Colorectal Adenoma and Cancer Divergence Evidence of Multilineage Progression (2008)
Jen-lan Tsao, Simon Tavaré, Reijo Salovaara, Jeremy R. Jass, Lauri A. Aaltonen, Darryl Shibata
Colorectal cancer progression involves changes in phenotype and genotype. Although usually illustrated as a linear process, more complex underlying pathways have not been excluded. The object of this...
Molecular pathology of hereditary colon cancer / (2004)
Diss. -- Helsingin yliopisto.
Genetic reconstruction of individual colorectal tumor histories
Tsao, Jen-Lan, Yatabe, Yasushi, Salovaara, Reijo, Järvinen, Heikki J., Mecklin, Jukka-Pekka, Aaltonen, Lauri A., ...
It is difficult to observe human tumor progression as precursor lesions are systematically removed. Alternatives to direct observations, commonly used to reveal the hidden past of species and...
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers
Kuismanen, Shannon A., Holmberg, Mari T., Salovaara, Reijo, Schweizer, Pascal, Aaltonen, Lauri A., De La Chapelle, Albert, ...
Aberrant DNA methylation is a common phenomenon in human cancer, but its patterns, causes, and consequences are poorly defined. Promoter methylation of the DNA mismatch repair gene MutL homologue...
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
Zhou, Xiao-Ping, Woodford-Richens, Kelly, Lehtonen, Rainer, Kurose, Keisuke, Aldred, Micheala, Hampel, Heather, ...
Juvenile polyposis syndrome (JPS) is an inherited hamartomatous-polyposis syndrome with a risk for colon cancer. JPS is a clinical diagnosis by exclusion, and, before susceptibility genes were...
Genetic reconstruction of individual colorectal tumor histories
Tsao, Jen-Lan, Yatabe, Yasushi, Salovaara, Reijo, Järvinen, Heikki J., Mecklin, Jukka-Pekka, Aaltonen, Lauri A., ...
It is difficult to observe human tumor progression as precursor lesions are systematically removed. Alternatives to direct observations, commonly used to reveal the hidden past of species and...
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers
Kuismanen, Shannon A., Holmberg, Mari T., Salovaara, Reijo, Schweizer, Pascal, Aaltonen, Lauri A., De La Chapelle, Albert, ...
Aberrant DNA methylation is a common phenomenon in human cancer, but its patterns, causes, and consequences are poorly defined. Promoter methylation of the DNA mismatch repair gene MutL homologue...
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
Zhou, Xiao-Ping, Woodford-Richens, Kelly, Lehtonen, Rainer, Kurose, Keisuke, Aldred, Micheala, Hampel, Heather, ...
Juvenile polyposis syndrome (JPS) is an inherited hamartomatous-polyposis syndrome with a risk for colon cancer. JPS is a clinical diagnosis by exclusion, and, before susceptibility genes were...
Lehtonen, Rainer, Kiuru, Maija, Vanharanta, Sakari, Sjöberg, Jari, Aaltonen, Leena-Maija, Aittomäki, Kristiina, ...
Germline mutations in the fumarate hydratase (FH) gene at 1q43 predispose to dominantly inherited cutaneous and uterine leiomyomas, uterine leiomyosarcoma, and papillary renal cell cancer (HLRCC...
Colorectal Pretumor Progression Before and After Loss of DNA Mismatch Repair
Calabrese, Peter, Tsao, Jen-Lan, Yatabe, Yasushi, Salovaara, Reijo, Mecklin, Jukka-Pekka, Järvinen, Heikki J., ...
A pretumor progression model predicts many oncogenic cancer mutations may first accumulate in normal appearing colon. Although direct observations of early pretumor mutations are impractical, it may...
Kuismanen, Shannon A., Holmberg, Mari T., Salovaara, Reijo, De La Chapelle, Albert, Peltomäki, Päivi
Microsatellite instability (MSI) is a hallmark of hereditary nonpolyposis colorectal cancer, and in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 and MLH1....
