Leary, Rebecca J., Lin, Jimmy C., Cummins, Jordan, Boca, Simina, Wood, Laura D., Parsons, D. Williams, ...
We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the...
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma (2007)
Wiencke, John K., Zheng, Shichun, Jelluma, Nanette, Tihan, Tarik, Vandenberg, Scott, Tamgüney, Tanja, ...
Glioblastoma multiforme (GBM) can present as either de novo or secondary tumors arising from previously diagnosed low-grade gliomas. Although these tumor types are phenotypically indistinguishable,...
Persson, Oscar, Krogh, Morten, Saal, Lao, Englund, Elisabet, Liu, Jian, Parsons, Ramon, ...
Abstract is not available
Is the small heat shock protein alphaB-crystallin an oncogene? (2006)
Gruvberger-Saal, Sofia K, Parsons, Ramon
Abstract is not available
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
HLTF gene silencing in human colon cancer. (2002)
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice (2001)
Li, Yi, Podsypanina, Katrina, Liu, Xiufan, Crane, Allison, Tan, Lee K, Parsons, Ramon, ...
Abstract Background Germline mutations in the tumor suppressor PTEN predispose human beings to breast cancer, and genetic and epigenetic alterations of PTEN are also detected in sporadic human breast...
APC truncation and increased {beta}-catenin levels in a human breast cancer cell line (2000)
Schlosshauer, Peter W., Brown, Stephen A., Eisinger, Katarina, Yan, Qingyou, Guglielminetti, Enrica R., Parsons, Ramon, ...
Mutations in the Adenomatous Polyposis Coli (APC) tumor suppressor gene or the β-catenin gene are present in most colon cancers and less frequently in other tumor types. In this study, we screened...
Genetic Dissection of PTEN Signaling Mechanisms in Prostate Cancer (1998)
Keniry, Megan E., Hannon, Greg, Parsons, Ramon
The goal of my traineeship is to employ genetic approaches to investigate PTEN signaling in prostate cancer. My first task was to construct expression vectors for a series of tumor-derived PTEN...
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., ...
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was...
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Myers, Michael P., Stolarov, Javor P., Eng, Charis, Li, Jing, Wang, Steven I., Wigler, Michael H., ...
Protein tyrosine phosphatases (PTPs) have long been thought to play a role in tumor suppression due to their ability to antagonize the growth promoting protein tyrosine kinases. Recently, a candidate...
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
Li, Yi, Podsypanina, Katrina, Liu, Xiufan, Crane, Allison, Tan, Lee K, Parsons, Ramon, ...
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice
Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, ...
PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary...
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
Kwabi-Addo, Bernard, Giri, Dipak, Schmidt, Karen, Podsypanina, Katrina, Parsons, Ramon, Greenberg, Norman, ...
The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of...
PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2
Simpson, Laura, Li, Jing, Liaw, Danny, Hennessy, Ian, Oliner, Jonathan, Christians, Fred, ...
PTEN is a tumor suppressor that antagonizes phosphatidylinositol-3 kinase (PI3K) by dephosphorylating the D3 position of phosphatidylinositol (3,4,5)-triphosphate (PtdIns-3,4,5-P3). Given the...
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice
You, Mingjian James, Castrillon, Diego H., Bastian, Boris C., O'Hagan, Rónán C., Bosenberg, Marcus W., Parsons, Ramon, ...
Dual inactivation of PTEN and INK4a/ARF tumor suppressor genes is a common feature observed in a broad spectrum of human cancer types. To validate functional collaboration between these genes in...
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis
Kim, Minjung J., Cardiff, Robert D., Desai, Nishita, Banach-Petrosky, Whitney A., Parsons, Ramon, Shen, Michael M., ...
Mouse models have provided significant insights into the molecular mechanisms of tumor suppressor gene function. Here we use mouse models of prostate carcinogenesis to demonstrate that the Nkx3.1...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
Is the small heat shock protein αB-crystallin an oncogene?
Gruvberger-Saal, Sofia K., Parsons, Ramon
In the last 5 years, global gene expression profiling has allowed for the subclassification of the heterogeneous disease of breast cancer into new subgroups with prognostic significance. However, for...
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., ...
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was...
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Myers, Michael P., Stolarov, Javor P., Eng, Charis, Li, Jing, Wang, Steven I., Wigler, Michael H., ...
Protein tyrosine phosphatases (PTPs) have long been thought to play a role in tumor suppression due to their ability to antagonize the growth promoting protein tyrosine kinases. Recently, a candidate...
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
Li, Yi, Podsypanina, Katrina, Liu, Xiufan, Crane, Allison, Tan, Lee K, Parsons, Ramon, ...
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice
Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, ...
PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary...
