Rebecca A. O'Donnell

Molecular Identification of a Malaria Merozoite Surface Sheddase (2005)

Philippa K. Harris, Sharon Yeoh, Anton R. Dluzewski, Rebecca A. O'Donnell, Chrislaine Withers-Martinez, Fiona Hackett, ...

Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the parasites disengage adhesin-receptor...

The Fine Specificity, but Not the Invasion Inhibitory Activity, of 19-Kilodalton Merozoite Surface Protein 1-Specific Antibodies Is Associated with Resistance to Malarial Parasitemia in a Cross-Sectional Survey in The Gambia†

Corran, Patrick H., O'Donnell, Rebecca A., Todd, Jim, Uthaipibull, Chairat, Holder, Anthony A., Crabb, Brendan S., ...

In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-119)-specific erythrocyte invasion...

Molecular Identification of a Malaria Merozoite Surface Sheddase

Harris, Philippa K, Yeoh, Sharon, Dluzewski, Anton R, O'Donnell, Rebecca A, Withers-Martinez, Chrislaine, Hackett, Fiona, ...

Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the parasites disengage adhesin-receptor...

A Set of Glycosylphosphatidyl Inositol-Anchored Membrane Proteins of Plasmodium falciparum Is Refractory to Genetic Deletion

Sanders, Paul R., Kats, Lev M., Drew, Damien R., O'Donnell, Rebecca A., O'Neill, Matthew, Maier, Alexander G., ...

Targeted gene disruption has proved to be a powerful approach for studying the function of important ligands involved in erythrocyte invasion by the extracellular merozoite form of the human malaria...

The Fine Specificity, but Not the Invasion Inhibitory Activity, of 19-Kilodalton Merozoite Surface Protein 1-Specific Antibodies Is Associated with Resistance to Malarial Parasitemia in a Cross-Sectional Survey in The Gambia†

Corran, Patrick H., O'Donnell, Rebecca A., Todd, Jim, Uthaipibull, Chairat, Holder, Anthony A., Crabb, Brendan S., ...

In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-119)-specific erythrocyte invasion...

Molecular Identification of a Malaria Merozoite Surface Sheddase

Harris, Philippa K, Yeoh, Sharon, Dluzewski, Anton R, O'Donnell, Rebecca A, Withers-Martinez, Chrislaine, Hackett, Fiona, ...

Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the parasites disengage adhesin-receptor...

A Set of Glycosylphosphatidyl Inositol-Anchored Membrane Proteins of Plasmodium falciparum Is Refractory to Genetic Deletion

Sanders, Paul R., Kats, Lev M., Drew, Damien R., O'Donnell, Rebecca A., O'Neill, Matthew, Maier, Alexander G., ...

Targeted gene disruption has proved to be a powerful approach for studying the function of important ligands involved in erythrocyte invasion by the extracellular merozoite form of the human malaria...

Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development.

Cowman, Alan F, Baldi, Deborah L, Duraisingh, Manoj, Healer, Julie, Mills, Kerry E, O'Donnell, Rebecca A, ...

Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative...

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

O'Donnell, Rebecca A., Hackett, Fiona, Howell, Steven A., Treeck, Moritz, Struck, Nicole, Krnajski, Zita, ...

Apicomplexan pathogens are obligate intracellular parasites. To enter cells, they must bind with high affinity to host cell receptors and then uncouple these interactions to complete invasion....

A New Rodent Model to Assess Blood Stage Immunity to the Plasmodium falciparum Antigen Merozoite Surface Protein 119 Reveals a Protective Role for Invasion Inhibitory Antibodies

O'Donnell, Rebecca A., Drew, Damien R., Thomson, Russell, Speed, Terence P., Crabb, Brendan S.

Antibodies capable of inhibiting the invasion of Plasmodium merozoites into erythrocytes are present in individuals that are clinically immune to the malaria parasite. Those targeting the 19-kD...

Antibodies against Merozoite Surface Protein (Msp)-119 Are a Major Component of the Invasion-Inhibitory Response in Individuals Immune to Malaria

O'Donnell, Rebecca A., Burt, Rachel A., Bockarie, Moses, Reeder, John C., Cowman, Alan F., ...

Antibodies that bind to antigens expressed on the merozoite form of the malaria parasite can inhibit parasite growth by preventing merozoite invasion of red blood cells. Inhibitory antibodies are...

Deletion of the Plasmodium falciparum Merozoite Surface Protein 7 Gene Impairs Parasite Invasion of Erythrocytes▿

Kadekoppala, Madhusudan, O'Donnell, Rebecca A., Grainger, Munira, Crabb, Brendan S., Holder, Anthony A.

Merozoite surface proteins have been implicated in the initial attachment to the host red blood cell membrane that begins the process of invasion, an important step in the life cycle of the malaria...

A Novel Family of Apicomplexan Glideosome-associated Proteins with an Inner Membrane-anchoring Role*

Bullen, Hayley E., Tonkin, Christopher J., O'Donnell, Rebecca A., Tham, Wai-Hong, Papenfuss, Anthony T., Gould, Sven, ...

The phylum Apicomplexa are a group of obligate intracellular parasites responsible for a wide range of important diseases. Central to the lifecycle of these unicellular parasites is their ability to...