Oda, Mayumi, Glass, Jacob L., Thompson, Reid F., Mo, Yongkai, Olivier, Emmanuel N., Figueroa, Maria E., ...
Many genome-wide assays involve the generation of a subset (or representation) of the genome following restriction enzyme digestion. The use of enzymes sensitive to cytosine methylation allows...
Thompson, Reid F., Suzuki, Masako, Lau, Kevin W., Greally, John M.
Motivation: DNA cytosine methylation is an important epigenetic regulator, critical for mammalian development and the control of gene expression. Numerous techniques using either restriction enzyme...
An analytical pipeline for genomic representations used for cytosine methylation studies (2008)
Thompson, Reid F., Reimers, Mark, Khulan, Batbayar, Gissot, Mathieu, Richmond, Todd A., Chen, Quan, ...
Motivation: Representations of the genome can be generated by the selection of a subpopulation of restriction fragments using ligation-mediated PCR. Such representations form the basis for a number...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay (2006)
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay (2006)
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
Comparative isoschizomer profiling of cytosine methylation: The HELP assay
Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...
The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...
CG dinucleotide clustering is a species-specific property of the genome
Glass, Jacob L., Thompson, Reid F., Khulan, Batbayar, Figueroa, Maria E., Olivier, Emmanuel N., Oakley, Erin J., ...
Cytosines at cytosine-guanine (CG) dinucleotides are the near-exclusive target of DNA methyltransferases in mammalian genomes. Spontaneous deamination of methylcytosine to thymine makes methylated...
An Integrative Genomic and Epigenomic Approach for the Study of Transcriptional Regulation
Figueroa, Maria E., Reimers, Mark, Thompson, Reid F., Ye, Kenny, Li, Yushan, Selzer, Rebecca R., ...
The molecular heterogeneity of acute leukemias and other tumors constitutes a major obstacle towards understanding disease pathogenesis and developing new targeted-therapies. Aberrant gene regulation...
Toxoplasma gondii and Cryptosporidium parvum Lack Detectable DNA Cytosine Methylation▿
Gissot, Mathieu, Choi, Sang-Woon, Thompson, Reid F., Greally, John M., Kim, Kami
Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine...
Oda, Mayumi, Glass, Jacob L., Thompson, Reid F., Mo, Yongkai, Olivier, Emmanuel N., Figueroa, Maria E., ...
Many genome-wide assays involve the generation of a subset (or representation) of the genome following restriction enzyme digestion. The use of enzymes sensitive to cytosine methylation allows...
Enhanced activation of a “nutrient-sensing” pathway with age contributes to insulin resistance
Einstein, Francine H., Fishman, Sigal, Bauman, Jeffery, Thompson, Reid F., Huffman, Derek M., Atzmon, Gil, ...
Calorie restriction improves life span whereas nutrient excess leads to obesity and unfavorable metabolic consequences, supporting the role for a cellular “nutrient sensor” in aging. Hexosamine...