Tsao, Jen-Lan, Zhang, Jingsong, Salovaara, Reijo, Li, Zhi-Hua, Järvinen, Heikki J., Mecklin, Jukka-Pekka, ...
Occult aspects of tumor proliferation are likely recorded genetically as their microsatellite (MS) loci become polymorphic. However, MS mutations generated by division may also be eliminated with...
Microsatellite Instability in Adenomas as a Marker for Hereditary Nonpolyposis Colorectal Cancer
Loukola, Anu, Salovaara, Reijo, Kristo, Paula, Moisio, Anu-Liisa, Kääriäinen, Helena, Ahtola, Heikki, ...
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common of the well-defined colorectal cancer syndromes, accounting for at least 2% of the total colorectal cancer burden and carrying a...
LKB1 Somatic Mutations in Sporadic Tumors
Avizienyte, Egle, Loukola, Anu, Roth, Stina, Hemminki, Akseli, Tarkkanen, Maija, Salovaara, Reijo, ...
Germline mutations of LKB1/Peutz-Jeghers syndrome gene predispose carriers to hamartomatous polyposis of the gastrointestinal tract as well as to cancer of different organ systems. Although...
Lassus, Heini, Salovaara, Reijo, Aaltonen, Lauri A., Butzow, Ralf
The distal half of chromosome arm 18q is frequently lost in ovarian carcinoma. To define the putative tumor suppressor locus/loci more precisely we performed allelic analysis with 27 polymorphic...
Kiuru, Maija, Launonen, Virpi, Hietala, Marja, Aittomäki, Kristiina, Vierimaa, Outi, Salovaara, Reijo, ...
Little has been known about the molecular background of familial multiple cutaneous leiomyomatosis (MCL). We report here a clinical, histopathological, and molecular study of a multiple cutaneous...
Woodford-Richens, Kelly L., Rowan, Andrew J., Poulsom, Richard, Bevan, Stephen, Salovaara, Reijo, Aaltonen, Lauri A., ...
Juvenile polyposis syndrome (JPS; OMIM 174900) is a rare disorder which is characterized by the presence of hamartomatous polyps throughout the gastrointestinal tract and an increased risk of...
Zhou, Xiao-Ping, Loukola, Anu, Salovaara, Reijo, Nystrom-Lahti, Minna, Peltomäki, Päivi, De La Chapelle, Albert, ...
PTEN on 10q23.3 encodes a dual-specificity phosphatase that negatively regulates the phosphoinositol-3-kinase/Akt pathway and mediates cell-cycle arrest and apoptosis. Germline PTEN mutations cause...
Kuismanen, Shannon A., Moisio, Anu-Liisa, Schweizer, Pascal, Truninger, Kaspar, Salovaara, Reijo, Arola, Johanna, ...
The colorectum and uterine endometrium are the two most commonly affected organs in hereditary nonpolyposis colon cancer (HNPCC), but the genetic basis of organ selection is poorly understood. As...
PolyA Deletions in Hereditary Nonpolyposis Colorectal Cancer : Mutations Before a Gatekeeper
Kim, Kyoung-Mee, Salovaara, Reijo, Mecklin, Jukka-Pekka, Järvinen, Heikki J., Aaltonen, Lauri A., Shibata, Darryl
Microsatellite instability (MSI) secondary to loss of DNA mismatch repair (MMR) is present in adenomas and colorectal carcinomas from individuals with hereditary nonpolyposis colorectal cancer...
Colorectal Adenoma and Cancer Divergence : Evidence of Multilineage Progression
Tsao, Jen-Lan, Tavaré, Simon, Salovaara, Reijo, Jass, Jeremy R., Aaltonen, Lauri A., Shibata, Darryl
Colorectal cancer progression involves changes in phenotype and genotype. Although usually illustrated as a linear process, more complex underlying pathways have not been excluded. The object of this...