Renukaradhya, Gourapura J., Khan, Masood A., Shaji, Daniel, Brutkiewicz, Randy R.
Natural killer T (NKT) cells are unique T lymphocytes that recognize CD1d-bound lipid antigens and play an important role in both innate and acquired immune responses against infectious diseases and...
Mann, Brandon A., Huang, Julia He, Li, Ping, Chang, Hua-Chen, Slee, Roger B., O'Sullivan, Audrey, ...
Blocking the function of Stat (signal transducer and activator of transcription) proteins, which are critical for antiviral responses, has evolved as a common mechanism for pathogen immune evasion....
Renukaradhya, Gourapura J., Khan, Masood A., Vieira, Marcus A. L., Du, Wenjun, Gervay-Hague, Jacquelyn, Brutkiewicz, Randy R.
Natural killer T (NKT) cells are a T-cell subpopulation known to possess immunoregulatory functions and recognize CD1d molecules. The majority of NKT cells express an invariant T-cell receptor (TCR)...
Khan, Masood A., Sriram, Venkataraman, Renukaradhya, Gourapura J., Du, Wenjun, Gervay-Hague, Jacquelyn, Brutkiewicz, Randy R.
The stimulation of programmed cell death can either enhance or inhibit antigen presentation by classic major histocompatibility complex molecules. In the current study, we report that the induction...
Multiple antigen-specific processing pathways for activating naive CD8+ T cells in vivo (2001)
Norbury, Christopher C., Princiotta, Michael F., Bacik, Igor, Brutkiewicz, Randy R., Wood, Phillip, Elliott, Tim, ...
Current knowledge of the processing of viral Ags into MHC class I-associated ligands is based almost completely on in vitro studies using nonprofessional APCs (pAPCs). This is two steps removed from...
NK cell response to viral infections in beta 2-microglobulin-deficient mice (1995)
Tay, Chin Hun, Welsh, Raymond M., Brutkiewicz, Randy R.
Because class I MHC Ags have been implicated as modulators of target cell sensitivity to NK cell-mediated lysis, the regulation of virus infections and the fate of NK cells and their natural targets...
Effects of virally expressed interleukin-10 on vaccinia virus infection in mice (1993)
Kurilla, Michael G., Swaminathan, Sankar, Welsh, Raymond M., Kieff, Elliott D., Brutkiewicz, Randy R.
To investigate the in vivo role of interleukin-10 (IL-10) in viral infection, we compared infections with a recombinant vaccinia virus (VV) expressing IL-10 (VV-IL10) under control of the VV P7.5...
Brutkiewicz, Randy R., O'Donnell, Carey L., Maciaszek, Joseph Walter, Welsh, Raymond M., Vargas-Cortes, Mauricio
We have previously described a monoclonal antibody (mAb), CZ-1, which reacts with an epitope expressed on most peripheral basophils, natural killer cells, B cells, and CD8+ T cells, but not with most...
The overall emphasis in this thesis is the study of the regulation of virus infections by natural killer (NK) cells. In initial analyses, vaccinia virus (VV)-infected cells were found to be more...
Thesis (Ph. D.)--University of Massachusetts Medical School, 1993.
Brutkiewicz, Randy R., Klaus, Stephen J., Welsh, Raymond M.
A time course study was performed in order to determine if vaccinia virus (VV)-infected targets were more susceptible to murine natural killer (NK) cell-mediated lysis during a discrete period of...
Hobbs, Jacqueline A., Cho, Sungyoo, Roberts, Tonya J., Sriram, Venkataraman, Zhang, Jianhua, Xu, Ming, ...
Natural killer T (NKT) cells, a unique subpopulation of T cells, coexpress markers also present on NK cells and recognize the major histocompatibility complex class I-like CD1d1 molecule. We studied...
Sriram, Venkataraman, Cho, Sungyoo, Li, Ping, O'Donnell, Patrick W., Dunn, Claire, Hayakawa, Kyoko, ...
Neoplastic transformation of cells is accompanied by an aberration of cell surface glycolipid composition. These tumor-associated, altered glycosphingolipids are often shed into the tumor cell...
Stanic, Aleksandar K., De Silva, A. Dharshan, Park, Jang-June, Sriram, Venkataraman, Ichikawa, Shinichi, Hirabyashi, Yoshio, ...
Va14Ja18 natural T (NKT) cells play an immunoregulatory role, which is controlled by a self glycolipid(s) presented by CD1d. Although the synthetic antigen α-D-galactosylceramide (α-D-GalCer)...
Hobbs, Jacqueline A., Cho, Sungyoo, Roberts, Tonya J., Sriram, Venkataraman, Zhang, Jianhua, Xu, Ming, ...
Natural killer T (NKT) cells, a unique subpopulation of T cells, coexpress markers also present on NK cells and recognize the major histocompatibility complex class I-like CD1d1 molecule. We studied...
Sriram, Venkataraman, Cho, Sungyoo, Li, Ping, O'Donnell, Patrick W., Dunn, Claire, Hayakawa, Kyoko, ...
Neoplastic transformation of cells is accompanied by an aberration of cell surface glycolipid composition. These tumor-associated, altered glycosphingolipids are often shed into the tumor cell...
Stanic, Aleksandar K., De Silva, A. Dharshan, Park, Jang-June, Sriram, Venkataraman, Ichikawa, Shinichi, Hirabyashi, Yoshio, ...
Va14Ja18 natural T (NKT) cells play an immunoregulatory role, which is controlled by a self glycolipid(s) presented by CD1d. Although the synthetic antigen α-D-galactosylceramide (α-D-GalCer)...
Spence, Philip M, Sriram, Venkataraman, Van Kaer, Luc, Hobbs, Jacqueline A, Brutkiewicz, Randy R
CD1 molecules are cell surface glycoproteins, structurally similar to major histocompatibility complex (MHC) class I molecules. The murine CD1d1 molecule has been shown to be essential for the...
Thymic selection pathway regulates the effector function of CD4 T cells
Li, Wei, Sofi, M. Hanief, Yeh, Norman, Sehra, Sarita, McCarthy, Brian P., Patel, Dipak R., ...
Recently, a new developmental pathway for CD4 T cells that is mediated by major histocompatibility complex class II–positive thymocytes was identified (Choi, E.Y., K.C. Jung, H.J. Park, D.H. Chung,...
Importance of N-linked glycosylation in the functional expression of murine CD1d1
Sriram, Venkataraman, Willard, Claire A, Liu, Jianyun, Brutkiewicz, Randy R
The mouse CD1d1 glycoprotein is specialized in presenting lipid antigens to a novel class of T cells called natural killer T (NKT) cells. CD1d1 is predicted to contain five potential N-linked...
Renukaradhya, Gourapura J., Khan, Masood A., Shaji, Daniel, Brutkiewicz, Randy R.
Natural killer T (NKT) cells are unique T lymphocytes that recognize CD1d-bound lipid antigens and play an important role in both innate and acquired immune responses against infectious diseases and...
Khan, Masood A, Sriram, Venkataraman, Renukaradhya, Gourapura J, Du, Wenjun, Gervay-Hague, Jacquelyn, Brutkiewicz, Randy R
The stimulation of programmed cell death can either enhance or inhibit antigen presentation by classic major histocompatibility complex molecules. In the current study, we report that the induction...