Role of BRCA gene dysfunction in breast and ovarian cancer predisposition (2000)
Abstract Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two...
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress (2000)
Tibbetts, Randal S., Cortez, David, Brumbaugh, Kathryn M., Scully, Ralph, Livingston, David, Elledge, Stephen J., ...
BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway (1999)
Chen, Junjie, Silver, Daniel P., Cantor, Sharon B., Livingston, David M., Scully, Ralph
The two major hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, are associated with early-onset breast and/or ovarian cancer and encode products that each interact with the product of...
Chen, Junjie, Silver, Daniel P., Walpita, Deepika, Cantor, Sharon B., Gazdar, Adi F., Tomlinson, Gail, ...
BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2...
Mechanisms in transplantation tolerance. (1994)
Thesis (Ph. D.)--University of Cambridge, 1994.
BRCA1 is a component of the RNA polymerase II holoenzyme
Scully, Ralph, Anderson, Stephen F., Chao, David M., Wei, Wanjiang, Ye, Liyan, Young, Richard A., ...
The familial breast–ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme...
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
Bassing, Craig H., Chua, Katrin F., Sekiguchi, JoAnn, Suh, Heikyung, Whitlow, Scott R., Fleming, James C., ...
In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX) in megabase chromatin domains flanking sites of DNA damage. To...
Role of BRCA gene dysfunction in breast and ovarian cancer predisposition
Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major...
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
Tibbetts, Randal S., Cortez, David, Brumbaugh, Kathryn M., Scully, Ralph, Livingston, David, Elledge, Stephen J., ...
The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been implicated in the DNA damage response, as DNA damage induces the...
BRCA1 is a component of the RNA polymerase II holoenzyme
Scully, Ralph, Anderson, Stephen F., Chao, David M., Wei, Wanjiang, Ye, Liyan, Young, Richard A., ...
The familial breast–ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme...
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
Bassing, Craig H., Chua, Katrin F., Sekiguchi, JoAnn, Suh, Heikyung, Whitlow, Scott R., Fleming, James C., ...
In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX) in megabase chromatin domains flanking sites of DNA damage. To...
Role of BRCA gene dysfunction in breast and ovarian cancer predisposition
Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major...
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
Tibbetts, Randal S., Cortez, David, Brumbaugh, Kathryn M., Scully, Ralph, Livingston, David, Elledge, Stephen J., ...
The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been implicated in the DNA damage response, as DNA damage induces the...
Nagaraju, Ganesh, Odate, Shobu, Xie, Anyong, Scully, Ralph
The Rad51 paralog Rad51C has been implicated in the control of homologous recombination. To study the role of Rad51C in vivo in mammalian cells, we analyzed short-tract and long-tract gene conversion...