Imagawa, Kiwamu, Fang, Yue, Sugiura, Reiko, Zhou, Xin, Ma, Yan, Kuno, Takayoshi
We have previously demonstrated that calcineurin and the Pmk1 MAP kinasepathway play an antagonistic role in Cl– homeostasis. Using this relationship, wescreened for mutations that show vic...
Studies on Fungal Pumilio Gene Family through Mining Multiple Genome-Scale Data Sets (2007)
Matsushima, Yutaka, Sugiura, Reiko, Kuno, Takayoshi
The genes belonging to Pumilio gene family of the fission yeast Schizosaccharomycespombe (S. pombe) were compared with genome information of the several fungi andtheir functions have been inferred...
Miyamoto, Rumi, Sugiura, Reiko, Kamitani, Shinya, Yada, Tomoko, Lu, Yabin, Sio, Susie O., ...
Lithium is the drug of choice for the treatment of bipolar affective disorder. The identification of an in vivo target of lithium in fission yeast as a model organism may help in the understanding of...
Cheng, Hong, Sugiura, Reiko, Wu, Wenlian, Fujita, Masaaki, Lu, Yabin, Sio, Susie O., ...
A genetic screen for mutations synthetically lethal with fission yeast calcineurin deletion led to the identification of Ypt3, a homolog of mammalian Rab11 GTP-binding protein. A mutant with the...
Ogiso, Yasunari, Sugiura, Reiko, Kamo, Tsuneyoshi, Yanagiya, Satoshi, Lu, Yabin, Okazaki, Koei, ...
Ubiquitin-dependent proteolysis plays a pivotal role in stress responses. To investigate the mechanisms of these cellular processes, we have been studying Schizosaccharomyces pombe mutants that have...
Kita, Ayako, Sugiura, Reiko, Shoji, Hiromi, He, Yi, Deng, Lu, Lu, Yabin, ...
Calcineurin is a highly conserved regulator of Ca2+ signaling in eukaryotes. In fission yeast, calcineurin is not essential for viability but is required for cytokinesis and Cl- homeostasis. In a...
Fujita, Masaaki, Sugiura, Reiko, Lu, Yabin, Xu, Linxiao, Xia, Yujie, Shuntoh, Hisato, ...
Calcineurin plays a critical role in Ca(2+) signaling in various cell types. In fission yeast, calcineurin is required for cytokinesis and chloride ion homeostasis. However, most of its physiological...
Miyamoto, Rumi, Sugiura, Reiko, Kamitani, Shinya, Yada, Tomoko, Lu, Yabin, Sio, Susie O., ...
Lithium is the drug of choice for the treatment of bipolar affective disorder. The identification of an in vivo target of lithium in fission yeast as a model organism may help in the understanding of...
Cheng, Hong, Sugiura, Reiko, Wu, Wenlian, Fujita, Masaaki, Lu, Yabin, Sio, Susie O., ...
A genetic screen for mutations synthetically lethal with fission yeast calcineurin deletion led to the identification of Ypt3, a homolog of mammalian Rab11 GTP-binding protein. A mutant with the...
Ogiso, Yasunari, Sugiura, Reiko, Kamo, Tsuneyoshi, Yanagiya, Satoshi, Lu, Yabin, Okazaki, Koei, ...
Ubiquitin-dependent proteolysis plays a pivotal role in stress responses. To investigate the mechanisms of these cellular processes, we have been studying Schizosaccharomyces pombe mutants that have...
Kita, Ayako, Sugiura, Reiko, Shoji, Hiromi, He, Yi, Deng, Lu, Lu, Yabin, ...
Calcineurin is a highly conserved regulator of Ca2+ signaling in eukaryotes. In fission yeast, calcineurin is not essential for viability but is required for cytokinesis and Cl- homeostasis. In a...
Fujita, Masaaki, Sugiura, Reiko, Lu, Yabin, Xu, Linxiao, Xia, Yujie, Shuntoh, Hisato, ...
Calcineurin plays a critical role in Ca(2+) signaling in various cell types. In fission yeast, calcineurin is required for cytokinesis and chloride ion homeostasis. However, most of its physiological...
Deng, Lu, Sugiura, Reiko, Takeuchi, Mai, Suzuki, Masahiro, Ebina, Hidemine, Takami, Tomonori, ...
In fission yeast, calcineurin dephosphorylates and activates the Prz1 transcription factor. Here, we identified the calcineurin-dependent response element (CDRE) in the promoter region of prz1+ gene...
Ma, Yan, Kuno, Takayoshi, Kita, Ayako, Asayama, Yuta, Sugiura, Reiko
We have previously demonstrated that knockout of the calcineurin gene or inhibition of calcineurin activity by immunosuppressants resulted in hypersensitivity to Cl− in fission yeast. We also...
Ma, Yan, Kuno, Takayoshi, Kita, Ayako, Nabata, Toshiya, Uno, Satoshi, Sugiura, Reiko
We have previously identified mutant alleles of genes encoding two Rab proteins, Ypt3 and Ryh1, through a genetic screen using the immunosuppressant drug FK506 in fission yeast. In the same screen,...
Valproic Acid Affects Membrane Trafficking and Cell-Wall Integrity in Fission Yeast
Miyatake, Makoto, Kuno, Takayoshi, Kita, Ayako, Katsura, Kosaku, Takegawa, Kaoru, Uno, Satoshi, ...
Valproic acid (VPA) is widely used to treat epilepsy and manic-depressive illness. Although VPA has been reported to exert a variety of biochemical effects, the exact mechanisms underlying its...
Kagota, Satomi, Tamashiro, Akiko, Yamaguchi, Yu, Sugiura, Reiko, Kuno, Takayoshi, Nakamura, Kazuki, ...
Cyclic guanosine monophosphate (cyclic GMP)-mediated mechanism plays an important role in vasodilatation and blood pressure regulation. We investigated the effects of high salt intake on the nitric...
Takada, Hirofumi, Nishimura, Masayuki, Asayama, Yuta, Mannse, Yoshiaki, Ishiwata, Shunji, Kita, Ayako, ...
In fission yeast, knockout of the calcineurin gene resulted in hypersensitivity to Cl−, and the overexpression of pmp1+ encoding a dual-specificity phosphatase for Pmk1 mitogen-activated protein...
Fang, Yue, Sugiura, Reiko, Ma, Yan, Yada-Matsushima, Tomoko, Umeno, Hirotatsu, Kuno, Takayoshi
We screened for mutations that confer sensitivities to the calcineurin inhibitor FK506 and to a high concentration of MgCl2 and isolated the cis4-1 mutant, an allele of the gene encoding a cation...
Satoh, Ryosuke, Morita, Takahiro, Takada, Hirofumi, Kita, Ayako, Ishiwata, Shunji, Doi, Akira, ...
Myosin II is an essential component of the actomyosin contractile ring and plays a crucial role in cytokinesis by generating the forces necessary for contraction of the actomyosin ring. Cdc4 is an...