter jejuni resistance to antibiotics in Germany, MICs of ciprofloxacin, moxifloxacin, erythromycin, clindamycin, and tetracycline were determined (using agar dilution) for 144...

Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus

Tenner-Racz, Klara, Hennig, Christiane Stahl, Überla, Klaus, Stoiber, Heribert, Ignatius, Ralf, Heeney, Jonathan, ...

Atraumatic application of attenuated SIVmac239Δnef vaccine to the tonsils of rhesus macaques provided protection against challenge 26 weeks later with infectious SIVmac251 applied through this...

Bartonella henselae-Specific Cell-Mediated Immune Responses Display a Predominantly Th1 Phenotype in Experimentally Infected C57BL/6 Mice

Arvand, Mardjan, Ignatius, Ralf, Regnath, Thomas, Hahn, Helmut, Mielke, Martin E. A.

Immune responses of the immunocompetent host to Bartonella henselae infection were investigated in the murine infection model using C57BL/6 mice. Following intraperitoneal infection with...

The Decreased Replicative Capacity of Simian Immunodeficiency Virus SIVmac239Δnef Is Manifest in Cultures of Immature Dendritic Cells and T Cells

Messmer, Davorka, Ignatius, Ralf, Santisteban, Christine, Steinman, Ralph M., Pope, Melissa

Transmission of simian immunodeficiency virus SIVmac239Δnef (Δnef) to macaques results in attenuated replication of the virus in most animals and ultimately induces protection against challenge...

Canarypox Virus-Induced Maturation of Dendritic Cells Is Mediated by Apoptotic Cell Death and Tumor Necrosis Factor Alpha Secretion

Ignatius, Ralf, Marovich, Mary, Mehlhop, Erin, Villamide, Loreley, Mahnke, Karsten, Cox, William I., ...

Recombinant avipox viruses are being widely evaluated as vaccines. To address how these viruses, which replicate poorly in mammalian cells, might be immunogenic, we studied how canarypox virus...

Increased Macrophage Infection upon Subcutaneous Inoculation of Rhesus Macaques with Simian Immunodeficiency Virus-Loaded Dendritic Cells or T Cells but Not with Cell-Free Virus

Ignatius, Ralf, Tenner-Racz, Klara, Messmer, Davorka, Gettie, Agegnehu, Blanchard, James, Luckay, Amara, ...

Information on the establishment of immunodeficiency virus infection through transmission of infected cells is sparse. Dendritic cells (DCs) and T cells may be central to the onset and subsequent...

Susceptibilities of Campylobacter jejuni Isolates from Germany to Ciprofloxacin, Moxifloxacin, Erythromycin, Clindamycin, and Tetracycline

Wagner, Jutta, Jabbusch, Miriam, Eisenblätter, Martin, Hahn, Helmut, Wendt, Constanze, Ignatius, Ralf

To elucidate Campylobacter jejuni resistance to antibiotics in Germany, MICs of ciprofloxacin, moxifloxacin, erythromycin, clindamycin, and tetracycline were determined (using agar dilution) for 144...

Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus

Tenner-Racz, Klara, Hennig, Christiane Stahl, Überla, Klaus, Stoiber, Heribert, Ignatius, Ralf, Heeney, Jonathan, ...

Atraumatic application of attenuated SIVmac239Δnef vaccine to the tonsils of rhesus macaques provided protection against challenge 26 weeks later with infectious SIVmac251 applied through this...

Acute childhood diarrhoea in northern Ghana: epidemiological, clinical and microbiological characteristics

Reither, Klaus, Ignatius, Ralf, Weitzel, Thomas, Seidu-Korkor, Andrew, Anyidoho, Louis, Saad, Eiman, ...

Field Evaluation of a Rota- and Adenovirus Immunochromatographic Assay Using Stool Samples from Children with Acute Diarrhea in Ghana▿

Weitzel, Thomas, Reither, Klaus, Mockenhaupt, Frank P., Stark, Klaus, Ignatius, Ralf, Saad, Eiman, ...

We evaluated the Rida Quick rotavirus/adenovirus Combi rapid immunochromatographic test (ICT) under field conditions with Ghanaian children with acute diarrhea. Compared to PCR results, sensitivities...

Aetiology of community-acquired, acute gastroenteritis in hospitalised adults: a prospective cohort study

Jansen, Andreas, Stark, Klaus, Kunkel, Jan, Schreier, Eckart, Ignatius, Ralf, Liesenfeld, Oliver, ...

Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

Stahl-Hennig, Christiane, Eisenblätter, Martin, Jasny, Edith, Rzehak, Tamara, Tenner-Racz, Klara, Trumpfheller, Christine, ...

Toll-like receptor (TLR) ligands are being considered as adjuvants for the induction of antigen-specific immune responses, as in the design of vaccines. Polyriboinosinic-polyribocytoidylic acid (poly...

Rapid and Accurate Diagnosis of Human Intestinal Spirochetosis by Fluorescence In Situ Hybridization▿

Schmiedel, Dinah, Epple, Hans-Jörg, Loddenkemper, Christoph, Ignatius, Ralf, Wagner, Jutta, Hammer, Bettina, ...

Human intestinal spirochetosis (HIS) is associated with overgrowth of the large intestine by spirochetes of the genus Brachyspira. The microbiological diagnosis of HIS is hampered by the fastidious...