Gupta, Rana K., Gao, Nan, Gorski, Regina K., White, Peter, Hardy, Olga T., Rafiq, Kiran, ...
The failure to expand functional pancreatic β-cell mass in response to increased metabolic demand is a hallmark of type 2 diabetes. Lineage tracing studies indicate that replication of existing...
The role of HNF-4alpha in the pancreatic beta-cell (2006)
Diabetes mellitus is a metabolic disorder that currently affects over 180 million people worldwide. Common to all forms of diabetes is the progressive loss of functional insulin-producing...
Olga T. Hardy, Hans E. Hohmeier, Thomas C. Becker, Elisabetta M, Nicolai M. Doliba, Rana K. Gupta, ...
Recent advances in functional genomics afford the opportunity to interrogate the expression profiles of thousands of genes simultaneously and examine the function of these genes in a high-throughput...
The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion
Gupta, Rana K., Vatamaniuk, Marko Z., Lee, Catherine S., Flaschen, Reed C., Fulmer, James T., Matschinsky, Franz M., ...
Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in maturity-onset diabetes of the young (MODY). To determine the contribution of HNF-4α to the maintenance of glucose...
The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion
Gupta, Rana K., Vatamaniuk, Marko Z., Lee, Catherine S., Flaschen, Reed C., Fulmer, James T., Matschinsky, Franz M., ...
Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in maturity-onset diabetes of the young (MODY). To determine the contribution of HNF-4α to the maintenance of glucose...
Expansion of adult β-cell mass in response to increased metabolic demand is dependent on HNF-4α
Gupta, Rana K., Gao, Nan, Gorski, Regina K., White, Peter, Hardy, Olga T., Rafiq, Kiran, ...
The failure to expand functional pancreatic β-cell mass in response to increased metabolic demand is a hallmark of type 2 diabetes. Lineage tracing studies indicate that replication of existing...