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
Kwabi-Addo, Bernard, Giri, Dipak, Schmidt, Karen, Podsypanina, Katrina, Parsons, Ramon, Greenberg, Norman, ...
The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of...
PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2
Simpson, Laura, Li, Jing, Liaw, Danny, Hennessy, Ian, Oliner, Jonathan, Christians, Fred, ...
PTEN is a tumor suppressor that antagonizes phosphatidylinositol-3 kinase (PI3K) by dephosphorylating the D3 position of phosphatidylinositol (3,4,5)-triphosphate (PtdIns-3,4,5-P3). Given the...
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice
You, Mingjian James, Castrillon, Diego H., Bastian, Boris C., O'Hagan, Rónán C., Bosenberg, Marcus W., Parsons, Ramon, ...
Dual inactivation of PTEN and INK4a/ARF tumor suppressor genes is a common feature observed in a broad spectrum of human cancer types. To validate functional collaboration between these genes in...
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis
Kim, Minjung J., Cardiff, Robert D., Desai, Nishita, Banach-Petrosky, Whitney A., Parsons, Ramon, Shen, Michael M., ...
Mouse models have provided significant insights into the molecular mechanisms of tumor suppressor gene function. Here we use mouse models of prostate carcinogenesis to demonstrate that the Nkx3.1...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
Is the small heat shock protein αB-crystallin an oncogene?
Gruvberger-Saal, Sofia K., Parsons, Ramon
In the last 5 years, global gene expression profiling has allowed for the subclassification of the heterogeneous disease of breast cancer into new subgroups with prognostic significance. However, for...
DNA Mismatch Repair Deficiency Accelerates Endometrial Tumorigenesis in Pten Heterozygous Mice
Wang, Hong, Douglas, Wayne, Lia, Marie, Edelmann, Winfried, Kucherlapati, Raju, Podsypanina, Katrina, ...
PTEN mutation and microsatellite instability are two of the most common genetic alterations in uterine endometrioid carcinoma. Furthermore, previous studies have suggested an association between the...
Nyström-Lahti, Minna, Parsons, Ramon, Sistonen, Pertti, Pylkkänen, Lea, Aaltonen, Lauri A., Leach, Fredrick S., ...
Two susceptibility loci for hereditary nonpolyposis colo-rectal cancer (HNPCC) have been identified, and each contains a mismatch repair gene: MSH2 on chromosome 2p and MLH1 on chromosome 3p. We...
Saal, Lao H., Johansson, Peter, Holm, Karolina, Gruvberger-Saal, Sofia K., She, Qing-Bai, Maurer, Matthew, ...
Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; however, currently, no reliable test...
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma
Wiencke, John K., Zheng, Shichun, Jelluma, Nanette, Tihan, Tarik, Vandenberg, Scott, Tamgüney, Tanja, ...
Glioblastoma multiforme (GBM) can present as either de novo or secondary tumors arising from previously diagnosed low-grade gliomas. Although these tumor types are phenotypically indistinguishable,...
Cell type-specific DNA methylation patterns in the human breast
Bloushtain-Qimron, Noga, Yao, Jun, Snyder, Eric L., Shipitsin, Michail, Campbell, Lauren L., Mani, Sendurai A., ...
Cellular identity and differentiation are determined by epigenetic programs. The characteristics of these programs in normal human mammary epithelium and their similarity to those in stem cells are...
Leary, Rebecca J., Lin, Jimmy C., Cummins, Jordan, Boca, Simina, Wood, Laura D., Parsons, D. Williams, ...
We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the...
Irs2 Inactivation Suppresses Tumor Progression in Pten+/− Mice
Szabolcs, Matthias, Keniry, Megan, Simpson, Laura, Reid, Latarsha J., Koujak, Susan, Schiff, Sarah C., ...
Mutations in the phosphatase and tensin homologue (PTEN)/phosphatidylinositol-3 kinase-α (PI3K) signaling pathway are frequently found in human cancer. In addition, Pten+/− mice develop tumors in...
PTEN Loss Promotes Mitochondrially Dependent Type II Fas-Induced Apoptosis via PEA-15▿
Peacock, James W., Palmer, Jodie, Fink, Dieter, Ip, Stephen, Pietras, Eric M., Mui, Alice L.-F., ...
Two distinct biochemical signals are delivered by the CD95/Fas death receptor. The molecular basis for the differential mitochondrially independent (type I) and mitochondrially dependent (type II)...
Gab2-Mediated Signaling Promotes Melanoma Metastasis
Horst, Basil, Gruvberger-Saal, Sofia K., Hopkins, Benjamin D., Bordone, Lindsey, Yang, Ying, Chernoff, Karen A., ...
Metastatic melanoma is a disease with a poor prognosis that currently lacks effective treatments. Critical biological features of metastasis include acquisition of migratory competence, growth factor...