Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions (2009)
Sos, Martin L., Michel, Kathrin, Zander, Thomas, Weiss, Jonathan, Frommolt, Peter, Peifer, Martin, ...
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. (2009)
Sos, Martin L., Michel, Kathrin, Zander, Thomas, Weiss, Jonathan, Frommolt, Peter, Peifer, Martin, ...
Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. However, no tools...
Major copy proportion analysis of tumor samples using SNP arrays (2008)
Li, Cheng, Beroukhim, Rameen, Weir, Barbara A, Winckler, Wendy, Garraway, Levi A, Sellers, William R, ...
Abstract Background Single nucleotide polymorphisms (SNPs) are the most common genetic variations in the human genome and are useful as genomic markers. Oligonucleotide SNP microarrays have been...
Modeling genomic diversity and tumor dependency in malignant melanoma (2008)
Lin, William M., Baker, Alissa C., Beroukhim, Rameen, Winckler, Wendy, Feng, Whei, Marmion, Jennifer M., ...
Demichelis, Francesca, Greulich, Heidi, Macoska, Jill A., Beroukhim, Rameen, Sellers, William R., Garraway, Levi, ...
Translational research hinges on the ability to make observations in model systems and to implement those findings into clinical applications, such as the development of diagnostic tools or targeted...
Cheng Li, Rameen Beroukhim, Barbara A Weir, Wendy Winckler, Levi A Garraway, William R Sellers, ...
© 2008 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Somatic alterations in cellular DNA underlie almost all human cancers(1). The prospect of targeted therapies(2) and the development of high-resolution, genome-wide approaches(3-8) are now spurring...
Corrigendum: High-throughput oncogene mutation profiling in human cancer. (2007)
Thomas, Roman K, Baker, Alissa C, Debiasi, Ralph M, Winckler, Wendy, Laframboise, Thomas, Lin, William M, ...
Systematic efforts are underway to decipher the genetic changes associated with tumor initiation and progression1, 2. However, widespread clinical application of this information is hampered by an...
High-throughput oncogene mutation profiling in human cancer (2007)
Thomas, Roman K., Baker, Alissa C., Debiasi, Ralph M., Winckler, Wendy, Laframboise, Thomas, Lin, William M., ...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...
BACKGROUND: Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...
Background Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
Jeffrey C. Lee, Igor Vivanco, Rameen Beroukhim, Whei L. Feng, Ralph M. DeBiasi, ...
BackgroundProtein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
Rameen Beroukhim, Ming Lin, Yuhyun Park, Ke Hao, Xiaojun Zhao, Levi A. Garraway, ...
Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on...
Rameen Beroukhim, Ming Lin, Yuhyun Park, Ke Hao, Xiaojun Zhao, Levi Alec Garraway, ...
Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on...
EGFR activation in glioblastoma through novel missense mutations in the extracellular domain (2006)
Lee, Jeffrey C., Huang, Julie H.Y., Beroukhim, Rameen, Feng, Whei L., DeBiasi, R.M., King, J.C., ...
Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis (2005)
Thomas LaFramboise, Barbara A. Weir, Xiaojun Zhao, Rameen Beroukhim, Cheng Li, David Harrington, ...
Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly...
Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis (2005)
Thomas LaFramboise, Barbara Weir, Xiaojun Zhao, Rameen Beroukhim, Cheng Li, David Harrington, ...
Amplification, deletion, and loss-of-heterozygosity (LOH) of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at...
Paez, J. Guillermo, Lin, Ming, Beroukhim, Rameen, Lee, Jeffrey C., Zhao, Xiaojun, Richter, Daniel J., ...
Major efforts are underway to systematically define the somatic and germline genetic variations causally associated with disease. Genome‐wide genetic analysis of actual clinical samples is,...
The proposal focused on the systematic mapping of large-scale genetic alterations in prostate cancer, and relating these mutations to prostate cancer progression. To that end, the proposal suggested...
Paez, J. Guillermo, Lin, Ming, Beroukhim, Rameen, Lee, Jeffrey C., Zhao, Xiaojun, Richter, Daniel J., ...
Major efforts are underway to systematically define the somatic and germline genetic variations causally associated with disease. Genome-wide genetic analysis of actual clinical samples is, however,...
Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis
LaFramboise, Thomas, Weir, Barbara A, Zhao, Xiaojun, Beroukhim, Rameen, Li, Cheng, Harrington, David, ...
Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly...
Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays
Beroukhim, Rameen, Lin, Ming, Park, Yuhyun, Hao, Ke, Zhao, Xiaojun, Garraway, Levi A, ...
Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on...
Paez, J. Guillermo, Lin, Ming, Beroukhim, Rameen, Lee, Jeffrey C., Zhao, Xiaojun, Richter, Daniel J., ...
Major efforts are underway to systematically define the somatic and germline genetic variations causally associated with disease. Genome-wide genetic analysis of actual clinical samples is, however,...
Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis
LaFramboise, Thomas, Weir, Barbara A, Zhao, Xiaojun, Beroukhim, Rameen, Li, Cheng, Harrington, David, ...
Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly...
Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays
Beroukhim, Rameen, Lin, Ming, Park, Yuhyun, Hao, Ke, Zhao, Xiaojun, Garraway, Levi A, ...
Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on...
Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H. Y, Feng, Whei L, DeBiasi, Ralph M, ...
Ingo Mellinghoff and colleagues sequenced theEGFR gene in glioblastoma samples and cell lines and identified missense mutations in the extracellular domain that suggest a new mechanism for EGFR...
Mertz, Kirsten D., Setlur, Sunita R., Dhanasekaran, Saravana M., Demichelis, Francesca, Perner, Sven, Tomlins, Scott, ...
Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5′ region of androgen-regulated TMPRSS2 and an ETS family transcription...
SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines
Demichelis, Francesca, Greulich, Heidi, Macoska, Jill A., Beroukhim, Rameen, Sellers, William R., Garraway, Levi, ...
Translational research hinges on the ability to make observations in model systems and to implement those findings into clinical applications, such as the development of diagnostic tools or targeted...
Major copy proportion analysis of tumor samples using SNP arrays
Li, Cheng, Beroukhim, Rameen, Weir, Barbara A, Winckler, Wendy, Garraway, Levi A, Sellers, William R, ...
Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, ...
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze cancer genomes...
Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions
Sos, Martin L., Michel, Kathrin, Zander, Thomas, Weiss, Jonathan, Frommolt, Peter, Peifer, Martin, ...
Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. However, no tools...
Highly parallel identification of essential genes in cancer cells
Luo, Biao, Cheung, Hiu Wing, Subramanian, Aravind, Sharifnia, Tanaz, Okamoto, Michael, Yang, Xiaoping, ...
More complete knowledge of the molecular mechanisms underlying cancer will improve prevention, diagnosis and treatment. Efforts such as The Cancer Genome Atlas are systematically characterizing the...
Sos, Martin L., Fischer, Stefanie, Ullrich, Roland, Peifer, Martin, Heuckmann, Johannes M., Koker, Mirjam, ...
In cancer, genetically activated proto-oncogenes often induce “upstream” dependency on the activity of the mutant oncoprotein. Therapeutic inhibition of these activated oncoproteins can induce...